TWAS
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Models
Genes
Traits
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Traits
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Blood Red Count
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chr1:67,452,322-68,998,658
Best TWAS P=9.13e-13 · Best GWAS P=1.26e-14 conditioned to 0.000253
67.4M
67.6M
67.8M
68M
68.2M
68.4M
68.6M
68.8M
69M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Lung Adenocarcinoma
GNG12
0.05
0.02
lasso
4
0.04
3.1e-05
-5.4
-7.1
9.1e-13
-0.64
0.12
0.86
TRUE
2
METSIM
Adipose
GADD45A
0.05
0.03
enet
35
0.02
1.1e-04
2.4
-5.3
1.4e-07
-0.07
0.47
0.02
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
GNG12
0.04
0.03
enet
9
0.04
1.0e-04
6.4
-6.3
3.0e-10
-0.79
0.15
0.78
FALSE
1
GTEx
Cells Transformed fibroblasts
GNG12
0.19
0.16
lasso
5
0.14
5.0e-11
-5.4
-5.4
6.1e-08
-0.29
1.00
0.00
FALSE