Best TWAS P=2.28e-19 · Best GWAS P=1.14e-29 conditioned to 5.49e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATM | 0.05 | 0.10 | lasso | 4 | 0.10 | 6.6e-12 | -7.9 | -7.9 | 2.9e-15 | -0.74 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | KDELC2 | 0.14 | 0.11 | lasso | 3 | 0.08 | 4.5e-05 | 1.3 | -5.1 | 2.8e-07 | -0.64 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Artery Tibial | ACAT1 | 0.12 | 0.08 | lasso | 7 | 0.11 | 3.9e-09 | 6.7 | -8.4 | 3.3e-17 | -0.84 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Artery Tibial | NPAT | 0.06 | 0.06 | lasso | 4 | 0.05 | 5.6e-05 | -7.7 | 7.8 | 9.5e-15 | 0.73 | 0.78 | 0.06 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | ACAT1 | 0.18 | 0.15 | lasso | 8 | 0.21 | 1.7e-15 | -6.4 | -7.4 | 1.8e-13 | -0.67 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | ATM | 0.07 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -7.9 | -7.9 | 2.8e-15 | -0.74 | 0.56 | 0.33 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ACAT1 | 0.10 | 0.12 | lasso | 5 | 0.13 | 4.9e-09 | 6.7 | -7.8 | 5.5e-15 | -0.83 | 0.27 | 0.73 | FALSE |
| 8 | GTEx | Esophagus Muscularis | ATM | 0.07 | 0.07 | lasso | 4 | 0.04 | 1.6e-03 | -7.7 | -7.9 | 3.1e-15 | -0.74 | 0.38 | 0.33 | FALSE |
| 9 | GTEx | Esophagus Muscularis | RP11-144G7.2 | 0.06 | 0.04 | lasso | 2 | 0.03 | 3.5e-03 | 6.7 | -6.8 | 1.4e-11 | -0.75 | 0.05 | 0.83 | FALSE |
| 10 | GTEx | Heart Left Ventricle | KDELC2 | 0.07 | 0.05 | lasso | 4 | 0.06 | 3.8e-04 | 3.2 | -6.1 | 1.0e-09 | -0.65 | 0.03 | 0.87 | FALSE |
| 11 | GTEx | Nerve Tibial | ACAT1 | 0.05 | 0.02 | lasso | 5 | 0.00 | 9.0e-01 | -7.9 | -8.9 | 8.0e-19 | -0.82 | 0.08 | 0.86 | FALSE |
| 12 | GTEx | Pituitary | ACAT1 | 0.16 | 0.09 | lasso | 10 | 0.08 | 5.3e-03 | 7.9 | 9.0 | 2.3e-19 | 0.87 | 0.03 | 0.88 | TRUE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | ACAT1 | 0.11 | 0.12 | lasso | 5 | 0.08 | 2.6e-05 | 6.7 | -7.3 | 3.9e-13 | -0.78 | 0.06 | 0.93 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | ACAT1 | 0.13 | 0.15 | lasso | 2 | 0.14 | 1.0e-11 | 6.7 | -6.6 | 5.2e-11 | -0.74 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Testis | ACAT1 | 0.17 | 0.04 | lasso | 6 | 0.08 | 3.0e-04 | 6.7 | 5.8 | 7.6e-09 | 0.63 | 0.08 | 0.74 | FALSE |
| 16 | NTR | Blood | NPAT | 0.02 | 0.01 | blup | 380 | 0.01 | 8.8e-05 | -7.8 | 5.5 | 3.4e-08 | 0.52 | 0.86 | 0.06 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | ATM | 0.05 | 0.05 | blup | 370 | 0.05 | 5.8e-07 | -7.9 | -8.0 | 1.5e-15 | -0.72 | 0.73 | 0.27 | FALSE |
| 18 | YFS | Blood | ACAT1 | 0.20 | 0.21 | enet | 32 | 0.34 | 1.3e-114 | -7.7 | -7.5 | 6.0e-14 | -0.78 | 1.00 | 0.00 | FALSE |
| 19 | YFS | Blood | NPAT | 0.06 | 0.08 | lasso | 8 | 0.09 | 3.2e-28 | -7.9 | 6.0 | 1.8e-09 | 0.52 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C11orf65 | 0.02 | 0.01 | blup | 75 | 0.02 | 7.4e-03 | -7.8 | 5.4 | 5.4e-08 | 0.52 | 0.06 | 0.07 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACAT1 | 0.02 | 0.01 | blup | 32 | 0.01 | 9.2e-03 | -3.0 | -5.8 | 5.2e-09 | -0.64 | 0.04 | 0.66 | TRUE |
| 22 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf65 | 0.03 | 0.01 | blup | 75 | 0.02 | 4.3e-03 | -7.9 | 5.8 | 5.5e-09 | 0.53 | 0.11 | 0.11 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATM | 0.05 | 0.03 | blup | 72 | 0.03 | 2.9e-04 | -7.9 | -7.4 | 1.8e-13 | -0.67 | 0.80 | 0.10 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ATM | 0.04 | 0.03 | lasso | 2 | 0.03 | 5.7e-03 | -7.9 | -7.9 | 3.0e-15 | -0.74 | 0.09 | 0.09 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | ATM | 0.08 | 0.05 | lasso | 4 | 0.05 | 6.5e-06 | -7.9 | -5.8 | 8.3e-09 | -0.52 | 0.75 | 0.02 | FALSE |