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chr1:52,457,159-54,234,580

Best TWAS P=2.32e-15 · Best GWAS P=1.22e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Not Sun Exposed Suprapubic	ZYG11B	0.17	0.09	lasso	2	0.12	6.4e-07	-7.8	-7.9	2.3e-15	0.98	0.03	0.96	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	ZYG11B	0.12	0.16	lasso	4	0.15	3.2e-19	-7.8	-7.8	7.0e-15	0.97	0.03	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZYG11B	0.04	0.04	lasso	4	0.04	3.0e-05	-7.5	-7.7	1.5e-14	0.97	0.03	0.97	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	ZYG11B	0.17	-0.01	lasso	7	0.05	1.6e-02	-7.8	-7.6	2.4e-14	0.79	0.03	0.76	FALSE
19	NTR	Blood	ECHDC2	0.03	0.04	lasso	2	0.04	1.9e-12	-7.2	7.5	4.3e-14	-0.90	0.25	0.75	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	ZYG11B	0.20	0.14	enet	9	0.16	1.6e-05	-5.8	-7.5	5.1e-14	0.94	0.02	0.97	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZYG11B	0.02	0.02	blup	64	0.01	2.6e-02	-7.5	-7.5	5.2e-14	0.96	0.02	0.83	FALSE
13	GTEx	Whole Blood	SCP2	0.06	0.01	lasso	3	0.00	1.4e-01	-7.2	7.4	9.7e-14	-0.88	0.21	0.49	FALSE
24	YFS	Blood	ZYG11B	0.13	0.20	lasso	23	0.23	4.5e-75	-7.6	-7.4	1.3e-13	0.93	0.09	0.91	FALSE
15	GTEx	Whole Blood	ZYG11B	0.05	0.02	lasso	4	0.01	7.9e-02	-6.9	-7.4	1.4e-13	0.90	0.04	0.88	FALSE
33	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZYG11B	0.11	0.06	blup	64	0.08	4.0e-03	6.5	-7.4	1.9e-13	0.85	0.05	0.47	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZYG11B	0.02	0.02	blup	64	0.02	4.0e-05	-5.8	-7.3	3.4e-13	0.86	0.33	0.62	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZYG11B	0.04	0.02	blup	64	0.04	3.6e-05	-7.2	-7.2	4.4e-13	0.91	0.16	0.82	FALSE
9	GTEx	Esophagus Mucosa	ZYG11B	0.11	0.12	enet	7	0.12	4.5e-08	-6.9	-7.2	7.9e-13	0.91	0.14	0.86	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZYG11B	0.06	0.06	lasso	3	0.05	1.4e-04	-6.9	-7.1	1.1e-12	0.88	0.11	0.74	FALSE
16	GTEx	Whole Blood	TUBBP10	0.10	0.07	lasso	2	0.08	1.5e-07	-7.0	7.1	1.6e-12	-0.84	0.53	0.46	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZYG11B	0.03	0.02	enet	6	0.02	1.1e-03	-7.8	-6.9	5.8e-12	0.83	0.04	0.91	FALSE
14	GTEx	Whole Blood	ECHDC2	0.09	0.09	lasso	5	0.08	1.9e-07	-7.0	6.9	6.2e-12	-0.79	0.16	0.84	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	TUBBP10	0.21	0.21	lasso	6	0.18	1.4e-06	-7.2	6.8	9.9e-12	-0.82	0.57	0.24	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	SCP2	0.38	0.25	enet	16	0.24	2.9e-08	-7.1	6.8	1.2e-11	-0.81	0.68	0.30	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SCP2	0.08	0.05	bslmm	490	0.04	2.3e-05	-7.2	6.6	3.8e-11	-0.71	0.19	0.81	FALSE
4	GTEx	Adipose Visceral Omentum	SELRC1	0.15	0.07	lasso	10	0.03	1.6e-02	-6.9	6.6	4.7e-11	-0.80	0.14	0.84	FALSE
31	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SCP2	0.14	0.01	enet	13	0.08	6.3e-04	-7.8	6.4	1.8e-10	-0.67	0.01	0.72	FALSE
5	GTEx	Brain Frontal Cortex BA9	RP11-334A14.2	0.26	-0.01	enet	20	0.00	2.9e-01	-7.8	6.4	1.9e-10	-0.78	0.05	0.40	FALSE
12	GTEx	Skin Sun Exposed Lower leg	ZYG11B	0.06	0.08	lasso	3	0.05	3.9e-05	-5.8	-6.3	3.3e-10	0.75	0.67	0.30	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	ZYG11A	0.04	0.03	lasso	3	0.02	1.7e-03	-5.8	6.2	6.6e-10	-0.84	0.08	0.84	FALSE
17	METSIM	Adipose	SELRC1	0.04	0.04	lasso	10	0.04	1.8e-06	5.3	6.1	1.3e-09	-0.66	0.95	0.04	FALSE
20	NTR	Blood	ZYG11B	0.01	0.01	lasso	5	0.01	2.2e-04	-3.2	-5.8	8.8e-09	0.62	0.19	0.77	FALSE
23	YFS	Blood	ECHDC2	0.32	0.23	lasso	10	0.33	3.5e-112	-7.2	5.7	1.1e-08	-0.63	0.82	0.18	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	ECHDC2	0.09	0.07	enet	41	0.07	2.4e-09	-7.0	-5.3	1.3e-07	0.68	0.77	0.23	FALSE
10	GTEx	Esophagus Muscularis	HIGD1AP11	0.16	0.01	lasso	7	0.02	1.3e-02	4.5	5.2	1.7e-07	-0.72	0.06	0.71	FALSE
18	METSIM	Adipose	ZYG11B	0.04	0.00	bslmm	404	0.02	4.3e-04	-1.1	-5.2	2.4e-07	0.62	0.06	0.72	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SELRC1	0.17	0.15	lasso	4	0.15	1.0e-17	5.2	-5.1	2.9e-07	0.54	1.00	0.00	FALSE