Best TWAS P=5.13e-08 · Best GWAS P=6.8e-12 conditioned to 2.2e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | CEP57 | 0.01 | 0.01 | lasso | 2 | -0.01 | 7.0e-01 | 5.1 | 5.2 | 1.9e-07 | 0.04 | 0.04 | 0.31 | FALSE |
| 2 | GTEx | Muscle Skeletal | CEP57 | 0.15 | 0.18 | lasso | 9 | 0.18 | 1.8e-17 | 5.3 | 5.5 | 5.1e-08 | 0.03 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Nerve Tibial | CEP57 | 0.15 | 0.08 | lasso | 6 | 0.07 | 1.9e-05 | 5.1 | 5.2 | 1.7e-07 | 0.04 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Nerve Tibial | AP001877.1 | 0.15 | 0.05 | lasso | 3 | 0.05 | 1.6e-04 | 5.4 | 5.2 | 2.4e-07 | 0.04 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Pancreas | CEP57 | 0.19 | 0.10 | lasso | 13 | 0.08 | 3.6e-04 | 5.0 | 5.2 | 2.4e-07 | 0.04 | 0.02 | 0.97 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | AP001877.1 | 0.17 | 0.27 | lasso | 12 | 0.27 | 3.6e-35 | 5.4 | 5.3 | 1.0e-07 | 0.03 | 0.02 | 0.98 | FALSE |
| 7 | YFS | Blood | FAM76B | 0.14 | 0.25 | lasso | 10 | 0.26 | 8.1e-83 | 5.4 | -5.4 | 6.6e-08 | -0.03 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CEP57 | 0.02 | 0.00 | blup | 53 | 0.01 | 6.0e-02 | 5.1 | 5.1 | 2.9e-07 | 0.02 | 0.02 | 0.61 | FALSE |