Hub : Genes

LOC388588

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0479 0.0184 7.6e-08 0.041 0.038 0.043 NA 0.045 6.1e-09 3.0e-08 3.4e-09 NA 1.6e-09
2 TCGA Colon Adenocarcinoma 0.0820 0.0420 4.0e-03 0.016 0.039 0.023 NA 0.030 3.7e-02 2.5e-03 1.7e-02 NA 7.5e-03
3 TCGA Brain Lower Grade Glioma 0.0318 0.0185 7.9e-03 0.014 0.007 0.000 NA 0.004 9.4e-03 4.8e-02 2.8e-01 NA 9.6e-02
4 TCGA Pancreatic Adenocarcinoma 0.1370 0.0640 7.3e-03 -0.007 0.064 0.005 NA -0.007 9.4e-01 1.1e-03 1.8e-01 NA 9.9e-01
5 TCGA Prostate Adenocarcinoma 0.0940 0.0341 2.2e-06 0.050 0.041 0.043 NA 0.060 5.4e-06 3.7e-05 2.6e-05 NA 6.6e-07
6 TCGA Thyroid Carcinoma 0.0640 0.0280 3.4e-05 0.011 0.045 0.031 NA 0.019 2.7e-02 2.9e-05 4.5e-04 NA 5.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.7 0.8 -0.0 -0.1 -1.3 0.7 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 4.0 0.2 0.8 0.1 -2.0 0.4 -0.4
Depressed Affect (Nagel 2018) 0.7 1.5 4.4 0.7 2.1 0.8 0.9 -0.1 1.6
Depression (Nagel 2018) 0.1 0.1 0.4 -0.2 0.6 0.4 -0.3 0.1 0.1
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.6 -0.9 0.2 -0.7 -1.3 0.5 -1.1
Neuroticism (Nagel 2018) 1.3 3.1 7.4 1.3 2.7 2.1 0.1 0.4 2.2
Schizophrenia (2018) 0.3 0.6 2.0 -0.4 1.2 0.3 -1.4 -0.1 -0.1
Schizophrenia vs Biploar Disorder 1.2 1.5 3.8 -1.0 -1.5 -0.8 1.0 -1.9 -0.7
Worry (Nagel 2018) 1.1 2.4 6.8 0.5 2.6 1.7 0.7 0.0 1.9
Alzheimer’s Disease (in mother) 2.3 2.7 3.7 -1.8 -1.6 -1.9 -0.5 -1.6 -1.9
Alzheimer’s Disease (in father) 0.4 0.5 1.5 -0.3 0.6 0.4 1.2 -0.3 0.8
Alzheimer’s Disease (including proxy) 0.9 1.2 3.0 -0.9 -1.3 -1.0 0.2 -1.7 -0.9
Crohns Disease (2017) 0.2 0.5 1.6 -1.3 -0.2 0.2 0.2 -0.6 -0.9
Irritable Bowel Disease (IBD) 0.2 0.4 0.5 -0.4 -0.6 0.7 0.7 -0.4 -0.7
Ulcerative Colitis (UC) 0.3 0.5 1.1 0.9 -0.5 1.1 1.0 0.2 0.2
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.0 0.0 0.1 0.1 -0.1 0.1 0.0 -0.4 0.2
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 -0.5 -0.1 -0.6 -0.2 0.3 -0.7
Breast Cancer 0.1 0.3 1.0 -0.5 0.3 0.3 1.0 -0.7 -0.2
Ovarian Cancer 1.9 2.5 4.6 1.6 1.7 2.1 -1.5 -0.1 1.6
Prostate Cancer 1.7 2.4 10.1 -0.7 -1.6 -0.8 3.2 -0.6 -0.5
Age at First Birth 0.9 1.3 3.8 1.2 1.2 1.9 -0.0 0.7 0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.9 0.2 -0.0 0.5 0.9 -0.5 0.1
Coronary Artery Disease (CAD) 0.7 0.9 2.3 -0.6 -1.5 -0.3 0.6 -1.2 -0.9
Crohns Disease (2012) 0.5 0.9 1.8 -1.1 -1.3 -0.3 -0.7 -0.0 -1.3
Mean Putamen Volume 1.6 1.8 4.5 -1.8 0.0 -2.1 -0.6 -1.3 -0.9
Fasting Glucose 0.6 0.7 2.0 0.8 0.5 -0.8 1.4 0.6 0.5
HbA1C 1.4 1.5 5.1 2.3 0.6 0.7 0.1 -0.8 1.7
HDL Cholesterol 1.5 2.5 5.3 -2.3 -0.4 -2.0 0.5 -1.4 -1.8
LDL Cholesterol 0.5 0.8 2.4 0.3 1.6 1.0 0.7 0.2 0.7
Lupus 0.4 0.7 1.4 0.5 1.0 1.2 -0.3 0.2 1.1
Neuroticism (2016) 0.6 0.8 2.0 -1.4 1.2 -0.9 -0.6 -0.6 -0.1
Primary Biliary Cirrhosis 0.4 0.6 2.2 -0.6 -1.0 0.2 0.1 -1.5 -0.3
Rheumatoid Arthritis 1.0 1.4 4.8 -1.0 -1.3 -0.2 0.4 -2.2 -0.7
Schizophrenia (2014) 0.3 0.7 1.5 -0.5 -0.8 0.3 -1.2 -0.6 -1.2
Triglycerides 0.4 0.7 1.4 1.2 -0.8 0.3 0.6 -0.6 1.1
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.5 1.6 -0.3 0.4 -1.2 1.0 0.4
Ulcerative Colitis 0.6 0.9 3.8 0.2 -1.9 0.5 -0.2 -0.9 -0.8
Blood Eosinophil Count 0.2 1.6 5.7 0.9 0.9 0.4 1.4 2.4 0.6
Blood Platelet Count 0.2 2.1 7.4 0.4 1.6 0.7 -1.2 2.7 0.5
Blood Red Count 1.2 11.4 29.1 -4.1 1.4 -5.4 1.4 3.4 -2.7
Blood White Count 0.1 0.6 1.6 -1.3 0.3 -1.0 -0.5 0.6 -0.7
Heel T-Score 0.0 0.2 0.7 0.2 0.1 -0.7 -0.9 0.1 -0.3
BMI 0.2 1.3 3.4 0.6 -1.8 -1.4 1.0 0.9 -0.8
Height 0.1 2.8 9.2 -1.2 -0.9 -1.6 3.0 -1.5 -0.8
Waist Hip Ratio (WHR) 0.3 1.3 2.5 1.2 1.3 1.6 -0.3 0.5 1.4
Systolic Blood Pressure 0.2 0.8 1.8 1.2 -0.0 0.9 0.1 -0.6 1.3
Smoking Status 0.4 1.0 2.8 0.6 -1.7 -1.1 -1.0 -0.1 -0.8
Allergy or Eczema 0.1 0.4 0.6 -0.8 0.6 0.6 -0.4 -0.7 -0.7
Cardiovascular Disease 0.2 0.5 2.0 1.4 0.0 0.6 -0.5 0.4 0.6
Hypothyroidism (self reported) 0.3 0.6 1.1 0.6 1.0 -0.3 -1.1 0.9 0.3
Respiratory disease 0.2 0.4 1.7 0.1 0.7 1.3 0.3 -0.4 0.3
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.5 0.5 -0.5 -0.8 0.3 1.2 0.5
Lung FEV1/FVC ratio 0.4 2.2 5.7 2.0 1.7 0.4 0.6 0.1 2.4
Lung FVC 0.3 1.4 7.7 0.2 -0.0 0.1 -2.8 -0.4 -0.6
Neuroticism 1.3 3.1 10.1 0.8 3.2 1.9 0.6 0.1 2.0
Chronotype (morning person) 1.9 4.3 6.7 2.3 2.2 1.4 1.1 2.5 2.6
Hair Pigment 0.0 0.3 0.9 0.2 -0.8 0.4 -0.5 0.9 -0.2
Tanning 0.5 5.7 10.2 -3.1 -1.9 -3.2 -0.4 -1.7 -2.7
Hand grip strength (left) 1.1 3.0 5.2 -1.3 -1.8 -1.7 0.4 -2.3 -2.1
Number of treatments/medications taken 0.1 0.2 0.4 -0.6 0.6 -0.2 -0.4 -0.2 -0.6
Average weekly spirits intake 0.5 0.6 1.5 -0.3 -0.5 -0.1 -1.0 1.2 -0.8
Sensitivity / hurt feelings 0.4 0.6 1.8 0.5 0.7 1.4 -1.0 -0.2 0.1
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.1 -0.9 -0.6 0.2 -0.9 -1.1 -1.1
Hearing difficulty/problems: Yes 0.1 0.2 0.5 -0.7 -0.2 -0.6 0.4 0.0 0.1
Relative age of first facial hair 1.2 2.5 5.2 -1.9 1.9 -1.4 2.3 0.1 -0.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.4 -0.5 0.7 0.4 0.1 -0.4 -0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.9 0.0 -0.4 -0.1 1.0 -0.7 0.8
Ever had hysterectomy (womb removed) 1.0 1.1 3.4 1.4 0.9 0.1 -0.6 1.9 0.4
Systolic blood pressure, automated reading 0.2 0.6 2.0 1.4 -0.5 0.1 -0.6 0.5 0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.2 1.1 -0.0 0.5 0.5 1.5 1.0
Angina 0.8 1.1 2.1 1.4 -0.4 0.6 -1.5 1.3 0.7
Medication for hormone replacement therapy 2.0 2.2 5.6 -1.3 -2.4 -1.0 -0.0 -1.7 -1.4
Vitamin and mineral supplements 0.9 1.2 2.7 -0.7 -1.6 -0.9 0.4 -1.4 -0.9
Supplements: Zinc 1.6 1.7 4.9 0.1 1.6 0.2 2.2 0.3 1.7
Medication: Co-codamol 0.5 0.6 1.3 -1.2 -0.2 -1.0 0.3 -0.6 -0.9
Medication: Metformin 0.9 1.2 4.6 0.9 -0.7 0.4 -1.2 2.1 -0.2
Diabetes (father) 0.1 0.1 0.4 0.2 -0.6 -0.6 0.1 0.1 0.0
Diabetes (mother) 0.3 0.4 1.4 1.2 -0.1 0.8 -0.6 0.3 0.2
Severe depression (siblings) 0.5 0.6 1.6 -0.2 0.9 -0.6 1.2 -0.3 0.7
Pack years adult smoking proportion 0.4 0.6 1.2 1.1 0.6 1.1 -0.2 0.8 0.7
Impedance of leg (right) 0.2 1.0 2.7 0.3 0.8 1.3 0.3 -1.0 1.6
Leg fat-free mass (left) 0.5 2.4 5.5 -0.1 -1.7 -2.0 2.3 0.6 -1.2
Trunk fat percentage 0.3 1.2 3.1 1.3 -0.6 -0.0 1.3 1.8 0.4
Hand grip strength (right) 0.9 2.5 5.1 -1.3 -1.0 -2.3 -0.2 -1.7 -2.0
Townsend deprivation index at recruitment 0.3 0.4 1.0 0.2 -0.1 0.8 -1.0 -0.1 -0.6
Current tobacco smoking 0.7 1.1 2.2 -1.0 -1.0 -1.5 1.1 -0.8 -1.0
Average weekly fortified wine intake 0.7 0.8 3.9 0.3 0.2 0.4 2.0 -0.3 0.6
Maternal smoking around birth 0.2 0.3 0.6 0.3 -0.7 0.8 -0.1 -0.6 -0.5
Fed-up feelings 0.5 0.9 2.0 0.4 0.9 0.4 1.4 -0.2 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 2.1 -1.0 -0.1 0.0 -1.5 -0.7 -0.9
Relative age voice broke 0.2 0.3 0.6 -0.4 0.7 0.2 0.8 -0.6 -0.1
Taking other prescription medications 0.3 0.5 1.5 -0.6 0.9 -1.2 0.0 0.3 -0.5
Age when periods started (menarche) 1.1 2.6 4.5 1.9 0.6 2.1 -0.9 2.0 1.5
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 3.1 1.0 0.7 -0.2 1.2 1.7 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 3.1 0.6 0.4 -0.2 1.8 0.3 1.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 -0.1 0.7 -0.7 0.7 0.4 0.4
Qualifications: CSEs or equivalent 0.5 0.7 3.1 -0.3 -0.0 -0.4 1.8 -0.7 0.5
Serious illness, injury or assault to yourself 0.7 0.8 2.9 -0.5 -0.3 0.8 -0.6 -1.7 -0.9
High blood pressure 0.7 2.1 3.9 2.0 1.1 1.4 -0.6 1.6 1.6
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.1 -0.2 1.0 0.8 -0.3 -0.1 -0.2
Multivitamins +/- minerals 1.3 1.7 2.8 1.1 1.7 1.6 -0.7 1.3 1.2
Stomach or abdominal pain in last month 0.2 0.2 0.6 -0.6 0.4 -0.3 -0.5 -0.7 -0.0
Supplements: Glucosamine 0.1 0.1 0.6 -0.3 0.8 -0.2 0.0 0.0 -0.2
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 2.7 -0.1 0.9 -1.4 1.6 1.4 1.3
Medication: Atenolol 2.8 3.5 9.8 3.1 0.1 2.4 -0.5 1.6 1.6
Medication: Levothyroxine sodium 0.5 0.9 1.7 1.1 1.2 -0.1 -1.3 0.8 0.6
Sitting height 0.4 3.2 5.7 -1.7 -1.4 -2.4 1.6 -1.8 -1.7
Chronic bronchitis/emphysema (father) 0.2 0.3 1.2 -0.1 0.2 -1.1 -0.6 0.1 -0.3
High blood pressure (mother) 0.9 1.3 3.0 1.2 -1.4 1.7 0.8 -0.7 0.3
Body mass index (BMI) 0.4 1.5 3.2 1.1 -1.5 -0.8 1.4 1.8 -0.4
Impedance of leg (left) 0.3 1.3 2.9 0.5 0.9 1.6 0.3 -1.1 1.7
Leg predicted mass (left) 0.5 2.5 5.8 -0.2 -1.8 -2.1 2.4 0.5 -1.3
Trunk fat mass 0.3 1.4 3.1 1.0 -1.2 -0.7 1.8 1.4 -0.0
Waist circumference 0.4 1.4 3.7 1.4 -0.6 -0.6 1.5 1.9 0.4
Number of incorrect matches in round 0.6 1.0 2.6 -1.1 -0.5 -1.0 -1.1 -0.2 -1.6
Past tobacco smoking 0.1 0.2 0.5 -0.5 0.7 0.0 0.6 0.3 0.2
Alcohol usually taken with meals 0.5 0.8 2.0 -0.6 -1.4 -0.3 1.2 -0.8 -0.4
Nervous feelings 1.0 1.9 4.5 0.3 2.1 1.7 0.9 -0.5 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.2 -1.2 -1.1 -0.2 -0.2 -1.5 -0.9
Hearing difficulty/problems with background noise 0.6 0.9 2.8 -0.9 -0.5 -1.7 1.1 -0.6 -0.1
Hair/balding pattern: Pattern 2 1.0 1.3 2.1 1.2 1.5 1.4 -0.5 0.9 1.2
Had menopause 0.5 0.6 1.8 0.2 -0.2 -0.8 1.4 0.1 1.0
Had other major operations 0.7 0.8 2.9 0.1 0.6 -1.2 0.1 1.7 0.2
Forced vital capacity (FVC) 0.3 1.0 2.6 -0.9 0.3 -0.8 -0.7 -1.6 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.2 -0.2 -0.1 -0.6 1.8 -0.2 0.6
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.9 0.7 2.0 1.1 0.6 1.2 1.4
Qualifications: None of the above 0.5 1.0 3.0 1.7 -0.4 0.7 0.4 1.5 0.4
Financial difficulties in last 2 years 0.7 0.9 1.9 0.5 -1.1 1.1 0.7 -1.4 0.3
Mouth/teeth dental problems 0.2 0.3 0.9 -0.2 -0.9 -0.6 0.2 0.1 -0.5
Heart attack 0.2 0.2 0.5 0.7 -0.6 0.4 0.1 0.1 0.6
Allergy 0.5 1.1 2.8 -0.1 -1.6 -1.7 0.9 0.0 -0.1
Pain all over the body in last month 1.2 1.3 2.7 -1.4 -0.7 0.3 -1.0 -1.2 -1.6
Diabetes (self-reported) 0.4 0.6 1.7 -0.2 -1.3 -1.1 0.6 0.1 -0.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.9 0.1 1.7 -0.1 1.5 1.4 0.9
Medication: Ramipril 0.3 0.4 1.0 0.1 -1.0 -0.8 0.6 -0.4 -0.4
Medication: Simvastatin 1.2 1.8 6.9 1.3 0.5 0.7 -2.6 1.1 0.4
Fluid intelligence score 0.4 0.8 1.1 -0.9 -1.0 -0.9 0.4 -0.9 -1.0
Illnesses of siblings 0.5 0.7 2.4 -0.7 -0.2 0.2 1.1 -1.6 -0.3
Neuroticism score 0.4 0.9 2.3 0.2 1.5 1.2 0.3 -0.7 0.8
Weight 0.5 2.3 5.5 0.4 -1.9 -1.8 2.3 0.8 -0.8
Impedance of arm (right) 0.5 2.5 5.7 0.8 2.4 2.2 -0.1 0.6 1.8
Arm fat percentage (right) 0.5 2.1 7.5 1.9 -0.3 0.3 1.1 2.7 0.5
Trunk fat-free mass 0.6 3.2 7.5 -0.3 -2.2 -2.7 2.4 -0.3 -1.2
Hip circumference 0.5 2.3 7.1 0.7 -0.9 -1.5 2.7 1.9 -0.1
Time employed in main current job 0.5 0.6 1.7 -0.1 -1.3 -0.1 1.2 0.2 -0.3
Alcohol intake versus 10 years previously 1.7 2.6 5.4 1.7 1.8 0.7 0.8 2.3 1.7
Father’s age at death 2.5 3.3 5.7 1.7 2.4 1.0 -0.6 2.2 2.3
Worrier / anxious feelings 0.6 1.1 2.6 0.7 1.6 1.5 -0.0 -0.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.3 -1.2 0.0 0.1 0.4 -0.8 -0.7
Falls in the last year 0.5 0.7 1.9 -0.1 1.4 1.0 -0.4 1.0 -0.2
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 -0.0 0.5 0.6 0.3 0.3 0.1
Number of live births 0.5 0.6 2.3 -0.3 -1.5 -0.5 0.7 0.2 -0.9
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.5 -0.3 1.0 -0.4 -0.4 -1.2 -0.3
Pulse rate 0.4 0.7 2.3 0.8 0.7 -0.3 -0.4 1.5 0.5
Happiness 0.2 0.3 0.7 -0.7 0.8 0.4 -0.5 0.1 -0.3
Noisy workplace 0.4 0.6 1.6 -0.6 -0.1 -0.6 -1.2 -0.4 -0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.4 -1.0 -0.0 -0.8 -0.8 -1.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.8 0.2 -0.2 -0.6 -0.2 1.4 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 1.3 0.0 -0.4 -0.2 -1.1 0.2 -0.3
Asthma 1.1 2.3 5.9 1.2 1.7 2.4 0.4 0.8 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.7 -0.9 -0.2 -1.0 0.6 -1.7 -0.3
Medication: Cholesterol lowering 1.5 2.3 7.5 1.2 0.6 1.7 -2.7 0.5 1.0
Depression (self-reported) 0.2 0.3 0.5 -0.6 0.7 0.5 -0.0 0.3 -0.6
Medication: Lansoprazole 0.4 0.4 1.5 -0.0 -0.7 -0.1 -0.2 -0.7 -1.2
Prospective memory result 1.2 1.5 2.2 1.4 1.0 1.5 -0.6 1.5 1.0
Lung cancer (father) 0.3 0.3 1.6 -0.3 1.3 -0.3 -0.0 0.4 0.2
Illnesses of mother 0.9 1.2 2.5 0.8 1.1 -0.0 1.1 1.2 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.6 0.7 1.9 1.0 -0.8 -1.2 0.5
Pulse wave Arterial Stiffness index 0.2 0.2 1.1 0.2 0.2 -0.2 0.5 1.0 0.0
Impedance of arm (left) 0.4 1.8 5.5 0.1 2.4 1.8 -1.0 0.1 1.1
Arm fat mass (right) 0.4 1.7 4.1 1.3 -0.9 -0.6 1.8 2.0 0.0
Trunk predicted mass 0.6 3.3 7.7 -0.4 -2.2 -2.8 2.4 -0.3 -1.2
Standing height 0.4 3.8 7.3 -1.6 -1.1 -2.5 2.7 -2.0 -1.1
Length of working week for main job 0.4 0.5 1.4 -0.8 0.4 -0.4 1.2 -0.5 0.4
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.3 0.5 0.8 -0.4 0.4 0.0
Breastfed as a baby 0.2 0.3 1.3 -0.2 0.3 -0.5 -0.4 1.2 -0.2
Tense / ‘highly strung’ 0.7 1.2 3.5 0.9 0.0 1.9 0.6 -0.4 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.7 0.8 0.1 0.3 -1.0 -0.2
Hair/balding pattern: Pattern 4 1.0 2.4 5.4 -1.1 -2.3 -1.3 0.6 -1.6 -1.6
Birth weight of first child 0.8 1.4 5.8 1.0 -0.2 -0.1 1.1 2.4 0.7
Peak expiratory flow (PEF) 0.1 0.3 1.2 0.1 1.1 -0.5 -0.5 -0.4 -0.1
Pulse wave reflection index 0.2 0.3 1.6 -0.1 -0.3 -0.1 1.3 0.2 0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.2 1.1 0.6 0.8 0.0 1.1 0.9
Loud music exposure frequency 0.3 0.4 1.0 -0.3 1.0 0.3 0.2 0.9 0.5
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.2 -1.3 -1.6 -1.4 0.2 -1.8 -1.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 0.2 1.1 -0.1 0.5 0.5 1.1
Blood clot in the leg (DVT) 1.0 1.3 2.2 1.0 1.5 1.2 -0.9 1.2 1.0
Medication: Paracetamol 0.2 0.3 1.0 0.2 1.0 0.8 -0.0 -0.2 0.4
Headache pain in last month 3.3 5.7 9.6 -3.1 -1.8 -2.7 1.4 -2.2 -2.7
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 3.1 -1.6 -0.2 -1.5 1.8 -0.4 -1.1
Glaucoma (self-reported) 1.2 1.4 4.0 0.5 1.6 2.0 -1.0 0.7 0.5
Gout (self-reported) 0.8 1.1 2.2 -0.7 -1.4 -0.3 0.7 -1.5 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.6 0.3 1.2 -0.7 0.1 0.2 0.7
Medication: Amlodipine 0.1 0.1 0.5 0.5 0.2 0.1 -0.0 0.3 0.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 0.0 0.1 0.5 0.6 0.3 -0.2
Birth weight 0.2 0.4 0.8 0.1 0.7 0.8 -0.5 0.9 0.0
Chronic bronchitis/emphysema (mother) 1.8 2.1 4.3 -2.1 -0.7 -1.4 0.6 -1.5 -1.7
High blood pressure (siblings) 0.6 0.9 2.6 0.1 -0.1 -1.1 -1.6 1.2 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.8 1.8 -0.1 1.3 0.6 -0.9 -1.4 -0.4
Body fat percentage 0.4 1.5 4.1 1.6 -0.6 0.1 1.2 2.0 0.6
Leg fat percentage (right) 0.5 1.8 4.8 1.6 -1.0 -0.4 1.3 2.2 0.5
Arm fat-free mass (right) 0.6 3.1 6.7 -0.6 -2.1 -2.6 2.3 -0.5 -1.2
Exposure to tobacco smoke outside home 0.9 1.3 7.2 0.6 0.0 -0.1 -2.7 -0.1 -0.1
Comparative body size at age 10 0.3 1.0 2.4 0.4 -0.8 0.9 -1.6 -0.1 -1.3
Number of full brothers 1.6 2.0 4.5 0.8 1.5 1.1 -1.8 2.1 -0.1
Worry too long after embarrassment 0.1 0.2 0.7 0.2 0.3 0.6 -0.6 -0.8 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.2 -0.6 1.6 0.1 -1.8 -0.0 -0.0
Wheeze or whistling in the chest in last year 0.2 0.4 1.2 0.1 0.4 0.5 1.1 0.2 0.8
Number of children fathered 0.4 0.4 0.8 -0.2 -0.6 -0.8 0.3 0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.3 -1.2 0.7 -0.3 -0.6 -0.7 -0.8
Age at first live birth 1.4 2.4 4.4 -1.9 -1.9 -0.5 0.4 -1.6 -2.1
Pulse wave peak to peak time 0.2 0.3 1.3 -0.1 -0.2 0.1 -0.4 -1.1 -0.0
Health satisfaction 0.8 1.0 2.5 0.8 1.6 0.9 0.2 0.6 1.3
Shortness of breath walking on level ground 2.9 3.4 5.0 2.2 1.5 2.2 1.3 1.7 2.0
Qualifications: College or University degree 0.4 1.2 4.3 -1.1 2.1 0.1 -1.3 0.1 -0.0
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.2 -0.4 -0.4 -0.2 -0.7 -0.7
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.8 0.1 0.4 0.2 1.7 -0.6 0.9
Emphysema/chronic bronchitis 0.2 0.3 0.9 0.2 0.1 -0.8 -0.2 1.0 0.2
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 0.6 -0.7 -0.3 0.7 0.2 0.5
Neck or shoulder pain in last month 0.3 0.4 1.0 0.5 0.1 -0.9 0.5 1.0 0.3
Medication: Blood pressure 0.4 0.7 1.7 1.3 0.1 1.1 -0.7 -0.1 0.9
Angina (self-reported) 0.8 1.1 2.5 1.4 -0.4 0.3 -1.6 1.3 0.4
Migraine (self-reported) 0.8 1.0 3.6 0.3 -1.9 0.1 0.6 -1.4 0.1
Medication: Ibuprofen 0.9 1.1 2.8 -0.8 -0.4 -0.8 1.7 -1.6 -0.2
Medication: Allopurinol 0.5 0.6 1.3 1.1 -0.8 1.1 -0.4 -0.6 0.4
Medication: Omeprazole 0.8 0.9 1.7 0.3 1.3 -0.1 -1.3 1.1 0.8
Medication: Seretide 50 evohaler 0.5 0.5 1.6 0.1 1.3 0.6 -0.8 0.7 0.3
Mean time to correctly identify matches 0.1 0.2 0.4 0.6 0.3 -0.2 0.1 0.5 0.6
Heart disease (mother) 0.7 0.8 2.5 -0.7 -0.7 -0.7 -0.9 -0.3 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.0 -1.0 -1.7 -1.4 -0.6 -1.7 -1.0
Whole body fat mass 0.4 1.6 3.5 1.4 -1.0 -0.5 1.9 1.7 0.3
Leg fat mass (right) 0.5 2.0 4.5 1.4 -1.2 -0.9 2.1 1.8 0.3
Arm predicted mass (right) 0.7 3.5 7.3 -0.5 -2.4 -2.7 2.3 -0.6 -1.3
Pulse rate, automated reading 0.3 0.9 3.7 -0.7 -0.1 -0.6 -1.9 -0.1 -0.9
Alcohol intake frequency. 0.3 0.6 2.1 -0.8 -0.4 -1.4 0.8 0.0 -0.4
Comparative height size at age 10 0.8 4.4 8.6 -1.6 -2.9 -2.3 0.7 -2.4 -1.9
Number of full sisters 0.6 0.7 2.2 1.5 0.0 0.8 0.3 0.4 1.0
Suffer from ‘nerves’ 0.6 1.0 2.3 0.1 1.5 1.0 0.6 -0.7 1.4
Overall health rating 0.3 0.6 1.8 1.0 0.3 0.1 -0.6 1.4 0.4
Chest pain or discomfort 0.1 0.1 0.4 -0.3 0.2 0.5 -0.4 0.6 0.1
Had major operations 0.1 0.2 0.2 -0.5 -0.4 -0.4 0.4 -0.2 -0.4
Age at last live birth 1.9 2.8 5.5 -1.8 -2.2 -0.8 -0.4 -1.4 -2.4
Family relationship satisfaction 0.5 0.6 1.4 0.2 1.1 0.3 -0.2 1.0 1.2
Leg pain on walking 0.9 1.2 1.9 1.4 1.2 0.0 0.4 1.3 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.1 -0.5 -0.0 -0.5 0.8 -1.1 -0.2
Commuting to job workplace: Car/motor vehicle 1.5 1.7 6.2 -1.4 -0.0 -2.5 1.2 0.3 -0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.7 -0.9 2.2 -0.3 0.0 0.5 0.5
Medication: Aspirin 2.0 2.7 4.2 0.9 2.1 1.4 -2.0 1.9 1.1
Supplements: Vitamin C 0.5 0.6 1.3 -0.7 0.1 -0.8 1.2 -0.9 -0.6
Knee pain experienced in last month 0.6 1.0 3.4 0.2 0.4 -1.5 -0.1 1.8 0.0
Hypertension (Self-reported) 0.6 1.6 2.9 1.7 0.9 1.4 -0.9 1.3 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 -0.7 -0.5 -1.0 -0.8 0.0 -0.6
Illnesses of father: Heart disease 1.1 1.5 3.8 1.3 -0.2 1.9 -1.6 0.5 0.8
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.5 -0.8 -0.8 -0.9 0.6 -0.8
Smoking status: Previous 0.3 0.5 1.0 1.0 -0.6 0.8 -0.9 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 6.2 0.2 0.1 0.7 2.5 -0.7 0.1
Whole body fat-free mass 0.5 2.9 6.2 -0.1 -2.0 -2.4 2.5 0.1 -1.1
Leg fat-free mass (right) 0.4 2.4 5.5 -0.2 -1.7 -2.0 2.3 0.4 -1.3
Arm fat percentage (left) 0.4 1.6 6.1 1.5 -0.2 0.2 0.8 2.5 0.3
Average weekly red wine intake 0.9 1.3 2.0 -1.4 -1.4 -1.1 -0.5 -0.9 -1.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.5 -0.3 0.2 -0.6 1.6 -0.2 -0.0
Mood swings 0.3 0.6 1.1 1.0 0.7 0.9 0.4 0.5 0.9
Loneliness, isolation 0.7 0.9 2.0 -1.4 -0.2 0.4 -0.5 -1.4 -1.1
Long-standing illness, disability or infirmity 0.1 0.2 0.6 -0.5 0.1 -0.0 0.7 0.0 -0.8
Ever had bowel cancer screening 0.4 0.5 1.9 -0.6 -0.5 -1.4 -0.3 -0.3 -0.4
Diabetes diagnosed by doctor 0.4 0.7 1.9 -0.4 -1.4 -0.7 1.2 0.3 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.7 0.2 0.1 -0.7 0.9 0.5 -0.1
Friendships satisfaction 0.6 0.7 1.7 -1.1 0.2 0.2 1.0 -1.3 -0.2
Qualifications: nursing, teaching 0.3 0.5 1.4 0.3 1.2 0.7 -0.5 -0.1 0.8
Commuting to job workplace: Walk 0.2 0.2 0.8 0.1 0.1 0.0 -0.9 0.3 -0.5
Eye problems/disorders: Cataract 0.3 0.4 0.9 -0.7 -0.7 -0.9 -0.3 -0.6 0.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 0.8 0.5 0.8 -0.2 0.1 0.5
Medication for cholesterol 0.9 1.3 2.6 1.4 0.8 1.6 0.2 0.4 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.5 1.4 0.6 0.5 0.1 1.6 0.2
Back pain experienced in last month 0.7 1.1 3.0 0.2 0.7 -1.2 1.7 1.0 0.5
Mineral and other dietary supplements 0.3 0.4 1.6 -0.2 -0.4 0.7 -1.2 -0.4 -0.3
Breast cancer (self-reported) 0.1 0.2 0.3 0.4 0.2 0.6 0.0 -0.3 0.6
Asthma (self-reported) 1.2 2.4 5.9 1.4 1.7 2.4 0.4 1.0 1.5
Osteoporosis (self-reported) 1.8 2.2 4.6 -2.1 -0.6 -1.5 0.2 -2.1 -1.3
Osteoarthritis (self-reported) 0.5 0.7 1.5 -0.5 1.0 -1.0 -0.7 1.2 -0.2
Medication: Aspirin 2.3 3.0 4.8 1.2 2.2 1.8 -1.5 2.1 1.4
Medication: Gliclazide 0.2 0.2 1.1 0.1 0.3 0.1 0.0 1.1 -0.4
Illnesses of father: None of the above (group 1) 1.6 1.9 4.3 -2.1 0.0 -1.4 1.0 -1.6 -1.4
Smoking status: Current 0.7 1.1 2.9 -0.9 -1.0 -1.7 0.9 -0.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.5 1.2 1.2 0.5 -1.2 0.1 0.4
Whole body water mass 0.5 3.0 6.1 -0.2 -2.2 -2.5 2.4 -0.0 -1.2
Leg predicted mass (right) 0.5 2.4 5.7 -0.2 -1.7 -2.0 2.4 0.4 -1.4
Arm fat mass (left) 0.4 1.6 3.8 1.1 -0.6 -0.7 1.9 2.0 -0.0
Number of self-reported non-cancer illnesses 0.2 0.4 1.5 0.7 0.3 1.2 -0.4 0.4 0.1
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.9 -0.4 0.0 -0.8 -0.4 -0.7
Miserableness 0.4 0.7 1.7 -0.6 0.2 -0.6 1.3 -1.3 0.2
Guilty feelings 0.8 1.2 2.3 0.9 1.3 0.8 -0.9 0.8 1.5
Wears glasses or contact lenses 0.1 0.2 0.6 0.7 0.1 0.0 -0.3 0.5 0.2
Ever taken oral contraceptive pill 0.9 1.0 3.8 0.0 -2.0 -0.3 0.4 -1.1 -0.6
Hearing aid user 0.2 0.2 0.7 0.4 0.3 -0.3 -0.1 0.6 0.8
Mother’s age at death 0.4 0.5 1.5 1.2 0.3 0.3 0.8 0.6 0.7
Financial situation satisfaction 0.9 1.2 4.0 -0.5 1.5 0.7 -2.0 -0.3 0.3
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 0.4 -0.7 -0.4 -0.6 -0.2 0.1
Commuting to job workplace: Public transport 1.0 1.2 4.9 -1.1 -0.8 0.4 -0.6 -2.2 -0.3
Eye problems/disorders: Glaucoma 2.1 2.5 4.6 1.0 2.1 1.8 -1.6 1.8 0.7
Medication: Blood pressure 0.2 0.4 1.6 0.5 0.7 -0.0 0.2 1.3 -0.0
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.2 1.2 1.6 -0.7 0.4 2.0 1.7
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.0 1.0 1.7 -0.2 1.0 1.4 1.3
High cholesterol (Self-reported) 1.0 1.8 5.2 0.7 1.3 1.1 -2.3 1.1 0.7
Medication: Bendroflumethiazide 0.5 0.7 2.0 1.1 -0.4 1.4 0.5 -0.7 0.1
Medication: Paracetamol 0.2 0.4 1.0 0.6 1.0 0.8 0.1 -0.1 0.6
Medication: Lisinopril 2.2 2.9 5.4 1.7 1.9 1.6 0.6 1.5 2.3
Medication: Atorvastatin 1.1 1.4 4.1 0.5 2.0 1.1 -0.8 1.0 0.9
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.2 0.5 0.9 -0.5 0.9 0.2
Alcohol drinker status: Never 0.9 1.1 2.8 0.8 0.5 0.9 1.0 1.0 1.7
Ever smoked 0.3 0.5 1.0 -0.7 -0.7 -1.0 0.1 -0.8 -0.9
Basal metabolic rate 0.5 2.9 7.2 -0.0 -2.0 -2.3 2.7 0.2 -1.1
Leg fat percentage (left) 0.4 1.6 3.8 1.6 -1.1 -0.2 1.3 2.0 0.4
Arm fat-free mass (left) 0.6 3.0 7.6 -0.2 -2.0 -2.5 2.8 -0.0 -0.8
Number of operations (self-reported) 0.9 1.4 3.0 1.7 0.8 0.6 -0.2 1.6 1.3
Average weekly beer plus cider intake 0.1 0.1 0.4 0.6 0.0 -0.3 -0.3 0.2 -0.2
Irritability 1.2 2.0 5.7 1.7 1.1 2.4 -0.4 0.7 1.2
Risk taking 0.2 0.3 1.5 0.2 -0.1 0.4 0.4 1.2 0.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.9 0.6 -0.1 -0.4 -0.9 0.7 -0.1
Fractured/broken bones in last 5 years 1.5 1.9 7.5 -1.6 0.4 -1.0 2.7 -0.7 0.2
Age started oral contraceptive pill 0.5 0.6 1.4 -0.7 -0.2 -0.5 1.2 -1.2 -0.3
Diastolic blood pressure, automated reading 0.2 0.6 2.0 1.4 -0.3 0.7 -0.9 0.6 0.4
Ever depressed for a whole week 0.8 1.0 4.8 -0.1 0.0 0.2 2.2 -0.2 1.0
Unable to work because of sickness or disability 0.9 1.1 3.7 1.2 -0.7 1.9 -0.1 1.0 0.0
Commuting to job workplace: Cycle 0.2 0.2 0.4 -0.1 0.5 -0.4 0.6 -0.4 0.4
Myopia 0.2 0.3 1.1 0.1 -0.3 1.0 -0.6 -0.2 -0.1
Vascular/heart problems diagnosed by doctor 0.8 2.1 4.6 -2.1 -0.8 -1.2 0.9 -1.7 -1.5
Cholesterol lowering medication 0.8 1.2 3.3 0.0 1.3 -0.3 -1.4 1.8 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.0 0.4 1.4 0.5 -0.9 0.9 0.9
Pain experienced in last month 1.8 3.0 8.2 1.9 1.1 2.9 -1.4 1.3 1.3
Supplements: Calcium 1.3 1.4 3.4 0.9 1.4 0.2 1.1 1.0 1.8
Basal cell carcinoma (self-reported) 1.2 1.4 3.1 -0.7 -1.4 -0.3 -1.2 -1.2 -1.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 0.8 -0.5 0.4 0.3 0.2 0.7
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.5 1.0 1.6 1.3 -1.1 0.9 1.0
Heart disease (siblings) 0.7 0.9 1.9 -1.1 -0.4 -0.7 1.1 -0.1 -1.4
Alcohol drinker status: Previous 0.2 0.2 1.0 -0.4 1.0 0.0 -0.2 -0.2 -0.0
Pack years of smoking 0.5 0.7 1.5 1.2 0.6 0.9 -0.4 0.9 0.9
Impedance of whole body 0.4 2.2 5.5 0.4 2.0 2.4 -0.8 -0.3 1.7
Leg fat mass (left) 0.5 2.0 4.6 1.3 -1.3 -0.8 2.1 1.7 0.1
Arm predicted mass (left) 0.7 3.4 8.4 -0.1 -2.3 -2.4 2.9 -0.1 -0.8