Best TWAS P=9.8e-10 · Best GWAS P=1.25e-09 conditioned to 0.195
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHCHD2 | 0.24 | 0.28 | lasso | 5 | 0.37 | 3.0e-47 | -3.2 | -5.1 | 2.9e-07 | -0.79 | 0.96 | 0.04 | FALSE |
| 2 | GTEx | Adrenal Gland | ZNF713 | 0.22 | 0.18 | lasso | 8 | 0.14 | 7.0e-06 | -6.0 | 6.0 | 1.9e-09 | 0.81 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | CHCHD2 | 0.15 | 0.00 | enet | 13 | 0.02 | 7.6e-02 | 6.1 | -5.7 | 1.1e-08 | -0.66 | 0.03 | 0.58 | FALSE |
| 4 | GTEx | Brain Cortex | CHCHD2 | 0.20 | 0.00 | enet | 14 | 0.08 | 3.8e-03 | -3.2 | -5.9 | 3.1e-09 | -0.78 | 0.02 | 0.84 | FALSE |
| 5 | GTEx | Heart Left Ventricle | CHCHD2 | 0.14 | 0.02 | enet | 24 | 0.11 | 1.6e-06 | -3.2 | -5.5 | 4.9e-08 | -0.77 | 0.02 | 0.97 | FALSE |
| 6 | GTEx | Muscle Skeletal | CHCHD2 | 0.08 | 0.01 | enet | 13 | 0.04 | 6.3e-05 | -6.0 | -6.0 | 1.6e-09 | -0.69 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Pancreas | CHCHD2 | 0.16 | 0.05 | lasso | 4 | 0.04 | 7.3e-03 | 6.1 | -6.1 | 9.8e-10 | -0.90 | 0.00 | 0.99 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CHCHD2 | 0.22 | 0.21 | lasso | 7 | 0.31 | 4.1e-41 | -3.3 | -5.4 | 6.7e-08 | -0.80 | 0.55 | 0.44 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUMF2 | 0.04 | 0.04 | enet | 5 | 0.04 | 1.4e-05 | 6.1 | 6.0 | 2.5e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PHKG1 | 0.07 | 0.06 | enet | 4 | 0.06 | 3.9e-06 | -5.6 | -5.6 | 2.2e-08 | -0.96 | 0.00 | 1.00 | FALSE |