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chr13:40,440,805-42,325,871

Best TWAS P=3.01e-23 · Best GWAS P=1.92e-28 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	CYCSP34	0.09	0.02	lasso	7	0.04	4.6e-04	-6.9	6.2	4.3e-10	0.09	0.76	0.01	TRUE
2	GTEx	Brain Caudate basal ganglia	CYCSP34	0.21	0.11	lasso	2	0.13	1.2e-04	-5.8	5.8	4.8e-09	0.25	0.33	0.05	FALSE
3	GTEx	Brain Cerebellar Hemisphere	TPTE2P5	0.39	0.27	lasso	4	0.19	1.6e-05	-5.3	5.1	2.9e-07	0.20	0.69	0.03	FALSE
4	GTEx	Brain Cerebellar Hemisphere	CYCSP34	0.37	0.29	lasso	6	0.25	4.8e-07	-5.3	5.8	6.3e-09	0.21	0.89	0.01	FALSE
5	GTEx	Brain Cerebellum	CYCSP34	0.39	0.27	lasso	9	0.29	3.1e-09	-5.3	5.9	3.3e-09	0.25	0.97	0.00	FALSE
6	GTEx	Brain Frontal Cortex BA9	TPTE2P5	0.22	-0.01	lasso	3	-0.01	5.4e-01	-4.6	5.3	1.1e-07	0.19	0.05	0.24	FALSE
7	GTEx	Brain Hippocampus	CYCSP34	0.16	0.25	lasso	2	0.22	6.1e-06	-5.3	5.3	1.2e-07	0.19	0.40	0.04	FALSE
8	GTEx	Nerve Tibial	CYCSP34	0.05	0.01	lasso	4	0.02	2.8e-02	-5.3	6.7	2.5e-11	0.21	0.29	0.03	TRUE
9	GTEx	Pituitary	TPTE2P5	0.28	0.10	lasso	13	0.10	1.8e-03	-5.6	5.6	2.2e-08	0.20	0.23	0.04	FALSE
10	GTEx	Small Intestine Terminal Ileum	CYCSP34	0.25	0.07	lasso	3	0.05	3.0e-02	-6.9	5.6	2.8e-08	0.07	0.09	0.08	FALSE
11	GTEx	Spleen	CYCSP34	0.32	0.07	lasso	4	0.06	1.2e-02	-5.1	5.7	1.4e-08	0.26	0.08	0.18	FALSE
12	METSIM	Adipose	ELF1	0.04	0.02	bslmm	386	0.02	1.1e-03	2.1	5.3	1.5e-07	0.25	0.17	0.02	TRUE
13	YFS	Blood	FOXO1	0.02	0.02	lasso	4	0.02	3.3e-08	-1.7	7.4	1.3e-13	0.48	0.64	0.23	FALSE
14	YFS	Blood	MRPS31	0.05	0.02	blup	387	0.03	6.5e-11	9.7	-7.8	5.2e-15	-0.61	0.82	0.18	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SUGT1L1	0.10	0.00	blup	58	0.04	3.9e-04	-5.8	8.0	9.4e-16	0.46	0.01	0.21	TRUE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUGT1L1	0.09	0.06	lasso	7	0.09	8.4e-18	-2.9	7.1	1.3e-12	0.56	0.97	0.03	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SUGT1L1	0.06	0.01	blup	58	0.03	1.9e-04	8.7	9.0	2.0e-19	0.51	0.02	0.69	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUGT1L1	0.29	0.23	lasso	8	0.25	1.7e-28	-2.9	6.0	2.2e-09	0.54	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUGT1L1	0.32	0.22	blup	59	0.27	1.3e-30	-2.9	6.9	6.4e-12	0.55	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	SUGT1L1	0.12	0.02	blup	58	0.05	1.4e-06	9.7	9.9	3.0e-23	0.65	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SUGT1L1	0.34	0.15	enet	17	0.17	9.3e-08	-2.8	6.7	1.9e-11	0.50	0.22	0.72	FALSE
22	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SUGT1L1	0.22	0.07	lasso	11	0.13	9.4e-06	8.7	6.7	2.7e-11	0.61	0.09	0.55	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	SUGT1L1	0.21	0.11	lasso	9	0.16	5.7e-16	-2.9	6.2	4.2e-10	0.53	0.99	0.01	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUGT1L1	0.09	0.06	blup	59	0.06	5.4e-05	8.7	8.2	2.9e-16	0.64	0.01	0.98	TRUE