Best TWAS P=6.42e-63 · Best GWAS P=7.47e-98 conditioned to 0.00188
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FIGNL1 | 0.21 | 0.21 | enet | 34 | 0.25 | 6.8e-30 | -7.24 | -8.7 | 5.3e-18 | -0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | FIGNL1 | 0.36 | 0.31 | enet | 37 | 0.43 | 5.3e-38 | -8.02 | -9.3 | 1.5e-20 | -0.43 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | FIGNL1 | 0.21 | 0.15 | lasso | 7 | 0.17 | 5.3e-09 | -7.24 | -8.9 | 4.5e-19 | -0.45 | 0.98 | 0.02 | FALSE |
| 4 | GTEx | Adrenal Gland | FIGNL1 | 0.43 | 0.40 | enet | 20 | 0.44 | 3.6e-17 | -7.24 | -9.6 | 8.8e-22 | -0.43 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | FIGNL1 | 0.31 | 0.27 | enet | 13 | 0.30 | 9.4e-17 | -7.24 | -7.4 | 1.3e-13 | -0.38 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | FIGNL1 | 0.30 | 0.07 | enet | 10 | 0.19 | 4.2e-07 | 8.60 | -10.3 | 8.1e-25 | -0.54 | 0.06 | 0.93 | FALSE |
| 7 | GTEx | Artery Tibial | FIGNL1 | 0.31 | 0.26 | lasso | 12 | 0.28 | 2.5e-22 | -7.88 | -9.6 | 1.3e-21 | -0.45 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Brain Caudate basal ganglia | FIGNL1 | 0.18 | 0.13 | lasso | 3 | 0.12 | 2.4e-04 | 9.32 | -9.4 | 3.4e-21 | -0.50 | 0.16 | 0.38 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | FIGNL1 | 0.49 | 0.48 | lasso | 7 | 0.54 | 3.0e-16 | 9.32 | -9.2 | 3.0e-20 | -0.45 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Brain Cerebellum | FIGNL1 | 0.54 | 0.54 | enet | 13 | 0.50 | 5.9e-17 | -7.24 | -8.7 | 2.9e-18 | -0.42 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Cortex | FIGNL1 | 0.27 | 0.17 | lasso | 4 | 0.17 | 1.8e-05 | 9.32 | -10.4 | 1.8e-25 | -0.52 | 0.18 | 0.46 | FALSE |
| 12 | GTEx | Brain Frontal Cortex BA9 | FIGNL1 | 0.24 | 0.19 | enet | 9 | 0.25 | 2.2e-07 | 9.32 | -8.1 | 5.9e-16 | -0.41 | 0.85 | 0.05 | FALSE |
| 13 | GTEx | Brain Hypothalamus | FIGNL1 | 0.27 | 0.09 | enet | 26 | 0.18 | 5.9e-05 | 9.32 | -10.2 | 2.6e-24 | -0.51 | 0.18 | 0.67 | FALSE |
| 14 | GTEx | Breast Mammary Tissue | FIGNL1 | 0.41 | 0.37 | lasso | 16 | 0.37 | 3.5e-20 | -7.88 | -8.6 | 8.6e-18 | -0.43 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Cells EBV-transformed lymphocytes | FIGNL1 | 0.31 | 0.28 | lasso | 15 | 0.33 | 1.6e-11 | -7.24 | -9.4 | 5.3e-21 | -0.46 | 0.98 | 0.01 | FALSE |
| 16 | GTEx | Cells Transformed fibroblasts | FIGNL1 | 0.18 | 0.10 | lasso | 7 | 0.17 | 1.2e-12 | -5.44 | -9.8 | 1.2e-22 | -0.42 | 0.97 | 0.03 | FALSE |
| 17 | GTEx | Colon Sigmoid | FIGNL1 | 0.21 | 0.21 | lasso | 4 | 0.25 | 2.0e-09 | -7.24 | -8.9 | 6.9e-19 | -0.45 | 0.93 | 0.05 | FALSE |
| 18 | GTEx | Colon Transverse | FIGNL1 | 0.32 | 0.28 | enet | 18 | 0.26 | 1.8e-12 | -7.88 | -8.5 | 2.1e-17 | -0.39 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Esophagus Gastroesophageal Junction | FIGNL1 | 0.40 | 0.23 | enet | 26 | 0.26 | 5.2e-10 | -8.02 | -9.5 | 1.9e-21 | -0.43 | 0.89 | 0.10 | FALSE |
| 20 | GTEx | Esophagus Mucosa | FIGNL1 | 0.34 | 0.31 | lasso | 9 | 0.32 | 3.3e-22 | -7.88 | -9.7 | 2.5e-22 | -0.46 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Esophagus Muscularis | FIGNL1 | 0.35 | 0.35 | enet | 20 | 0.35 | 5.0e-22 | -7.88 | -9.5 | 1.4e-21 | -0.46 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Heart Atrial Appendage | FIGNL1 | 0.30 | 0.28 | lasso | 7 | 0.27 | 1.2e-12 | -7.24 | -8.2 | 2.4e-16 | -0.48 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Heart Left Ventricle | FIGNL1 | 0.12 | 0.10 | lasso | 4 | 0.12 | 5.2e-07 | -8.02 | -8.3 | 9.6e-17 | -0.44 | 0.92 | 0.04 | FALSE |
| 24 | GTEx | Lung | FIGNL1 | 0.28 | 0.22 | lasso | 8 | 0.26 | 1.3e-19 | -7.88 | -11.5 | 2.0e-30 | -0.55 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Nerve Tibial | FIGNL1 | 0.36 | 0.36 | enet | 38 | 0.45 | 2.4e-35 | -7.24 | -9.3 | 1.9e-20 | -0.44 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Ovary | FIGNL1 | 0.48 | 0.34 | enet | 11 | 0.29 | 6.3e-08 | -7.88 | -7.6 | 3.5e-14 | -0.41 | 0.73 | 0.11 | FALSE |
| 27 | GTEx | Pancreas | FIGNL1 | 0.36 | 0.28 | enet | 27 | 0.25 | 8.2e-11 | -7.88 | -9.7 | 4.1e-22 | -0.45 | 0.95 | 0.05 | FALSE |
| 28 | GTEx | Pituitary | FIGNL1 | 0.27 | 0.28 | lasso | 4 | 0.24 | 9.2e-07 | -7.24 | -9.7 | 2.8e-22 | -0.51 | 0.09 | 0.77 | FALSE |
| 29 | GTEx | Prostate | FIGNL1 | 0.52 | 0.29 | enet | 13 | 0.40 | 2.6e-11 | -5.00 | -8.4 | 6.4e-17 | -0.38 | 0.42 | 0.57 | FALSE |
| 30 | GTEx | Skin Not Sun Exposed Suprapubic | FIGNL1 | 0.47 | 0.37 | enet | 24 | 0.43 | 1.8e-25 | -5.44 | -8.6 | 9.9e-18 | -0.38 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Skin Sun Exposed Lower leg | FIGNL1 | 0.46 | 0.41 | enet | 16 | 0.49 | 3.9e-46 | -8.02 | -9.2 | 3.0e-20 | -0.45 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Small Intestine Terminal Ileum | FIGNL1 | 0.21 | 0.23 | lasso | 4 | 0.22 | 1.3e-05 | -5.00 | -6.0 | 2.3e-09 | -0.27 | 0.16 | 0.44 | FALSE |
| 33 | GTEx | Spleen | FIGNL1 | 0.58 | 0.48 | enet | 19 | 0.52 | 1.9e-15 | -7.88 | -8.9 | 7.6e-19 | -0.48 | 0.82 | 0.18 | FALSE |
| 34 | GTEx | Stomach | FIGNL1 | 0.30 | 0.12 | enet | 20 | 0.23 | 1.7e-11 | -7.24 | -8.6 | 1.0e-17 | -0.42 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Testis | FIGNL1 | 0.35 | 0.24 | enet | 28 | 0.27 | 3.0e-12 | -7.24 | -9.1 | 9.3e-20 | -0.42 | 1.00 | 0.00 | FALSE |
| 36 | GTEx | Thyroid | FIGNL1 | 0.39 | 0.42 | enet | 11 | 0.42 | 7.5e-35 | -7.24 | -9.6 | 6.6e-22 | -0.46 | 1.00 | 0.00 | FALSE |
| 37 | GTEx | Uterus | FIGNL1 | 0.28 | 0.06 | lasso | 5 | 0.07 | 1.9e-02 | -5.44 | -6.0 | 2.8e-09 | -0.33 | 0.14 | 0.06 | FALSE |
| 38 | GTEx | Vagina | FIGNL1 | 0.37 | 0.05 | lasso | 7 | 0.22 | 1.1e-05 | -7.24 | -16.7 | 6.4e-63 | -0.79 | 0.01 | 0.98 | TRUE |
| 39 | METSIM | Adipose | FIGNL1 | 0.15 | 0.17 | lasso | 12 | 0.15 | 2.2e-21 | -7.24 | -8.0 | 1.3e-15 | -0.43 | 1.00 | 0.00 | TRUE |
| 40 | ROSMAP | Brain Pre-frontal Cortex | FIGNL1 | 0.29 | 0.30 | lasso | 6 | 0.32 | 1.1e-42 | -7.24 | -8.8 | 1.0e-18 | -0.44 | 1.00 | 0.00 | FALSE |
| 41 | YFS | Blood | FIGNL1 | 0.07 | 0.05 | bslmm | 472 | 0.05 | 2.6e-17 | -7.24 | -11.9 | 1.7e-32 | -0.48 | 1.00 | 0.00 | FALSE |
| 42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FIGNL1 | 0.06 | 0.02 | enet | 11 | 0.05 | 6.9e-05 | 9.07 | -10.6 | 1.9e-26 | -0.36 | 0.02 | 0.92 | FALSE |
| 43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FIGNL1 | 0.07 | 0.06 | enet | 9 | 0.06 | 1.9e-12 | -8.02 | -8.5 | 1.3e-17 | -0.44 | 1.00 | 0.00 | FALSE |
| 44 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FIGNL1 | 0.04 | 0.03 | lasso | 1 | 0.02 | 6.2e-03 | -7.24 | -7.2 | 4.6e-13 | -0.39 | 0.02 | 0.35 | FALSE |
| 45 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FIGNL1 | 0.12 | 0.07 | blup | 67 | 0.12 | 1.3e-13 | 9.22 | -9.9 | 2.9e-23 | -0.42 | 0.12 | 0.88 | FALSE |
| 46 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FIGNL1 | 0.19 | 0.10 | enet | 14 | 0.15 | 1.1e-08 | -8.02 | -10.3 | 7.2e-25 | -0.39 | 0.01 | 0.99 | FALSE |
| 47 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FIGNL1 | 0.24 | 0.16 | enet | 21 | 0.15 | 6.5e-17 | -8.02 | -7.6 | 2.7e-14 | -0.31 | 1.00 | 0.00 | FALSE |
| 48 | The Cancer Genome Atlas | Lung Adenocarcinoma | FIGNL1 | 0.03 | 0.01 | blup | 69 | 0.02 | 4.7e-03 | -7.24 | -8.4 | 3.3e-17 | -0.45 | 0.06 | 0.38 | FALSE |
| 49 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FIGNL1 | 0.07 | 0.08 | lasso | 4 | 0.07 | 1.1e-08 | -8.02 | -8.9 | 3.4e-19 | -0.46 | 0.92 | 0.08 | FALSE |
| 50 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IKZF1 | 0.03 | 0.00 | blup | 81 | 0.01 | 3.7e-02 | -0.54 | 6.1 | 1.1e-09 | 0.35 | 0.02 | 0.05 | FALSE |
| 51 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DDC | 0.10 | 0.07 | lasso | 4 | 0.09 | 3.2e-09 | -7.24 | 8.1 | 6.3e-16 | 0.44 | 1.00 | 0.00 | FALSE |
| 52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FIGNL1 | 0.14 | 0.15 | blup | 69 | 0.17 | 2.2e-17 | -8.02 | -8.6 | 9.9e-18 | -0.42 | 1.00 | 0.00 | FALSE |
| 53 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FIGNL1 | 0.06 | 0.06 | lasso | 1 | 0.03 | 3.9e-03 | 9.32 | -9.3 | 1.2e-20 | -0.50 | 0.03 | 0.44 | FALSE |
| 54 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FIGNL1 | 0.05 | 0.00 | blup | 68 | 0.01 | 5.4e-02 | -5.44 | -6.7 | 2.2e-11 | -0.36 | 0.02 | 0.17 | FALSE |
| 55 | The Cancer Genome Atlas | Thyroid Carcinoma | FIGNL1 | 0.16 | 0.10 | lasso | 4 | 0.10 | 3.8e-10 | 9.32 | -9.9 | 5.7e-23 | -0.50 | 0.91 | 0.09 | FALSE |
| 56 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FIGNL1 | 0.13 | 0.13 | lasso | 10 | 0.16 | 2.4e-05 | 8.46 | -8.2 | 1.9e-16 | -0.41 | 0.27 | 0.43 | FALSE |