Hub : Genes

LOC388588

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0479	0.0184	7.6e-08	0.041	0.038	0.043	NA	0.045	6.1e-09	3.0e-08	3.4e-09	NA	1.6e-09
2	TCGA	Colon Adenocarcinoma	0.0820	0.0420	4.0e-03	0.016	0.039	0.023	NA	0.030	3.7e-02	2.5e-03	1.7e-02	NA	7.5e-03
3	TCGA	Brain Lower Grade Glioma	0.0318	0.0185	7.9e-03	0.014	0.007	0.000	NA	0.004	9.4e-03	4.8e-02	2.8e-01	NA	9.6e-02
4	TCGA	Pancreatic Adenocarcinoma	0.1370	0.0640	7.3e-03	-0.007	0.064	0.005	NA	-0.007	9.4e-01	1.1e-03	1.8e-01	NA	9.9e-01
5	TCGA	Prostate Adenocarcinoma	0.0940	0.0341	2.2e-06	0.050	0.041	0.043	NA	0.060	5.4e-06	3.7e-05	2.6e-05	NA	6.6e-07
6	TCGA	Thyroid Carcinoma	0.0640	0.0280	3.4e-05	0.011	0.045	0.031	NA	0.019	2.7e-02	2.9e-05	4.5e-04	NA	5.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.7	0.8	-0.0	-0.1	-1.3	0.7	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	4.0	0.2	0.8	0.1	-2.0	0.4	-0.4
Depressed Affect (Nagel 2018)	0.7	1.5	4.4	0.7	2.1	0.8	0.9	-0.1	1.6
Depression (Nagel 2018)	0.1	0.1	0.4	-0.2	0.6	0.4	-0.3	0.1	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.6	-0.9	0.2	-0.7	-1.3	0.5	-1.1
Neuroticism (Nagel 2018)	1.3	3.1	7.4	1.3	2.7	2.1	0.1	0.4	2.2
Schizophrenia (2018)	0.3	0.6	2.0	-0.4	1.2	0.3	-1.4	-0.1	-0.1
Schizophrenia vs Biploar Disorder	1.2	1.5	3.8	-1.0	-1.5	-0.8	1.0	-1.9	-0.7
Worry (Nagel 2018)	1.1	2.4	6.8	0.5	2.6	1.7	0.7	0.0	1.9
Alzheimer’s Disease (in mother)	2.3	2.7	3.7	-1.8	-1.6	-1.9	-0.5	-1.6	-1.9
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-0.3	0.6	0.4	1.2	-0.3	0.8
Alzheimer’s Disease (including proxy)	0.9	1.2	3.0	-0.9	-1.3	-1.0	0.2	-1.7	-0.9
Crohns Disease (2017)	0.2	0.5	1.6	-1.3	-0.2	0.2	0.2	-0.6	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.5	-0.4	-0.6	0.7	0.7	-0.4	-0.7
Ulcerative Colitis (UC)	0.3	0.5	1.1	0.9	-0.5	1.1	1.0	0.2	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.0	0.1	0.1	-0.1	0.1	0.0	-0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.5	-0.1	-0.6	-0.2	0.3	-0.7
Breast Cancer	0.1	0.3	1.0	-0.5	0.3	0.3	1.0	-0.7	-0.2
Ovarian Cancer	1.9	2.5	4.6	1.6	1.7	2.1	-1.5	-0.1	1.6
Prostate Cancer	1.7	2.4	10.1	-0.7	-1.6	-0.8	3.2	-0.6	-0.5
Age at First Birth	0.9	1.3	3.8	1.2	1.2	1.9	-0.0	0.7	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	0.2	-0.0	0.5	0.9	-0.5	0.1
Coronary Artery Disease (CAD)	0.7	0.9	2.3	-0.6	-1.5	-0.3	0.6	-1.2	-0.9
Crohns Disease (2012)	0.5	0.9	1.8	-1.1	-1.3	-0.3	-0.7	-0.0	-1.3
Mean Putamen Volume	1.6	1.8	4.5	-1.8	0.0	-2.1	-0.6	-1.3	-0.9
Fasting Glucose	0.6	0.7	2.0	0.8	0.5	-0.8	1.4	0.6	0.5
HbA1C	1.4	1.5	5.1	2.3	0.6	0.7	0.1	-0.8	1.7
HDL Cholesterol	1.5	2.5	5.3	-2.3	-0.4	-2.0	0.5	-1.4	-1.8
LDL Cholesterol	0.5	0.8	2.4	0.3	1.6	1.0	0.7	0.2	0.7
Lupus	0.4	0.7	1.4	0.5	1.0	1.2	-0.3	0.2	1.1
Neuroticism (2016)	0.6	0.8	2.0	-1.4	1.2	-0.9	-0.6	-0.6	-0.1
Primary Biliary Cirrhosis	0.4	0.6	2.2	-0.6	-1.0	0.2	0.1	-1.5	-0.3
Rheumatoid Arthritis	1.0	1.4	4.8	-1.0	-1.3	-0.2	0.4	-2.2	-0.7
Schizophrenia (2014)	0.3	0.7	1.5	-0.5	-0.8	0.3	-1.2	-0.6	-1.2
Triglycerides	0.4	0.7	1.4	1.2	-0.8	0.3	0.6	-0.6	1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	1.6	-0.3	0.4	-1.2	1.0	0.4
Ulcerative Colitis	0.6	0.9	3.8	0.2	-1.9	0.5	-0.2	-0.9	-0.8
Blood Eosinophil Count	0.2	1.6	5.7	0.9	0.9	0.4	1.4	2.4	0.6
Blood Platelet Count	0.2	2.1	7.4	0.4	1.6	0.7	-1.2	2.7	0.5
Blood Red Count	1.2	11.4	29.1	-4.1	1.4	-5.4	1.4	3.4	-2.7
Blood White Count	0.1	0.6	1.6	-1.3	0.3	-1.0	-0.5	0.6	-0.7
Heel T-Score	0.0	0.2	0.7	0.2	0.1	-0.7	-0.9	0.1	-0.3
BMI	0.2	1.3	3.4	0.6	-1.8	-1.4	1.0	0.9	-0.8
Height	0.1	2.8	9.2	-1.2	-0.9	-1.6	3.0	-1.5	-0.8
Waist Hip Ratio (WHR)	0.3	1.3	2.5	1.2	1.3	1.6	-0.3	0.5	1.4
Systolic Blood Pressure	0.2	0.8	1.8	1.2	-0.0	0.9	0.1	-0.6	1.3
Smoking Status	0.4	1.0	2.8	0.6	-1.7	-1.1	-1.0	-0.1	-0.8
Allergy or Eczema	0.1	0.4	0.6	-0.8	0.6	0.6	-0.4	-0.7	-0.7
Cardiovascular Disease	0.2	0.5	2.0	1.4	0.0	0.6	-0.5	0.4	0.6
Hypothyroidism (self reported)	0.3	0.6	1.1	0.6	1.0	-0.3	-1.1	0.9	0.3
Respiratory disease	0.2	0.4	1.7	0.1	0.7	1.3	0.3	-0.4	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	0.5	-0.5	-0.8	0.3	1.2	0.5
Lung FEV1/FVC ratio	0.4	2.2	5.7	2.0	1.7	0.4	0.6	0.1	2.4
Lung FVC	0.3	1.4	7.7	0.2	-0.0	0.1	-2.8	-0.4	-0.6
Neuroticism	1.3	3.1	10.1	0.8	3.2	1.9	0.6	0.1	2.0
Chronotype (morning person)	1.9	4.3	6.7	2.3	2.2	1.4	1.1	2.5	2.6
Hair Pigment	0.0	0.3	0.9	0.2	-0.8	0.4	-0.5	0.9	-0.2
Tanning	0.5	5.7	10.2	-3.1	-1.9	-3.2	-0.4	-1.7	-2.7
Hand grip strength (left)	1.1	3.0	5.2	-1.3	-1.8	-1.7	0.4	-2.3	-2.1
Number of treatments/medications taken	0.1	0.2	0.4	-0.6	0.6	-0.2	-0.4	-0.2	-0.6
Average weekly spirits intake	0.5	0.6	1.5	-0.3	-0.5	-0.1	-1.0	1.2	-0.8
Sensitivity / hurt feelings	0.4	0.6	1.8	0.5	0.7	1.4	-1.0	-0.2	0.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.1	-0.9	-0.6	0.2	-0.9	-1.1	-1.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.7	-0.2	-0.6	0.4	0.0	0.1
Relative age of first facial hair	1.2	2.5	5.2	-1.9	1.9	-1.4	2.3	0.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.5	0.7	0.4	0.1	-0.4	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.0	-0.4	-0.1	1.0	-0.7	0.8
Ever had hysterectomy (womb removed)	1.0	1.1	3.4	1.4	0.9	0.1	-0.6	1.9	0.4
Systolic blood pressure, automated reading	0.2	0.6	2.0	1.4	-0.5	0.1	-0.6	0.5	0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	1.1	-0.0	0.5	0.5	1.5	1.0
Angina	0.8	1.1	2.1	1.4	-0.4	0.6	-1.5	1.3	0.7
Medication for hormone replacement therapy	2.0	2.2	5.6	-1.3	-2.4	-1.0	-0.0	-1.7	-1.4
Vitamin and mineral supplements	0.9	1.2	2.7	-0.7	-1.6	-0.9	0.4	-1.4	-0.9
Supplements: Zinc	1.6	1.7	4.9	0.1	1.6	0.2	2.2	0.3	1.7
Medication: Co-codamol	0.5	0.6	1.3	-1.2	-0.2	-1.0	0.3	-0.6	-0.9
Medication: Metformin	0.9	1.2	4.6	0.9	-0.7	0.4	-1.2	2.1	-0.2
Diabetes (father)	0.1	0.1	0.4	0.2	-0.6	-0.6	0.1	0.1	0.0
Diabetes (mother)	0.3	0.4	1.4	1.2	-0.1	0.8	-0.6	0.3	0.2
Severe depression (siblings)	0.5	0.6	1.6	-0.2	0.9	-0.6	1.2	-0.3	0.7
Pack years adult smoking proportion	0.4	0.6	1.2	1.1	0.6	1.1	-0.2	0.8	0.7
Impedance of leg (right)	0.2	1.0	2.7	0.3	0.8	1.3	0.3	-1.0	1.6
Leg fat-free mass (left)	0.5	2.4	5.5	-0.1	-1.7	-2.0	2.3	0.6	-1.2
Trunk fat percentage	0.3	1.2	3.1	1.3	-0.6	-0.0	1.3	1.8	0.4
Hand grip strength (right)	0.9	2.5	5.1	-1.3	-1.0	-2.3	-0.2	-1.7	-2.0
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.2	-0.1	0.8	-1.0	-0.1	-0.6
Current tobacco smoking	0.7	1.1	2.2	-1.0	-1.0	-1.5	1.1	-0.8	-1.0
Average weekly fortified wine intake	0.7	0.8	3.9	0.3	0.2	0.4	2.0	-0.3	0.6
Maternal smoking around birth	0.2	0.3	0.6	0.3	-0.7	0.8	-0.1	-0.6	-0.5
Fed-up feelings	0.5	0.9	2.0	0.4	0.9	0.4	1.4	-0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.1	-1.0	-0.1	0.0	-1.5	-0.7	-0.9
Relative age voice broke	0.2	0.3	0.6	-0.4	0.7	0.2	0.8	-0.6	-0.1
Taking other prescription medications	0.3	0.5	1.5	-0.6	0.9	-1.2	0.0	0.3	-0.5
Age when periods started (menarche)	1.1	2.6	4.5	1.9	0.6	2.1	-0.9	2.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.1	1.0	0.7	-0.2	1.2	1.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.1	0.6	0.4	-0.2	1.8	0.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.1	0.7	-0.7	0.7	0.4	0.4
Qualifications: CSEs or equivalent	0.5	0.7	3.1	-0.3	-0.0	-0.4	1.8	-0.7	0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.9	-0.5	-0.3	0.8	-0.6	-1.7	-0.9
High blood pressure	0.7	2.1	3.9	2.0	1.1	1.4	-0.6	1.6	1.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.1	-0.2	1.0	0.8	-0.3	-0.1	-0.2
Multivitamins +/- minerals	1.3	1.7	2.8	1.1	1.7	1.6	-0.7	1.3	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.6	0.4	-0.3	-0.5	-0.7	-0.0
Supplements: Glucosamine	0.1	0.1	0.6	-0.3	0.8	-0.2	0.0	0.0	-0.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.7	-0.1	0.9	-1.4	1.6	1.4	1.3
Medication: Atenolol	2.8	3.5	9.8	3.1	0.1	2.4	-0.5	1.6	1.6
Medication: Levothyroxine sodium	0.5	0.9	1.7	1.1	1.2	-0.1	-1.3	0.8	0.6
Sitting height	0.4	3.2	5.7	-1.7	-1.4	-2.4	1.6	-1.8	-1.7
Chronic bronchitis/emphysema (father)	0.2	0.3	1.2	-0.1	0.2	-1.1	-0.6	0.1	-0.3
High blood pressure (mother)	0.9	1.3	3.0	1.2	-1.4	1.7	0.8	-0.7	0.3
Body mass index (BMI)	0.4	1.5	3.2	1.1	-1.5	-0.8	1.4	1.8	-0.4
Impedance of leg (left)	0.3	1.3	2.9	0.5	0.9	1.6	0.3	-1.1	1.7
Leg predicted mass (left)	0.5	2.5	5.8	-0.2	-1.8	-2.1	2.4	0.5	-1.3
Trunk fat mass	0.3	1.4	3.1	1.0	-1.2	-0.7	1.8	1.4	-0.0
Waist circumference	0.4	1.4	3.7	1.4	-0.6	-0.6	1.5	1.9	0.4
Number of incorrect matches in round	0.6	1.0	2.6	-1.1	-0.5	-1.0	-1.1	-0.2	-1.6
Past tobacco smoking	0.1	0.2	0.5	-0.5	0.7	0.0	0.6	0.3	0.2
Alcohol usually taken with meals	0.5	0.8	2.0	-0.6	-1.4	-0.3	1.2	-0.8	-0.4
Nervous feelings	1.0	1.9	4.5	0.3	2.1	1.7	0.9	-0.5	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.2	-1.2	-1.1	-0.2	-0.2	-1.5	-0.9
Hearing difficulty/problems with background noise	0.6	0.9	2.8	-0.9	-0.5	-1.7	1.1	-0.6	-0.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.1	1.2	1.5	1.4	-0.5	0.9	1.2
Had menopause	0.5	0.6	1.8	0.2	-0.2	-0.8	1.4	0.1	1.0
Had other major operations	0.7	0.8	2.9	0.1	0.6	-1.2	0.1	1.7	0.2
Forced vital capacity (FVC)	0.3	1.0	2.6	-0.9	0.3	-0.8	-0.7	-1.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.2	-0.2	-0.1	-0.6	1.8	-0.2	0.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.9	0.7	2.0	1.1	0.6	1.2	1.4
Qualifications: None of the above	0.5	1.0	3.0	1.7	-0.4	0.7	0.4	1.5	0.4
Financial difficulties in last 2 years	0.7	0.9	1.9	0.5	-1.1	1.1	0.7	-1.4	0.3
Mouth/teeth dental problems	0.2	0.3	0.9	-0.2	-0.9	-0.6	0.2	0.1	-0.5
Heart attack	0.2	0.2	0.5	0.7	-0.6	0.4	0.1	0.1	0.6
Allergy	0.5	1.1	2.8	-0.1	-1.6	-1.7	0.9	0.0	-0.1
Pain all over the body in last month	1.2	1.3	2.7	-1.4	-0.7	0.3	-1.0	-1.2	-1.6
Diabetes (self-reported)	0.4	0.6	1.7	-0.2	-1.3	-1.1	0.6	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.9	0.1	1.7	-0.1	1.5	1.4	0.9
Medication: Ramipril	0.3	0.4	1.0	0.1	-1.0	-0.8	0.6	-0.4	-0.4
Medication: Simvastatin	1.2	1.8	6.9	1.3	0.5	0.7	-2.6	1.1	0.4
Fluid intelligence score	0.4	0.8	1.1	-0.9	-1.0	-0.9	0.4	-0.9	-1.0
Illnesses of siblings	0.5	0.7	2.4	-0.7	-0.2	0.2	1.1	-1.6	-0.3
Neuroticism score	0.4	0.9	2.3	0.2	1.5	1.2	0.3	-0.7	0.8
Weight	0.5	2.3	5.5	0.4	-1.9	-1.8	2.3	0.8	-0.8
Impedance of arm (right)	0.5	2.5	5.7	0.8	2.4	2.2	-0.1	0.6	1.8
Arm fat percentage (right)	0.5	2.1	7.5	1.9	-0.3	0.3	1.1	2.7	0.5
Trunk fat-free mass	0.6	3.2	7.5	-0.3	-2.2	-2.7	2.4	-0.3	-1.2
Hip circumference	0.5	2.3	7.1	0.7	-0.9	-1.5	2.7	1.9	-0.1
Time employed in main current job	0.5	0.6	1.7	-0.1	-1.3	-0.1	1.2	0.2	-0.3
Alcohol intake versus 10 years previously	1.7	2.6	5.4	1.7	1.8	0.7	0.8	2.3	1.7
Father’s age at death	2.5	3.3	5.7	1.7	2.4	1.0	-0.6	2.2	2.3
Worrier / anxious feelings	0.6	1.1	2.6	0.7	1.6	1.5	-0.0	-0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.3	-1.2	0.0	0.1	0.4	-0.8	-0.7
Falls in the last year	0.5	0.7	1.9	-0.1	1.4	1.0	-0.4	1.0	-0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	-0.0	0.5	0.6	0.3	0.3	0.1
Number of live births	0.5	0.6	2.3	-0.3	-1.5	-0.5	0.7	0.2	-0.9
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.5	-0.3	1.0	-0.4	-0.4	-1.2	-0.3
Pulse rate	0.4	0.7	2.3	0.8	0.7	-0.3	-0.4	1.5	0.5
Happiness	0.2	0.3	0.7	-0.7	0.8	0.4	-0.5	0.1	-0.3
Noisy workplace	0.4	0.6	1.6	-0.6	-0.1	-0.6	-1.2	-0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.4	-1.0	-0.0	-0.8	-0.8	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.8	0.2	-0.2	-0.6	-0.2	1.4	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.3	0.0	-0.4	-0.2	-1.1	0.2	-0.3
Asthma	1.1	2.3	5.9	1.2	1.7	2.4	0.4	0.8	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.7	-0.9	-0.2	-1.0	0.6	-1.7	-0.3
Medication: Cholesterol lowering	1.5	2.3	7.5	1.2	0.6	1.7	-2.7	0.5	1.0
Depression (self-reported)	0.2	0.3	0.5	-0.6	0.7	0.5	-0.0	0.3	-0.6
Medication: Lansoprazole	0.4	0.4	1.5	-0.0	-0.7	-0.1	-0.2	-0.7	-1.2
Prospective memory result	1.2	1.5	2.2	1.4	1.0	1.5	-0.6	1.5	1.0
Lung cancer (father)	0.3	0.3	1.6	-0.3	1.3	-0.3	-0.0	0.4	0.2
Illnesses of mother	0.9	1.2	2.5	0.8	1.1	-0.0	1.1	1.2	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.6	0.7	1.9	1.0	-0.8	-1.2	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	0.2	0.2	-0.2	0.5	1.0	0.0
Impedance of arm (left)	0.4	1.8	5.5	0.1	2.4	1.8	-1.0	0.1	1.1
Arm fat mass (right)	0.4	1.7	4.1	1.3	-0.9	-0.6	1.8	2.0	0.0
Trunk predicted mass	0.6	3.3	7.7	-0.4	-2.2	-2.8	2.4	-0.3	-1.2
Standing height	0.4	3.8	7.3	-1.6	-1.1	-2.5	2.7	-2.0	-1.1
Length of working week for main job	0.4	0.5	1.4	-0.8	0.4	-0.4	1.2	-0.5	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.3	0.5	0.8	-0.4	0.4	0.0
Breastfed as a baby	0.2	0.3	1.3	-0.2	0.3	-0.5	-0.4	1.2	-0.2
Tense / ‘highly strung’	0.7	1.2	3.5	0.9	0.0	1.9	0.6	-0.4	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.7	0.8	0.1	0.3	-1.0	-0.2
Hair/balding pattern: Pattern 4	1.0	2.4	5.4	-1.1	-2.3	-1.3	0.6	-1.6	-1.6
Birth weight of first child	0.8	1.4	5.8	1.0	-0.2	-0.1	1.1	2.4	0.7
Peak expiratory flow (PEF)	0.1	0.3	1.2	0.1	1.1	-0.5	-0.5	-0.4	-0.1
Pulse wave reflection index	0.2	0.3	1.6	-0.1	-0.3	-0.1	1.3	0.2	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	1.1	0.6	0.8	0.0	1.1	0.9
Loud music exposure frequency	0.3	0.4	1.0	-0.3	1.0	0.3	0.2	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.2	-1.3	-1.6	-1.4	0.2	-1.8	-1.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	0.2	1.1	-0.1	0.5	0.5	1.1
Blood clot in the leg (DVT)	1.0	1.3	2.2	1.0	1.5	1.2	-0.9	1.2	1.0
Medication: Paracetamol	0.2	0.3	1.0	0.2	1.0	0.8	-0.0	-0.2	0.4
Headache pain in last month	3.3	5.7	9.6	-3.1	-1.8	-2.7	1.4	-2.2	-2.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.1	-1.6	-0.2	-1.5	1.8	-0.4	-1.1
Glaucoma (self-reported)	1.2	1.4	4.0	0.5	1.6	2.0	-1.0	0.7	0.5
Gout (self-reported)	0.8	1.1	2.2	-0.7	-1.4	-0.3	0.7	-1.5	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	0.3	1.2	-0.7	0.1	0.2	0.7
Medication: Amlodipine	0.1	0.1	0.5	0.5	0.2	0.1	-0.0	0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.0	0.1	0.5	0.6	0.3	-0.2
Birth weight	0.2	0.4	0.8	0.1	0.7	0.8	-0.5	0.9	0.0
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.3	-2.1	-0.7	-1.4	0.6	-1.5	-1.7
High blood pressure (siblings)	0.6	0.9	2.6	0.1	-0.1	-1.1	-1.6	1.2	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	-0.1	1.3	0.6	-0.9	-1.4	-0.4
Body fat percentage	0.4	1.5	4.1	1.6	-0.6	0.1	1.2	2.0	0.6
Leg fat percentage (right)	0.5	1.8	4.8	1.6	-1.0	-0.4	1.3	2.2	0.5
Arm fat-free mass (right)	0.6	3.1	6.7	-0.6	-2.1	-2.6	2.3	-0.5	-1.2
Exposure to tobacco smoke outside home	0.9	1.3	7.2	0.6	0.0	-0.1	-2.7	-0.1	-0.1
Comparative body size at age 10	0.3	1.0	2.4	0.4	-0.8	0.9	-1.6	-0.1	-1.3
Number of full brothers	1.6	2.0	4.5	0.8	1.5	1.1	-1.8	2.1	-0.1
Worry too long after embarrassment	0.1	0.2	0.7	0.2	0.3	0.6	-0.6	-0.8	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.2	-0.6	1.6	0.1	-1.8	-0.0	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.1	0.4	0.5	1.1	0.2	0.8
Number of children fathered	0.4	0.4	0.8	-0.2	-0.6	-0.8	0.3	0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-1.2	0.7	-0.3	-0.6	-0.7	-0.8
Age at first live birth	1.4	2.4	4.4	-1.9	-1.9	-0.5	0.4	-1.6	-2.1
Pulse wave peak to peak time	0.2	0.3	1.3	-0.1	-0.2	0.1	-0.4	-1.1	-0.0
Health satisfaction	0.8	1.0	2.5	0.8	1.6	0.9	0.2	0.6	1.3
Shortness of breath walking on level ground	2.9	3.4	5.0	2.2	1.5	2.2	1.3	1.7	2.0
Qualifications: College or University degree	0.4	1.2	4.3	-1.1	2.1	0.1	-1.3	0.1	-0.0
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.2	-0.4	-0.4	-0.2	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.8	0.1	0.4	0.2	1.7	-0.6	0.9
Emphysema/chronic bronchitis	0.2	0.3	0.9	0.2	0.1	-0.8	-0.2	1.0	0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.6	-0.7	-0.3	0.7	0.2	0.5
Neck or shoulder pain in last month	0.3	0.4	1.0	0.5	0.1	-0.9	0.5	1.0	0.3
Medication: Blood pressure	0.4	0.7	1.7	1.3	0.1	1.1	-0.7	-0.1	0.9
Angina (self-reported)	0.8	1.1	2.5	1.4	-0.4	0.3	-1.6	1.3	0.4
Migraine (self-reported)	0.8	1.0	3.6	0.3	-1.9	0.1	0.6	-1.4	0.1
Medication: Ibuprofen	0.9	1.1	2.8	-0.8	-0.4	-0.8	1.7	-1.6	-0.2
Medication: Allopurinol	0.5	0.6	1.3	1.1	-0.8	1.1	-0.4	-0.6	0.4
Medication: Omeprazole	0.8	0.9	1.7	0.3	1.3	-0.1	-1.3	1.1	0.8
Medication: Seretide 50 evohaler	0.5	0.5	1.6	0.1	1.3	0.6	-0.8	0.7	0.3
Mean time to correctly identify matches	0.1	0.2	0.4	0.6	0.3	-0.2	0.1	0.5	0.6
Heart disease (mother)	0.7	0.8	2.5	-0.7	-0.7	-0.7	-0.9	-0.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.0	-1.0	-1.7	-1.4	-0.6	-1.7	-1.0
Whole body fat mass	0.4	1.6	3.5	1.4	-1.0	-0.5	1.9	1.7	0.3
Leg fat mass (right)	0.5	2.0	4.5	1.4	-1.2	-0.9	2.1	1.8	0.3
Arm predicted mass (right)	0.7	3.5	7.3	-0.5	-2.4	-2.7	2.3	-0.6	-1.3
Pulse rate, automated reading	0.3	0.9	3.7	-0.7	-0.1	-0.6	-1.9	-0.1	-0.9
Alcohol intake frequency.	0.3	0.6	2.1	-0.8	-0.4	-1.4	0.8	0.0	-0.4
Comparative height size at age 10	0.8	4.4	8.6	-1.6	-2.9	-2.3	0.7	-2.4	-1.9
Number of full sisters	0.6	0.7	2.2	1.5	0.0	0.8	0.3	0.4	1.0
Suffer from ‘nerves’	0.6	1.0	2.3	0.1	1.5	1.0	0.6	-0.7	1.4
Overall health rating	0.3	0.6	1.8	1.0	0.3	0.1	-0.6	1.4	0.4
Chest pain or discomfort	0.1	0.1	0.4	-0.3	0.2	0.5	-0.4	0.6	0.1
Had major operations	0.1	0.2	0.2	-0.5	-0.4	-0.4	0.4	-0.2	-0.4
Age at last live birth	1.9	2.8	5.5	-1.8	-2.2	-0.8	-0.4	-1.4	-2.4
Family relationship satisfaction	0.5	0.6	1.4	0.2	1.1	0.3	-0.2	1.0	1.2
Leg pain on walking	0.9	1.2	1.9	1.4	1.2	0.0	0.4	1.3	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.5	-0.0	-0.5	0.8	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	6.2	-1.4	-0.0	-2.5	1.2	0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.7	-0.9	2.2	-0.3	0.0	0.5	0.5
Medication: Aspirin	2.0	2.7	4.2	0.9	2.1	1.4	-2.0	1.9	1.1
Supplements: Vitamin C	0.5	0.6	1.3	-0.7	0.1	-0.8	1.2	-0.9	-0.6
Knee pain experienced in last month	0.6	1.0	3.4	0.2	0.4	-1.5	-0.1	1.8	0.0
Hypertension (Self-reported)	0.6	1.6	2.9	1.7	0.9	1.4	-0.9	1.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.7	-0.5	-1.0	-0.8	0.0	-0.6
Illnesses of father: Heart disease	1.1	1.5	3.8	1.3	-0.2	1.9	-1.6	0.5	0.8
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.5	-0.8	-0.8	-0.9	0.6	-0.8
Smoking status: Previous	0.3	0.5	1.0	1.0	-0.6	0.8	-0.9	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	6.2	0.2	0.1	0.7	2.5	-0.7	0.1
Whole body fat-free mass	0.5	2.9	6.2	-0.1	-2.0	-2.4	2.5	0.1	-1.1
Leg fat-free mass (right)	0.4	2.4	5.5	-0.2	-1.7	-2.0	2.3	0.4	-1.3
Arm fat percentage (left)	0.4	1.6	6.1	1.5	-0.2	0.2	0.8	2.5	0.3
Average weekly red wine intake	0.9	1.3	2.0	-1.4	-1.4	-1.1	-0.5	-0.9	-1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.5	-0.3	0.2	-0.6	1.6	-0.2	-0.0
Mood swings	0.3	0.6	1.1	1.0	0.7	0.9	0.4	0.5	0.9
Loneliness, isolation	0.7	0.9	2.0	-1.4	-0.2	0.4	-0.5	-1.4	-1.1
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.5	0.1	-0.0	0.7	0.0	-0.8
Ever had bowel cancer screening	0.4	0.5	1.9	-0.6	-0.5	-1.4	-0.3	-0.3	-0.4
Diabetes diagnosed by doctor	0.4	0.7	1.9	-0.4	-1.4	-0.7	1.2	0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	0.2	0.1	-0.7	0.9	0.5	-0.1
Friendships satisfaction	0.6	0.7	1.7	-1.1	0.2	0.2	1.0	-1.3	-0.2
Qualifications: nursing, teaching	0.3	0.5	1.4	0.3	1.2	0.7	-0.5	-0.1	0.8
Commuting to job workplace: Walk	0.2	0.2	0.8	0.1	0.1	0.0	-0.9	0.3	-0.5
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.7	-0.7	-0.9	-0.3	-0.6	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.8	0.5	0.8	-0.2	0.1	0.5
Medication for cholesterol	0.9	1.3	2.6	1.4	0.8	1.6	0.2	0.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.5	1.4	0.6	0.5	0.1	1.6	0.2
Back pain experienced in last month	0.7	1.1	3.0	0.2	0.7	-1.2	1.7	1.0	0.5
Mineral and other dietary supplements	0.3	0.4	1.6	-0.2	-0.4	0.7	-1.2	-0.4	-0.3
Breast cancer (self-reported)	0.1	0.2	0.3	0.4	0.2	0.6	0.0	-0.3	0.6
Asthma (self-reported)	1.2	2.4	5.9	1.4	1.7	2.4	0.4	1.0	1.5
Osteoporosis (self-reported)	1.8	2.2	4.6	-2.1	-0.6	-1.5	0.2	-2.1	-1.3
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.5	1.0	-1.0	-0.7	1.2	-0.2
Medication: Aspirin	2.3	3.0	4.8	1.2	2.2	1.8	-1.5	2.1	1.4
Medication: Gliclazide	0.2	0.2	1.1	0.1	0.3	0.1	0.0	1.1	-0.4
Illnesses of father: None of the above (group 1)	1.6	1.9	4.3	-2.1	0.0	-1.4	1.0	-1.6	-1.4
Smoking status: Current	0.7	1.1	2.9	-0.9	-1.0	-1.7	0.9	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	1.2	1.2	0.5	-1.2	0.1	0.4
Whole body water mass	0.5	3.0	6.1	-0.2	-2.2	-2.5	2.4	-0.0	-1.2
Leg predicted mass (right)	0.5	2.4	5.7	-0.2	-1.7	-2.0	2.4	0.4	-1.4
Arm fat mass (left)	0.4	1.6	3.8	1.1	-0.6	-0.7	1.9	2.0	-0.0
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	0.7	0.3	1.2	-0.4	0.4	0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.9	-0.4	0.0	-0.8	-0.4	-0.7
Miserableness	0.4	0.7	1.7	-0.6	0.2	-0.6	1.3	-1.3	0.2
Guilty feelings	0.8	1.2	2.3	0.9	1.3	0.8	-0.9	0.8	1.5
Wears glasses or contact lenses	0.1	0.2	0.6	0.7	0.1	0.0	-0.3	0.5	0.2
Ever taken oral contraceptive pill	0.9	1.0	3.8	0.0	-2.0	-0.3	0.4	-1.1	-0.6
Hearing aid user	0.2	0.2	0.7	0.4	0.3	-0.3	-0.1	0.6	0.8
Mother’s age at death	0.4	0.5	1.5	1.2	0.3	0.3	0.8	0.6	0.7
Financial situation satisfaction	0.9	1.2	4.0	-0.5	1.5	0.7	-2.0	-0.3	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.4	-0.7	-0.4	-0.6	-0.2	0.1
Commuting to job workplace: Public transport	1.0	1.2	4.9	-1.1	-0.8	0.4	-0.6	-2.2	-0.3
Eye problems/disorders: Glaucoma	2.1	2.5	4.6	1.0	2.1	1.8	-1.6	1.8	0.7
Medication: Blood pressure	0.2	0.4	1.6	0.5	0.7	-0.0	0.2	1.3	-0.0
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.2	1.2	1.6	-0.7	0.4	2.0	1.7
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.0	1.0	1.7	-0.2	1.0	1.4	1.3
High cholesterol (Self-reported)	1.0	1.8	5.2	0.7	1.3	1.1	-2.3	1.1	0.7
Medication: Bendroflumethiazide	0.5	0.7	2.0	1.1	-0.4	1.4	0.5	-0.7	0.1
Medication: Paracetamol	0.2	0.4	1.0	0.6	1.0	0.8	0.1	-0.1	0.6
Medication: Lisinopril	2.2	2.9	5.4	1.7	1.9	1.6	0.6	1.5	2.3
Medication: Atorvastatin	1.1	1.4	4.1	0.5	2.0	1.1	-0.8	1.0	0.9
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.2	0.5	0.9	-0.5	0.9	0.2
Alcohol drinker status: Never	0.9	1.1	2.8	0.8	0.5	0.9	1.0	1.0	1.7
Ever smoked	0.3	0.5	1.0	-0.7	-0.7	-1.0	0.1	-0.8	-0.9
Basal metabolic rate	0.5	2.9	7.2	-0.0	-2.0	-2.3	2.7	0.2	-1.1
Leg fat percentage (left)	0.4	1.6	3.8	1.6	-1.1	-0.2	1.3	2.0	0.4
Arm fat-free mass (left)	0.6	3.0	7.6	-0.2	-2.0	-2.5	2.8	-0.0	-0.8
Number of operations (self-reported)	0.9	1.4	3.0	1.7	0.8	0.6	-0.2	1.6	1.3
Average weekly beer plus cider intake	0.1	0.1	0.4	0.6	0.0	-0.3	-0.3	0.2	-0.2
Irritability	1.2	2.0	5.7	1.7	1.1	2.4	-0.4	0.7	1.2
Risk taking	0.2	0.3	1.5	0.2	-0.1	0.4	0.4	1.2	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.6	-0.1	-0.4	-0.9	0.7	-0.1
Fractured/broken bones in last 5 years	1.5	1.9	7.5	-1.6	0.4	-1.0	2.7	-0.7	0.2
Age started oral contraceptive pill	0.5	0.6	1.4	-0.7	-0.2	-0.5	1.2	-1.2	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.0	1.4	-0.3	0.7	-0.9	0.6	0.4
Ever depressed for a whole week	0.8	1.0	4.8	-0.1	0.0	0.2	2.2	-0.2	1.0
Unable to work because of sickness or disability	0.9	1.1	3.7	1.2	-0.7	1.9	-0.1	1.0	0.0
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.1	0.5	-0.4	0.6	-0.4	0.4
Myopia	0.2	0.3	1.1	0.1	-0.3	1.0	-0.6	-0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.6	-2.1	-0.8	-1.2	0.9	-1.7	-1.5
Cholesterol lowering medication	0.8	1.2	3.3	0.0	1.3	-0.3	-1.4	1.8	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	0.4	1.4	0.5	-0.9	0.9	0.9
Pain experienced in last month	1.8	3.0	8.2	1.9	1.1	2.9	-1.4	1.3	1.3
Supplements: Calcium	1.3	1.4	3.4	0.9	1.4	0.2	1.1	1.0	1.8
Basal cell carcinoma (self-reported)	1.2	1.4	3.1	-0.7	-1.4	-0.3	-1.2	-1.2	-1.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.8	-0.5	0.4	0.3	0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.5	1.0	1.6	1.3	-1.1	0.9	1.0
Heart disease (siblings)	0.7	0.9	1.9	-1.1	-0.4	-0.7	1.1	-0.1	-1.4
Alcohol drinker status: Previous	0.2	0.2	1.0	-0.4	1.0	0.0	-0.2	-0.2	-0.0
Pack years of smoking	0.5	0.7	1.5	1.2	0.6	0.9	-0.4	0.9	0.9
Impedance of whole body	0.4	2.2	5.5	0.4	2.0	2.4	-0.8	-0.3	1.7
Leg fat mass (left)	0.5	2.0	4.6	1.3	-1.3	-0.8	2.1	1.7	0.1
Arm predicted mass (left)	0.7	3.4	8.4	-0.1	-2.3	-2.4	2.9	-0.1	-0.8