Hub : Genes

TMEM71

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0316	0.0107	6.3e-05	0.003	0.014	0.001	0.013	0.002	3.2e-02	1.6e-05	2.0e-01	2.5e-05	5.9e-02
2	YFS	Blood	0.3475	0.0336	0.0e+00	0.180	0.252	0.275	0.281	0.272	2.0e-56	6.4e-82	2.4e-90	9.4e-93	3.2e-89
3	TCGA	Glioblastoma Multiforme	0.4070	0.1360	2.0e-03	0.040	0.002	0.028	NA	0.020	2.2e-02	2.8e-01	4.9e-02	NA	8.2e-02
4	TCGA	Lung Adenocarcinoma	0.0750	0.0338	9.7e-05	0.026	0.007	0.014	NA	0.010	4.3e-04	5.0e-02	8.6e-03	NA	2.2e-02
5	TCGA	Prostate Adenocarcinoma	0.0420	0.0283	7.2e-03	-0.002	0.005	0.002	NA	-0.003	5.2e-01	8.8e-02	1.8e-01	NA	9.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	2.9	-1.7	1.0	1.2	-0.1	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	2.6	-0.7	0.9	0.1	0.3	1.6
Depressed Affect (Nagel 2018)	0.6	1.3	4.3	0.9	0.2	-2.1	0.8	-0.6
Depression (Nagel 2018)	0.8	1.2	2.3	-0.4	1.2	-0.8	1.2	1.5
Intelligence (Savage-Jansen 2018)	1.0	2.9	8.0	-1.1	1.6	2.8	0.2	1.7
Neuroticism (Nagel 2018)	0.4	1.0	1.8	-0.4	1.4	-0.6	1.2	1.2
Schizophrenia (2018)	0.3	0.7	2.2	0.5	0.3	-0.9	0.5	1.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.8	-0.0	-0.8	0.8	-0.1
Worry (Nagel 2018)	0.9	1.9	4.3	-2.1	0.9	0.3	0.2	2.0
Alzheimer’s Disease (in mother)	1.1	1.2	4.8	-0.2	1.0	-0.0	2.2	0.6
Alzheimer’s Disease (in father)	4.7	5.1	7.1	2.2	-2.2	-2.7	-1.6	-2.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.2	-0.2	0.6	-1.0	1.1	-0.3
Crohns Disease (2017)	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.6	1.5	4.0	-2.0	0.7	1.3	-0.8	0.7
Ulcerative Colitis (UC)	1.9	3.6	9.2	-3.0	0.9	1.9	-0.9	1.9
Major Depression (MDD)	1.4	1.7	4.0	1.7	0.5	-2.0	1.1	-0.1
Reaction Time	0.1	0.2	0.5	0.3	0.3	-0.7	-0.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.2	-0.3	1.8	0.8	0.6	2.1
Breast Cancer	0.1	0.3	0.7	-0.5	0.3	0.4	0.7	0.8
Ovarian Cancer	1.0	1.4	3.4	0.3	1.4	-0.4	1.9	1.1
Prostate Cancer	0.1	0.1	0.2	0.3	0.5	-0.4	0.2	-0.1
Age at First Birth	0.9	1.3	3.1	-1.8	0.8	0.3	-0.4	1.5
Bipolar Disorder (2011)	2.0	2.0	3.9	-1.7	0.7	1.7	-0.2	2.0
Body Mass Index (BMI) (2010)	0.9	1.3	4.1	-0.8	0.7	-0.6	0.9	2.0
Coronary Artery Disease (CAD)	0.9	1.1	2.3	0.8	-1.1	-1.5	-0.3	-1.0
Crohns Disease (2012)	2.2	3.6	5.3	2.3	-1.7	-1.7	-1.5	-2.2
Mean Putamen Volume	1.0	1.1	4.2	-0.3	2.0	0.1	1.0	0.4
Fasting Glucose	1.8	2.2	4.9	-1.7	1.5	2.2	0.2	0.9
HbA1C	0.1	0.1	0.3	0.2	0.3	0.3	0.6	-0.3
HDL Cholesterol	0.2	0.4	0.8	-0.5	-0.3	0.9	-0.9	-0.1
LDL Cholesterol	2.6	4.0	6.9	1.5	-2.3	-1.1	-2.6	-2.1
Lupus	0.5	0.7	2.4	-0.2	0.4	-0.6	0.7	1.5
Neuroticism (2016)	0.5	0.7	1.3	0.2	0.3	-1.1	0.9	1.1
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.4	-0.5	-0.0	-0.5	-0.1
Rheumatoid Arthritis	0.3	0.3	0.6	-0.3	0.8	0.8	0.5	0.3
Schizophrenia (2014)	0.3	0.6	2.1	-0.2	0.3	-0.3	0.9	1.5
Triglycerides	1.6	2.6	4.2	0.6	-2.0	-2.0	-1.7	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	-0.1	0.3	-0.3	1.3	1.2
Ulcerative Colitis	0.5	0.7	1.8	-1.3	0.1	0.9	-0.9	0.4
Blood Eosinophil Count	0.4	3.4	8.1	-0.3	2.9	-0.7	2.6	1.4
Blood Platelet Count	0.3	3.5	11.2	3.3	-0.7	-2.3	-0.5	-0.7
Blood Red Count	1.2	12.0	39.1	-2.7	0.4	6.2	-0.3	3.7
Blood White Count	0.1	1.0	3.3	1.8	1.1	-0.2	0.7	-0.2
Heel T-Score	0.0	0.1	0.5	-0.1	0.2	-0.2	0.1	0.7
BMI	0.1	0.6	1.7	1.3	-0.2	-0.8	0.6	0.5
Height	0.5	8.7	18.0	3.8	-1.4	-3.0	-0.2	-4.2
Waist Hip Ratio (WHR)	1.1	5.1	7.9	1.6	-2.5	-1.0	-2.8	-2.8
Systolic Blood Pressure	0.1	0.5	1.0	1.0	-0.7	0.7	0.4	0.3
Smoking Status	2.3	5.4	10.7	2.8	-0.8	-3.3	0.9	-2.7
Allergy or Eczema	0.2	0.7	3.0	0.3	-0.3	-1.7	-0.3	0.1
Cardiovascular Disease	0.3	1.1	2.4	1.6	-0.0	-1.2	1.4	0.1
Hypothyroidism (self reported)	5.4	12.5	26.6	-4.2	1.6	4.0	0.4	5.2
Respiratory disease	0.1	0.3	0.7	0.8	-0.3	-0.8	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.6	2.1	-0.5	-0.7	0.7	-0.8
Lung FEV1/FVC ratio	0.3	1.4	2.9	0.7	-0.9	1.3	-1.2	-1.7
Lung FVC	1.5	7.9	14.2	-1.6	3.5	-0.7	3.2	3.8
Neuroticism	1.2	2.8	4.9	-0.1	2.2	-1.1	2.1	1.8
Chronotype (morning person)	0.4	1.0	1.6	0.5	1.2	0.5	1.3	1.3
Hair Pigment	0.2	5.8	11.2	2.4	-2.0	-3.4	-1.3	-2.6
Tanning	0.1	0.8	1.3	1.2	-0.6	-1.1	-0.7	-0.7
Hand grip strength (left)	0.2	0.4	1.0	0.7	0.3	-1.0	0.4	-0.7
Number of treatments/medications taken	0.1	0.1	0.2	0.3	-0.2	-0.2	0.5	-0.2
Average weekly spirits intake	4.5	5.5	10.2	-0.1	-3.1	-0.5	-3.2	-2.8
Sensitivity / hurt feelings	2.4	4.2	6.4	-1.1	2.5	2.2	1.6	2.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.4	-0.8	1.3	0.1	1.2	1.6
Hearing difficulty/problems: Yes	1.1	1.6	3.5	1.8	-0.4	1.0	0.4	-1.9
Relative age of first facial hair	0.1	0.3	0.9	-0.7	-0.0	0.1	-0.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.1	-0.3	0.8	-0.7	-0.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.7	2.2	-1.0	-0.8	1.0	-1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	-0.8	-0.2	0.6	-1.2	-0.2
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.3	-0.4	0.8	0.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.6	0.7	0.0	0.3	0.4	0.0
Angina	1.7	2.3	3.5	1.2	1.7	-1.5	1.9	1.0
Medication for hormone replacement therapy	6.6	7.3	20.1	0.7	3.4	-0.3	4.5	2.1
Vitamin and mineral supplements	0.4	0.6	1.2	0.5	-0.6	-0.4	-1.1	-1.0
Supplements: Zinc	0.1	0.1	0.3	0.2	0.3	0.0	-0.5	0.2
Medication: Co-codamol	1.0	1.2	3.2	0.9	-0.9	-1.8	0.9	0.8
Medication: Metformin	1.5	2.1	7.6	2.8	0.3	-0.8	1.3	-0.6
Diabetes (father)	0.2	0.3	1.1	-0.4	-0.0	-1.1	0.1	-0.3
Diabetes (mother)	1.6	2.1	3.8	1.7	-2.0	0.1	-1.5	-1.2
Severe depression (siblings)	0.8	0.9	1.8	1.4	0.5	0.2	1.0	1.3
Pack years adult smoking proportion	4.7	7.1	17.3	4.2	-1.6	-2.5	-0.9	-2.9
Impedance of leg (right)	0.1	0.6	1.3	-1.2	-0.7	-0.6	-0.8	0.5
Leg fat-free mass (left)	0.4	1.9	4.9	2.2	-0.7	-1.2	-0.6	-1.6
Trunk fat percentage	0.2	0.8	1.1	1.0	-1.0	-0.9	-1.0	0.3
Hand grip strength (right)	0.2	0.6	1.3	0.8	0.0	-1.1	-0.1	-1.1
Townsend deprivation index at recruitment	2.0	2.7	4.8	1.9	-1.7	-1.4	-0.8	-2.2
Current tobacco smoking	1.3	2.1	5.3	2.3	-0.2	-1.0	0.7	-2.0
Average weekly fortified wine intake	1.3	1.5	4.3	-1.4	0.6	2.1	0.6	0.5
Maternal smoking around birth	0.5	0.8	1.8	1.3	0.2	0.3	1.2	-0.6
Fed-up feelings	0.2	0.4	1.7	0.0	-0.2	-1.3	0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.7	0.8	0.4	-1.6	1.3	0.6
Relative age voice broke	0.3	0.4	1.8	-1.3	0.1	0.3	0.1	-0.4
Taking other prescription medications	0.2	0.4	0.9	-0.8	0.3	0.9	0.4	0.4
Age when periods started (menarche)	0.1	0.2	0.8	-0.9	0.1	-0.5	-0.2	0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.1	1.4	0.5	-1.3	0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.4	0.3	0.9	-0.9	1.2	1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.4	-0.7	-0.8	-0.9	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	1.9	1.1	-0.9	-1.4	-0.1	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.7	0.9	-0.6	1.4	0.1
High blood pressure	0.6	1.6	5.0	2.2	0.1	-1.2	1.3	0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.8	0.4	0.1	-2.2	-0.1	0.7
Multivitamins +/- minerals	0.2	0.3	0.5	-0.7	-0.0	0.6	0.4	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	0.2	-0.4	-0.3	-0.4
Supplements: Glucosamine	1.1	1.4	3.2	1.8	-0.1	-1.3	0.5	-1.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.6	-0.4	-0.3	-0.2	0.2
Medication: Atenolol	0.4	0.5	1.1	0.6	0.9	0.1	1.1	0.2
Medication: Levothyroxine sodium	4.0	6.8	13.0	-2.6	1.9	2.9	1.4	3.6
Sitting height	0.3	2.1	4.5	2.1	-0.1	-1.2	0.5	-2.1
Chronic bronchitis/emphysema (father)	0.7	0.8	3.1	-0.4	-0.4	-0.1	-0.9	-1.8
High blood pressure (mother)	2.7	3.8	7.5	1.0	2.7	0.7	2.3	2.1
Body mass index (BMI)	0.1	0.4	1.1	1.1	-0.5	-0.6	-0.2	0.2
Impedance of leg (left)	0.1	0.4	0.9	-0.9	0.3	-0.5	0.3	0.9
Leg predicted mass (left)	0.4	2.0	5.0	2.2	-0.7	-1.3	-0.5	-1.6
Trunk fat mass	0.3	1.2	3.0	1.7	-0.7	-1.4	-0.6	-0.3
Waist circumference	0.2	0.7	2.6	1.6	-0.6	-0.7	-0.4	-0.4
Number of incorrect matches in round	2.0	3.3	7.2	-2.7	0.2	2.4	1.0	1.6
Past tobacco smoking	2.2	4.1	10.2	-1.7	1.6	2.2	-0.0	3.2
Alcohol usually taken with meals	0.5	0.8	1.8	-0.3	1.2	1.3	0.6	0.7
Nervous feelings	1.9	3.6	5.9	-2.4	1.3	2.2	0.7	2.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.5	1.5	-1.1	-1.6	-0.4	-1.1
Hearing difficulty/problems with background noise	1.3	2.2	5.6	1.7	1.4	0.2	2.4	-0.3
Hair/balding pattern: Pattern 2	0.5	0.7	1.7	1.3	-0.4	1.2	-0.1	0.3
Had menopause	0.5	0.6	1.7	-0.4	-0.3	1.3	0.7	-0.7
Had other major operations	0.5	0.7	2.6	0.1	-0.4	1.6	0.4	0.6
Forced vital capacity (FVC)	0.5	1.8	4.0	-1.0	2.0	-0.3	1.6	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.8	-0.6	1.4	0.2	1.4	1.7
Ever unenthusiastic/disinterested for a whole week	3.3	4.1	12.0	2.4	-0.3	-3.5	1.4	-0.9
Qualifications: None of the above	2.3	4.9	7.4	2.7	-2.0	-2.5	0.1	-2.5
Financial difficulties in last 2 years	1.8	2.5	5.1	2.3	0.2	-2.1	1.6	-0.5
Mouth/teeth dental problems	1.1	1.7	4.8	-2.2	0.6	1.2	0.0	1.4
Heart attack	0.2	0.3	0.4	0.4	0.2	-0.7	0.4	-0.6
Allergy	0.4	1.0	3.8	0.0	0.6	1.9	0.8	0.0
Pain all over the body in last month	0.6	0.6	2.3	0.3	-0.4	-1.5	-0.8	-0.3
Diabetes (self-reported)	1.4	2.1	7.3	2.7	-0.1	-1.3	1.2	-0.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.5	1.0	-1.5	-1.6	-0.8	-1.0
Medication: Ramipril	0.5	0.7	1.4	-0.6	-1.1	-0.2	-1.2	-0.5
Medication: Simvastatin	0.2	0.3	0.8	0.9	0.1	-0.5	0.5	-0.2
Fluid intelligence score	1.6	3.2	6.4	-1.8	1.4	2.5	0.2	2.1
Illnesses of siblings	0.3	0.5	1.2	-1.1	-0.4	0.3	-0.4	0.8
Neuroticism score	0.3	0.7	2.0	0.7	0.3	-1.4	0.9	0.3
Weight	0.3	1.6	4.4	2.1	-0.6	-1.3	-0.3	-1.2
Impedance of arm (right)	0.6	2.7	5.4	-2.3	-1.1	0.9	-2.3	1.0
Arm fat percentage (right)	0.1	0.5	1.2	0.1	-0.5	-0.4	-1.1	0.8
Trunk fat-free mass	0.4	2.3	4.7	2.1	0.2	-1.3	0.7	-2.2
Hip circumference	0.0	0.1	0.3	0.5	-0.2	-0.0	-0.1	0.2
Time employed in main current job	2.1	2.4	7.5	-2.1	-0.3	2.7	0.1	-0.4
Alcohol intake versus 10 years previously	0.8	1.2	3.0	1.7	-1.2	-1.1	-0.6	-0.4
Father’s age at death	0.1	0.1	0.3	0.3	0.6	-0.1	-0.3	-0.0
Worrier / anxious feelings	0.5	1.0	2.3	-1.5	0.9	0.4	0.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	8.7	2.3	-1.7	-2.9	-0.4	-1.0
Falls in the last year	1.0	1.3	4.7	2.2	-0.5	-0.5	0.5	-1.0
Hair/balding pattern: Pattern 3	0.4	0.5	1.2	0.9	-0.4	-0.6	-0.5	-1.1
Number of live births	0.3	0.4	1.0	0.5	-0.6	0.6	-0.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.5	-0.8	1.9	0.0	1.2	0.9
Pulse rate	0.5	0.9	2.9	1.7	-0.7	-0.9	-0.2	-0.3
Happiness	0.9	1.0	4.0	0.8	0.6	-2.0	0.1	-0.3
Noisy workplace	4.8	5.9	10.0	3.2	-1.5	-2.9	-0.9	-2.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.1	-0.1	0.5	2.0	0.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.2	-0.4	-0.6	-0.8	-0.6	-1.5
Mouth/teeth dental problems: Dentures	1.1	1.9	3.2	0.7	-1.5	-1.1	-1.5	-1.8
Asthma	0.1	0.2	0.5	0.4	-0.7	-0.6	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	0.9	0.5	-1.3	0.0	0.0
Medication: Cholesterol lowering	1.4	2.1	6.4	2.5	0.9	-0.9	1.6	-0.4
Depression (self-reported)	2.5	3.0	6.5	1.2	-2.1	-2.5	-1.1	-1.2
Medication: Lansoprazole	1.0	1.1	2.5	-1.6	-1.1	1.0	-0.8	-0.4
Prospective memory result	0.6	0.7	1.2	-1.1	1.0	-0.8	0.3	0.6
Lung cancer (father)	3.4	4.0	10.6	3.2	-0.0	-2.0	1.4	-1.8
Illnesses of mother	1.7	2.1	5.7	-1.5	0.6	-2.4	0.0	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.5	-0.4	1.9	-0.9	1.5	0.8
Pulse wave Arterial Stiffness index	0.6	0.8	2.6	1.6	-0.1	-0.5	-0.2	-0.9
Impedance of arm (left)	0.7	3.1	7.5	-2.1	-1.8	0.6	-2.7	0.6
Arm fat mass (right)	0.1	0.5	1.0	1.0	-0.5	-0.9	-0.7	0.1
Trunk predicted mass	0.4	2.1	4.6	2.0	0.2	-1.2	0.7	-2.1
Standing height	0.3	3.0	7.2	2.4	-0.1	-1.4	0.1	-2.7
Length of working week for main job	1.9	2.1	4.6	2.0	-1.0	-2.1	-0.1	-1.2
Exposure to tobacco smoke at home	0.8	0.9	1.7	0.9	1.0	-0.5	1.3	0.7
Breastfed as a baby	0.9	1.1	3.0	-0.2	0.9	1.7	1.2	0.1
Tense / ‘highly strung’	0.9	1.4	3.1	0.5	0.7	-1.8	1.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.9	-0.1	-1.4	-0.9	-1.2	0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.6	0.1	-1.0	0.6	-0.7
Birth weight of first child	1.6	2.9	6.6	-1.1	1.4	1.7	1.4	2.6
Peak expiratory flow (PEF)	0.7	1.6	2.8	-1.2	1.7	1.3	0.9	1.1
Pulse wave reflection index	0.3	0.4	0.7	-0.7	-0.4	0.8	-0.5	-0.6
Ever highly irritable/argumentative for 2 days	3.1	3.8	8.0	2.6	-1.0	-2.8	0.7	-1.7
Loud music exposure frequency	2.5	2.7	8.1	1.3	1.2	-2.9	1.4	-0.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	5.6	-1.3	0.5	2.4	0.5	2.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	0.9	1.2	-0.9	0.6	0.8
Blood clot in the leg (DVT)	0.3	0.3	0.8	-0.6	0.9	-0.1	0.8	0.2
Medication: Paracetamol	0.3	0.5	1.8	0.6	-0.4	-1.3	-0.0	0.3
Headache pain in last month	0.6	1.1	3.3	1.8	-0.0	-0.8	1.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.3	-1.8	-0.1	0.5	-0.9	0.4
Glaucoma (self-reported)	0.4	0.5	1.9	1.4	0.2	0.4	0.1	-0.5
Gout (self-reported)	0.3	0.4	0.8	0.2	-0.9	0.1	-0.7	-0.7
Hypothyroidism/myxoedema (self-reported)	4.7	9.1	17.6	-3.6	1.5	3.4	0.8	4.2
Medication: Amlodipine	2.0	2.8	5.7	2.4	-2.2	-0.8	-0.5	-1.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	1.5	-1.0	0.4	0.6	-1.0
Birth weight	0.3	0.6	1.6	0.8	-0.7	0.0	-0.7	-1.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.3	0.3	0.3	0.8	0.3
High blood pressure (siblings)	1.5	2.2	6.2	1.0	2.5	-0.1	1.8	0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	4.0	-0.4	2.0	-0.7	1.8	1.0
Body fat percentage	0.2	0.7	1.1	1.0	-0.7	-1.1	-0.8	0.5
Leg fat percentage (right)	0.3	1.1	2.6	1.0	-1.0	-1.6	-0.9	0.2
Arm fat-free mass (right)	0.5	2.6	6.3	2.5	-0.1	-1.2	0.7	-2.2
Exposure to tobacco smoke outside home	7.8	10.4	20.7	4.5	-2.4	-3.8	-1.1	-3.2
Comparative body size at age 10	0.2	0.6	1.1	-0.9	-0.7	0.1	-1.0	-0.8
Number of full brothers	3.4	4.3	12.1	3.5	-0.1	-1.9	1.7	-1.7
Worry too long after embarrassment	1.8	3.1	5.7	-0.2	2.1	1.4	2.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	0.4	-0.5	0.7	0.2
Wheeze or whistling in the chest in last year	1.6	2.9	7.7	2.1	-1.2	-2.8	0.3	-0.9
Number of children fathered	0.2	0.2	0.5	-0.7	-0.2	0.4	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	8.3	-1.8	1.6	1.0	0.7	2.9
Age at first live birth	1.0	1.7	3.7	-1.9	1.6	1.1	0.2	1.1
Pulse wave peak to peak time	0.6	0.7	2.3	-1.5	0.2	0.5	0.3	0.8
Health satisfaction	1.2	1.6	5.2	1.1	0.6	-2.3	0.2	-1.0
Shortness of breath walking on level ground	0.9	1.1	2.2	1.5	0.8	-0.6	1.4	-0.2
Qualifications: College or University degree	1.3	4.2	11.7	-2.6	0.4	3.4	-1.0	1.0
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.6	1.2	0.7	0.6	1.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.7	2.2	-0.1	-1.9	0.3	-1.1
Emphysema/chronic bronchitis	1.2	1.4	3.0	0.3	-1.4	-0.7	-1.7	-1.2
Medication for pain relief, constipation, heartburn	1.8	3.1	7.6	-2.8	0.9	2.2	0.0	1.5
Neck or shoulder pain in last month	0.3	0.4	1.1	0.0	-0.4	-1.1	0.7	0.4
Medication: Blood pressure	0.3	0.6	1.9	1.4	-0.1	0.0	0.4	-0.9
Angina (self-reported)	2.0	2.7	4.3	1.3	1.7	-1.7	2.1	1.3
Migraine (self-reported)	0.7	0.9	2.1	-0.1	-1.0	1.5	-0.8	-0.9
Medication: Ibuprofen	0.3	0.3	0.8	0.9	0.2	-0.7	-0.1	0.5
Medication: Allopurinol	0.7	0.9	1.5	1.1	-1.2	-0.4	-0.5	-1.1
Medication: Omeprazole	2.6	3.1	11.3	3.4	0.1	-1.9	0.5	-0.8
Medication: Seretide 50 evohaler	1.0	1.1	2.3	1.3	-0.9	-1.5	-0.7	-0.6
Mean time to correctly identify matches	0.2	0.4	0.6	0.5	0.8	-0.5	0.6	-0.7
Heart disease (mother)	1.7	2.1	3.9	0.7	-1.5	1.6	-1.1	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.8	-1.0	1.0	-0.3	0.1
Whole body fat mass	0.2	1.0	2.7	1.6	-0.7	-1.3	-0.5	-0.2
Leg fat mass (right)	0.4	1.4	3.3	1.7	-0.6	-1.8	-0.5	-0.1
Arm predicted mass (right)	0.6	2.9	7.8	2.8	-0.1	-1.3	0.9	-2.1
Pulse rate, automated reading	1.1	3.4	9.5	3.1	-1.0	-2.4	-0.7	-0.4
Alcohol intake frequency.	0.2	0.5	1.3	-0.1	-0.9	0.1	-1.1	0.6
Comparative height size at age 10	0.1	0.6	1.9	1.4	0.6	-0.3	0.7	-0.5
Number of full sisters	0.2	0.2	0.5	-0.1	-0.7	-0.7	0.3	-0.2
Suffer from ‘nerves’	2.8	4.3	10.0	-2.2	2.0	0.9	1.4	3.2
Overall health rating	0.5	1.1	3.0	1.3	0.1	-1.7	0.6	0.5
Chest pain or discomfort	1.4	1.9	4.4	2.0	0.3	-2.1	1.1	0.1
Had major operations	0.5	0.6	1.6	0.5	1.1	-0.4	1.3	-0.1
Age at last live birth	0.6	0.9	2.3	-1.5	0.3	-0.3	-1.1	-0.9
Family relationship satisfaction	1.1	1.4	2.2	0.0	1.4	-1.5	1.5	0.8
Leg pain on walking	2.5	3.2	5.4	2.2	-1.5	-1.8	-0.4	-2.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.3	-0.3	-0.8	-0.5	-0.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.9	-0.5	-1.2	-0.2	-1.7	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.9	-0.2	0.6	-1.1	0.9
Medication: Aspirin	1.9	2.5	4.4	2.0	-0.7	-2.1	-0.1	-1.8
Supplements: Vitamin C	0.6	0.7	2.6	-0.3	0.1	1.6	0.9	0.5
Knee pain experienced in last month	1.0	1.6	4.6	1.8	0.1	0.0	2.1	0.2
Hypertension (Self-reported)	0.6	1.7	5.1	2.3	0.1	-1.4	1.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.0	1.0	0.2	-1.4	0.3	-0.6
Illnesses of father: Heart disease	1.1	1.5	3.7	1.9	0.5	0.1	1.9	-0.4
Illnesses of siblings: Diabetes	0.5	0.6	2.5	1.6	-0.5	-0.4	0.2	-0.4
Smoking status: Previous	1.1	1.7	3.8	0.9	-1.0	-1.6	0.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.3	1.2	-0.0	0.0	-0.0	-0.6
Whole body fat-free mass	0.4	2.3	5.5	2.4	-0.1	-1.2	0.4	-2.0
Leg fat-free mass (right)	0.3	1.7	5.0	2.2	-0.3	-1.1	-0.1	-1.5
Arm fat percentage (left)	0.2	0.7	1.8	0.4	-0.8	-0.6	-1.3	0.5
Average weekly red wine intake	0.4	0.5	0.9	-0.7	-0.5	1.0	-0.5	-0.8
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.6	-0.5	1.3	0.5	1.9	1.4
Mood swings	0.8	1.4	4.4	1.3	-0.4	-2.1	0.1	-0.8
Loneliness, isolation	0.8	1.0	2.0	1.0	1.3	-0.6	1.4	0.3
Long-standing illness, disability or infirmity	0.5	0.7	2.9	0.1	0.4	1.7	0.5	0.6
Ever had bowel cancer screening	0.6	0.7	1.8	-0.4	-1.0	1.3	-0.6	-0.6
Diabetes diagnosed by doctor	1.2	2.0	7.0	2.6	-0.5	-1.1	1.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	1.5	0.8	-1.0	0.5	-0.6
Friendships satisfaction	1.0	1.2	2.5	-0.7	0.9	1.0	1.1	1.6
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.4	-0.1	0.5	-0.7	0.4
Commuting to job workplace: Walk	0.9	0.9	1.8	0.9	-1.2	-0.5	-0.6	-1.3
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.9	-0.3	-0.6	0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.0	2.0	-1.3	-0.0	-0.8	-1.4
Medication for cholesterol	2.5	3.9	11.0	-0.3	-2.2	0.1	-3.3	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.6	0.1	-0.2	0.5	0.5
Back pain experienced in last month	1.2	1.7	4.9	1.4	0.5	-0.5	2.2	1.1
Mineral and other dietary supplements	1.2	1.6	2.9	-1.7	-0.5	1.6	-1.5	0.4
Breast cancer (self-reported)	1.5	1.8	4.8	-0.7	1.0	2.2	1.2	1.0
Asthma (self-reported)	0.1	0.2	0.4	0.3	-0.6	-0.6	0.2	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.8	0.1	0.3	-0.4	0.5
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.5	-0.3	0.1	0.3	0.8
Medication: Aspirin	2.7	3.6	6.3	2.3	-1.0	-2.5	-0.4	-2.2
Medication: Gliclazide	0.9	1.0	2.1	1.4	-1.3	-0.1	-0.3	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.2	2.8	-1.7	0.7	0.4	-0.5	1.5
Smoking status: Current	1.1	1.8	3.6	1.9	-0.1	-1.2	0.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	6.2	-1.7	2.5	0.3	1.6	2.4
Whole body water mass	0.4	2.2	5.3	2.3	-0.1	-1.1	0.4	-2.1
Leg predicted mass (right)	0.3	1.7	4.8	2.2	-0.4	-1.1	-0.2	-1.5
Arm fat mass (left)	0.2	0.8	1.3	1.1	-0.8	-1.0	-0.9	-0.2
Number of self-reported non-cancer illnesses	0.4	0.6	2.6	1.6	-0.1	-0.5	0.3	-0.6
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.5	0.7	-0.1	0.7	0.8
Miserableness	1.4	2.5	5.8	1.3	-1.8	-2.4	-0.7	-1.1
Guilty feelings	0.3	0.4	0.8	0.3	0.7	-0.9	0.7	0.5
Wears glasses or contact lenses	0.8	0.9	2.8	-1.3	-0.2	1.7	0.3	-0.0
Ever taken oral contraceptive pill	0.6	0.7	2.5	0.2	0.6	0.1	0.8	1.6
Hearing aid user	0.7	0.8	2.1	-1.1	-0.3	1.5	0.1	-0.6
Mother’s age at death	1.1	1.4	4.0	-0.8	-1.1	2.0	-0.9	-0.3
Financial situation satisfaction	1.0	1.2	2.5	1.6	-0.8	-1.2	-0.3	-1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.5	-0.1	-0.5	0.0	-1.0
Commuting to job workplace: Public transport	1.1	1.3	2.9	1.7	0.1	-1.6	1.0	0.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.6	1.6	0.0	-0.4	0.1	-0.2
Medication: Blood pressure	0.4	0.7	1.8	-0.1	0.2	0.3	1.2	1.4
Pain type(s) experienced in last month: Hip pain	1.7	2.2	5.2	2.3	0.8	-1.4	1.8	-0.3
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.7	1.4	0.4	-1.3	1.6	-1.0
High cholesterol (Self-reported)	0.4	0.7	1.3	0.9	0.7	-0.4	1.1	0.8
Medication: Bendroflumethiazide	0.8	1.3	5.1	-0.6	0.1	2.2	0.2	0.9
Medication: Paracetamol	0.2	0.4	0.6	-0.3	-0.7	-0.7	-0.6	0.8
Medication: Lisinopril	1.0	1.2	3.1	0.0	1.0	0.7	1.8	1.2
Medication: Atorvastatin	1.3	1.6	4.4	1.3	1.4	0.1	2.1	0.2
Illnesses of father: High blood pressure	0.7	0.9	2.9	1.7	0.1	-0.8	0.1	-1.0
Alcohol drinker status: Never	0.8	0.9	1.7	1.3	1.3	-0.2	0.9	0.7
Ever smoked	2.3	4.1	10.0	1.9	-2.1	-1.5	-0.5	-3.2
Basal metabolic rate	0.4	2.0	5.2	2.3	-0.3	-1.3	0.1	-1.8
Leg fat percentage (left)	0.2	0.7	2.1	1.0	-0.2	-1.5	0.2	0.5
Arm fat-free mass (left)	0.4	2.1	4.4	2.1	0.0	-1.0	0.8	-2.1
Number of operations (self-reported)	0.2	0.3	0.9	1.0	-0.1	-0.5	0.2	0.4
Average weekly beer plus cider intake	0.7	1.1	3.0	1.7	-0.7	-1.2	-0.3	-0.4
Irritability	3.6	6.0	11.8	3.1	-2.0	-3.4	-0.4	-2.1
Risk taking	3.9	5.7	10.9	3.3	-0.9	-3.3	-0.3	-2.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.0	0.3	-0.2	-0.7	-0.0	-1.4
Fractured/broken bones in last 5 years	0.5	0.7	1.5	1.2	0.8	-0.6	0.9	-0.4
Age started oral contraceptive pill	0.4	0.5	2.1	-1.4	0.0	0.7	-0.2	0.0
Diastolic blood pressure, automated reading	0.2	0.6	2.0	1.4	-0.8	0.3	0.1	0.7
Ever depressed for a whole week	2.6	3.2	5.4	1.9	-1.2	-2.3	-0.2	-2.3
Unable to work because of sickness or disability	0.5	0.7	1.4	1.2	0.2	-0.7	1.1	0.5
Commuting to job workplace: Cycle	2.5	3.0	5.0	-2.2	1.9	2.1	1.0	0.9
Myopia	0.5	0.7	1.4	0.9	1.1	-0.3	1.2	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.3	-2.5	-0.8	1.6	-1.9	-0.3
Cholesterol lowering medication	0.0	0.1	0.3	0.1	-0.1	-0.6	-0.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	10.8	3.3	0.0	-2.0	0.0	-1.0
Pain experienced in last month	1.1	1.8	5.4	-1.4	-1.0	0.5	-2.3	0.4
Supplements: Calcium	0.3	0.3	0.9	0.0	-0.1	1.0	-0.6	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-0.2	1.1	0.7	1.1	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.6	0.3	-0.8	0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.2	0.9	-0.6	0.9	0.2
Heart disease (siblings)	1.3	1.6	4.9	1.4	-0.4	-1.1	0.2	-2.2
Alcohol drinker status: Previous	0.9	1.0	1.6	0.6	-1.1	-1.2	-0.6	-1.3
Pack years of smoking	5.0	7.3	16.8	4.1	-1.6	-2.6	-1.0	-3.1
Impedance of whole body	0.2	1.3	2.5	-1.6	-0.9	0.4	-1.5	0.7
Leg fat mass (left)	0.3	1.2	3.2	1.8	-0.1	-1.7	0.2	-0.0
Arm predicted mass (left)	0.4	2.1	4.3	2.1	0.1	-1.0	0.9	-2.0