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chr1:2,993,638-4,514,453

Best TWAS P=1.05e-26 · Best GWAS P=2.88e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Whole Blood	SMIM1	0.18	0.17	lasso	2	0.15	8.6e-14	10.60	10.7	1.1e-26	1.00	0.00	1.00	TRUE
8	GTEx	Thyroid	LRRC47	0.13	0.01	enet	15	0.01	8.8e-02	9.03	10.2	2.8e-24	0.68	0.01	0.92	FALSE
11	METSIM	Adipose	SMIM1	0.09	0.05	lasso	5	0.04	4.4e-07	9.03	8.7	2.8e-18	0.75	0.08	0.92	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA0562	0.04	0.02	enet	11	0.02	3.1e-03	-6.50	-8.7	3.2e-18	-0.59	0.14	0.40	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0562	0.09	0.02	lasso	5	0.04	1.4e-05	9.53	-7.7	1.5e-14	-0.49	0.13	0.59	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA0562	0.04	0.02	enet	5	0.01	1.0e-02	-7.40	-7.5	5.4e-14	-0.47	0.36	0.04	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	C1orf174	0.04	0.00	bslmm	431	0.01	4.4e-02	-2.78	-7.2	7.6e-13	-0.41	0.02	0.56	FALSE
15	YFS	Blood	LRRC47	0.33	0.30	bslmm	433	0.34	6.2e-118	6.63	-7.0	3.5e-12	-0.63	1.00	0.00	FALSE
2	GTEx	Artery Coronary	CEP104	0.28	0.12	lasso	4	0.07	3.1e-03	-6.09	-7.0	3.6e-12	-0.44	0.24	0.05	FALSE
7	GTEx	Spleen	CEP104	0.51	0.28	enet	34	0.24	6.9e-07	-6.49	-6.9	5.1e-12	-0.36	0.78	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CEP104	0.12	0.14	lasso	2	0.13	1.2e-15	-6.65	6.6	3.6e-11	0.41	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA0562	0.06	0.10	lasso	2	0.08	2.9e-05	-6.49	-6.5	8.5e-11	-0.41	0.79	0.01	FALSE
6	GTEx	Nerve Tibial	LRRC47	0.21	0.09	lasso	6	0.06	3.9e-05	-6.41	6.2	7.1e-10	0.29	0.67	0.05	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KIAA0562	0.08	0.07	enet	17	0.06	1.4e-05	-6.18	-5.8	6.4e-09	-0.35	0.96	0.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	LRRC47	0.08	0.04	bslmm	453	0.06	5.6e-08	6.65	5.7	1.5e-08	0.41	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	KIAA0495	0.07	0.01	blup	62	0.02	7.8e-03	0.34	5.6	1.7e-08	0.30	0.05	0.09	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA0562	0.05	0.04	blup	83	0.05	7.6e-10	-6.49	-5.6	1.8e-08	-0.30	1.00	0.00	FALSE
5	GTEx	Nerve Tibial	CEP104	0.35	0.37	enet	16	0.38	2.2e-28	-6.49	-5.6	2.0e-08	-0.36	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRC47	0.06	0.00	blup	74	0.01	5.0e-02	-6.21	5.6	2.2e-08	0.34	0.07	0.09	FALSE
18	The Cancer Genome Atlas	Glioblastoma Multiforme	KIAA0562	0.14	0.03	blup	83	0.07	3.1e-03	-6.18	-5.5	3.0e-08	-0.24	0.05	0.05	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KIAA0562	0.10	0.02	blup	83	0.07	5.7e-05	-6.50	-5.5	4.1e-08	-0.27	0.56	0.04	FALSE
10	METSIM	Adipose	CEP104	0.14	0.15	bslmm	482	0.16	7.8e-23	-6.49	-5.5	4.3e-08	-0.32	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	KIAA0562	0.05	0.07	enet	10	0.07	2.9e-08	-6.49	-5.5	4.4e-08	-0.29	1.00	0.00	FALSE
12	NTR	Blood	KIAA0562	0.08	0.06	blup	402	0.07	3.4e-22	6.04	-5.4	6.9e-08	-0.52	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC388588	0.03	0.01	blup	58	0.01	4.8e-02	-6.55	-5.4	6.9e-08	-0.38	0.04	0.09	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf174	0.05	0.03	lasso	5	0.03	1.3e-04	-3.11	5.3	1.2e-07	0.34	0.04	0.50	FALSE
4	GTEx	Lung	CEP104	0.26	0.27	lasso	4	0.24	3.7e-18	-6.49	-5.2	1.6e-07	-0.31	1.00	0.00	FALSE
3	GTEx	Cells Transformed fibroblasts	CEP104	0.26	0.22	lasso	3	0.24	2.8e-18	-6.49	-5.1	2.8e-07	-0.29	1.00	0.00	FALSE