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chr1:88,453,303-90,145,331

Best TWAS P=1.16e-16 · Best GWAS P=8.74e-17 conditioned to 0.00846

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCBL2	0.58	0.68	lasso	7	0.69	1.4e-117	7.0	-7.1	1.1e-12	-0.65	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CCBL2	0.26	0.21	enet	15	0.23	1.2e-18	7.0	-6.5	1.1e-10	-0.61	0.99	0.01	FALSE
3	GTEx	Adipose Visceral Omentum	PKN2	0.09	0.04	enet	8	0.05	1.2e-03	6.7	7.9	2.0e-15	0.67	0.34	0.31	FALSE
4	GTEx	Adipose Visceral Omentum	CCBL2	0.21	0.10	enet	7	0.15	5.2e-08	6.9	-6.7	2.8e-11	-0.66	0.89	0.09	FALSE
5	GTEx	Adrenal Gland	CCBL2	0.18	0.13	enet	46	0.14	1.4e-05	7.4	-5.3	1.3e-07	-0.52	0.16	0.78	FALSE
6	GTEx	Artery Aorta	CCBL2	0.29	0.20	enet	24	0.24	1.5e-13	6.9	-6.2	7.4e-10	-0.59	0.98	0.02	FALSE
7	GTEx	Artery Coronary	CCBL2	0.29	0.19	enet	5	0.14	1.6e-05	7.2	-7.1	9.7e-13	-0.61	0.68	0.14	FALSE
8	GTEx	Artery Tibial	CCBL2	0.30	0.24	lasso	8	0.29	4.9e-23	7.0	-6.3	3.0e-10	-0.67	0.99	0.01	FALSE
9	GTEx	Brain Caudate basal ganglia	CCBL2	0.27	0.21	enet	30	0.29	7.0e-09	6.9	-5.2	1.5e-07	-0.57	0.64	0.32	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CCBL2	0.31	0.18	lasso	5	0.23	1.7e-06	6.7	-8.0	1.1e-15	-0.85	0.04	0.94	FALSE
11	GTEx	Brain Cerebellum	CCBL2	0.39	0.30	enet	23	0.33	1.7e-10	6.9	-5.8	7.4e-09	-0.57	0.66	0.32	FALSE
12	GTEx	Brain Cortex	CCBL2	0.59	0.39	enet	13	0.37	3.0e-11	6.7	-7.2	8.6e-13	-0.68	0.89	0.11	FALSE
13	GTEx	Brain Frontal Cortex BA9	CCBL2	0.47	0.38	enet	25	0.48	1.5e-14	6.9	-6.6	4.8e-11	-0.65	0.76	0.24	FALSE
14	GTEx	Brain Hippocampus	CCBL2	0.39	0.27	lasso	5	0.13	5.1e-04	7.0	6.4	2.1e-10	0.55	0.21	0.29	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	CCBL2	0.38	0.44	enet	20	0.32	2.1e-09	7.1	-7.4	1.5e-13	-0.71	0.59	0.40	FALSE
16	GTEx	Brain Putamen basal ganglia	CCBL2	0.35	0.26	enet	21	0.25	1.2e-06	6.9	-7.3	3.6e-13	-0.57	0.20	0.72	FALSE
17	GTEx	Breast Mammary Tissue	CCBL2	0.15	0.11	lasso	5	0.09	1.8e-05	7.0	-7.0	2.7e-12	-0.59	0.74	0.22	FALSE
18	GTEx	Breast Mammary Tissue (Male)	CCBL2	0.14	0.03	lasso	2	0.02	8.8e-02	7.0	-7.0	2.5e-12	-0.59	0.06	0.24	FALSE
19	GTEx	Cells Transformed fibroblasts	CCBL2	0.65	0.61	enet	32	0.67	6.1e-67	7.0	-6.9	4.7e-12	-0.63	0.99	0.01	FALSE
20	GTEx	Colon Sigmoid	CCBL2	0.22	0.12	enet	4	0.09	5.2e-04	6.9	-6.8	1.3e-11	-0.58	0.37	0.31	FALSE
21	GTEx	Colon Transverse	CCBL2	0.30	0.19	lasso	8	0.26	1.2e-12	6.9	-6.8	1.1e-11	-0.69	0.97	0.03	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CCBL2	0.27	0.20	enet	33	0.18	4.4e-07	6.9	-5.3	9.3e-08	-0.48	0.77	0.05	FALSE
23	GTEx	Esophagus Muscularis	CCBL2	0.25	0.29	enet	18	0.28	1.6e-17	7.0	-7.0	2.3e-12	-0.66	0.99	0.01	FALSE
24	GTEx	Heart Atrial Appendage	CCBL2	0.30	0.20	enet	11	0.15	3.4e-07	7.0	-7.0	1.9e-12	-0.61	0.98	0.02	FALSE
25	GTEx	Lung	CCBL2	0.15	0.13	enet	13	0.17	4.8e-13	6.9	-5.9	3.1e-09	-0.58	0.98	0.02	FALSE
26	GTEx	Muscle Skeletal	CCBL2	0.12	0.15	enet	9	0.16	5.4e-15	7.0	-7.0	2.1e-12	-0.59	0.99	0.01	FALSE
27	GTEx	Nerve Tibial	CCBL2	0.42	0.33	enet	38	0.38	3.4e-28	7.0	-6.8	8.3e-12	-0.60	0.99	0.01	FALSE
28	GTEx	Pancreas	CCBL2	0.26	0.21	lasso	4	0.23	5.3e-10	6.7	-5.2	2.2e-07	-0.68	0.25	0.73	FALSE
29	GTEx	Pituitary	CCBL2	0.45	0.30	lasso	2	0.26	2.7e-07	6.7	-7.2	5.9e-13	-0.71	0.44	0.53	FALSE
30	GTEx	Skin Sun Exposed Lower leg	CCBL2	0.18	0.09	enet	12	0.17	4.0e-14	7.1	-5.2	1.7e-07	-0.57	0.94	0.06	FALSE
31	GTEx	Stomach	CCBL2	0.16	0.08	lasso	4	0.15	9.0e-08	6.9	-7.8	7.0e-15	-0.71	0.10	0.89	FALSE
32	GTEx	Testis	CCBL2	0.47	0.56	lasso	5	0.57	1.2e-30	6.9	-7.0	2.8e-12	-0.59	0.99	0.01	FALSE
33	GTEx	Thyroid	CCBL2	0.22	0.15	enet	22	0.22	9.8e-17	6.7	-6.2	7.4e-10	-0.67	0.97	0.03	FALSE
34	GTEx	Whole Blood	CCBL2	0.08	0.07	lasso	3	0.06	3.1e-06	7.0	-6.9	4.1e-12	-0.54	0.82	0.14	FALSE
35	METSIM	Adipose	CCBL2	0.27	0.14	lasso	6	0.18	6.4e-27	7.0	-7.4	1.4e-13	-0.71	0.99	0.01	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	CCBL2	0.43	0.56	enet	31	0.56	1.1e-87	7.0	-7.4	1.5e-13	-0.67	0.99	0.01	FALSE
37	YFS	Blood	GTF2B	0.01	0.00	lasso	3	0.01	2.3e-04	8.1	8.3	1.2e-16	0.82	0.06	0.79	TRUE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCBL2	0.14	0.09	enet	12	0.10	1.5e-08	6.9	-6.0	1.5e-09	-0.49	0.41	0.59	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCBL2	0.20	0.36	lasso	5	0.36	1.7e-78	6.9	-7.0	2.7e-12	-0.58	0.44	0.56	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	PKN2	0.02	0.01	enet	5	0.01	2.3e-03	5.7	5.6	2.1e-08	0.86	0.03	0.70	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCBL2	0.09	0.08	blup	61	0.07	3.6e-04	7.0	-5.9	3.0e-09	-0.46	0.21	0.71	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	CCBL2	0.23	0.28	lasso	3	0.26	3.9e-15	7.0	-6.7	2.8e-11	-0.52	0.39	0.61	FALSE
43	The Cancer Genome Atlas	Glioblastoma Multiforme	CCBL2	0.36	0.32	enet	37	0.33	6.4e-11	6.9	-6.7	1.7e-11	-0.68	0.10	0.90	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCBL2	0.07	0.06	lasso	2	0.05	1.2e-06	7.0	-6.2	6.8e-10	-0.54	0.23	0.76	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCBL2	0.37	0.48	enet	20	0.50	1.5e-63	6.9	-6.3	3.6e-10	-0.56	0.49	0.51	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCBL2	0.28	0.42	enet	15	0.40	1.5e-24	7.0	-7.0	3.4e-12	-0.60	0.38	0.62	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCBL2	0.28	0.32	enet	24	0.31	2.5e-35	6.9	-7.0	2.1e-12	-0.62	0.40	0.60	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	PKN2	0.05	0.01	enet	8	0.02	1.6e-03	7.4	6.7	2.2e-11	0.79	0.04	0.93	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	CCBL2	0.09	0.12	enet	10	0.11	8.7e-13	7.0	-6.8	8.8e-12	-0.55	0.39	0.61	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCBL2	0.10	0.07	enet	12	0.08	2.0e-09	7.1	-6.1	1.1e-09	-0.55	0.32	0.67	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CCBL2	0.14	0.13	enet	15	0.12	9.7e-09	6.9	-6.0	1.9e-09	-0.40	0.42	0.58	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCBL2	0.15	0.18	lasso	2	0.16	3.5e-07	7.2	-7.2	8.0e-13	-0.63	0.23	0.75	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCBL2	0.37	0.47	enet	19	0.46	3.1e-20	7.1	-7.2	4.3e-13	-0.63	0.37	0.63	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCBL2	0.20	0.34	lasso	2	0.35	9.5e-38	7.1	-7.1	1.6e-12	-0.60	0.37	0.63	FALSE
55	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCBL2	0.35	0.27	lasso	6	0.25	1.7e-06	7.1	-7.2	5.7e-13	-0.62	0.18	0.77	FALSE
56	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCBL2	0.28	0.32	enet	21	0.32	8.7e-20	7.0	-7.0	2.8e-12	-0.60	0.40	0.60	FALSE
57	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CCBL2	0.24	0.20	enet	12	0.17	2.7e-05	6.9	-6.8	7.3e-12	-0.57	0.21	0.44	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCBL2	0.11	0.13	enet	14	0.11	1.7e-08	6.9	-6.8	1.5e-11	-0.56	0.36	0.64	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CCBL2	0.17	0.13	blup	61	0.16	2.4e-06	7.1	-5.5	3.1e-08	-0.37	0.08	0.72	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	CCBL2	0.45	0.64	enet	13	0.66	1.4e-86	7.0	-7.1	1.6e-12	-0.59	0.42	0.58	FALSE
61	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CCBL2	0.20	0.22	enet	16	0.18	8.6e-06	6.9	-6.3	3.0e-10	-0.46	0.20	0.75	FALSE