Hub : Genes

PHF20L1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.3070	0.1040	5.0e-03	-0.009	NA	-0.006	NA	0.026	6.3e-01	NA	0.47000	NA	7.4e-02
2	GTEx	Cells Transformed fibroblasts	0.1450	0.0490	2.2e-03	0.036	NA	0.028	NA	0.037	9.3e-04	NA	0.00340	NA	9.0e-04
3	GTEx	Nerve Tibial	0.1009	0.0465	9.7e-03	0.071	NA	0.063	NA	0.064	9.6e-06	NA	0.00003	NA	2.6e-05
4	GTEx	Testis	0.1890	0.0730	7.5e-03	0.005	NA	-0.006	NA	-0.006	1.8e-01	NA	0.85000	NA	8.4e-01
5	YFS	Blood	0.0386	0.0115	1.5e-06	0.005	0.012	0.011	0.012	0.013	7.6e-03	4.8e-05	0.00012	4.4e-05	3.2e-05
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0350	0.0199	4.3e-03	0.022	0.005	0.004	NA	0.008	1.5e-03	8.6e-02	0.11000	NA	4.2e-02
7	TCGA	Pancreatic Adenocarcinoma	0.1590	0.0720	8.3e-04	0.095	0.075	0.081	NA	0.078	8.4e-05	4.5e-04	0.00028	NA	3.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	0.9	3.4	1.0	-0.4	0.9	-1.8	-0.9	-0.1	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.7	1.3	-0.0	-0.1	-0.9	0.7	0.6	-0.1
Depressed Affect (Nagel 2018)	1.3	2.8	6.4	-0.5	-1.6	-2.5	-0.9	0.0	-2.5	-1.8
Depression (Nagel 2018)	0.5	0.8	2.9	0.5	0.5	-0.8	-0.8	1.7	-0.6	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.2	-0.7	0.3	1.3	0.3	-1.5	1.0	0.5
Neuroticism (Nagel 2018)	0.5	1.1	2.8	0.1	-0.9	-1.1	-1.6	1.7	-0.4	-0.6
Schizophrenia (2018)	0.3	0.7	2.4	0.8	0.2	-0.9	0.3	1.6	0.9	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-1.0	0.2	-1.0	0.8	0.6	0.1	0.3
Worry (Nagel 2018)	0.8	1.7	4.5	0.1	-1.1	-0.2	-1.8	2.1	1.5	-0.6
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	0.3	1.0	0.7	0.3	0.6	0.1	0.5
Alzheimer’s Disease (in father)	3.2	3.5	8.0	1.2	-1.4	-2.5	0.2	-2.2	-2.8	-1.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.2	1.1	0.5	-0.7	0.4	-0.7	-1.0	-0.2
Crohns Disease (2017)	1.2	2.6	8.1	-1.1	-2.7	-0.6	-0.1	-0.7	-0.9	-2.8
Irritable Bowel Disease (IBD)	0.7	1.6	5.2	-0.8	-2.3	0.3	0.1	0.6	0.4	-2.1
Ulcerative Colitis (UC)	0.7	1.4	4.0	-0.4	-1.1	0.9	0.4	2.0	1.7	-0.4
Major Depression (MDD)	0.8	0.9	3.1	-0.6	-0.0	-1.8	1.3	0.2	-0.9	0.5
Reaction Time	0.2	0.4	1.8	0.0	-0.4	-0.3	-1.3	0.6	0.5	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.8	-0.1	-0.1	0.1	0.2	-1.3	0.8	0.3
Breast Cancer	0.3	0.8	2.4	0.6	-0.8	-0.3	-0.4	-1.6	-0.4	-1.2
Ovarian Cancer	1.0	1.4	4.8	0.8	2.2	0.8	-0.5	0.4	0.7	1.7
Prostate Cancer	0.5	0.7	1.7	1.3	-0.7	-0.1	-0.4	-0.4	-1.2	-1.0
Age at First Birth	0.5	0.7	2.7	0.3	-1.6	-0.2	0.2	-0.2	0.4	-1.5
Bipolar Disorder (2011)	0.8	0.8	2.1	1.1	-0.1	0.9	-0.1	1.3	1.4	0.1
Body Mass Index (BMI) (2010)	0.5	0.7	3.2	0.0	-0.2	-0.8	-0.7	1.8	0.9	0.2
Coronary Artery Disease (CAD)	1.4	1.6	3.3	-1.8	-0.9	-1.5	0.7	-1.2	-1.4	-1.1
Crohns Disease (2012)	1.3	2.2	5.0	-0.6	-2.2	-1.4	-0.0	-1.1	-1.4	-2.2
Mean Putamen Volume	0.6	0.7	2.8	0.1	0.7	0.6	-1.7	-0.7	-0.2	0.7
Fasting Glucose	1.4	1.6	4.0	0.3	1.4	2.0	-1.2	1.5	1.0	0.9
HbA1C	0.4	0.4	1.3	-0.5	1.1	0.5	0.9	-0.1	-0.7	0.0
HDL Cholesterol	0.3	0.4	1.4	0.8	-0.5	0.6	0.6	0.0	1.2	-0.2
LDL Cholesterol	0.8	1.2	2.6	0.0	-0.9	-1.5	0.3	-1.6	-1.3	-0.9
Lupus	0.3	0.4	1.0	-0.5	-0.0	-1.0	-0.2	0.9	0.6	0.7
Neuroticism (2016)	0.5	0.8	2.2	0.1	0.5	-1.5	-0.9	1.4	-0.3	0.4
Primary Biliary Cirrhosis	0.7	1.1	4.1	1.7	0.7	0.0	-2.0	0.0	-0.2	0.1
Rheumatoid Arthritis	0.4	0.6	1.4	-0.7	1.2	0.6	-0.8	0.4	-0.0	1.0
Schizophrenia (2014)	0.3	0.6	2.4	0.8	0.5	-0.5	0.1	1.5	0.8	0.4
Triglycerides	1.2	1.9	4.8	-0.3	-1.3	-2.2	-0.3	-1.0	-2.0	-1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.8	-2.2	-0.6	-0.0	-0.4	1.6	1.0	-0.4
Ulcerative Colitis	0.7	1.0	4.0	-0.6	-0.7	0.2	-0.2	2.0	1.3	-0.5
Blood Eosinophil Count	0.1	1.0	3.5	0.9	0.4	-0.3	1.9	-0.8	-1.2	0.4
Blood Platelet Count	0.4	4.4	20.2	-4.5	-1.1	-1.7	2.1	-0.5	-0.6	-1.2
Blood Red Count	1.8	17.3	47.9	0.7	2.9	5.6	0.8	4.6	6.9	3.3
Blood White Count	0.1	0.5	1.2	-1.1	0.6	0.5	-0.5	-0.9	0.3	0.3
Heel T-Score	0.0	0.3	1.2	-0.5	-1.1	-0.5	0.2	-0.8	-0.1	-0.3
BMI	0.1	0.7	3.1	1.8	0.4	-0.7	0.8	0.1	0.3	0.4
Height	0.6	10.7	27.5	-1.2	-1.0	-3.0	3.7	-4.4	-5.2	-1.7
Waist Hip Ratio (WHR)	0.3	1.3	2.8	-1.6	-1.7	-0.6	1.0	-0.2	0.4	-1.5
Systolic Blood Pressure	0.7	3.6	5.8	-1.6	2.2	2.0	-0.2	2.4	1.8	2.3
Smoking Status	2.7	6.4	16.6	0.8	-1.9	-3.7	0.9	-2.5	-4.1	-2.0
Allergy or Eczema	0.2	0.5	2.7	1.6	0.1	-0.7	-0.4	0.4	0.3	0.4
Cardiovascular Disease	0.3	1.0	2.0	-0.4	1.1	-0.9	1.4	0.9	-0.4	1.4
Hypothyroidism (self reported)	6.4	14.8	46.0	-0.5	0.7	3.7	-0.3	6.4	6.8	1.4
Respiratory disease	0.2	0.4	2.1	1.5	0.2	-0.4	-0.2	0.2	-0.0	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.1	0.5	-0.5	0.0	-0.4	-0.3	-0.1
Lung FEV1/FVC ratio	0.3	1.7	9.8	-3.1	0.5	1.0	-0.3	-0.5	-0.6	0.5
Lung FVC	0.4	2.1	6.2	0.7	1.7	0.6	-0.2	2.5	1.1	1.9
Neuroticism	0.5	1.2	3.5	0.6	0.2	-1.0	-1.9	1.6	-0.9	0.3
Chronotype (morning person)	1.0	2.3	5.9	-0.6	0.9	1.8	-0.7	2.4	1.9	1.2
Hair Pigment	0.2	5.3	9.4	-1.0	-2.6	-3.1	1.8	-2.4	-2.4	-2.3
Tanning	0.0	0.5	1.7	-1.3	-0.3	-0.8	0.8	-0.3	-0.3	0.1
Hand grip strength (left)	1.5	4.1	9.6	0.3	-1.4	-1.5	2.0	-2.6	-3.1	-2.0
Number of treatments/medications taken	0.2	0.4	1.0	-0.6	0.5	-0.4	0.1	1.0	-0.5	0.8
Average weekly spirits intake	0.3	0.4	0.8	-0.6	-0.9	-0.5	0.6	-0.4	-0.4	-0.8
Sensitivity / hurt feelings	0.8	1.3	4.1	0.3	1.1	1.6	0.2	2.0	0.9	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.3	0.5	0.5	-0.3	-0.6	1.8	-0.1	0.9
Hearing difficulty/problems: Yes	1.1	1.7	6.6	-1.1	1.1	1.3	2.6	-0.3	-0.1	1.1
Relative age of first facial hair	0.5	1.1	4.1	-0.9	-0.0	0.0	2.0	-1.6	-0.6	-0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.7	-0.7	-1.6	0.1	1.0	0.4	0.0	-1.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.4	-1.2	0.9	-1.2	0.5	-1.6	-1.9	0.5
Ever had hysterectomy (womb removed)	0.4	0.5	2.0	-1.4	-0.4	-0.0	-0.2	0.3	0.9	0.0
Systolic blood pressure, automated reading	0.8	2.3	4.5	-1.0	1.4	1.8	0.0	2.1	1.3	1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.7	-0.2	0.3	-0.1	0.7	0.7	-0.4
Angina	0.6	0.8	2.1	-0.4	0.9	-1.4	0.9	0.1	-1.0	0.9
Medication for hormone replacement therapy	0.9	1.0	3.7	-0.0	1.1	-0.4	-0.5	-1.2	-1.9	0.6
Vitamin and mineral supplements	0.2	0.3	0.8	0.5	-0.6	-0.1	0.9	-0.5	0.1	-0.5
Supplements: Zinc	1.3	1.4	3.5	0.7	-1.0	-1.3	-1.9	-0.6	-1.1	-1.3
Medication: Co-codamol	0.9	1.1	2.6	1.6	-1.3	-1.1	-0.8	0.8	-0.1	-1.0
Medication: Metformin	0.6	0.9	1.9	-0.8	-0.3	-0.8	-0.3	-1.1	-1.2	-1.4
Diabetes (father)	0.4	0.5	1.6	-0.1	-0.0	-1.2	-1.0	-0.9	-0.6	0.0
Diabetes (mother)	0.4	0.5	1.1	0.3	-1.0	-0.8	-0.5	-0.6	0.4	-0.9
Severe depression (siblings)	1.2	1.3	3.7	-0.3	1.3	0.0	-0.5	1.9	0.6	1.7
Pack years adult smoking proportion	0.5	0.8	1.5	1.0	0.2	-1.0	-0.6	-1.2	-1.2	0.6
Impedance of leg (right)	0.3	1.5	4.4	-2.1	-0.2	-0.7	-1.6	1.4	1.0	-0.0
Leg fat-free mass (left)	0.8	4.1	14.1	0.6	-0.9	-1.3	3.8	-2.4	-2.2	-1.1
Trunk fat percentage	0.2	0.6	1.2	-0.9	-1.1	-0.8	0.4	0.9	0.6	-0.5
Hand grip strength (right)	1.0	2.6	5.0	-0.3	-1.0	-1.0	1.6	-2.2	-2.2	-1.8
Townsend deprivation index at recruitment	1.6	2.2	3.5	-0.4	-1.5	-1.4	1.9	-1.6	-1.7	-1.4
Current tobacco smoking	1.6	2.6	8.3	1.0	-0.7	-1.6	1.7	-1.3	-2.9	-1.2
Average weekly fortified wine intake	1.0	1.1	3.0	0.1	1.5	1.7	0.3	0.6	0.7	1.2
Maternal smoking around birth	0.7	1.0	3.2	-0.1	1.8	1.0	0.8	0.2	0.6	1.2
Fed-up feelings	1.3	2.3	4.8	1.0	-1.7	-2.2	-1.0	0.3	-1.5	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.0	0.3	-0.3	-1.5	0.5	0.0	-2.0	-0.3
Relative age voice broke	1.5	2.2	10.9	-0.4	-0.9	-0.6	3.3	-1.0	-0.3	-1.5
Taking other prescription medications	0.5	0.8	2.1	-1.2	-0.1	0.2	1.5	1.4	0.1	-0.1
Age when periods started (menarche)	0.1	0.2	0.5	0.7	0.2	0.6	0.7	-0.3	-0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.6	-0.9	0.0	-1.9	0.7	-0.8	-1.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.5	-1.0	-0.1	-1.5	-1.6	-0.8	-0.7	0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.5	-0.5	-0.3	-0.4	-0.5	0.6	-0.7
Qualifications: CSEs or equivalent	0.6	0.7	2.6	1.6	0.2	-1.0	-0.2	1.1	0.4	0.4
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-0.8	-0.7	-0.7	1.1	0.1	-0.5	-0.2
High blood pressure	0.3	0.7	2.1	-0.7	0.8	-1.4	0.3	0.3	-0.9	1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	0.5	0.6	-1.4	1.3	0.5	0.3	0.7
Multivitamins +/- minerals	0.2	0.3	1.0	-0.4	0.2	0.3	-0.1	1.0	0.7	0.4
Stomach or abdominal pain in last month	0.3	0.4	1.3	0.3	-0.4	0.4	-1.1	0.4	-0.2	-0.8
Supplements: Glucosamine	0.5	0.7	1.2	-0.9	1.0	-0.6	0.0	-0.8	-1.0	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.2	-1.8	-0.1	0.1	-0.5	-0.5	-1.1	-0.4
Medication: Atenolol	0.3	0.4	0.8	0.3	0.9	-0.1	0.7	-0.0	-0.9	0.8
Medication: Levothyroxine sodium	3.4	5.8	14.9	-0.9	1.3	2.4	1.1	3.9	3.7	1.6
Sitting height	0.9	6.2	18.1	-0.4	0.0	-1.4	4.2	-3.7	-3.0	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.7	-0.8	-0.1	0.1	-0.1	-0.6	-0.6
High blood pressure (mother)	1.6	2.2	4.3	1.0	1.9	1.6	-0.3	1.5	1.5	2.1
Body mass index (BMI)	0.1	0.4	1.0	0.6	-0.7	-0.6	1.0	0.3	0.1	-0.7
Impedance of leg (left)	0.4	1.9	5.0	-2.0	-0.0	-0.2	-2.2	1.7	0.9	0.3
Leg predicted mass (left)	0.8	4.4	14.1	0.6	-1.0	-1.4	3.8	-2.5	-2.3	-1.2
Trunk fat mass	0.2	0.8	1.5	-0.5	-1.2	-1.2	1.2	-0.2	-0.6	-0.8
Waist circumference	0.3	1.2	4.7	-1.0	-1.0	-0.7	2.2	0.3	-0.0	-1.1
Number of incorrect matches in round	3.1	5.2	14.2	-0.0	0.6	2.8	-2.4	3.8	2.6	1.1
Past tobacco smoking	2.0	3.8	8.1	-0.5	1.3	2.5	-1.7	2.3	2.8	1.4
Alcohol usually taken with meals	0.7	1.1	4.8	-2.2	1.1	0.5	0.0	0.1	0.5	1.2
Nervous feelings	1.5	2.7	7.7	0.0	0.5	1.8	-0.7	2.8	2.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	8.4	-0.1	-1.9	-2.9	-0.5	-0.8	-2.3	-2.1
Hearing difficulty/problems with background noise	1.1	1.7	4.1	0.7	2.0	1.7	0.0	0.8	-0.3	2.0
Hair/balding pattern: Pattern 2	0.8	1.0	3.9	-1.3	-0.3	1.0	2.0	-0.3	0.0	-0.2
Had menopause	0.3	0.4	1.1	-0.2	0.9	1.0	-0.0	-0.1	-0.6	0.5
Had other major operations	0.7	0.8	2.4	0.7	0.1	1.2	0.3	1.0	1.6	0.5
Forced vital capacity (FVC)	0.2	0.6	2.9	0.4	0.8	0.0	1.7	-0.1	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.6	0.7	-0.4	-1.0	-0.3	-0.1	1.0
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	6.8	0.8	0.1	-2.6	2.1	-0.6	-2.6	0.1
Qualifications: None of the above	0.7	1.5	4.6	0.0	-0.8	-2.1	0.2	-0.5	-2.1	-0.8
Financial difficulties in last 2 years	0.5	0.6	1.4	0.4	0.4	-1.2	0.8	0.9	-1.1	0.4
Mouth/teeth dental problems	0.6	1.0	2.7	1.7	0.3	1.2	-0.2	1.2	0.9	0.4
Heart attack	0.3	0.3	1.0	0.2	0.8	-0.3	-0.4	-0.0	-0.5	1.0
Allergy	0.3	0.7	2.8	-0.3	0.5	1.7	-1.1	-0.5	-0.0	-0.1
Pain all over the body in last month	2.1	2.2	4.5	-1.3	-2.0	-1.8	0.7	-0.8	-0.9	-2.1
Diabetes (self-reported)	0.2	0.3	0.8	-0.6	0.2	-0.8	-0.3	-0.6	-0.9	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.8	-1.3	0.8	-0.6	0.4	-0.1	0.4	1.2
Medication: Ramipril	0.4	0.5	1.2	-1.1	-0.5	-1.0	-0.3	0.8	0.6	-0.4
Medication: Simvastatin	0.5	0.7	2.0	-1.4	-0.8	-0.6	0.7	-0.6	-1.1	-0.4
Fluid intelligence score	0.6	1.2	5.6	0.1	0.4	1.2	-0.6	0.3	2.4	0.8
Illnesses of siblings	0.3	0.5	1.6	1.3	0.2	0.0	0.2	0.1	1.2	-0.3
Neuroticism score	0.8	1.8	4.8	0.2	-1.2	-2.2	-0.2	0.2	-1.9	-1.5
Weight	0.5	2.5	9.4	-0.2	-0.9	-1.3	3.1	-1.4	-1.5	-1.1
Impedance of arm (right)	0.6	2.8	5.5	-2.2	-0.6	-0.2	-2.1	2.1	2.3	0.3
Arm fat percentage (right)	0.2	0.8	1.9	-0.3	-1.4	-0.6	-0.4	1.1	1.1	-0.8
Trunk fat-free mass	1.0	6.0	13.1	1.3	-0.7	-1.3	3.6	-3.6	-3.2	-1.3
Hip circumference	0.2	1.0	5.2	0.1	-0.8	-0.5	2.3	-0.1	-0.1	-0.8
Time employed in main current job	1.5	1.7	5.5	-0.0	1.0	1.8	-2.4	0.9	1.2	0.0
Alcohol intake versus 10 years previously	1.6	2.3	6.3	0.2	-2.5	-1.6	-1.6	-0.4	-0.6	-2.0
Father’s age at death	0.7	0.9	2.8	0.3	-0.5	-0.9	-0.1	-1.7	-1.1	-1.1
Worrier / anxious feelings	0.5	1.0	4.4	1.0	0.3	0.2	-0.5	2.1	1.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	12.0	-1.1	-2.4	-3.5	1.3	-0.2	-2.1	-2.2
Falls in the last year	0.3	0.5	0.9	-0.1	0.5	-0.9	-0.6	0.3	-0.9	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	0.6	-0.2	-0.5	-0.6	-0.7	-1.0	-0.1
Number of live births	0.3	0.5	1.1	-0.5	0.6	0.7	1.0	0.3	0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	-0.5	1.1	0.3	1.1	-0.3	-0.7	0.7
Pulse rate	0.2	0.3	1.1	0.0	0.4	-1.0	0.0	-0.1	-0.3	0.8
Happiness	0.5	0.6	2.2	-0.1	-0.0	-1.5	0.3	-0.3	-1.2	-0.2
Noisy workplace	1.2	1.5	4.3	-0.5	-0.6	-1.8	2.1	-0.4	-1.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.0	-0.5	0.7	1.0	-1.1	-0.6	1.7	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.5	0.4	-1.4	-1.0	-0.6	-1.0	-1.6	-1.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.7	0.0	-0.8	-0.6	0.4	-1.3	-0.6	-0.5
Asthma	0.1	0.3	0.8	0.7	0.2	-0.2	0.2	0.9	0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	-0.3	-0.9	-1.7	-0.5	-0.6	-1.1	-0.9
Medication: Cholesterol lowering	0.9	1.4	4.3	0.3	1.8	-0.4	0.7	-0.0	-1.1	2.1
Depression (self-reported)	2.1	2.5	9.2	-1.3	-1.9	-3.0	0.1	0.2	-0.9	-1.5
Medication: Lansoprazole	0.5	0.5	1.1	0.1	-1.0	-0.7	0.2	0.2	-1.0	-1.0
Prospective memory result	0.3	0.4	1.0	0.8	-0.5	0.4	-0.5	1.0	-0.6	0.0
Lung cancer (father)	1.0	1.1	2.6	0.8	1.6	-0.6	0.5	-0.5	-1.1	1.6
Illnesses of mother	1.3	1.6	5.3	-0.9	-1.6	-2.3	-0.7	-0.3	-0.5	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	3.0	-0.4	0.9	-0.1	1.7	-0.4	-1.1	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.5	0.0	-0.4	1.2	-0.8	-1.1	-0.5
Impedance of arm (left)	0.5	2.4	5.3	-2.0	-0.6	-0.3	-1.8	2.0	2.3	0.2
Arm fat mass (right)	0.2	0.7	1.8	-0.2	-1.4	-0.9	1.1	-0.0	0.0	-1.0
Trunk predicted mass	1.0	5.9	12.8	1.3	-0.7	-1.2	3.6	-3.6	-3.2	-1.4
Standing height	0.8	7.7	20.4	-1.6	-0.4	-1.7	4.5	-3.6	-3.7	-0.9
Length of working week for main job	0.5	0.5	2.1	0.3	0.4	-1.5	-0.7	-0.6	-0.3	0.8
Exposure to tobacco smoke at home	0.3	0.3	1.8	-1.4	0.4	-0.2	0.2	0.2	0.1	0.3
Breastfed as a baby	1.0	1.3	3.8	-2.0	-0.1	1.3	1.7	0.1	-0.5	-0.6
Tense / ‘highly strung’	0.9	1.4	4.1	0.9	-0.4	-2.0	-1.9	0.9	-0.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.4	6.7	-1.7	-2.6	-2.4	1.1	-0.4	-1.1	-2.5
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	0.2	0.2	-0.2	-1.1	-0.0	0.2	0.1
Birth weight of first child	0.8	1.4	3.2	0.2	0.6	1.1	-1.3	1.8	1.6	0.8
Peak expiratory flow (PEF)	0.4	0.9	2.2	-0.9	1.0	1.5	0.3	0.8	0.5	1.1
Pulse wave reflection index	0.3	0.4	1.2	0.7	-0.4	0.2	1.1	-0.1	-0.1	-1.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	5.2	0.7	-0.3	-2.3	0.3	-0.9	-1.9	-0.5
Loud music exposure frequency	2.9	3.2	8.8	0.5	-0.7	-2.2	1.9	-1.9	-3.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	5.2	0.5	1.1	1.3	-0.5	0.6	2.3	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.0	-0.1	0.4	-0.6	-1.7	0.3	0.6	0.8
Blood clot in the leg (DVT)	0.0	0.1	0.2	0.2	-0.3	-0.5	0.2	0.1	0.1	0.1
Medication: Paracetamol	1.4	2.3	6.7	-0.4	-2.0	-1.2	-2.6	1.1	-0.5	-1.5
Headache pain in last month	0.2	0.3	1.2	-0.0	0.0	-0.5	0.4	1.1	-0.8	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.8	-0.2	-1.1	-0.1	-0.7	-0.5	0.5	-1.7
Glaucoma (self-reported)	0.7	0.8	2.5	-1.0	-0.3	0.2	1.6	-0.7	-0.9	-0.7
Gout (self-reported)	0.5	0.7	2.3	0.5	-0.4	-1.0	1.5	-0.2	-0.9	-0.7
Hypothyroidism/myxoedema (self-reported)	5.0	9.8	28.0	-0.8	1.2	3.0	-0.4	5.3	5.2	1.6
Medication: Amlodipine	0.2	0.3	0.8	0.8	-0.0	-0.7	0.9	0.2	-0.1	-0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.9	0.7	1.0	1.0	0.6	1.0	0.2	0.6
Birth weight	0.8	1.7	3.5	1.5	-1.3	-0.4	0.7	-1.2	-1.6	-1.9
Chronic bronchitis/emphysema (mother)	0.7	0.9	3.2	-0.3	-0.9	-0.9	-1.8	-0.1	-0.3	-1.1
High blood pressure (siblings)	0.4	0.6	1.7	-0.5	0.5	0.1	-1.3	0.7	-0.9	0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	4.5	0.6	0.5	0.2	2.1	-0.0	-0.5	-0.1
Body fat percentage	0.2	0.6	1.2	-0.9	-1.0	-0.8	0.4	1.1	0.6	-0.5
Leg fat percentage (right)	0.2	0.7	1.6	-0.8	-1.2	-1.2	-0.0	1.1	0.4	-0.6
Arm fat-free mass (right)	1.1	5.5	15.4	1.3	-0.4	-0.8	3.9	-3.1	-3.0	-1.2
Exposure to tobacco smoke outside home	4.3	5.7	12.2	-0.8	-2.3	-3.5	0.7	-2.0	-3.5	-2.2
Comparative body size at age 10	0.2	0.4	1.5	1.2	-0.5	-0.0	0.5	-0.7	-0.0	-0.6
Number of full brothers	2.6	3.2	7.2	-0.4	-0.6	-2.5	0.8	-2.6	-2.7	-1.1
Worry too long after embarrassment	0.7	1.1	2.9	-0.4	1.7	0.8	0.1	1.1	0.7	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.0	-0.7	0.0	-1.0	0.4	-0.1	-0.7	0.3
Wheeze or whistling in the chest in last year	1.2	2.1	8.3	1.1	-0.7	-2.9	0.7	0.5	-1.8	-0.5
Number of children fathered	0.4	0.5	1.9	1.4	-0.1	-0.4	0.3	-0.7	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	8.5	0.3	-0.8	0.4	-2.9	0.8	1.5	-0.6
Age at first live birth	0.5	0.8	3.1	1.8	0.5	1.3	0.2	-0.0	-0.4	0.6
Pulse wave peak to peak time	0.4	0.4	1.1	0.5	0.2	0.4	-0.9	0.6	1.0	0.7
Health satisfaction	1.3	1.7	5.1	-0.1	-0.6	-2.0	0.4	-1.4	-2.3	-0.7
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.6	-0.2	-1.0	0.9	-0.5	-1.0	-1.1
Qualifications: College or University degree	1.0	3.2	10.7	-0.3	2.0	2.3	0.5	0.3	3.3	1.5
Eye problems/disorders: None of the above	0.7	0.8	1.8	0.8	0.7	1.3	-1.2	-0.1	1.1	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.6	-0.1	0.3	-1.5	-0.4	-0.9	-1.6	0.4
Emphysema/chronic bronchitis	1.1	1.3	5.8	0.4	-2.4	-0.9	-0.6	0.2	0.2	-1.4
Medication for pain relief, constipation, heartburn	1.3	2.3	6.1	-0.1	1.3	2.1	1.0	0.9	2.5	1.2
Neck or shoulder pain in last month	0.2	0.3	1.3	-0.1	-0.2	-1.1	0.1	0.9	-0.1	-0.0
Medication: Blood pressure	0.4	0.7	2.9	0.5	1.3	0.4	0.1	-0.1	-0.3	1.7
Angina (self-reported)	0.6	0.8	2.6	-0.5	0.8	-1.6	0.7	0.4	-0.9	1.0
Migraine (self-reported)	0.9	1.1	2.5	-1.0	-1.5	0.2	1.6	0.1	0.1	-1.4
Medication: Ibuprofen	0.5	0.6	1.8	-0.7	-0.7	-1.3	-0.6	-0.3	-0.6	-0.9
Medication: Allopurinol	0.3	0.4	1.3	0.3	0.1	-1.1	1.0	0.2	-0.6	-0.1
Medication: Omeprazole	0.3	0.3	0.6	0.6	0.3	-0.6	-0.8	-0.0	-0.7	0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.4	0.2	0.5	-0.5	0.8	0.8	-0.1	1.2
Mean time to correctly identify matches	0.2	0.4	1.7	-0.3	0.2	0.1	-0.7	0.2	0.2	1.3
Heart disease (mother)	0.3	0.3	1.4	0.3	0.6	1.2	0.1	-0.6	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.0	-0.7	-1.2	-0.6	-0.0	0.3	-0.7	-2.0
Whole body fat mass	0.2	0.8	2.0	-0.5	-1.1	-1.1	1.4	-0.0	-0.4	-0.8
Leg fat mass (right)	0.3	1.2	2.6	-0.8	-1.5	-1.6	1.1	-0.1	-0.6	-1.1
Arm predicted mass (right)	1.1	5.5	16.2	0.9	-0.4	-1.0	4.0	-3.1	-3.0	-1.2
Pulse rate, automated reading	0.4	1.2	4.7	-0.0	-1.0	-2.2	1.3	-0.4	-0.7	-0.6
Alcohol intake frequency.	0.8	1.9	6.7	-1.1	-2.6	-1.0	-0.9	-0.4	0.6	-1.7
Comparative height size at age 10	0.2	1.2	4.0	0.5	0.9	0.5	2.0	0.5	-1.1	1.4
Number of full sisters	0.2	0.3	0.7	-0.2	0.5	-0.8	0.3	0.4	0.0	0.8
Suffer from ‘nerves’	1.1	1.7	5.1	-0.1	-0.3	0.7	-2.3	2.2	1.3	0.1
Overall health rating	1.5	3.2	5.7	-1.7	-2.3	-2.4	1.0	-0.2	-1.7	-2.1
Chest pain or discomfort	1.0	1.5	5.7	-0.8	-0.9	-2.4	-0.3	-0.3	-1.5	-0.9
Had major operations	0.8	1.0	2.2	-1.3	0.8	0.0	1.2	-0.7	-1.5	0.4
Age at last live birth	0.6	0.9	1.9	1.3	-0.3	0.1	1.1	-1.4	-1.3	-0.1
Family relationship satisfaction	1.1	1.4	3.2	0.1	1.6	-0.8	1.8	0.8	-0.3	1.6
Leg pain on walking	1.3	1.7	3.8	0.1	-1.2	-1.6	0.1	-1.6	-1.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	-0.4	-1.2	-0.9	-1.0	-0.3	-0.7	-0.9
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.3	-1.0	-1.4	-0.8	-1.5	-0.2	-0.3	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	-0.9	0.1	0.8	-0.4	0.6	1.4	0.3
Medication: Aspirin	1.5	2.0	5.8	-0.7	-0.4	-2.4	0.7	-1.6	-2.2	-0.5
Supplements: Vitamin C	1.6	1.9	3.6	1.3	1.9	1.6	-1.1	1.0	0.8	1.6
Knee pain experienced in last month	0.8	1.3	4.3	-1.4	1.1	0.3	0.1	2.1	0.2	1.2
Hypertension (Self-reported)	0.3	0.7	2.3	-0.8	0.5	-1.5	0.5	0.5	-0.8	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	-0.1	0.7	-1.0	-1.3	0.2	-1.0	1.3
Illnesses of father: Heart disease	0.8	1.1	2.7	0.5	1.7	0.5	1.0	1.1	-0.2	1.4
Illnesses of siblings: Diabetes	0.5	0.6	3.6	-1.9	0.0	0.0	0.9	0.3	-0.0	0.3
Smoking status: Previous	0.6	0.9	1.9	0.2	-0.3	-1.4	1.1	-1.3	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	-0.2	0.1	-0.7	1.5	-1.2	-1.0	-0.1
Whole body fat-free mass	1.0	5.7	15.2	1.0	-0.7	-1.3	3.9	-3.3	-3.0	-1.3
Leg fat-free mass (right)	0.8	4.0	12.8	0.7	-0.9	-1.2	3.6	-2.5	-2.3	-1.1
Arm fat percentage (left)	0.2	0.7	2.1	-0.2	-1.4	-0.7	-0.2	0.8	0.9	-0.9
Average weekly red wine intake	1.2	1.8	3.6	-0.9	1.9	1.4	1.0	-0.4	1.3	1.8
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.2	0.3	-0.5	-0.0	0.6	-0.5	-0.0
Mood swings	1.6	2.9	8.3	0.4	-1.5	-2.9	-1.4	-0.4	-2.4	-1.4
Loneliness, isolation	0.3	0.4	1.1	-0.9	-0.0	-0.9	0.5	-0.1	-1.1	-0.3
Long-standing illness, disability or infirmity	0.6	0.9	2.2	-1.0	-1.0	1.0	0.5	1.5	0.8	-0.6
Ever had bowel cancer screening	0.9	1.0	3.2	-0.8	0.7	1.8	0.8	1.2	0.8	0.6
Diabetes diagnosed by doctor	0.4	0.7	3.0	-1.7	-0.1	-0.7	-0.4	-0.7	-0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.3	0.7	-0.6	0.3	-0.6	-0.7	0.7
Friendships satisfaction	1.5	1.9	3.5	-0.7	1.2	0.7	1.8	1.9	1.5	1.3
Qualifications: nursing, teaching	0.3	0.4	1.2	-0.9	-0.3	0.1	-1.1	-0.5	0.5	-0.5
Commuting to job workplace: Walk	1.1	1.2	3.1	-0.8	-0.4	-1.4	1.3	-1.8	-1.1	-0.5
Eye problems/disorders: Cataract	1.3	1.5	2.8	-1.0	-0.8	-1.5	1.4	-0.8	-1.7	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.6	-1.9	-1.0	-1.1	0.3	-1.1	-1.4	-1.6
Medication for cholesterol	0.4	0.6	1.7	1.0	-1.3	0.2	0.1	-0.2	0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	-0.1	-1.1	-0.4	-0.7	-0.2	-0.4	-1.2
Back pain experienced in last month	0.8	1.1	1.9	-0.4	-1.3	-1.0	1.3	0.3	-1.1	-1.4
Mineral and other dietary supplements	0.9	1.3	3.9	-0.0	-1.3	0.6	1.1	0.3	2.0	-1.2
Breast cancer (self-reported)	0.3	0.4	1.3	0.3	0.7	0.7	0.3	-0.1	-0.2	1.1
Asthma (self-reported)	0.2	0.5	1.2	0.7	0.6	-0.1	0.2	1.1	0.4	1.1
Osteoporosis (self-reported)	1.1	1.4	5.2	0.7	-1.4	0.2	-2.3	0.0	0.9	-1.2
Osteoarthritis (self-reported)	0.6	0.7	2.2	-0.6	-1.5	0.1	-0.2	1.2	0.4	-1.0
Medication: Aspirin	1.6	2.0	6.0	-0.7	-0.2	-2.4	-0.2	-1.7	-2.2	-0.3
Medication: Gliclazide	0.2	0.3	0.7	-0.3	-0.2	0.4	0.8	0.6	0.7	0.0
Illnesses of father: None of the above (group 1)	0.8	1.0	3.3	-1.8	-0.9	0.2	-0.7	-0.3	1.4	-0.6
Smoking status: Current	2.0	3.2	10.2	0.4	-1.2	-2.0	1.5	-1.3	-3.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	0.5	1.1	1.1	-1.4	1.2	0.7	1.0
Whole body water mass	0.9	5.4	14.7	1.1	-0.6	-1.1	3.8	-3.2	-2.9	-1.1
Leg predicted mass (right)	0.7	3.9	12.2	0.7	-0.9	-1.1	3.5	-2.5	-2.2	-1.1
Arm fat mass (left)	0.2	0.7	1.8	-0.1	-1.3	-1.0	1.1	-0.1	-0.1	-1.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	-0.3	-0.8	-0.5	1.3	0.6	-1.0	-0.3
Average weekly champagne plus white wine intake	0.9	1.2	4.4	-0.4	0.9	0.3	-2.1	1.0	0.5	1.2
Miserableness	3.4	5.9	12.1	-1.0	-2.8	-3.3	0.1	-0.6	-3.0	-3.5
Guilty feelings	0.4	0.6	1.2	-0.5	-0.7	-1.1	0.2	0.8	-1.1	-0.7
Wears glasses or contact lenses	1.1	1.3	3.3	-0.3	0.6	1.8	-1.0	1.7	1.1	0.3
Ever taken oral contraceptive pill	0.4	0.5	1.3	1.2	-0.1	0.4	-0.7	0.9	0.8	-0.1
Hearing aid user	0.5	0.5	1.8	0.2	0.7	0.6	1.3	0.2	-0.1	1.0
Mother’s age at death	0.6	0.7	2.3	0.1	-0.7	0.7	1.5	-0.1	1.3	-0.4
Financial situation satisfaction	0.8	1.0	5.4	0.2	0.4	-0.6	2.3	-0.5	-0.8	0.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.1	-0.4	-0.9	-0.8	1.8	0.6	-1.4	-0.6
Commuting to job workplace: Public transport	0.6	0.7	2.0	-0.6	0.8	-0.7	0.9	0.6	0.6	1.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	0.0	0.2	-0.0	0.9	-0.5	-0.9	-0.0
Medication: Blood pressure	0.9	1.7	2.8	-1.6	1.4	0.3	1.0	1.7	1.4	1.4
Pain type(s) experienced in last month: Hip pain	1.0	1.2	5.9	-0.1	-0.7	-1.3	-0.2	-0.3	-2.4	-0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.9	1.1	1.9	-0.2	-0.3	-0.3	-2.0	1.9
High cholesterol (Self-reported)	0.3	0.6	2.1	-1.4	0.1	-0.4	0.8	0.8	-0.7	0.3
Medication: Bendroflumethiazide	0.4	0.6	1.4	-0.6	-0.1	1.0	-1.2	0.6	1.1	0.2
Medication: Paracetamol	1.8	2.8	5.8	-1.0	-2.4	-1.6	-2.1	1.0	-0.5	-2.1
Medication: Lisinopril	0.6	0.8	2.0	-0.4	1.0	1.4	0.3	1.2	0.2	0.9
Medication: Atorvastatin	1.2	1.5	4.9	-1.1	2.2	0.3	0.7	0.6	-0.8	1.7
Illnesses of father: High blood pressure	0.8	1.0	2.7	-1.6	0.0	-1.2	-0.2	-0.1	-1.7	-0.5
Alcohol drinker status: Never	0.2	0.2	1.0	-1.0	-0.3	0.4	-0.3	0.2	0.0	0.2
Ever smoked	2.5	4.4	7.2	0.7	-1.8	-2.5	2.2	-2.1	-2.7	-2.0
Basal metabolic rate	0.8	4.5	13.3	0.7	-0.8	-1.3	3.6	-2.8	-2.5	-1.2
Leg fat percentage (left)	0.1	0.5	1.5	-0.4	-0.8	-0.8	-0.4	1.2	0.4	-0.2
Arm fat-free mass (left)	0.9	4.8	14.1	0.7	-0.4	-0.8	3.8	-2.9	-2.9	-1.2
Number of operations (self-reported)	1.1	1.6	2.4	-0.7	-1.5	-1.4	-1.5	-0.9	-1.2	-1.4
Average weekly beer plus cider intake	0.5	0.8	3.6	1.9	-0.3	-1.1	0.3	-0.5	-0.5	0.0
Irritability	3.9	6.6	18.7	-0.0	-2.3	-4.3	-0.2	-1.6	-3.7	-2.4
Risk taking	2.6	3.8	7.9	-0.2	-1.8	-2.8	0.3	-1.9	-2.8	-1.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.8	1.0	1.2	0.3	1.5	0.7	-0.2	1.7
Fractured/broken bones in last 5 years	0.7	0.9	3.3	-0.4	-0.4	-1.1	1.0	-0.6	-1.8	-0.4
Age started oral contraceptive pill	0.6	0.8	2.0	-0.5	0.7	1.4	1.4	0.1	-0.1	0.9
Diastolic blood pressure, automated reading	1.3	4.0	8.7	-2.4	1.7	1.3	0.5	3.0	2.0	2.1
Ever depressed for a whole week	1.9	2.4	6.3	1.0	-0.4	-2.3	0.8	-1.5	-2.5	-0.9
Unable to work because of sickness or disability	0.5	0.6	1.5	-0.7	-0.9	-1.2	-0.5	0.7	-0.3	-0.7
Commuting to job workplace: Cycle	1.1	1.4	6.2	0.1	0.3	1.5	2.5	0.1	1.0	0.1
Myopia	0.3	0.4	1.0	-0.9	0.6	-1.0	-0.4	-0.2	-0.4	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.4	1.0	-1.0	1.6	-0.8	-0.3	1.1	-1.2
Cholesterol lowering medication	1.4	2.1	7.6	-2.8	-1.5	-0.9	0.6	-0.3	-1.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	0.4	0.0	-1.1	-0.1	-0.8	-1.6	0.4
Pain experienced in last month	0.9	1.5	6.7	1.0	-0.0	0.9	-0.5	1.0	2.6	0.7
Supplements: Calcium	0.4	0.4	1.1	0.1	-1.0	0.8	-0.7	-0.0	0.7	-0.5
Basal cell carcinoma (self-reported)	1.4	1.7	3.3	0.7	1.4	1.4	1.8	1.0	1.2	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.4	0.8	-0.3	-0.3	0.0	-0.4	1.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.7	0.4	0.1	-0.8	0.3	0.1	-0.2	0.5
Heart disease (siblings)	0.6	0.8	2.5	-0.1	0.9	-0.3	0.8	-1.1	-1.6	0.5
Alcohol drinker status: Previous	1.0	1.2	3.2	1.1	0.2	-1.3	-1.8	-1.2	-0.6	0.4
Pack years of smoking	0.6	0.8	1.6	0.7	0.3	-1.0	-0.8	-1.2	-1.3	0.8
Impedance of whole body	0.5	2.4	4.9	-2.1	-0.2	-0.1	-2.2	2.0	1.8	0.3
Leg fat mass (left)	0.2	0.8	1.8	-0.6	-1.2	-1.4	0.9	-0.0	-0.8	-0.9
Arm predicted mass (left)	0.9	4.6	14.1	0.9	-0.3	-0.8	3.8	-2.9	-2.8	-0.9