Best TWAS P=4.43e-12 · Best GWAS P=4.17e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | LRRC6 | 0.11 | 0.01 | lasso | 3 | 0.01 | 8.5e-02 | -6.5 | -6.0 | 2.3e-09 | 0.68 | 0.05 | 0.72 | FALSE |
| 2 | GTEx | Heart Left Ventricle | LRRC6 | 0.18 | 0.10 | enet | 15 | 0.11 | 2.3e-06 | 4.1 | -6.0 | 2.7e-09 | 0.63 | 0.83 | 0.16 | FALSE |
| 3 | GTEx | Nerve Tibial | PHF20L1 | 0.10 | 0.07 | lasso | 5 | 0.06 | 2.6e-05 | -6.3 | 5.6 | 2.4e-08 | -0.67 | 0.35 | 0.59 | FALSE |
| 4 | METSIM | Adipose | TG | 0.22 | 0.26 | enet | 27 | 0.27 | 5.8e-41 | -6.9 | 6.4 | 1.3e-10 | -0.95 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TG | 0.10 | 0.07 | lasso | 7 | 0.10 | 1.7e-20 | -6.8 | 6.8 | 1.3e-11 | -0.86 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | TMEM71 | 0.41 | 0.04 | enet | 9 | 0.03 | 4.9e-02 | -6.4 | 6.2 | 4.0e-10 | -0.59 | 0.02 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PHF20L1 | 0.04 | 0.02 | lasso | 2 | 0.01 | 4.2e-02 | -6.9 | 6.9 | 4.4e-12 | -1.00 | 0.01 | 0.74 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TG | 0.03 | 0.00 | lasso | 8 | 0.01 | 1.6e-02 | -6.9 | 6.5 | 9.8e-11 | -0.95 | 0.02 | 0.92 | FALSE |