Best TWAS P=4.03e-11 · Best GWAS P=7.1e-11 conditioned to 0.0161
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RRM2B | 0.12 | 0.06 | enet | 20 | 0.02 | 2.1e-02 | -6.5 | -6.5 | 9.4e-11 | 0.82 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Artery Aorta | FZD6 | 0.19 | 0.13 | enet | 14 | 0.13 | 1.1e-07 | 5.2 | 5.5 | 3.0e-08 | 0.02 | 0.16 | 0.84 | TRUE |
| 3 | GTEx | Artery Aorta | CTHRC1 | 0.17 | 0.14 | enet | 7 | 0.13 | 8.7e-08 | 5.3 | 5.1 | 3.1e-07 | 0.00 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Artery Aorta | RP11-318M2.2 | 0.21 | 0.09 | enet | 6 | 0.11 | 9.1e-07 | 5.3 | 5.2 | 1.7e-07 | 0.03 | 0.12 | 0.87 | FALSE |
| 5 | GTEx | Artery Aorta | KB-1507C5.2 | 0.20 | 0.17 | lasso | 9 | 0.16 | 2.8e-09 | -5.7 | 5.6 | 1.8e-08 | 0.07 | 0.02 | 0.98 | TRUE |
| 6 | GTEx | Artery Tibial | RRM2B | 0.26 | 0.15 | lasso | 6 | 0.16 | 1.1e-12 | -6.5 | -6.6 | 4.0e-11 | 0.95 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Testis | RRM2B | 0.30 | 0.16 | enet | 15 | 0.20 | 2.1e-09 | 4.9 | 5.3 | 1.2e-07 | -0.41 | 0.95 | 0.04 | FALSE |
| 8 | GTEx | Uterus | FZD6 | 0.30 | 0.19 | lasso | 7 | 0.19 | 1.1e-04 | 5.1 | 5.1 | 3.0e-07 | 0.03 | 0.09 | 0.69 | FALSE |
| 9 | YFS | Blood | RRM2B | 0.22 | 0.21 | bslmm | 492 | 0.22 | 3.7e-70 | -6.5 | 6.6 | 4.5e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RRM2B | 0.16 | 0.05 | blup | 65 | 0.10 | 1.1e-04 | -6.5 | -6.5 | 5.6e-11 | 0.85 | 0.00 | 0.96 | FALSE |