Hub : Genes

ACAT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0220 1.4e-03 0.032 0.028 0.030 0.029 0.029 8.2e-05 2.0e-04 1.4e-04 1.5e-04 1.5e-04
2 GTEx Artery Aorta 0.0790 0.0350 3.6e-03 0.074 NA 0.095 NA 0.104 6.9e-05 NA 6.5e-06 NA 2.5e-06
3 GTEx Artery Tibial 0.1222 0.0352 6.6e-08 0.085 NA 0.109 NA 0.113 3.7e-07 NA 7.4e-09 NA 3.9e-09
4 GTEx Cells Transformed fibroblasts 0.1850 0.0470 7.3e-13 0.151 NA 0.206 NA 0.207 2.1e-11 NA 2.2e-15 NA 1.7e-15
5 GTEx Esophagus Mucosa 0.1040 0.0310 6.3e-08 0.122 NA 0.094 NA 0.131 1.7e-08 NA 7.2e-07 NA 4.9e-09
6 GTEx Muscle Skeletal 0.2765 0.0537 5.5e-13 0.155 NA 0.166 NA 0.173 5.5e-15 NA 4.8e-16 NA 1.1e-16
7 GTEx Nerve Tibial 0.0513 0.0240 2.3e-03 0.022 NA -0.004 NA -0.004 9.6e-03 NA 9.2e-01 NA 9.0e-01
8 GTEx Pituitary 0.1640 0.0650 1.2e-03 0.086 NA 0.066 NA 0.078 3.6e-03 NA 9.6e-03 NA 5.3e-03
9 GTEx Skin Not Sun Exposed Suprapubic 0.1120 0.0440 2.6e-04 0.115 NA 0.059 NA 0.083 7.7e-07 NA 3.7e-04 NA 2.6e-05
10 GTEx Skin Sun Exposed Lower leg 0.1340 0.0390 1.5e-08 0.149 NA 0.132 NA 0.141 2.5e-12 NA 5.0e-11 NA 1.0e-11
11 GTEx Testis 0.1670 0.0620 3.2e-04 0.043 NA 0.068 NA 0.076 5.3e-03 NA 5.9e-04 NA 3.0e-04
12 GTEx Thyroid 0.3180 0.0500 0.0e+00 0.336 NA 0.364 NA 0.357 1.6e-26 NA 5.0e-29 NA 2.2e-28
13 NTR Blood 0.0334 0.0115 1.9e-06 0.017 0.023 0.020 0.023 0.018 2.9e-06 6.0e-08 2.5e-07 5.5e-08 9.9e-07
14 YFS Blood 0.2022 0.0354 0.0e+00 0.212 0.319 0.336 0.327 0.332 1.6e-67 1.2e-107 1.3e-114 1.3e-110 5.1e-113
15 TCGA Kidney Renal Clear Cell Carcinoma 0.0240 0.0136 1.6e-03 0.014 0.014 0.012 NA 0.012 1.0e-02 9.2e-03 1.3e-02 NA 1.4e-02
16 TCGA Thyroid Carcinoma 0.1450 0.0470 0.0e+00 0.163 0.203 0.224 NA 0.217 1.3e-15 1.6e-19 1.5e-21 NA 7.2e-21

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 1.4 2.3 7.4 0.7 1.2 1.0 -0.2 -0.4 -2.7 -0.9 -1.2 0.3 0.4 -1.2 -2.7 2.4 -0.2 1.7 -2.4
Bipolar Disorder or Schizophrenia 0.4 1.0 6.0 0.0 -0.1 -0.1 -0.7 -1.1 -2.5 -1.2 0.2 -0.7 -0.8 -0.5 -1.4 1.3 -1.0 0.3 -1.2
Depressed Affect (Nagel 2018) 1.1 2.3 4.7 0.5 -0.9 -1.6 0.4 -1.5 -0.4 -0.1 2.0 -2.2 -2.1 2.1 1.7 -1.6 -0.9 -1.8 1.8
Depression (Nagel 2018) 0.6 1.0 4.1 1.1 -0.5 0.0 0.9 0.8 1.6 1.4 -0.3 0.3 0.3 0.5 1.3 -2.0 0.7 -0.3 1.2
Intelligence (Savage-Jansen 2018) 1.0 3.2 7.4 0.6 2.5 1.8 0.2 1.6 -0.1 -0.4 -1.2 2.3 2.5 -2.7 -2.1 1.3 1.4 2.1 -2.4
Neuroticism (Nagel 2018) 0.4 1.0 2.4 1.0 -0.3 -0.4 1.3 -0.6 0.4 0.8 0.9 -1.1 -1.1 1.4 1.5 -1.3 -0.0 -1.0 1.6
Schizophrenia (2018) 0.4 0.8 1.8 -0.6 -1.1 -1.0 -0.7 -1.1 -1.0 -0.7 1.2 -1.2 -1.3 0.4 0.3 -0.3 -1.1 -1.0 0.4
Schizophrenia vs Biploar Disorder 0.9 1.2 3.1 0.2 -1.0 -1.0 0.4 -0.4 1.4 0.6 1.1 -1.0 -0.9 1.0 1.8 -1.6 0.1 -1.2 1.7
Worry (Nagel 2018) 0.2 0.3 1.8 1.0 -0.3 0.5 1.3 -0.6 -0.1 0.6 -0.1 -0.6 -0.5 0.5 0.4 0.2 -0.0 -0.3 0.7
Alzheimer’s Disease (in mother) 2.9 3.4 6.2 1.7 1.5 2.3 1.9 2.4 0.0 1.9 -2.0 2.3 2.4 -1.9 -1.3 -0.1 2.5 2.0 -1.1
Alzheimer’s Disease (in father) 0.8 0.9 5.3 -2.3 -0.2 0.4 -1.3 1.0 1.6 0.5 -0.5 1.2 1.0 -0.6 0.4 0.1 -0.2 -0.1 -0.2
Alzheimer’s Disease (including proxy) 1.7 2.4 5.3 -0.3 1.1 2.1 0.7 2.0 0.4 1.4 -1.8 2.3 2.3 -1.9 -1.2 0.3 1.7 1.6 -1.4
Crohns Disease (2017) 0.1 0.3 1.3 0.8 -0.1 0.1 1.1 -0.2 -0.4 0.8 0.0 -0.5 -0.5 0.1 0.1 -1.0 0.5 0.0 0.3
Irritable Bowel Disease (IBD) 0.5 1.1 4.0 1.5 1.2 1.2 2.0 0.8 -0.0 1.6 -1.0 0.6 0.4 -1.0 -0.4 0.2 1.4 0.9 -0.2
Ulcerative Colitis (UC) 1.0 1.9 3.7 1.5 1.5 1.6 1.9 1.4 0.7 1.6 -1.6 1.5 1.2 -1.6 -0.6 1.1 1.7 1.2 -0.5
Major Depression (MDD) 0.2 0.2 0.6 0.0 0.1 -0.7 -0.6 -0.4 0.4 -0.6 0.7 -0.4 -0.6 -0.1 0.4 -0.1 -0.6 -0.4 0.1
Reaction Time 0.4 0.7 2.5 0.7 0.4 0.6 -0.4 -0.2 -1.6 -0.8 -0.1 0.2 0.3 -0.9 -1.5 1.1 -0.0 0.8 -1.5
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.9 -0.1 1.4 -0.0 -0.8 0.1 1.1 -0.8 0.1 0.6 0.8 -0.7 -0.2 0.7 0.0 0.4 -0.7
Breast Cancer 0.1 0.3 1.6 -1.3 -0.7 -0.2 -0.8 0.1 0.4 -0.3 -0.1 0.3 0.1 0.3 0.3 0.2 -0.8 -0.2 0.1
Ovarian Cancer 0.3 0.4 1.6 -1.1 -0.9 -0.6 -0.5 -0.2 0.4 0.1 0.4 -0.6 -0.7 0.3 0.5 -1.3 -0.5 -0.5 0.6
Prostate Cancer 0.2 0.3 1.4 -0.7 -0.4 -0.2 -0.4 -0.3 -1.2 -0.5 0.1 -0.2 -0.4 -0.1 -0.7 0.2 -0.4 0.2 -0.9
Age at First Birth 0.2 0.3 0.8 0.1 0.5 -0.8 -0.2 -0.7 -0.8 -0.6 0.7 -0.8 -0.9 -0.1 -0.1 -0.1 -0.4 -0.4 -0.1
Bipolar Disorder (2011) 1.4 1.4 3.2 1.2 0.7 1.3 0.6 0.3 -1.8 0.3 -1.5 0.6 0.7 -1.1 -1.8 1.7 0.5 1.5 -1.5
Body Mass Index (BMI) (2010) 0.1 0.2 0.6 0.7 0.3 -0.1 0.6 -0.2 -0.5 0.4 0.0 -0.6 -0.6 -0.1 0.1 -0.7 0.4 0.1 0.2
Coronary Artery Disease (CAD) 0.3 0.4 0.9 -0.3 0.7 0.6 0.6 0.9 0.8 0.7 -0.6 0.9 0.9 -0.1 -0.1 -0.5 0.6 0.4 -0.0
Crohns Disease (2012) 0.3 0.4 1.3 0.8 0.6 0.9 1.0 0.0 -1.2 0.6 -0.6 0.0 -0.2 -0.6 -0.7 0.1 0.7 0.6 -0.5
Mean Putamen Volume 1.7 1.9 5.4 -0.9 -0.8 -1.4 -1.7 -2.0 -1.1 -2.3 1.2 -1.5 -1.2 0.9 -0.2 1.6 -2.0 -1.0 -0.2
Fasting Glucose 0.4 0.5 1.9 1.4 0.3 0.6 0.7 0.8 0.1 1.2 -0.8 0.4 0.3 -0.4 0.1 -0.7 0.9 0.3 0.2
HbA1C 0.4 0.4 1.4 -0.0 1.2 0.3 -0.4 0.7 0.3 -0.1 -0.7 1.0 1.1 -0.5 -0.6 0.1 0.3 0.6 -0.7
HDL Cholesterol 2.1 3.5 7.1 1.8 1.2 2.3 2.7 2.3 0.6 2.1 -2.2 2.2 2.0 -2.1 -0.6 0.5 2.6 1.6 -0.6
LDL Cholesterol 0.9 1.5 3.1 -0.1 1.8 1.1 1.3 1.6 0.9 1.2 -1.2 1.5 1.5 -1.1 -0.4 -1.0 1.6 1.1 -0.7
Lupus 1.0 1.5 6.5 -0.9 0.3 -1.0 -1.7 -1.1 -1.6 -2.5 1.4 -0.4 -0.3 -0.3 -1.2 1.1 -1.4 -0.0 -1.2
Neuroticism (2016) 0.6 0.9 2.1 0.7 -0.2 -1.3 -0.3 -1.2 -0.3 -0.9 1.5 -1.4 -1.1 1.0 0.6 -1.2 -0.7 -0.8 0.5
Primary Biliary Cirrhosis 0.1 0.1 0.3 0.4 0.6 0.2 0.2 -0.1 -0.0 -0.2 -0.1 0.0 0.0 -0.0 -0.3 0.4 0.1 0.4 -0.4
Rheumatoid Arthritis 2.5 3.5 20.4 0.6 -1.8 -1.1 1.2 0.6 2.5 1.6 1.3 -0.5 -0.2 1.4 2.4 -4.5 0.9 -1.4 2.6
Schizophrenia (2014) 0.1 0.2 1.0 0.6 -0.5 0.1 0.7 0.3 -0.6 0.7 0.2 0.0 -0.0 -0.7 0.1 -1.0 0.5 0.1 0.3
Triglycerides 1.4 2.4 7.6 0.1 1.9 0.9 -1.1 0.1 -1.5 -1.5 -0.7 1.1 1.3 -1.3 -2.5 2.5 -0.3 1.7 -2.8
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.4 0.8 -0.2 1.1 1.1 0.3 -1.2 0.5 -0.6 0.3 0.5 -0.4 -0.8 0.4 0.7 0.7 -0.5
Ulcerative Colitis 3.6 5.3 9.2 1.9 2.6 2.9 2.4 1.8 -1.0 1.7 -3.0 2.1 1.8 -3.0 -2.2 2.3 2.4 2.6 -2.0
Blood Eosinophil Count 5.4 41.3 148.8 -2.7 -1.1 -4.9 -9.0 -8.5 -8.1 -12.2 5.5 -5.4 -4.6 2.2 -4.5 7.5 -8.8 -2.0 -4.3
Blood Platelet Count 4.0 46.1 125.4 -4.2 -2.3 -7.9 -9.1 -9.6 -5.8 -11.2 7.8 -7.8 -7.0 5.1 -1.1 3.4 -9.4 -4.5 -1.0
Blood Red Count 3.9 37.9 81.0 -4.3 -2.2 -8.4 -7.4 -7.8 -2.5 -8.9 9.0 -7.3 -6.6 5.8 2.2 -1.5 -7.5 -5.8 2.1
Blood White Count 3.3 24.3 49.6 -3.0 -3.0 -6.5 -5.4 -6.4 -2.5 -6.7 7.0 -6.1 -5.4 4.8 1.6 -1.1 -6.2 -4.6 2.0
Heel T-Score 1.0 7.6 15.4 2.7 2.0 3.9 2.9 3.2 -0.5 3.0 -3.4 3.2 3.0 -2.8 -1.9 1.4 3.5 3.0 -1.2
BMI 0.2 1.4 10.7 0.5 -0.4 -1.1 0.4 0.3 1.4 0.0 1.7 -0.2 0.1 0.3 1.5 -3.3 0.5 -0.9 1.1
Height 0.2 3.2 9.2 -1.4 0.3 -2.5 -2.0 -2.4 -0.5 -3.0 3.0 -2.0 -1.7 1.3 0.5 0.4 -2.2 -1.5 0.1
Waist Hip Ratio (WHR) 0.6 2.8 5.8 -2.2 -0.8 -2.1 -1.7 -1.6 0.6 -1.6 2.4 -1.6 -1.7 1.6 1.4 -1.3 -1.7 -2.1 1.3
Systolic Blood Pressure 1.3 6.7 10.2 -3.0 -3.1 -3.1 -2.0 -2.0 1.2 -1.1 3.1 -2.6 -2.6 2.8 2.8 -2.5 -2.5 -3.2 2.6
Smoking Status 0.1 0.1 0.4 0.7 0.4 -0.2 0.2 -0.3 -0.6 -0.0 -0.0 -0.4 -0.2 0.1 -0.5 -0.5 0.2 0.4 -0.3
Allergy or Eczema 0.3 0.7 2.2 1.5 0.5 1.0 1.0 0.5 -0.9 0.1 -0.8 0.7 0.6 -0.6 -1.0 0.7 0.5 0.7 -1.0
Cardiovascular Disease 0.8 2.8 7.8 -0.9 -2.0 -2.4 -1.7 -1.6 0.4 -1.5 2.8 -1.5 -1.5 1.2 1.2 -2.0 -1.6 -2.0 0.9
Hypothyroidism (self reported) 0.1 0.2 0.7 0.0 -0.2 0.4 0.4 0.2 -0.2 -0.0 -0.6 0.3 0.4 -0.5 -0.7 0.3 0.0 0.4 -0.8
Respiratory disease 0.2 0.5 2.9 1.5 -0.4 -0.2 0.4 -0.2 -1.7 -0.2 0.5 -0.5 -0.4 0.4 -0.7 -0.6 0.2 0.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 6.5 -1.4 -1.3 -0.6 -0.7 0.3 2.5 0.3 0.9 0.2 0.3 0.6 1.5 -1.5 -0.5 -1.3 1.1
Lung FEV1/FVC ratio 0.1 0.6 2.2 -0.6 0.0 -0.3 -1.5 -0.8 -0.6 -1.1 -0.3 -0.1 0.3 0.0 -1.0 1.0 -1.1 0.2 -1.0
Lung FVC 0.1 0.6 1.8 1.3 -0.2 0.3 1.3 -0.0 -0.2 1.2 -0.4 -0.5 -0.7 0.5 0.9 1.0 0.7 -0.2 1.0
Neuroticism 0.1 0.3 0.6 0.4 -0.1 -0.2 0.6 -0.4 0.5 0.3 0.7 -0.6 -0.5 0.8 0.7 -0.8 -0.1 -0.6 0.5
Chronotype (morning person) 0.4 0.9 2.1 -0.4 -0.7 -1.2 -0.9 -1.3 -0.4 -1.5 1.3 -1.1 -0.9 0.7 0.3 0.3 -1.3 -1.1 0.2
Hair Pigment 0.1 2.2 7.1 -0.2 -0.2 0.4 2.2 1.4 1.9 2.6 -0.1 0.3 0.2 0.0 1.9 -2.7 1.8 -0.4 2.0
Tanning 0.1 1.1 3.8 0.2 0.7 0.3 -0.6 -0.5 -2.0 -1.3 -0.2 0.1 -0.0 -0.9 -1.8 1.6 -0.5 0.9 -1.6
Hand grip strength (left) 0.5 1.3 3.0 0.9 1.7 1.3 0.9 0.9 -0.1 0.4 -1.2 1.1 1.3 -1.4 -1.3 0.9 1.2 1.6 -1.3
Number of treatments/medications taken 1.1 2.1 4.7 -0.2 -1.9 -1.7 0.1 -1.5 -1.0 -0.7 1.7 -2.0 -2.2 1.6 1.1 -1.2 -1.2 -1.6 1.4
Average weekly spirits intake 0.4 0.5 1.3 0.6 -0.6 0.5 1.0 1.1 0.8 1.2 -0.5 0.8 0.7 -0.6 0.5 -0.7 0.9 0.2 0.5
Sensitivity / hurt feelings 0.1 0.1 1.0 -0.4 0.8 -0.0 0.3 0.1 0.2 -0.2 0.5 0.2 0.3 0.1 -0.1 -1.0 0.2 0.0 -0.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.4 1.1 -0.7 -0.8 0.1 -0.7 -0.1 -0.2 1.0 -0.9 -0.7 1.6 0.6 -1.2 -0.4 -0.7 0.9
Hearing difficulty/problems: Yes 0.7 1.1 4.3 1.4 2.1 0.6 0.7 0.4 -1.3 -0.1 -0.1 0.4 0.4 -1.3 -1.3 -0.3 1.1 1.3 -1.3
Relative age of first facial hair 0.1 0.3 1.1 -0.2 0.8 0.3 -0.2 -0.1 -0.3 -0.3 -0.2 0.0 0.2 -0.6 -1.1 0.1 -0.1 0.7 -0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.6 0.9 0.1 0.9 1.3 1.1 0.2 1.1 -1.0 0.9 0.6 -0.5 -0.1 -0.4 1.2 0.4 0.0
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.0 -1.0 -0.4 -0.6 -0.3 0.0 0.6 -0.3 0.6 -0.2 -0.1 0.4 0.5 -0.4 -0.4 -0.3 0.4
Ever had hysterectomy (womb removed) 0.8 0.9 1.8 -0.2 -0.6 -1.2 -0.1 -0.8 -1.0 -0.2 1.1 -1.3 -1.3 1.0 0.8 -1.3 -0.5 -0.8 1.1
Systolic blood pressure, automated reading 0.8 2.2 5.0 -1.8 -1.7 -1.6 -0.7 -0.4 1.6 0.3 1.4 -1.0 -1.2 1.3 2.2 -2.1 -0.8 -1.9 2.0
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 0.8 0.4 0.9 0.4 0.9 -0.9 -0.0 -0.6 1.1 1.3 -1.4 -1.4 0.4 0.8 1.1 -1.3
Angina 0.9 1.2 7.4 0.4 -0.8 0.3 1.0 0.9 2.7 1.2 -0.2 0.7 0.6 0.2 1.5 -1.1 0.5 -0.5 1.5
Medication for hormone replacement therapy 2.3 2.5 5.4 -1.8 -0.9 -1.9 -1.9 -2.0 0.1 -1.6 1.2 -2.0 -2.1 2.1 0.7 0.7 -2.3 -1.3 0.5
Vitamin and mineral supplements 1.9 2.6 6.8 -0.9 1.5 1.8 0.0 2.0 2.1 1.1 -1.9 2.5 2.6 -2.1 -0.5 0.5 1.1 1.5 -1.2
Supplements: Zinc 0.3 0.3 1.3 1.2 0.1 0.4 0.1 -0.5 -0.9 -0.2 -0.6 -0.4 -0.5 0.6 -0.7 0.6 -0.2 0.4 -0.5
Medication: Co-codamol 0.4 0.4 1.7 0.1 -1.3 -0.1 1.0 -0.0 0.1 0.8 -0.1 -0.3 -0.3 0.2 0.8 -1.2 0.2 -0.7 1.0
Medication: Metformin 1.7 2.4 5.8 -0.8 -2.0 -1.2 0.2 -0.5 1.7 0.8 1.1 -1.3 -1.1 2.0 2.4 -2.1 -0.6 -2.0 2.4
Diabetes (father) 0.2 0.3 0.8 -0.3 0.5 0.8 0.1 0.8 -0.0 0.4 -0.7 0.9 0.7 -0.4 -0.4 0.0 0.6 0.6 -0.5
Diabetes (mother) 0.3 0.4 1.1 1.0 -0.1 0.3 0.6 0.9 1.0 0.7 -0.1 0.8 0.9 -0.2 0.4 -0.7 0.8 0.1 0.2
Severe depression (siblings) 0.2 0.2 1.3 0.8 0.1 -0.1 -0.3 -0.4 -1.1 -0.6 0.1 -0.3 -0.4 -0.2 -0.6 0.0 -0.3 0.3 -0.6
Pack years adult smoking proportion 0.5 0.8 1.9 0.5 0.0 -1.4 -0.6 -1.3 -0.3 -1.2 1.4 -1.3 -1.0 0.9 0.2 -0.5 -0.8 -0.5 -0.0
Impedance of leg (right) 0.6 2.8 10.1 0.2 1.7 2.7 0.9 1.3 -0.1 1.3 -2.7 1.8 1.6 -1.1 -1.2 3.2 1.1 1.6 -1.0
Leg fat-free mass (left) 1.0 5.2 13.9 -1.7 -1.4 -3.5 -2.1 -2.3 0.8 -2.5 3.7 -2.4 -2.1 2.0 1.9 -2.3 -2.2 -2.6 1.3
Trunk fat percentage 0.1 0.5 2.8 -1.7 -0.0 -0.3 -1.2 -0.1 1.4 -0.7 0.5 0.2 0.2 -0.1 0.7 -0.0 -0.7 -0.7 -0.0
Hand grip strength (right) 0.2 0.5 1.2 0.7 0.6 0.9 1.1 0.6 0.2 0.7 -0.8 0.7 0.6 -0.8 -0.5 0.2 0.9 0.8 -0.4
Townsend deprivation index at recruitment 0.5 0.6 2.6 1.1 0.1 0.7 1.6 1.0 0.4 0.9 -0.5 0.9 0.7 -0.5 0.2 -0.8 1.2 0.2 0.1
Current tobacco smoking 0.9 1.4 2.9 1.2 0.9 1.5 1.1 1.1 -0.6 1.3 -1.7 1.1 1.2 -1.3 -1.1 0.0 1.3 1.6 -0.9
Average weekly fortified wine intake 1.3 1.6 4.0 0.3 2.0 1.1 0.1 0.7 -1.1 -0.0 -1.1 0.9 1.2 -1.5 -1.9 0.8 0.8 1.9 -1.9
Maternal smoking around birth 0.1 0.2 0.5 -0.5 -0.2 -0.4 -0.3 -0.2 0.7 0.2 0.5 -0.4 -0.5 0.5 0.7 -0.5 -0.4 -0.6 0.4
Fed-up feelings 1.7 3.2 8.2 -0.0 -1.4 -1.9 -0.3 -2.2 -1.1 -0.9 2.1 -2.6 -2.6 2.9 1.2 -1.3 -1.6 -2.0 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 4.0 1.1 -0.1 -0.1 0.6 0.4 0.6 0.7 0.2 0.1 0.3 0.2 0.5 -2.0 0.7 -0.0 0.5
Relative age voice broke 0.2 0.3 0.8 0.1 -0.2 -0.6 0.0 -0.7 -0.9 -0.5 0.7 -0.9 -0.8 0.5 -0.2 -0.4 -0.4 -0.3 0.0
Taking other prescription medications 0.6 1.0 2.9 0.5 -1.7 -1.0 0.9 -0.6 -0.1 -0.1 0.8 -1.0 -1.2 1.0 1.0 -1.3 -0.4 -1.2 1.3
Age when periods started (menarche) 0.2 0.4 0.9 0.7 1.0 0.6 0.8 0.4 -0.7 0.4 -0.6 0.2 0.3 -0.2 -0.8 0.2 0.7 0.8 -0.5
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 9.7 -0.5 -2.1 -1.9 -0.3 0.1 2.0 0.4 1.6 -0.6 -0.6 0.8 2.4 -3.1 -0.2 -1.6 2.1
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 4.9 1.1 1.4 2.2 0.6 1.5 0.4 0.7 -2.0 2.0 2.1 -2.2 -1.7 1.4 1.2 2.1 -1.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.5 -0.6 1.1 0.1 -1.2 -0.2 -1.1 -0.7 -0.3 0.1 0.2 -1.0 -1.2 0.8 -0.3 0.6 -1.2
Qualifications: CSEs or equivalent 0.5 0.6 2.2 -1.3 -1.5 -0.6 -1.0 -0.5 0.4 -0.4 0.7 -0.3 -0.2 0.7 0.4 -0.6 -1.0 -1.0 0.3
Serious illness, injury or assault to yourself 0.3 0.4 2.5 0.7 0.1 -0.2 -0.1 -0.7 -1.6 -0.8 0.1 -0.5 -0.6 0.2 -0.7 0.8 -0.4 0.2 -0.3
High blood pressure 0.8 2.2 4.6 -1.2 -1.6 -2.1 -1.3 -1.1 0.7 -0.6 2.1 -1.4 -1.5 1.2 1.5 -2.1 -1.2 -1.7 1.2
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.3 0.8 0.7 0.7 0.3 -0.0 -1.5 -0.8 -0.1 0.4 0.4 -0.7 -1.4 1.1 0.0 0.7 -1.4
Multivitamins +/- minerals 1.8 2.3 5.8 0.7 -1.6 -1.8 -0.2 -2.0 -1.6 -1.0 1.8 -2.3 -2.4 1.7 0.8 -0.5 -1.2 -1.5 1.3
Stomach or abdominal pain in last month 0.7 0.9 3.4 0.3 1.8 0.2 -0.5 -0.2 -1.5 -1.0 0.1 0.2 0.1 -1.2 -1.4 1.1 0.0 1.1 -1.4
Supplements: Glucosamine 0.2 0.3 0.9 0.4 0.3 -0.7 0.5 -0.7 -0.5 -0.6 0.8 -1.0 -0.8 0.7 0.0 0.3 -0.1 -0.3 0.3
Diverticular disease/diverticulitis (self-reported) 2.8 3.4 7.9 1.3 0.3 1.3 2.2 2.6 2.5 2.8 -1.2 1.9 1.7 -1.5 1.0 -2.4 2.7 0.7 0.9
Medication: Atenolol 2.0 2.5 11.3 -0.9 -1.7 -1.2 -0.4 -0.1 3.4 0.6 1.0 -0.5 -0.8 1.5 2.5 -2.1 -0.6 -1.7 2.2
Medication: Levothyroxine sodium 0.4 0.7 2.4 0.0 0.8 0.8 0.7 -0.0 -1.6 -0.1 -1.1 0.1 0.2 -0.5 -1.5 1.3 0.1 0.9 -1.2
Sitting height 0.3 1.8 4.5 -1.0 0.1 -1.7 -1.6 -1.9 -0.9 -2.1 1.8 -1.6 -1.7 0.8 0.1 0.7 -1.6 -1.1 -0.1
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 -0.5 0.0 -0.6 -0.6 -0.9 -0.8 -0.7 0.6 -1.0 -0.9 0.7 0.1 0.1 -0.7 -0.4 0.1
High blood pressure (mother) 2.3 3.2 5.5 -2.0 -2.3 -2.3 -2.1 -1.7 -0.6 -1.9 2.3 -1.8 -1.6 1.4 1.0 -1.1 -2.3 -1.9 1.0
Body mass index (BMI) 0.4 1.6 6.1 -0.8 -0.9 -1.8 -0.9 -0.6 1.3 -1.0 1.9 -0.9 -0.5 0.8 1.4 -2.5 -0.8 -1.3 0.8
Impedance of leg (left) 0.9 4.2 13.5 0.2 2.0 3.2 1.0 1.5 -1.0 1.3 -3.1 2.1 1.8 -1.7 -2.1 3.7 1.2 2.2 -1.7
Leg predicted mass (left) 1.0 5.0 13.5 -1.6 -1.4 -3.5 -2.1 -2.2 0.8 -2.5 3.7 -2.3 -2.0 1.9 1.8 -2.3 -2.2 -2.5 1.2
Trunk fat mass 0.2 1.0 3.0 -1.7 -0.2 -1.1 -1.4 -0.5 1.5 -1.1 1.2 -0.4 -0.3 0.4 1.1 -0.7 -1.0 -1.1 0.3
Waist circumference 0.9 3.4 8.0 -1.5 -1.3 -2.5 -1.3 -1.3 1.6 -1.2 2.7 -1.6 -1.5 1.7 2.2 -2.8 -1.3 -2.4 1.7
Number of incorrect matches in round 3.3 5.5 9.2 2.5 2.7 2.9 1.5 1.8 -2.0 1.3 -3.0 2.1 2.1 -2.5 -2.9 1.7 2.0 3.0 -2.4
Past tobacco smoking 0.5 1.0 2.4 -0.4 0.4 1.5 0.2 1.0 0.1 0.7 -1.5 1.3 1.2 -1.4 -0.8 0.9 0.5 0.9 -1.1
Alcohol usually taken with meals 0.1 0.1 0.4 0.4 -0.3 -0.1 0.6 -0.2 -0.3 0.4 0.3 -0.4 -0.3 0.4 0.2 -0.5 0.2 -0.1 0.5
Nervous feelings 0.2 0.3 1.7 1.0 -0.2 0.9 1.3 -0.0 -0.3 0.8 -0.6 -0.2 -0.2 -0.2 -0.2 -0.1 0.5 0.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 2.0 1.4 0.5 -0.1 1.2 -0.1 -0.7 0.4 0.4 -0.4 -0.3 0.3 0.2 -1.2 0.7 0.1 0.5
Hearing difficulty/problems with background noise 0.8 1.3 4.1 1.9 2.0 0.8 1.6 0.6 -1.2 0.3 0.0 0.4 0.5 -1.2 -1.1 -0.7 1.4 1.4 -0.9
Hair/balding pattern: Pattern 2 0.4 0.6 1.8 0.6 -0.7 -0.5 0.6 -0.3 1.1 0.4 0.3 -0.7 -0.6 0.8 1.3 -0.8 -0.2 -0.9 1.1
Had menopause 1.6 1.9 4.2 0.2 1.0 1.9 0.5 1.1 -0.3 0.4 -1.9 1.7 1.6 -1.9 -1.5 2.0 0.9 1.5 -1.6
Had other major operations 0.4 0.4 3.2 -0.8 -0.3 -0.6 0.4 0.2 0.5 0.4 0.2 -0.3 -0.4 0.4 0.7 -1.8 0.0 -0.6 0.9
Forced vital capacity (FVC) 0.5 1.9 3.5 -0.8 -1.1 -1.4 -0.9 -1.9 -0.8 -1.5 1.5 -1.8 -1.8 1.4 0.6 1.5 -1.6 -1.5 0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 5.2 0.9 1.3 2.3 0.8 1.4 0.2 1.1 -2.1 1.6 1.8 -2.0 -1.5 0.9 1.3 2.0 -1.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.9 0.5 0.2 -0.6 -0.4 -1.0 -0.1 -0.6 0.4 -0.7 -0.8 0.6 0.3 0.8 -0.8 -0.5 0.4
Qualifications: None of the above 1.6 3.3 8.5 1.7 -1.3 -0.1 2.2 1.0 2.6 2.7 -0.2 0.1 0.0 1.2 2.7 -2.9 1.4 -1.0 2.9
Financial difficulties in last 2 years 0.4 0.5 1.0 0.9 1.0 0.7 0.5 0.5 0.1 0.8 -0.9 0.5 0.7 -0.1 -0.5 -0.8 0.9 0.7 -0.6
Mouth/teeth dental problems 1.7 2.6 7.7 -0.9 -0.9 -0.8 -2.3 -2.0 -2.3 -2.2 0.3 -1.4 -1.6 0.5 -1.0 2.8 -2.3 -0.5 -0.9
Heart attack 0.4 0.6 2.9 -0.4 -0.1 0.0 0.7 0.2 1.7 0.7 -0.2 0.1 -0.0 0.5 1.4 -1.0 0.1 -0.8 1.1
Allergy 0.5 1.1 4.0 -1.7 -0.6 -1.0 -0.8 -0.4 2.0 0.3 0.2 -0.7 -0.6 0.7 1.7 -0.7 -0.7 -1.1 1.2
Pain all over the body in last month 2.0 2.2 4.2 -0.5 -0.8 -1.7 -1.3 -2.0 -0.8 -1.9 2.1 -1.8 -1.8 1.7 0.6 -0.1 -1.9 -1.4 0.9
Diabetes (self-reported) 0.4 0.6 1.5 -1.2 -1.1 -0.6 -1.2 -0.3 1.1 -0.6 0.7 -0.1 -0.0 0.7 0.7 0.1 -0.9 -1.0 0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 6.8 0.7 0.7 0.4 0.3 -0.6 -2.6 -0.9 -0.2 -0.2 -0.3 -0.5 -1.5 1.7 -0.1 0.7 -1.3
Medication: Ramipril 0.3 0.4 1.1 0.0 -0.4 -0.7 -0.3 -0.9 -0.3 -0.6 0.7 -0.9 -1.0 0.6 0.4 -0.1 -0.7 -0.6 0.3
Medication: Simvastatin 1.8 2.6 7.5 -0.6 -2.3 -1.6 0.2 -0.6 0.9 0.5 1.8 -1.3 -1.4 1.4 2.4 -2.3 -0.5 -2.1 2.7
Fluid intelligence score 0.4 0.8 2.2 -1.1 1.0 -0.1 -1.5 -0.2 0.9 -1.3 0.1 0.5 0.7 -0.8 -0.5 1.5 -0.7 0.2 -1.0
Illnesses of siblings 0.2 0.2 0.6 -0.7 -0.4 0.5 0.7 0.4 0.6 0.8 -0.6 0.2 0.2 0.4 0.4 -0.3 0.4 0.0 0.2
Neuroticism score 0.1 0.2 0.9 0.6 0.6 0.3 0.6 -0.3 -1.0 -0.0 0.2 -0.3 -0.2 0.2 -0.5 -0.2 0.2 0.2 -0.3
Weight 0.4 2.0 5.2 -1.4 -0.6 -2.1 -1.4 -1.1 1.4 -1.5 2.3 -1.1 -0.9 1.0 1.4 -1.7 -1.3 -1.6 0.7
Impedance of arm (right) 0.8 3.6 15.9 0.5 1.9 2.9 0.8 1.3 -0.2 0.7 -2.8 2.0 1.6 -1.8 -1.8 4.0 1.1 1.6 -1.7
Arm fat percentage (right) 0.1 0.4 2.2 -0.7 0.1 -0.7 -0.7 -0.0 1.5 -0.6 0.7 -0.1 0.1 0.1 0.9 -1.1 -0.3 -0.7 0.2
Trunk fat-free mass 0.7 4.2 11.9 -1.0 -0.7 -3.4 -1.5 -2.0 0.9 -2.0 3.5 -2.3 -1.9 1.9 1.8 -2.3 -1.7 -2.1 1.3
Hip circumference 0.4 1.9 5.2 -1.2 -0.8 -2.0 -1.5 -1.3 0.9 -1.6 2.3 -1.2 -1.0 0.9 1.3 -1.3 -1.4 -1.6 0.7
Time employed in main current job 0.2 0.2 0.7 0.4 0.2 -0.2 0.9 -0.2 0.7 0.3 -0.1 -0.4 -0.4 0.6 0.6 -0.3 0.0 -0.5 0.7
Alcohol intake versus 10 years previously 1.5 2.3 4.6 -0.6 -1.2 -2.1 -0.5 -0.9 1.0 -0.2 1.8 -1.4 -1.5 1.9 2.1 -2.0 -0.7 -2.0 2.0
Father’s age at death 0.6 0.8 2.0 1.0 -0.0 0.7 0.2 1.2 -0.2 0.4 -1.0 1.3 1.4 -1.2 -0.9 -0.4 0.9 0.9 -0.8
Worrier / anxious feelings 0.1 0.2 1.1 1.0 0.0 0.3 0.9 -0.5 -0.1 0.1 0.3 -0.5 -0.3 0.6 0.2 -0.0 -0.0 -0.3 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.0 10.9 -0.4 -0.8 -1.3 0.6 -0.4 0.5 0.7 1.6 -1.2 -1.1 1.8 1.9 -3.3 -0.0 -1.4 2.0
Falls in the last year 3.5 4.8 10.6 2.8 1.9 2.1 2.8 2.9 0.9 2.5 -2.2 2.4 2.3 -2.4 -0.4 -1.1 3.2 1.8 -0.5
Hair/balding pattern: Pattern 3 0.2 0.3 3.3 1.8 -0.3 0.1 0.8 0.1 -0.4 0.3 -0.3 -0.1 -0.0 -0.3 0.0 -0.3 0.3 0.2 0.2
Number of live births 0.1 0.1 0.3 0.1 0.5 0.1 0.1 0.4 -0.3 0.3 0.2 0.2 0.3 -0.1 0.1 -0.3 0.5 0.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.6 -0.9 -1.3 -1.6 -1.2 -1.9 -0.6 -1.7 1.8 -1.7 -1.6 1.5 0.7 1.1 -1.7 -1.6 0.7
Pulse rate 0.3 0.5 1.6 0.9 -0.3 0.5 1.3 0.8 0.0 1.2 -0.4 0.4 0.3 -0.2 0.3 -1.2 0.8 0.2 0.6
Happiness 0.2 0.3 1.3 0.8 0.6 -0.5 -0.1 -0.2 -1.1 -0.5 0.6 -0.2 -0.0 -0.2 -0.7 -0.7 -0.0 0.5 -0.5
Noisy workplace 1.5 1.8 3.9 1.9 1.6 1.1 1.4 0.9 -2.0 0.0 -0.4 1.0 0.9 -1.7 -1.9 -0.1 1.4 1.7 -1.4
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.8 1.9 1.7 1.3 1.2 0.5 -1.7 -0.4 -0.8 0.7 1.0 -1.4 -2.2 1.7 1.0 1.9 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.8 -0.0 0.9 -0.4 -0.1 -0.1 -0.7 -0.0 -0.0 -0.5 -0.5 0.5 -0.1 -0.2 -0.1 0.1 0.0
Mouth/teeth dental problems: Dentures 0.6 1.0 2.1 0.4 0.4 1.1 0.7 1.4 1.0 1.3 -1.4 1.4 1.4 -0.9 -0.1 -0.4 1.2 0.8 -0.3
Asthma 0.6 1.1 6.3 1.9 -0.4 -0.6 0.4 -1.1 -2.5 -1.1 1.3 -1.2 -1.0 0.8 -0.7 -0.0 -0.2 -0.0 -0.0
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.3 0.3 -0.6 -1.6 -1.0 -1.8 -0.7 -1.4 1.4 -1.6 -1.6 1.3 0.2 0.4 -1.4 -1.0 0.2
Medication: Cholesterol lowering 2.1 3.3 6.5 -1.9 -1.9 -1.7 -0.7 -1.5 0.9 0.1 1.6 -2.0 -2.4 2.0 2.5 -1.3 -1.6 -2.5 2.5
Depression (self-reported) 0.1 0.2 0.5 0.5 -0.7 -0.7 -0.5 -0.1 -0.2 -0.7 0.7 0.1 0.2 0.1 -0.2 -0.4 -0.1 -0.0 0.0
Medication: Lansoprazole 0.7 0.8 3.2 -0.2 -0.2 -1.0 -0.5 -0.3 1.8 -0.4 1.1 -0.4 -0.4 0.8 1.4 -0.8 -0.4 -1.0 1.1
Prospective memory result 0.2 0.2 1.6 0.2 -0.3 -0.3 -0.8 -0.3 -1.3 -0.3 -0.0 -0.3 -0.5 -0.3 -0.6 -0.3 -0.3 0.0 -0.4
Lung cancer (father) 3.0 3.5 7.6 -1.9 -2.4 -1.9 -0.8 -1.0 1.8 0.2 1.8 -1.6 -1.7 2.1 2.8 -2.3 -1.3 -2.4 2.3
Illnesses of mother 0.4 0.5 2.1 -0.6 0.7 0.7 0.3 0.7 0.3 0.7 -1.4 0.7 0.5 -0.6 -0.5 0.5 0.5 0.8 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.3 -0.2 -0.7 -1.2 -0.9 -1.8 -0.9 -1.7 1.4 -1.5 -1.3 1.1 0.2 1.4 -1.4 -1.1 0.3
Pulse wave Arterial Stiffness index 1.4 1.7 5.7 1.3 1.3 1.1 2.4 1.4 0.7 2.3 -0.9 0.7 0.5 -0.8 0.4 -1.6 1.9 0.7 0.5
Impedance of arm (left) 0.8 3.6 16.1 0.1 1.7 3.0 0.5 1.3 -0.5 0.8 -2.9 2.0 1.6 -1.8 -1.8 4.0 0.9 1.7 -1.7
Arm fat mass (right) 0.3 1.0 2.4 -0.9 -0.2 -1.5 -1.2 -0.6 1.4 -1.2 1.6 -0.6 -0.3 0.5 1.0 -1.3 -0.9 -1.1 0.3
Trunk predicted mass 0.7 4.0 11.5 -1.0 -0.7 -3.4 -1.4 -2.0 0.9 -2.0 3.4 -2.3 -1.9 1.9 1.8 -2.3 -1.7 -2.1 1.3
Standing height 0.2 1.6 4.0 -1.7 0.7 -1.3 -1.7 -1.6 0.1 -2.0 1.6 -1.0 -1.1 0.6 0.2 1.6 -1.6 -1.1 -0.3
Length of working week for main job 0.2 0.2 1.2 -0.4 -0.5 -0.2 -0.0 0.3 1.1 0.1 0.2 0.2 0.1 0.4 0.5 -0.7 -0.1 -0.4 0.6
Exposure to tobacco smoke at home 0.4 0.4 1.3 0.0 -1.0 -0.7 0.5 0.1 0.3 0.1 0.9 -0.3 -0.3 0.4 0.9 -1.1 0.2 -0.7 1.1
Breastfed as a baby 0.5 0.6 1.6 0.1 0.8 1.1 0.1 0.4 -1.1 0.5 -1.3 0.6 0.6 -0.5 -1.1 0.7 0.3 0.9 -0.8
Tense / ‘highly strung’ 0.4 0.6 3.3 1.3 0.1 0.4 1.8 -0.5 -1.2 0.7 0.1 -0.9 -1.0 0.3 0.2 0.0 0.5 -0.0 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 5.1 1.5 -0.8 -0.5 0.2 -0.8 -2.2 -0.9 0.5 -0.8 -0.7 0.0 -0.9 0.0 -0.4 0.4 -0.5
Hair/balding pattern: Pattern 4 0.9 2.2 6.1 0.1 2.5 1.9 0.5 1.4 -0.1 0.5 -1.4 1.9 1.7 -1.8 -1.4 1.5 1.3 1.6 -1.5
Birth weight of first child 0.4 0.7 2.1 -0.1 -0.1 -0.5 -1.0 -1.1 -1.3 -1.5 0.2 -0.7 -0.6 0.1 -0.8 0.9 -1.1 0.0 -0.9
Peak expiratory flow (PEF) 0.6 1.5 3.1 -0.9 -1.3 -1.6 -0.9 -1.4 0.2 -1.4 1.8 -1.3 -1.1 1.3 0.8 0.1 -1.5 -1.6 0.8
Pulse wave reflection index 2.7 3.3 6.1 1.5 2.1 2.0 2.5 2.2 1.7 2.5 -1.8 1.9 2.0 -1.6 0.0 -0.5 2.4 1.5 -0.2
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 0.2 -0.3 -0.4 0.5 -0.2 -0.4 0.4 0.9 -0.6 -0.6 0.6 0.6 -0.9 0.4 -0.4 0.9
Loud music exposure frequency 1.6 1.8 3.8 0.7 1.0 1.6 0.4 1.4 -0.7 0.6 -1.5 1.6 1.6 -1.9 -1.7 0.1 1.2 1.7 -1.7
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 4.3 0.7 2.0 0.9 0.3 0.1 -1.5 -0.8 -0.6 0.5 0.7 -1.1 -2.1 1.8 0.5 1.5 -2.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.0 -0.7 0.7 -0.5 -0.0 -0.0 0.1 -0.2 1.0 -0.2 -0.2 0.4 0.2 -0.9 0.2 -0.3 0.2
Blood clot in the leg (DVT) 0.7 0.9 2.5 0.9 1.6 0.9 0.1 0.6 -1.3 0.3 -0.6 0.7 0.3 -0.9 -1.3 1.0 0.8 1.2 -1.2
Medication: Paracetamol 0.8 1.3 3.6 -0.7 -0.8 -1.5 -0.2 -0.9 0.2 -0.0 1.5 -1.5 -1.3 1.5 1.3 -1.9 -0.6 -1.2 1.1
Headache pain in last month 0.3 0.6 1.8 -0.3 0.4 -0.0 -1.0 -0.1 -1.0 -1.0 0.2 0.3 0.4 -0.8 -1.2 0.8 -0.4 0.6 -1.4
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 5.1 1.8 1.7 1.6 1.0 1.3 -0.6 0.0 -1.6 1.8 2.3 -1.7 -2.1 1.2 1.6 2.1 -2.0
Glaucoma (self-reported) 1.5 1.7 4.4 0.6 -0.2 1.2 1.0 1.9 2.1 1.7 -0.9 1.9 2.1 -1.0 0.4 -1.0 1.5 0.7 0.2
Gout (self-reported) 0.5 0.8 3.3 -1.0 0.1 -0.3 -1.8 -0.6 -0.4 -1.4 0.1 -0.0 0.1 -0.0 -0.7 1.5 -1.1 0.1 -1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.7 -0.0 -0.1 0.6 0.8 0.1 -0.5 0.2 -0.8 0.1 0.1 -0.3 -0.6 0.5 0.1 0.3 -0.6
Medication: Amlodipine 4.0 5.6 10.7 -1.8 -3.3 -3.1 -2.3 -2.5 -0.9 -2.1 3.1 -2.6 -2.8 2.1 1.6 -1.5 -2.7 -2.6 1.6
Medication: Ventolin 100micrograms inhaler 1.3 1.7 4.3 0.7 -1.2 -1.5 0.3 -1.2 -0.6 -0.3 1.6 -1.7 -1.6 2.1 1.1 -1.7 -0.7 -1.2 1.6
Birth weight 0.2 0.4 1.4 0.2 0.2 0.6 -0.4 0.2 -0.2 -0.3 -0.5 0.6 0.7 -0.7 -0.9 1.0 0.1 0.7 -1.2
Chronic bronchitis/emphysema (mother) 0.6 0.6 2.2 0.8 -0.3 0.4 1.4 0.1 0.6 1.5 -0.1 -0.5 -0.6 0.9 1.0 -0.4 0.6 -0.4 1.3
High blood pressure (siblings) 0.9 1.2 2.7 -0.8 -0.5 -1.6 -1.6 -1.1 -0.1 -1.2 1.7 -1.0 -1.2 0.6 0.8 -0.8 -1.4 -1.3 0.7
Forced vital capacity (FVC), Best measure 0.6 2.1 4.4 -0.1 -1.1 -1.6 -0.5 -2.1 -0.9 -1.5 1.7 -2.0 -2.1 1.6 0.9 1.3 -1.5 -1.6 0.9
Body fat percentage 0.1 0.4 1.9 -1.4 -0.1 -0.3 -0.9 0.1 1.4 -0.4 0.4 0.2 0.2 -0.0 0.8 -0.5 -0.4 -0.6 0.1
Leg fat percentage (right) 0.2 0.6 2.0 -0.9 -0.5 -0.5 -0.3 -0.0 1.3 0.1 0.7 -0.2 -0.1 0.6 1.3 -1.4 -0.2 -0.8 0.8
Arm fat-free mass (right) 0.7 3.7 10.1 -1.4 -1.3 -3.0 -1.7 -2.0 0.4 -2.0 3.2 -2.1 -1.8 1.7 1.5 -2.1 -1.9 -2.0 1.1
Exposure to tobacco smoke outside home 0.5 0.7 2.9 1.3 1.0 0.2 1.4 0.6 -0.5 1.0 0.0 0.0 -0.1 0.0 0.1 -1.7 1.4 0.4 0.2
Comparative body size at age 10 0.2 0.4 2.1 -0.8 0.2 -0.2 -1.4 -0.2 -0.2 -0.8 -0.1 0.4 0.4 -0.3 -0.5 1.2 -0.6 0.4 -1.0
Number of full brothers 0.8 1.0 3.1 0.7 1.8 0.5 -0.4 0.5 -1.0 -0.2 -0.3 0.8 1.2 -0.9 -1.5 0.7 0.6 1.6 -1.7
Worry too long after embarrassment 0.1 0.2 0.8 -0.5 0.8 -0.2 -0.4 -0.5 0.0 -0.9 0.4 -0.2 -0.1 0.1 -0.2 0.1 -0.4 -0.2 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.9 1.4 0.8 1.2 1.4 1.3 -0.4 0.5 -0.7 1.4 1.2 -1.7 -1.1 -0.3 1.5 1.4 -1.0
Wheeze or whistling in the chest in last year 0.8 1.4 7.6 0.8 -0.4 -0.6 -0.5 -1.6 -2.8 -1.8 1.0 -1.3 -1.2 -0.1 -0.9 1.1 -1.1 -0.2 -0.6
Number of children fathered 0.2 0.2 0.8 0.1 0.6 -0.3 0.2 -0.1 0.9 0.5 0.2 -0.4 -0.4 0.5 0.8 -0.4 0.2 -0.1 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.7 0.7 0.2 0.9 1.2 0.3 -1.3 0.0 -0.3 0.4 0.3 -0.5 -0.8 1.2 0.6 0.5 -0.4
Age at first live birth 1.0 1.8 4.2 -1.2 0.2 -1.1 -2.0 -1.9 -1.2 -2.0 0.8 -1.5 -1.4 0.7 -0.6 1.8 -2.0 -0.4 -0.8
Pulse wave peak to peak time 1.6 1.9 6.5 -1.5 -1.4 -1.2 -2.5 -1.5 -0.6 -2.4 1.0 -0.7 -0.6 0.9 -0.4 1.7 -2.0 -0.9 -0.5
Health satisfaction 0.5 0.6 4.3 0.4 -0.5 -0.7 0.4 -0.7 -2.1 -0.5 0.9 -1.0 -0.8 0.3 -0.5 -0.7 -0.3 -0.0 -0.1
Shortness of breath walking on level ground 0.6 0.7 2.7 0.2 -1.6 -0.0 1.1 0.3 0.3 1.3 -0.2 -0.1 -0.2 0.6 0.8 -1.6 0.3 -0.4 1.2
Qualifications: College or University degree 0.2 0.7 1.7 1.0 0.5 1.0 1.3 0.5 -1.3 0.0 -0.3 0.5 0.4 -0.9 -1.0 0.9 0.9 0.9 -0.7
Eye problems/disorders: None of the above 0.5 0.6 2.8 0.1 1.7 -0.3 -0.8 -0.6 -0.9 -1.1 -0.0 -0.3 -0.2 -0.2 -0.9 0.9 -0.2 0.4 -1.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.6 -0.2 1.0 0.3 0.5 1.2 1.6 0.8 -0.4 1.1 1.2 -0.9 0.1 -1.2 1.0 0.6 -0.5
Emphysema/chronic bronchitis 0.3 0.3 0.8 0.4 -0.0 0.2 0.8 0.5 0.7 0.9 -0.0 0.1 0.1 0.6 0.6 -0.9 0.4 -0.1 0.9
Medication for pain relief, constipation, heartburn 1.2 2.0 4.2 0.9 1.2 1.9 0.4 1.4 0.2 0.6 -2.1 1.9 1.9 -1.7 -1.3 1.4 1.2 1.6 -1.3
Neck or shoulder pain in last month 0.3 0.4 1.7 -0.1 -0.0 0.6 0.0 1.1 0.1 0.1 -0.4 1.1 1.3 -0.8 -0.5 -0.3 0.5 0.5 -0.4
Medication: Blood pressure 1.2 2.1 4.1 -2.0 -1.5 -1.6 -1.5 -1.2 0.7 -0.5 1.6 -1.4 -1.8 1.4 1.6 -0.9 -1.6 -1.8 1.3
Angina (self-reported) 1.0 1.3 7.6 0.4 -0.7 0.4 1.2 1.1 2.8 1.4 -0.4 0.8 0.7 0.1 1.5 -1.2 0.7 -0.4 1.4
Migraine (self-reported) 0.5 0.6 1.3 0.5 0.7 0.9 0.7 0.9 -0.2 0.3 -0.5 1.0 1.0 -0.9 -1.0 -0.1 0.9 1.1 -0.9
Medication: Ibuprofen 1.2 1.4 3.0 -0.0 -1.1 -1.5 -1.1 -1.7 -0.5 -1.4 1.4 -1.6 -1.5 1.4 0.3 0.7 -1.6 -1.1 0.2
Medication: Allopurinol 1.0 1.3 3.7 -0.8 1.0 -0.2 -1.8 -0.8 -1.3 -1.9 0.1 -0.0 0.0 -0.6 -1.4 1.9 -1.1 0.5 -1.8
Medication: Omeprazole 2.0 2.4 5.1 0.6 1.9 1.7 1.1 1.1 -2.3 0.7 -1.7 1.1 1.0 -2.0 -2.1 0.9 1.2 2.0 -2.0
Medication: Seretide 50 evohaler 1.0 1.1 3.0 1.2 -0.4 -0.9 0.7 -1.1 -1.4 -0.3 1.0 -1.7 -1.7 1.6 0.5 -0.7 -0.4 -0.7 0.9
Mean time to correctly identify matches 0.4 0.8 1.9 0.5 0.9 1.0 -0.0 0.3 -1.3 0.1 -1.0 0.6 0.4 -1.3 -1.3 1.2 0.5 1.1 -1.4
Heart disease (mother) 0.3 0.4 1.7 1.3 0.4 -0.0 0.2 -0.7 -1.0 -0.8 0.6 -0.5 -0.4 0.2 -0.4 0.8 -0.1 0.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.6 0.4 -0.7 0.2 0.9 0.5 -0.1 0.6 0.1 -0.0 0.1 0.1 -0.0 -1.3 0.3 0.1 0.4
Whole body fat mass 0.2 0.8 1.9 -1.4 -0.2 -1.0 -1.2 -0.3 1.4 -0.8 1.2 -0.3 -0.2 0.3 1.0 -1.1 -0.7 -0.9 0.3
Leg fat mass (right) 0.3 1.3 3.3 -1.2 -0.6 -1.4 -1.0 -0.6 1.4 -0.7 1.7 -0.8 -0.5 0.9 1.4 -1.8 -0.8 -1.2 0.8
Arm predicted mass (right) 0.9 4.5 11.4 -1.7 -1.5 -3.3 -1.9 -2.1 0.5 -2.1 3.4 -2.3 -1.9 1.9 1.7 -2.3 -2.1 -2.2 1.2
Pulse rate, automated reading 0.2 0.5 2.4 -0.1 -0.4 0.6 0.7 1.0 0.4 1.5 -0.6 0.5 0.3 -0.1 0.7 -1.2 0.8 -0.0 0.9
Alcohol intake frequency. 0.7 1.6 5.1 0.2 -1.7 -0.8 0.8 -0.2 1.5 0.8 0.6 -0.7 -0.7 1.8 2.0 -1.7 -0.1 -1.5 2.3
Comparative height size at age 10 0.9 5.2 8.6 -2.4 -0.8 -2.8 -2.4 -2.9 -0.2 -2.4 2.6 -2.7 -2.9 2.4 1.7 0.8 -2.9 -2.6 1.4
Number of full sisters 0.7 0.9 2.0 0.5 0.5 -1.4 -0.3 -1.3 0.1 -1.1 1.4 -1.3 -1.1 1.1 0.9 -0.4 -0.5 -1.1 0.7
Suffer from ‘nerves’ 1.3 2.1 4.0 1.2 1.0 2.0 1.6 1.0 -1.6 1.1 -1.9 1.0 0.9 -1.6 -1.7 1.0 1.5 1.7 -1.5
Overall health rating 1.3 2.8 6.0 1.3 -2.1 -1.7 1.0 -1.2 -0.2 0.3 2.0 -2.0 -1.8 2.2 1.9 -2.5 -0.4 -1.7 2.3
Chest pain or discomfort 0.2 0.2 0.9 0.4 1.0 0.3 0.6 0.4 -0.0 0.9 -0.0 0.1 0.1 -0.3 0.2 -0.6 0.8 0.3 0.3
Had major operations 0.8 0.9 2.7 0.6 0.5 0.6 1.4 1.3 1.1 1.6 -0.6 0.8 0.6 -0.4 0.7 -1.6 1.3 0.4 0.6
Age at last live birth 1.4 2.0 5.2 -0.6 0.0 -1.7 -1.5 -2.0 -1.2 -2.3 2.0 -1.9 -1.6 1.1 -0.2 0.4 -1.7 -0.9 -0.3
Family relationship satisfaction 0.8 1.0 3.0 -1.2 -1.0 -1.1 -1.3 -1.2 -0.6 -1.3 1.1 -1.0 -0.9 1.0 0.0 0.2 -1.7 -0.7 0.1
Leg pain on walking 0.1 0.2 1.1 -0.2 -1.1 0.1 0.2 -0.1 -0.4 0.4 0.2 -0.3 -0.3 0.4 0.1 -0.5 -0.2 -0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 5.8 -2.4 0.1 -1.0 -1.9 -1.2 -1.2 -1.4 0.6 -1.1 -1.0 0.7 -0.8 -0.2 -1.7 -0.4 -0.9
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.6 -0.8 0.4 0.7 -0.4 0.5 -0.4 0.1 -0.5 0.6 0.6 -0.3 -0.7 0.6 0.3 0.5 -0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.5 -1.2 -1.0 -0.7 -1.0 -0.7 0.6 -0.9 0.7 -0.5 -0.6 0.0 0.5 0.5 -1.2 -0.7 0.2
Medication: Aspirin 1.7 2.2 4.7 -1.4 -1.2 -1.7 -0.2 -0.8 1.3 -0.2 1.8 -1.4 -1.6 1.6 2.1 -1.6 -0.9 -2.0 2.2
Supplements: Vitamin C 0.3 0.4 1.2 0.1 0.5 0.1 -0.8 -0.1 -0.5 -1.0 -0.3 0.3 0.3 -0.1 -1.1 1.0 -0.5 0.4 -1.1
Knee pain experienced in last month 0.4 0.6 2.0 0.1 -0.4 0.8 0.9 1.1 0.5 1.4 -1.0 1.0 0.9 -0.3 -0.0 -1.0 0.8 0.5 -0.0
Hypertension (Self-reported) 0.7 2.1 4.4 -1.3 -1.7 -2.0 -1.7 -1.3 0.3 -1.1 2.1 -1.5 -1.5 1.1 1.1 -1.5 -1.5 -1.6 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.7 -0.8 0.6 0.1 -0.2 0.1 0.5 0.3 -0.2 0.2 -0.2 -0.3 0.3 0.2 -0.2 -0.1 -0.0
Illnesses of father: Heart disease 0.3 0.4 1.1 0.3 0.3 0.6 0.4 0.9 0.1 0.5 -1.0 1.0 1.0 -0.9 -0.4 0.2 0.7 0.6 -0.6
Illnesses of siblings: Diabetes 0.4 0.5 1.4 1.0 0.1 0.4 0.5 0.7 0.7 1.1 -0.1 0.5 0.7 0.1 0.4 -1.2 1.0 0.4 0.5
Smoking status: Previous 1.0 1.5 3.4 -0.3 -0.4 -1.7 -0.3 -1.1 0.4 -0.6 1.7 -1.6 -1.6 1.9 1.4 -0.9 -0.8 -1.4 1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.3 -0.3 0.8 0.4 -0.2 0.1 0.1 -0.6 -0.3 0.6 0.7 -0.6 -0.9 1.2 -0.3 0.7 -1.1
Whole body fat-free mass 0.9 5.1 13.8 -1.5 -1.1 -3.6 -1.9 -2.2 0.9 -2.4 3.7 -2.4 -2.1 2.0 1.9 -2.4 -2.1 -2.4 1.3
Leg fat-free mass (right) 0.7 3.8 11.0 -1.4 -1.1 -3.1 -1.9 -2.0 0.3 -2.4 3.3 -2.1 -1.8 1.4 1.3 -2.0 -2.0 -2.1 0.7
Arm fat percentage (left) 0.1 0.5 2.1 -1.1 -0.2 -0.7 -1.0 -0.1 1.5 -0.6 0.7 -0.0 0.1 0.1 0.9 -1.0 -0.5 -0.7 0.2
Average weekly red wine intake 1.2 1.8 3.3 1.1 1.2 1.6 0.8 1.3 -0.4 0.5 -1.3 1.6 1.7 -1.8 -1.5 0.9 1.2 1.8 -1.6
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.9 0.4 0.2 -1.0 0.4 -0.4 0.7 0.2 1.4 -1.0 -0.8 1.4 1.3 -2.0 -0.0 -0.9 1.6
Mood swings 0.9 1.6 3.5 1.6 -0.7 -1.0 1.3 -1.3 -1.2 -0.0 1.6 -1.9 -1.8 1.8 0.9 -0.9 -0.3 -0.9 1.3
Loneliness, isolation 0.3 0.4 2.1 1.4 0.5 0.1 1.0 0.0 -0.1 0.8 0.2 -0.3 -0.1 0.2 0.4 -1.4 0.7 0.1 0.5
Long-standing illness, disability or infirmity 0.5 0.7 1.3 0.5 -1.1 -1.1 0.0 -0.8 -0.2 -0.8 1.1 -1.0 -1.1 0.8 0.7 -0.9 -0.7 -1.1 0.7
Ever had bowel cancer screening 0.7 0.8 2.2 -1.2 -0.1 -0.7 -0.4 -0.5 0.9 0.1 0.6 -0.8 -1.0 1.0 1.5 -0.3 -0.7 -1.2 1.4
Diabetes diagnosed by doctor 0.3 0.6 1.8 -1.3 -1.4 -0.6 -1.1 -0.5 0.5 -0.7 0.7 -0.3 -0.2 0.6 0.4 0.1 -1.1 -0.9 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.8 -0.5 0.8 -0.0 -1.4 -0.2 -0.6 -1.2 0.0 0.3 0.5 -0.3 -1.0 0.7 -0.6 0.4 -1.4
Friendships satisfaction 0.6 0.8 2.1 -1.1 -0.7 -1.1 -1.4 -1.0 -0.0 -0.9 0.8 -0.9 -1.0 0.5 0.4 -0.5 -1.2 -0.9 0.3
Qualifications: nursing, teaching 0.9 1.4 3.8 0.8 1.1 1.3 1.1 0.3 -2.0 0.1 -0.7 0.5 0.2 -1.7 -1.8 1.3 0.7 1.5 -1.5
Commuting to job workplace: Walk 1.7 1.8 5.9 -0.9 0.4 -0.6 -1.4 -1.8 -2.4 -2.0 0.7 -1.3 -1.4 0.6 -1.2 1.6 -1.7 -0.0 -1.2
Eye problems/disorders: Cataract 3.3 3.8 7.6 -1.9 -2.8 -1.8 -0.9 -1.1 2.1 -0.0 1.8 -1.7 -1.6 2.2 2.7 -1.9 -1.6 -2.5 2.5
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 6.5 1.1 0.1 -0.3 2.0 0.8 1.6 1.1 1.0 0.2 0.4 0.8 1.5 -2.6 1.3 -0.4 1.7
Medication for cholesterol 2.7 4.1 8.6 0.4 2.4 2.9 0.9 2.3 -0.1 1.6 -2.9 2.5 2.4 -2.2 -1.6 1.7 1.8 2.2 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.5 0.1 -0.6 -0.4 0.4 -0.5 -0.3 0.1 0.5 -0.7 -0.5 0.5 0.6 -0.2 -0.1 -0.5 0.7
Back pain experienced in last month 0.6 0.9 3.4 -0.6 -0.8 -0.2 0.9 0.6 1.1 1.2 0.4 0.1 -0.3 1.1 1.3 -1.9 0.5 -0.9 1.4
Mineral and other dietary supplements 1.2 1.6 3.8 -1.1 0.8 1.5 0.2 1.7 1.8 1.3 -1.6 1.9 2.0 -1.2 -0.3 -0.2 1.0 1.1 -0.8
Breast cancer (self-reported) 1.0 1.2 4.6 -0.6 -0.8 0.3 1.1 1.3 2.2 1.4 -0.1 0.9 1.0 0.2 1.2 -1.5 1.0 -0.3 1.3
Asthma (self-reported) 0.5 1.1 6.7 2.0 -0.4 -0.5 0.6 -0.9 -2.6 -0.9 1.1 -1.0 -0.8 0.6 -0.8 -0.2 -0.0 0.2 -0.2
Osteoporosis (self-reported) 0.7 0.9 3.0 0.5 0.4 0.6 1.6 1.3 0.5 1.4 -0.3 0.7 0.4 -0.4 0.6 -1.7 1.3 0.2 0.6
Osteoarthritis (self-reported) 0.2 0.3 0.8 0.0 0.2 0.5 0.6 0.8 0.5 0.9 -0.9 0.7 0.6 -0.3 0.0 -0.5 0.7 0.3 0.2
Medication: Aspirin 1.7 2.2 3.7 -1.5 -1.2 -1.9 -0.6 -1.1 1.1 -0.6 1.8 -1.4 -1.6 1.5 1.9 -1.4 -1.3 -1.9 1.9
Medication: Gliclazide 0.7 0.8 3.4 0.3 -1.9 -0.4 0.6 0.1 1.2 0.4 0.6 -0.1 -0.1 0.8 1.4 -0.8 0.1 -1.1 1.5
Illnesses of father: None of the above (group 1) 0.3 0.3 1.3 0.3 0.5 -0.2 -0.3 -0.9 -0.2 -0.9 0.4 -0.7 -0.4 0.5 -0.3 1.1 -0.7 0.1 -0.2
Smoking status: Current 1.0 1.5 2.9 1.3 0.8 1.4 1.0 1.0 -1.0 1.1 -1.7 1.1 1.2 -1.4 -1.4 0.2 1.3 1.7 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 1.6 0.8 -0.2 0.2 0.3 0.2 -0.6 -0.3 -0.0 0.3 0.4 -0.3 -0.3 1.3 0.2 0.2 -0.2
Whole body water mass 0.8 4.7 13.2 -1.3 -1.1 -3.5 -1.8 -2.1 0.9 -2.3 3.6 -2.3 -2.0 2.0 1.8 -2.4 -2.0 -2.4 1.3
Leg predicted mass (right) 0.7 3.9 11.1 -1.4 -1.1 -3.1 -2.0 -2.0 0.3 -2.4 3.3 -2.1 -1.9 1.4 1.3 -2.0 -2.0 -2.1 0.7
Arm fat mass (left) 0.3 1.3 2.7 -1.1 -0.5 -1.6 -1.3 -0.6 1.6 -1.1 1.6 -0.7 -0.4 0.6 1.3 -1.5 -0.9 -1.3 0.6
Number of self-reported non-cancer illnesses 0.1 0.2 0.9 0.6 -0.2 -0.1 0.9 0.1 -0.6 0.2 0.3 -0.2 -0.4 -0.2 -0.1 -0.9 0.3 -0.0 0.1
Average weekly champagne plus white wine intake 1.4 2.0 7.0 -1.8 0.2 -1.0 -2.2 -1.6 -1.2 -2.6 1.3 -0.9 -0.7 0.2 -1.1 1.5 -1.9 -0.3 -1.1
Miserableness 1.2 2.2 4.5 -0.0 -1.2 -1.7 -0.5 -1.9 -1.8 -1.4 2.1 -2.0 -2.1 1.8 0.5 -0.1 -1.3 -1.4 0.8
Guilty feelings 0.2 0.4 1.6 1.3 0.9 0.4 1.0 0.1 -0.5 0.7 -0.1 -0.2 -0.2 -0.1 0.2 -0.4 0.8 0.3 0.4
Wears glasses or contact lenses 0.7 0.7 4.2 -2.0 -0.5 -0.6 -1.5 -0.2 1.4 -0.2 -0.1 -0.2 -0.4 0.7 0.8 -0.2 -1.0 -0.7 0.3
Ever taken oral contraceptive pill 1.4 1.6 4.7 0.7 2.2 1.0 0.0 -0.2 -1.4 -0.6 -0.9 0.3 0.7 -0.6 -2.0 2.0 0.0 1.7 -2.1
Hearing aid user 2.2 2.5 5.4 -0.6 -1.0 -2.1 -0.3 -1.6 0.2 -0.7 2.3 -2.0 -2.1 1.5 1.8 -1.8 -0.9 -1.9 1.8
Mother’s age at death 0.4 0.5 1.7 0.0 -0.5 -0.3 -0.7 -0.5 -1.3 -1.2 0.5 -0.1 0.1 -0.4 -0.9 1.1 -0.4 0.1 -0.8
Financial situation satisfaction 0.8 0.9 2.0 -0.2 -0.4 -1.3 -1.3 -1.4 -1.0 -1.4 1.1 -1.2 -1.0 0.7 -0.3 -0.5 -1.3 -0.6 -0.4
Tinnitus: Yes, now most or all of the time 2.6 3.0 11.2 1.3 -0.6 -0.0 3.4 0.5 0.3 2.5 0.6 -0.8 -1.2 1.2 2.0 -3.3 1.4 -0.8 2.6
Commuting to job workplace: Public transport 1.3 1.5 4.4 0.1 1.2 1.0 -0.3 0.5 -0.4 -0.9 -0.8 1.1 1.3 -1.8 -1.8 2.1 0.0 1.5 -1.9
Eye problems/disorders: Glaucoma 0.5 0.6 2.9 0.4 -0.2 0.7 0.6 1.0 1.7 1.0 -0.2 1.0 1.2 -0.3 0.5 -0.6 0.7 0.3 0.4
Medication: Blood pressure 3.2 6.0 12.3 -1.4 -3.0 -3.5 -1.5 -1.9 1.5 -1.3 3.5 -2.4 -2.2 2.5 2.7 -3.0 -1.9 -2.9 2.5
Pain type(s) experienced in last month: Hip pain 1.3 1.6 4.4 -0.9 -1.1 -1.5 -2.1 -1.5 -0.9 -1.5 1.3 -1.5 -1.3 1.2 0.1 0.5 -1.8 -1.0 0.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.4 1.3 -1.1 -0.9 0.0 -1.3 -1.6 -0.8 1.0 -1.3 -1.4 1.1 0.2 0.2 -0.7 -0.7 0.7
High cholesterol (Self-reported) 1.6 2.8 5.2 -1.8 -2.3 -1.9 -1.1 -1.5 0.5 -0.6 1.7 -1.7 -1.9 1.6 2.0 -1.0 -1.6 -2.2 1.9
Medication: Bendroflumethiazide 2.9 4.4 8.9 -1.1 -2.2 -3.0 -1.1 -2.0 0.2 -1.1 2.8 -2.6 -2.6 2.1 2.0 -2.5 -1.7 -2.4 1.9
Medication: Paracetamol 1.1 1.7 3.7 -1.0 -1.4 -1.6 -0.1 -1.0 0.1 0.1 1.5 -1.7 -1.6 1.8 1.5 -1.9 -0.9 -1.3 1.4
Medication: Lisinopril 1.6 2.0 3.7 -0.2 -1.8 -1.1 0.1 -1.0 0.5 0.3 1.7 -1.7 -1.9 1.8 1.9 -1.6 -0.6 -1.9 1.9
Medication: Atorvastatin 2.0 2.5 5.5 -2.2 -1.1 -1.7 -1.9 -2.0 -0.3 -1.6 1.3 -1.8 -1.9 1.5 0.8 0.3 -2.3 -1.7 0.4
Illnesses of father: High blood pressure 0.1 0.2 0.6 0.4 -0.8 -0.2 -0.0 -0.3 -0.3 0.1 0.3 -0.4 -0.5 0.2 0.3 -0.6 -0.2 -0.6 0.5
Alcohol drinker status: Never 0.1 0.1 0.3 0.5 -0.3 0.4 0.5 0.4 -0.1 0.3 -0.3 0.4 0.1 -0.2 0.0 0.0 0.4 0.1 0.1
Ever smoked 0.2 0.4 1.6 0.8 0.4 -0.9 -0.4 -0.8 -0.9 -1.2 1.1 -0.6 -0.4 0.3 -0.4 0.0 -0.3 -0.0 -0.1
Basal metabolic rate 0.8 4.4 12.1 -1.4 -1.1 -3.3 -1.9 -2.0 1.0 -2.3 3.5 -2.2 -1.8 1.8 1.8 -2.2 -2.0 -2.3 1.1
Leg fat percentage (left) 0.1 0.3 1.3 -0.9 -0.5 -0.4 -0.5 -0.1 0.6 -0.1 0.6 -0.2 -0.1 0.3 0.8 -1.1 -0.4 -0.6 0.4
Arm fat-free mass (left) 0.8 4.1 11.5 -1.1 -1.3 -3.3 -1.5 -1.9 0.9 -2.0 3.4 -2.2 -1.8 1.8 1.8 -2.4 -1.8 -2.2 1.3
Number of operations (self-reported) 0.9 1.3 6.3 -0.3 1.0 -0.2 1.1 1.2 2.1 1.3 0.1 0.5 0.4 0.0 1.3 -2.5 1.1 -0.1 1.2
Average weekly beer plus cider intake 1.6 2.3 4.9 -1.3 0.0 -1.4 -1.7 -2.2 -1.6 -1.9 1.1 -2.1 -2.1 1.7 -0.1 1.1 -1.9 -1.0 -0.1
Irritability 1.2 2.0 6.3 0.9 -0.8 -1.1 1.7 -0.4 0.3 1.1 1.3 -1.3 -1.7 1.6 2.0 -2.5 0.5 -1.3 2.2
Risk taking 1.0 1.4 3.0 0.4 1.7 1.4 1.1 1.5 -0.9 1.5 -1.2 1.3 0.8 -1.1 -0.9 -0.5 1.5 1.3 -0.8
Ever had prostate specific antigen (PSA) test 1.6 1.9 5.7 0.6 -0.5 -1.6 -0.4 -1.8 -1.4 -0.7 1.7 -2.2 -2.4 1.5 0.8 -0.7 -1.0 -1.1 1.3
Fractured/broken bones in last 5 years 1.5 1.9 4.8 -0.1 1.0 1.3 0.2 2.0 1.1 1.0 -1.7 2.1 2.2 -1.9 -0.9 -0.4 1.2 1.5 -1.2
Age started oral contraceptive pill 0.5 0.6 1.4 0.9 0.7 0.7 0.4 0.6 0.2 -0.0 -0.7 0.8 1.1 -1.2 -0.7 1.1 0.8 0.7 -0.6
Diastolic blood pressure, automated reading 0.2 0.6 4.0 -1.1 0.9 -0.9 -0.7 0.2 0.9 0.0 0.9 -0.1 -0.1 -0.0 0.7 -2.0 0.1 -0.4 0.3
Ever depressed for a whole week 0.1 0.1 0.4 0.6 0.7 0.0 0.0 -0.1 0.2 -0.4 0.1 0.1 0.0 -0.4 -0.0 0.3 0.1 0.1 -0.1
Unable to work because of sickness or disability 0.4 0.5 1.5 0.1 -0.5 -0.8 -0.0 -0.7 0.2 -0.1 0.8 -0.9 -0.9 1.2 0.7 -0.8 -0.4 -0.7 0.9
Commuting to job workplace: Cycle 3.2 3.9 10.1 -2.2 -3.2 -2.3 -2.0 -1.8 0.6 -1.6 2.2 -1.7 -1.6 1.9 1.7 -0.5 -2.6 -2.4 1.5
Myopia 2.7 4.0 10.1 2.7 0.5 2.1 3.2 2.6 1.4 2.9 -2.1 2.0 1.7 -1.3 0.1 -1.1 2.9 1.1 0.2
Vascular/heart problems diagnosed by doctor 0.9 2.3 5.2 1.5 1.7 2.0 1.1 0.7 -1.6 0.3 -2.0 1.1 1.2 -1.1 -1.9 2.3 1.0 1.9 -1.6
Cholesterol lowering medication 0.2 0.3 1.9 1.4 -0.8 -0.3 1.0 0.0 -0.3 -0.2 0.6 -0.1 0.2 -0.1 0.1 -1.0 0.5 -0.1 0.5
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.8 0.2 1.3 1.2 0.8 0.8 -1.9 0.6 -1.1 0.7 0.4 -1.5 -1.4 0.8 0.8 1.3 -1.3
Pain experienced in last month 0.3 0.5 2.0 0.7 -0.2 0.4 1.3 0.4 0.6 1.4 -0.5 -0.1 -0.1 0.1 0.7 -0.7 0.8 0.0 0.8
Supplements: Calcium 2.3 2.6 5.6 -1.6 -1.0 -1.9 -1.8 -1.9 -0.3 -2.2 1.7 -1.7 -1.7 1.9 0.8 0.5 -2.4 -1.7 0.8
Basal cell carcinoma (self-reported) 0.3 0.4 2.2 -0.7 -0.4 -0.9 -0.9 -0.1 1.5 -0.7 0.7 0.1 0.2 0.0 0.6 -0.4 -0.6 -0.5 0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.2 -0.2 -0.1 0.0 0.7 0.2 1.5 0.5 -0.1 0.1 0.0 0.4 1.1 -0.9 0.2 -0.7 0.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.9 1.1 1.7 1.0 0.2 0.7 -1.3 0.3 -0.7 0.7 0.4 -0.9 -1.3 1.1 0.9 1.3 -1.2
Heart disease (siblings) 1.0 1.2 3.6 1.9 1.0 1.2 1.1 0.7 -1.1 0.6 -1.2 0.6 0.5 -1.3 -1.0 1.4 1.0 1.2 -0.7
Alcohol drinker status: Previous 0.6 0.7 2.0 -0.3 -1.2 -0.2 0.4 -0.5 0.2 0.5 0.4 -0.9 -0.9 1.2 0.8 -1.4 -0.3 -0.9 1.2
Pack years of smoking 0.6 0.8 1.9 0.1 -0.3 -1.4 -0.6 -1.3 -0.1 -1.0 1.4 -1.4 -1.2 1.0 0.5 -0.8 -0.8 -0.8 0.3
Impedance of whole body 0.9 4.6 19.7 0.2 2.0 3.3 0.6 1.3 -1.0 0.8 -3.1 2.2 1.8 -2.0 -2.2 4.4 1.0 2.0 -2.0
Leg fat mass (left) 0.3 1.0 2.9 -1.3 -0.5 -1.3 -1.0 -0.6 1.0 -0.8 1.6 -0.7 -0.5 0.6 1.1 -1.7 -0.8 -1.1 0.6
Arm predicted mass (left) 0.8 3.9 11.1 -0.9 -1.1 -3.3 -1.4 -1.9 0.8 -2.1 3.3 -2.2 -1.7 1.7 1.7 -2.3 -1.7 -2.1 1.2