Best TWAS P=5.1e-09 · Best GWAS P=1.09e-09 conditioned to 0.162
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | WDR91 | 0.34 | 0.17 | lasso | 11 | 0.12 | 6.5e-05 | -4.7 | 5.4 | 7.8e-08 | -0.56 | 0.32 | 0.64 | FALSE |
| 2 | GTEx | Artery Coronary | C7orf49 | 0.21 | 0.08 | enet | 28 | 0.16 | 3.9e-06 | -3.1 | -5.8 | 7.5e-09 | 0.24 | 0.30 | 0.05 | TRUE |
| 3 | GTEx | Lung | WDR91 | 0.13 | 0.08 | lasso | 3 | 0.07 | 3.6e-06 | -4.5 | 5.3 | 1.3e-07 | -0.38 | 0.80 | 0.17 | TRUE |
| 4 | METSIM | Adipose | AGBL3 | 0.05 | 0.05 | lasso | 1 | 0.03 | 5.8e-06 | 5.8 | 5.8 | 5.1e-09 | -0.63 | 0.01 | 0.99 | TRUE |
| 5 | METSIM | Adipose | WDR91 | 0.08 | 0.07 | lasso | 5 | 0.08 | 1.1e-12 | -3.9 | 5.1 | 3.0e-07 | -0.60 | 0.76 | 0.24 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TMEM140 | 0.04 | 0.01 | bslmm | 449 | 0.02 | 2.0e-03 | 5.4 | -5.4 | 5.7e-08 | 0.50 | 0.24 | 0.46 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | WDR91 | 0.07 | 0.02 | blup | 61 | 0.05 | 2.4e-03 | 3.8 | -5.5 | 4.0e-08 | 0.39 | 0.01 | 0.75 | FALSE |