Best TWAS P=2.23e-10 · Best GWAS P=1.2e-09 conditioned to 0.676
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | METSIM | Adipose | CAPZA2 | 0.05 | 0.04 | lasso | 7 | 0.02 | 1.2e-04 | 5.7 | -6.3 | 2.2e-10 | -0.94 | 0.02 | 0.98 | TRUE |
| 1 | GTEx | Artery Tibial | CAPZA2 | 0.11 | 0.08 | lasso | 4 | 0.08 | 1.3e-06 | 6.1 | -6.2 | 4.1e-10 | -0.99 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Muscularis | CAPZA2 | 0.20 | 0.12 | enet | 19 | 0.15 | 2.3e-09 | 6.0 | -6.2 | 6.9e-10 | -0.95 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CAPZA2 | 0.05 | 0.05 | lasso | 2 | 0.04 | 2.2e-05 | 6.1 | -6.1 | 1.2e-09 | -1.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | CAPZA2 | 0.12 | 0.05 | lasso | 1 | 0.03 | 7.1e-03 | 6.1 | -6.1 | 1.3e-09 | -1.00 | 0.01 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CAPZA2 | 0.04 | 0.00 | blup | 62 | 0.01 | 5.3e-02 | 6.1 | -5.7 | 1.6e-08 | -0.84 | 0.01 | 0.72 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | CAPZA2 | 0.03 | 0.03 | lasso | 1 | 0.02 | 6.8e-04 | 5.3 | -5.3 | 1.4e-07 | -0.81 | 0.04 | 0.75 | FALSE |