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chr11:107,277,331-109,054,930

Best TWAS P=2.28e-19 · Best GWAS P=1.14e-29 conditioned to 5.49e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Pituitary	ACAT1	0.16	0.09	lasso	10	0.08	5.3e-03	7.9	9.0	2.3e-19	0.87	0.03	0.88	TRUE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACAT1	0.02	0.01	blup	32	0.01	9.2e-03	-3.0	-5.8	5.2e-09	-0.64	0.04	0.66	TRUE
11	GTEx	Nerve Tibial	ACAT1	0.05	0.02	lasso	5	0.00	9.0e-01	-7.9	-8.9	8.0e-19	-0.82	0.08	0.86	FALSE
3	GTEx	Artery Tibial	ACAT1	0.12	0.08	lasso	7	0.11	3.9e-09	6.7	-8.4	3.3e-17	-0.84	0.04	0.96	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	ATM	0.05	0.05	blup	370	0.05	5.8e-07	-7.9	-8.0	1.5e-15	-0.72	0.73	0.27	FALSE
6	GTEx	Cells Transformed fibroblasts	ATM	0.07	0.06	lasso	2	0.05	2.2e-04	-7.9	-7.9	2.8e-15	-0.74	0.56	0.33	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATM	0.05	0.10	lasso	4	0.10	6.6e-12	-7.9	-7.9	2.9e-15	-0.74	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	ATM	0.04	0.03	lasso	2	0.03	5.7e-03	-7.9	-7.9	3.0e-15	-0.74	0.09	0.09	FALSE
8	GTEx	Esophagus Muscularis	ATM	0.07	0.07	lasso	4	0.04	1.6e-03	-7.7	-7.9	3.1e-15	-0.74	0.38	0.33	FALSE
7	GTEx	Esophagus Mucosa	ACAT1	0.10	0.12	lasso	5	0.13	4.9e-09	6.7	-7.8	5.5e-15	-0.83	0.27	0.73	FALSE
4	GTEx	Artery Tibial	NPAT	0.06	0.06	lasso	4	0.05	5.6e-05	-7.7	7.8	9.5e-15	0.73	0.78	0.06	FALSE
18	YFS	Blood	ACAT1	0.20	0.21	enet	32	0.34	1.3e-114	-7.7	-7.5	6.0e-14	-0.78	1.00	0.00	FALSE
5	GTEx	Cells Transformed fibroblasts	ACAT1	0.18	0.15	lasso	8	0.21	1.7e-15	-6.4	-7.4	1.8e-13	-0.67	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATM	0.05	0.03	blup	72	0.03	2.9e-04	-7.9	-7.4	1.8e-13	-0.67	0.80	0.10	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	ACAT1	0.11	0.12	lasso	5	0.08	2.6e-05	6.7	-7.3	3.9e-13	-0.78	0.06	0.93	FALSE
9	GTEx	Esophagus Muscularis	RP11-144G7.2	0.06	0.04	lasso	2	0.03	3.5e-03	6.7	-6.8	1.4e-11	-0.75	0.05	0.83	FALSE
14	GTEx	Skin Sun Exposed Lower leg	ACAT1	0.13	0.15	lasso	2	0.14	1.0e-11	6.7	-6.6	5.2e-11	-0.74	1.00	0.00	FALSE
10	GTEx	Heart Left Ventricle	KDELC2	0.07	0.05	lasso	4	0.06	3.8e-04	3.2	-6.1	1.0e-09	-0.65	0.03	0.87	FALSE
19	YFS	Blood	NPAT	0.06	0.08	lasso	8	0.09	3.2e-28	-7.9	6.0	1.8e-09	0.52	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf65	0.03	0.01	blup	75	0.02	4.3e-03	-7.9	5.8	5.5e-09	0.53	0.11	0.11	FALSE
15	GTEx	Testis	ACAT1	0.17	0.04	lasso	6	0.08	3.0e-04	6.7	5.8	7.6e-09	0.63	0.08	0.74	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	ATM	0.08	0.05	lasso	4	0.05	6.5e-06	-7.9	-5.8	8.3e-09	-0.52	0.75	0.02	FALSE
16	NTR	Blood	NPAT	0.02	0.01	blup	380	0.01	8.8e-05	-7.8	5.5	3.4e-08	0.52	0.86	0.06	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C11orf65	0.02	0.01	blup	75	0.02	7.4e-03	-7.8	5.4	5.4e-08	0.52	0.06	0.07	FALSE
2	GTEx	Adipose Visceral Omentum	KDELC2	0.14	0.11	lasso	3	0.08	4.5e-05	1.3	-5.1	2.8e-07	-0.64	0.06	0.92	FALSE