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chr8:144,102,493-145,856,021

Best TWAS P=4.31e-11 · Best GWAS P=2.59e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PLEC	0.05	0.07	enet	9	0.07	8.5e-09	-6.7	6.6	4.3e-11	-0.95	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	PLEC	0.14	0.14	enet	13	0.16	6.2e-13	-5.5	5.7	1.6e-08	-0.94	0.23	0.77	FALSE
3	GTEx	Adipose Visceral Omentum	PLEC	0.17	0.15	lasso	5	0.18	9.2e-10	-5.8	6.0	2.6e-09	-0.96	0.02	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	PARP10	0.07	0.03	lasso	4	0.01	6.7e-02	-5.1	5.3	9.1e-08	-0.87	0.06	0.69	FALSE
5	GTEx	Artery Aorta	PLEC	0.18	0.16	lasso	3	0.16	2.6e-09	-5.7	5.6	1.7e-08	-0.93	0.02	0.98	FALSE
6	GTEx	Artery Tibial	PLEC	0.19	0.17	lasso	2	0.20	2.2e-15	-5.7	5.6	1.8e-08	-0.94	0.32	0.68	FALSE
7	GTEx	Artery Tibial	PARP10	0.08	0.01	enet	16	0.02	1.6e-02	-5.7	5.9	4.6e-09	-0.73	0.05	0.73	FALSE
8	GTEx	Brain Cerebellar Hemisphere	PLEC	0.20	0.21	enet	12	0.22	2.2e-06	-5.6	6.1	1.1e-09	-0.94	0.02	0.98	FALSE
9	GTEx	Brain Cerebellum	PLEC	0.33	0.15	enet	16	0.15	2.6e-05	-6.2	6.1	1.0e-09	-0.95	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue	PLEC	0.17	0.20	lasso	4	0.22	1.3e-11	-5.5	5.8	6.1e-09	-0.95	0.17	0.83	FALSE
11	GTEx	Breast Mammary Tissue (Male)	PLEC	0.24	0.19	lasso	4	0.18	5.3e-05	-5.8	5.9	3.4e-09	-0.96	0.02	0.95	FALSE
12	GTEx	Breast Mammary Tissue (Female)	PLEC	0.19	0.17	lasso	2	0.17	7.9e-06	-5.5	5.8	6.3e-09	-0.96	0.11	0.74	FALSE
13	GTEx	Cells Transformed fibroblasts	PLEC	0.30	0.30	lasso	4	0.40	4.0e-32	-5.5	5.7	1.0e-08	-0.94	0.36	0.64	FALSE
14	GTEx	Colon Sigmoid	PLEC	0.36	0.06	lasso	2	0.02	5.1e-02	-5.1	5.5	4.5e-08	-0.89	0.26	0.60	FALSE
15	GTEx	Colon Transverse	PARP10	0.10	0.04	lasso	8	0.06	9.0e-04	-5.1	5.8	4.8e-09	-0.87	0.10	0.79	FALSE
16	GTEx	Esophagus Mucosa	PLEC	0.11	0.04	lasso	4	0.05	2.7e-04	-5.7	5.9	3.9e-09	-0.93	0.03	0.95	FALSE
17	GTEx	Esophagus Mucosa	PARP10	0.08	0.03	enet	17	0.04	1.0e-03	-5.9	6.2	7.4e-10	-0.79	0.08	0.82	FALSE
18	GTEx	Esophagus Muscularis	PLEC	0.20	0.11	enet	18	0.13	2.3e-08	-5.8	5.8	7.4e-09	-0.86	0.09	0.91	FALSE
19	GTEx	Lung	PLEC	0.26	0.29	lasso	6	0.30	2.6e-23	-5.7	5.7	1.3e-08	-0.94	0.24	0.76	FALSE
20	GTEx	Muscle Skeletal	GRINA	0.08	0.06	lasso	5	0.06	3.8e-06	-5.0	-5.3	8.7e-08	0.87	0.10	0.89	FALSE
21	GTEx	Nerve Tibial	PLEC	0.27	0.30	enet	27	0.38	2.4e-28	-5.8	6.3	3.1e-10	-0.93	0.25	0.75	FALSE
22	GTEx	Nerve Tibial	PARP10	0.08	0.06	enet	7	0.07	2.2e-05	-4.7	5.9	3.4e-09	-0.85	0.35	0.62	FALSE
23	GTEx	Ovary	PARP10	0.22	0.05	lasso	4	0.07	6.8e-03	-5.5	6.1	1.0e-09	-0.86	0.03	0.38	FALSE
24	GTEx	Pancreas	PLEC	0.15	0.10	lasso	3	0.13	3.5e-06	4.2	6.0	1.6e-09	-0.69	0.03	0.95	FALSE
25	GTEx	Pituitary	PLEC	0.31	0.39	lasso	4	0.44	2.7e-12	-5.5	5.9	3.5e-09	-0.97	0.06	0.94	FALSE
26	GTEx	Prostate	PLEC	0.22	0.12	lasso	4	0.18	2.7e-05	-5.9	6.0	1.4e-09	-0.92	0.03	0.94	FALSE
27	GTEx	Skin Sun Exposed Lower leg	PLEC	0.05	0.03	lasso	4	0.03	2.4e-03	-6.1	6.0	1.9e-09	-0.96	0.05	0.82	FALSE
28	GTEx	Skin Sun Exposed Lower leg	PARP10	0.06	0.04	lasso	3	0.04	1.4e-04	-5.5	5.8	8.5e-09	-0.93	0.06	0.91	FALSE
29	GTEx	Spleen	KIAA1875	0.25	0.11	lasso	4	0.13	3.3e-04	-4.0	5.2	1.8e-07	-0.45	0.15	0.50	FALSE
30	GTEx	Testis	PLEC	0.25	0.23	lasso	7	0.27	1.9e-12	-5.7	6.0	2.4e-09	-0.96	0.13	0.87	FALSE
31	GTEx	Thyroid	PLEC	0.20	0.26	lasso	7	0.29	9.2e-23	-5.7	5.7	9.2e-09	-0.94	0.26	0.74	FALSE
32	GTEx	Thyroid	PARP10	0.08	0.09	enet	6	0.09	4.0e-07	-5.4	5.3	1.2e-07	-0.85	0.82	0.17	FALSE
33	GTEx	Whole Blood	PLEC	0.15	0.15	enet	9	0.19	2.1e-17	-6.2	6.1	8.4e-10	-0.98	0.01	0.99	FALSE
34	GTEx	Whole Blood	KIAA1875	0.07	0.05	lasso	5	0.06	5.0e-06	-4.3	5.5	3.4e-08	-0.51	0.14	0.79	FALSE
35	METSIM	Adipose	PARP10	0.08	0.13	lasso	4	0.13	1.4e-18	-5.4	5.4	6.1e-08	-0.87	0.43	0.57	FALSE
36	METSIM	Adipose	PLEC	0.08	0.09	bslmm	256	0.09	1.1e-13	-5.9	6.3	2.1e-10	-0.94	0.01	0.99	FALSE
37	NTR	Blood	GRINA	0.02	0.03	lasso	5	0.02	1.8e-08	-5.4	5.4	8.2e-08	-0.85	0.26	0.74	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	PLEC	0.34	0.16	lasso	5	0.16	5.7e-20	-5.5	5.6	2.5e-08	-0.91	0.00	1.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	PARP10	0.10	0.08	lasso	4	0.08	3.7e-10	-5.5	6.0	1.4e-09	-0.88	0.00	1.00	FALSE
40	YFS	Blood	GRINA	0.37	0.54	enet	14	0.55	2.3e-221	-5.0	5.2	2.3e-07	-0.84	0.94	0.06	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLEC	0.03	0.02	lasso	2	0.02	8.9e-05	-5.5	5.3	8.6e-08	-0.91	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEC	0.05	0.04	lasso	1	0.03	8.9e-05	-5.5	5.5	4.1e-08	-0.92	0.00	0.99	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PLEC	0.06	0.05	enet	2	0.05	1.0e-03	-5.5	5.7	1.5e-08	-0.92	0.00	0.89	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	PLEC	0.07	0.05	lasso	1	0.05	8.1e-07	-5.5	5.5	4.1e-08	-0.92	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEC	0.02	0.01	blup	4	0.01	1.1e-02	-5.5	5.6	1.9e-08	-0.83	0.00	0.85	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	PLEC	0.13	0.13	lasso	2	0.13	7.9e-13	-5.5	5.5	4.1e-08	-0.92	0.00	1.00	FALSE