TWAS hub - ELF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0426	0.0189	4.8e-03	0.019	0.016	0.006	0.017	0.014	5.9e-04	1.7e-03	3.6e-02	1.1e-03	3.0e-03
2	YFS	Blood	0.0517	0.0134	2.7e-10	0.038	0.031	0.032	0.032	0.035	1.6e-12	2.2e-10	1.1e-10	7.2e-11	1.4e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Tinnitus: Yes, but not now, but have in the past	5.2	5.6	10.8	0.6	-3.3
Medication: Allopurinol	4.9	6.5	9.4	-1.9	-3.1
Heart attack/myocardial infarction (self-reported)	4.6	5.9	8.9	-3.0	-1.7
Heart attack	4.3	5.5	8.2	-2.9	-1.6
Blood Platelet Count	4.2	48.3	95.0	9.7	1.3
Crohns Disease (2017)	3.6	8.0	12.2	-3.5	-1.9
Major Depression (MDD)	3.6	4.3	8.1	-2.8	-0.7
Bipolar Disorder (2011)	3.6	3.5	7.0	-2.6	0.0
Type 2 Diabetes (T2D) (2012)	3.5	4.0	7.4	-2.7	-0.8
Medication: Gliclazide	3.2	3.6	5.8	-1.2	-2.4
Gout (self-reported)	3.1	4.2	6.6	-1.3	-2.6
Medication: Aspirin	3.1	4.1	7.6	-2.8	-0.7
Age started oral contraceptive pill	3.0	3.8	5.3	-1.5	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	4.1	1.7	2.0
Blood Eosinophil Count	2.8	21.5	40.2	6.3	1.7
Allergy	2.8	6.4	12.9	-3.6	-0.0
Had menopause	2.7	3.4	6.8	0.2	-2.6
Asthma	2.7	5.4	9.2	3.0	-1.2
Number of full sisters	2.7	3.3	6.0	0.7	2.5
Risk taking	2.7	4.0	6.2	1.4	2.5
Fed-up feelings	2.6	4.8	7.2	2.7	1.5
Medication: Cholesterol lowering	2.6	4.0	5.9	-2.4	-1.4
Prospective memory result	2.6	3.2	4.3	2.1	1.5
Medication: Metformin	2.5	3.5	3.6	-1.9	-1.8
Hayfever, allergic rhinitis or eczema	2.5	5.4	10.7	3.3	0.3
Hair/balding pattern: Pattern 3	2.4	3.6	5.9	-2.4	-1.1
Supplements: Vitamin C	2.3	2.7	4.6	2.1	-0.9
Asthma (self-reported)	2.2	4.3	7.7	2.8	-1.0
Ever taken oral contraceptive pill	2.2	2.5	4.9	2.2	0.2
Leg pain on walking	2.1	2.6	3.7	1.3	1.9
Crohns Disease (2012)	2.0	3.2	6.5	-2.5	-0.1
Noisy workplace	2.0	2.4	3.9	1.0	2.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.2	-1.2	-1.8
Number of live births	1.9	2.7	3.3	1.5	1.8
Intelligence (Savage-Jansen 2018)	1.8	5.5	7.9	-2.8	1.7
Irritable Bowel Disease (IBD)	1.8	4.4	5.7	-2.4	-1.8
Mean time to correctly identify matches	1.8	3.5	4.2	-2.1	-1.7
Prostate Cancer	1.7	2.4	4.4	-0.7	-2.1
Blood Red Count	1.7	16.0	27.7	5.3	2.1
Respiratory disease	1.7	3.7	6.9	2.6	-0.7
Ever had hysterectomy (womb removed)	1.7	2.0	3.4	1.8	-0.7
Pulse rate	1.7	2.9	4.6	1.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	3.7	1.9	0.0
Mother’s age at death	1.7	2.1	3.4	-1.8	-0.9
Illnesses of father: High blood pressure	1.7	2.1	2.3	1.5	1.4
Coronary Artery Disease (CAD)	1.6	1.9	3.8	-2.0	0.2
Glaucoma (self-reported)	1.6	1.9	3.4	-1.8	-0.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	5.1	-2.3	1.1
Breast cancer (self-reported)	1.6	2.0	3.7	1.9	-0.5
Heart disease (siblings)	1.6	1.9	3.8	-2.0	0.2
Chronic bronchitis/emphysema (father)	1.5	1.7	3.4	-0.3	-1.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.1	1.7	1.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.3	1.8	0.7
Commuting to job workplace: Walk	1.5	1.6	2.9	-0.6	-1.7
Eye problems/disorders: Glaucoma	1.5	1.7	2.4	-1.5	-1.1
Pack years adult smoking proportion	1.4	2.1	3.3	1.8	0.9
Relative age voice broke	1.4	2.1	3.7	1.9	0.7
Number of children fathered	1.4	1.6	2.7	-1.6	-0.8
Eye problems/disorders: None of the above	1.4	1.6	2.1	1.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	4.8	-1.0	2.2
Medication: Aspirin	1.4	1.9	3.7	-1.9	-0.2
Diastolic blood pressure, automated reading	1.4	4.2	4.7	1.9	2.2
Depressed Affect (Nagel 2018)	1.3	2.8	5.1	2.3	0.7
Townsend deprivation index at recruitment	1.3	1.9	3.6	-0.3	-1.9
Medication: Levothyroxine sodium	1.3	2.3	3.5	-1.9	1.0
Financial difficulties in last 2 years	1.3	1.7	2.9	0.8	1.7
Medication: Ramipril	1.3	1.7	2.6	-1.6	-0.8
Headache pain in last month	1.3	2.2	4.3	0.3	2.1
Leg predicted mass (right)	1.3	6.9	13.7	-3.7	-0.1
Average weekly champagne plus white wine intake	1.3	1.8	3.5	-1.9	-0.2
High cholesterol (Self-reported)	1.3	2.2	2.4	-1.6	-1.4
Pack years of smoking	1.3	2.0	3.7	1.9	0.5
Allergy or Eczema	1.2	3.1	6.1	2.5	-0.4
Lung FEV1/FVC ratio	1.2	6.2	12.2	-3.5	0.5
Leg fat-free mass (left)	1.2	6.4	12.7	-3.6	-0.1
Leg predicted mass (left)	1.2	6.6	13.1	-3.6	-0.1
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.7	-2.2	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.1	2.3	-1.4	-1.5
Heart disease (mother)	1.2	1.5	2.9	-1.7	-0.2
Comparative height size at age 10	1.2	6.4	12.1	-3.5	-0.8
Had major operations	1.2	1.4	1.9	1.0	1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.9	1.7	-0.2
Leg fat-free mass (right)	1.2	6.7	13.3	-3.6	-0.2
Ever depressed for a whole week	1.2	1.4	1.9	-1.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.7	1.6	0.5
Alzheimer’s Disease (in mother)	1.1	1.3	2.6	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.4	-2.1	1.0
Rheumatoid Arthritis	1.1	1.6	3.0	1.7	-0.4
Schizophrenia (2014)	1.1	2.5	4.9	-2.2	-0.0
Diabetes (father)	1.1	1.3	1.7	-1.0	-1.3
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	1.6	0.3
Weight	1.1	5.3	10.6	-3.3	-0.2
Worrier / anxious feelings	1.1	2.0	4.0	0.1	-2.0
Falls in the last year	1.1	1.5	2.7	0.5	-1.6
Blood clot in the leg (DVT)	1.1	1.4	2.7	0.4	1.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.4	1.8	-0.1
Hearing aid user	1.1	1.3	2.1	-1.5	0.6
Medication: Paracetamol	1.1	1.7	3.3	1.8	0.0
Basal metabolic rate	1.1	6.1	12.0	-3.5	-0.3
Arm fat-free mass (left)	1.1	5.5	10.6	-3.2	-0.6
Fasting Glucose	1.0	1.2	1.7	-0.9	1.3
Vitamin and mineral supplements	1.0	1.3	2.6	0.1	1.6
Diabetes (mother)	1.0	1.3	2.2	-1.5	0.6
Arm fat mass (right)	1.0	4.0	7.4	-2.7	-0.7
Pulse wave reflection index	1.0	1.2	2.5	1.6	0.1
Medication: Paracetamol	1.0	1.7	3.1	1.8	-0.4
High blood pressure (siblings)	1.0	1.5	3.0	-0.2	1.7
Illnesses of siblings: Diabetes	1.0	1.3	1.7	-1.3	-0.9
Whole body fat-free mass	1.0	5.7	11.2	-3.4	-0.3
Whole body water mass	1.0	5.8	11.5	-3.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.2	0.5	1.5
Arm predicted mass (left)	1.0	5.3	10.3	-3.2	-0.4
Ovarian Cancer	0.9	1.2	1.4	-1.0	-1.2
BMI	0.9	5.5	10.9	-3.3	0.2
Hypothyroidism (self reported)	0.9	2.1	3.2	-1.8	1.0
Number of treatments/medications taken	0.9	1.6	2.1	-1.1	-1.5
Multivitamins +/- minerals	0.9	1.1	2.2	-1.5	0.2
Number of incorrect matches in round	0.9	1.4	2.1	0.9	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.4	0.6	1.6
Pain all over the body in last month	0.9	1.0	1.0	1.0	1.0
Illnesses of siblings	0.9	1.3	2.5	1.6	0.2
Hip circumference	0.9	3.9	7.6	-2.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	3.7	-1.9	1.6
Lung cancer (father)	0.9	1.0	1.6	0.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.8	0.1	1.7
Arm fat-free mass (right)	0.9	4.8	9.5	-3.1	-0.3
Medication: Blood pressure	0.9	1.6	2.1	-1.1	-1.4
Arm predicted mass (right)	0.9	4.8	9.1	-3.0	-0.6
Ever had bowel cancer screening	0.9	1.1	1.7	-1.3	-0.6
Diabetes diagnosed by doctor	0.9	1.5	2.2	-1.5	-0.8
Qualifications: nursing, teaching	0.9	1.4	2.9	-1.7	-0.1
Medication for cholesterol	0.9	1.3	1.8	1.3	0.9
Arm fat mass (left)	0.9	3.5	6.5	-2.6	-0.7
Unable to work because of sickness or disability	0.9	1.1	2.2	0.3	1.5
Basal cell carcinoma (self-reported)	0.9	1.0	1.4	-1.2	0.8
Bipolar Disorder or Schizophrenia	0.8	1.9	3.6	-1.9	0.5
Current tobacco smoking	0.8	1.3	1.5	1.2	1.1
Taking other prescription medications	0.8	1.3	2.3	-0.6	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.6	0.3	1.9
High blood pressure (mother)	0.8	1.2	2.2	0.4	1.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.8	-1.3	0.3
Fluid intelligence score	0.8	1.6	3.2	-1.8	-0.1
Trunk fat-free mass	0.8	4.8	9.5	-3.1	-0.2
Time employed in main current job	0.8	0.9	1.7	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	3.2	-1.8	1.2
Trunk predicted mass	0.8	4.8	9.5	-3.1	-0.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	1.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.5	-1.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.1	-0.1	1.5
Smoking status: Previous	0.8	1.2	1.8	-1.4	-0.8
Back pain experienced in last month	0.8	1.1	2.0	0.5	-1.4
Financial situation satisfaction	0.8	1.0	2.0	0.0	1.4
Medication: Atorvastatin	0.8	1.0	1.8	-1.3	-0.5
Cholesterol lowering medication	0.8	1.1	2.2	-1.5	-0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	1.4	0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	0.4	1.3
Impedance of leg (right)	0.7	3.5	6.8	2.6	0.6
Hand grip strength (right)	0.7	2.0	3.1	-1.7	1.0
Maternal smoking around birth	0.7	1.0	2.0	1.4	-0.3
Impedance of leg (left)	0.7	3.3	6.5	2.6	0.3
Trunk fat mass	0.7	3.2	5.9	-2.4	-0.7
Waist circumference	0.7	2.6	5.2	-2.3	-0.1
Medication: Simvastatin	0.7	1.1	1.2	-1.0	-1.1
Neuroticism score	0.7	1.5	3.0	1.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	0.9	-0.9	0.9
Whole body fat mass	0.7	3.1	5.7	-2.4	-0.7
Pulse rate, automated reading	0.7	2.4	2.5	1.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.1	0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.6	0.3	-1.3
Alcohol drinker status: Previous	0.7	0.8	1.3	-0.5	1.1
Reaction Time	0.6	1.1	1.4	-1.2	-0.9
Systolic Blood Pressure	0.6	2.9	3.2	1.8	1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	-1.4	-0.5
Average weekly spirits intake	0.6	0.7	1.4	-0.2	1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	-1.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	1.1	0.5
Past tobacco smoking	0.6	1.1	1.3	1.2	0.9
Nervous feelings	0.6	1.2	1.5	1.0	1.2
Hearing difficulty/problems with background noise	0.6	1.0	2.0	1.4	0.0
Forced vital capacity (FVC)	0.6	2.2	2.3	-1.4	1.5
Illnesses of mother	0.6	0.7	1.0	1.0	0.6
Standing height	0.6	6.2	12.4	-3.5	-0.0
Hair/balding pattern: Pattern 4	0.6	1.5	2.9	-0.3	-1.7
Osteoporosis (self-reported)	0.6	0.7	1.4	1.2	0.1
Medication: Lisinopril	0.6	0.7	0.8	-0.8	-0.9
Commuting to job workplace: Cycle	0.6	0.8	1.0	0.7	-1.0
Myopia	0.6	0.8	1.4	0.4	-1.2
Bipolar Disorder (2018)	0.5	0.8	1.4	-1.2	0.3
Neuroticism (Nagel 2018)	0.5	1.1	1.8	1.3	0.7
Schizophrenia (2018)	0.5	1.1	2.1	-1.5	0.3
Primary Biliary Cirrhosis	0.5	0.7	1.2	-1.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	0.9	-0.7
Severe depression (siblings)	0.5	0.6	1.1	0.4	-1.0
Trunk fat percentage	0.5	2.0	3.3	-1.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	0.3	1.5
Qualifications: None of the above	0.5	1.0	2.0	0.1	-1.4
Arm fat percentage (right)	0.5	1.9	3.3	-1.8	-0.7
Wheeze or whistling in the chest in last year	0.5	0.8	1.6	0.3	-1.3
Pulse wave peak to peak time	0.5	0.6	1.2	-1.1	-0.1
Shortness of breath walking on level ground	0.5	0.6	0.9	0.5	0.9
Qualifications: College or University degree	0.5	1.6	3.2	-0.2	1.8
Migraine (self-reported)	0.5	0.7	1.3	-0.2	1.1
Medication: Omeprazole	0.5	0.5	1.0	1.0	0.2
Leg fat mass (right)	0.5	1.9	3.8	-1.9	0.1
Arm fat percentage (left)	0.5	1.9	3.4	-1.8	-0.6
Mood swings	0.5	0.9	1.9	1.4	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.0	-0.4	1.0
Smoking status: Current	0.5	0.8	0.9	0.8	1.0
Miserableness	0.5	0.8	0.9	0.9	0.9
Guilty feelings	0.5	0.7	1.1	1.1	0.5
Commuting to job workplace: Public transport	0.5	0.6	0.9	-0.6	0.9
Alcohol drinker status: Never	0.5	0.6	1.1	-0.2	-1.0
Fractured/broken bones in last 5 years	0.5	0.7	1.3	-1.2	0.0
Leg fat mass (left)	0.5	2.0	4.0	-2.0	-0.1
Ulcerative Colitis (UC)	0.4	0.7	1.5	-0.2	-1.2
Age at First Birth	0.4	0.6	0.9	0.6	1.0
HDL Cholesterol	0.4	0.7	0.7	0.8	0.8
Height	0.4	7.2	13.4	-3.7	-1.0
Sensitivity / hurt feelings	0.4	0.8	1.5	-0.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.2	1.0
Angina	0.4	0.5	0.8	-0.9	0.5
Supplements: Zinc	0.4	0.5	0.9	0.9	0.3
Diabetes (self-reported)	0.4	0.6	0.7	-0.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.7	-0.5	0.8
Depression (self-reported)	0.4	0.5	1.0	1.0	-0.3
Breastfed as a baby	0.4	0.5	0.5	-0.7	0.7
Body fat percentage	0.4	1.7	3.1	-1.8	-0.6
Emphysema/chronic bronchitis	0.4	0.5	0.7	-0.5	-0.8
Angina (self-reported)	0.4	0.6	0.8	-0.9	0.6
Family relationship satisfaction	0.4	0.5	1.0	1.0	-0.1
Long-standing illness, disability or infirmity	0.4	0.6	1.0	0.4	1.0
Mineral and other dietary supplements	0.4	0.5	0.8	0.9	0.4
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	-1.3	0.3
Medication: Bendroflumethiazide	0.4	0.6	1.0	-0.4	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-1.0	-0.2
Supplements: Calcium	0.4	0.4	0.9	-0.9	0.1
Mean Putamen Volume	0.3	0.4	0.5	0.4	0.7
Triglycerides	0.3	0.5	0.9	-1.0	-0.4
Heel T-Score	0.3	2.4	2.7	-1.6	1.5
Tanning	0.3	4.0	7.7	0.6	2.8
Average weekly fortified wine intake	0.3	0.3	0.6	0.1	-0.8
Age when periods started (menarche)	0.3	0.6	0.7	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.8	-0.2
Body mass index (BMI)	0.3	1.4	2.8	-1.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.4	0.6	0.6
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.9	-0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.8	0.1
Peak expiratory flow (PEF)	0.3	0.7	0.8	-0.9	0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	1.8	-0.8	1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.4	0.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.8	0.1
Age at first live birth	0.3	0.5	0.9	-0.9	-0.2
Medication: Ibuprofen	0.3	0.3	0.5	0.5	0.7
Overall health rating	0.3	0.5	0.8	0.9	0.5
Average weekly red wine intake	0.3	0.4	0.6	-0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.0	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.8	0.4	0.9
Ever smoked	0.3	0.6	1.0	-0.4	-1.0
Irritability	0.3	0.6	0.6	0.8	0.8
Impedance of whole body	0.3	1.4	2.6	1.6	0.5
Worry (Nagel 2018)	0.2	0.4	0.5	0.7	0.5
Breast Cancer	0.2	0.5	0.9	-0.3	-1.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	0.4
Lupus	0.2	0.4	0.5	-0.7	-0.4
Ulcerative Colitis	0.2	0.3	0.4	-0.4	0.6
Blood White Count	0.2	1.7	3.3	0.2	1.8
Neuroticism	0.2	0.4	0.7	0.9	0.4
Chronotype (morning person)	0.2	0.4	0.6	0.8	0.4
Relative age of first facial hair	0.2	0.4	0.7	0.2	-0.8
Medication: Co-codamol	0.2	0.2	0.3	-0.4	0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.2	0.7
Length of working week for main job	0.2	0.2	0.3	-0.4	0.5
Exposure to tobacco smoke at home	0.2	0.3	0.3	0.5	-0.5
Tense / ‘highly strung’	0.2	0.3	0.7	0.8	-0.1
Loud music exposure frequency	0.2	0.3	0.4	0.3	0.7
Number of full brothers	0.2	0.2	0.3	-0.4	-0.5
Worry too long after embarrassment	0.2	0.4	0.7	0.9	0.3
Health satisfaction	0.2	0.2	0.4	0.6	0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.5	0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.3	0.5
Chest pain or discomfort	0.2	0.3	0.3	-0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.3	0.5	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.6	-0.2
Loneliness, isolation	0.2	0.3	0.6	-0.0	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	1.0	0.4
Depression (Nagel 2018)	0.1	0.2	0.3	0.5	0.3
HbA1C	0.1	0.1	0.2	0.2	0.4
LDL Cholesterol	0.1	0.1	0.2	0.4	0.1
Cardiovascular Disease	0.1	0.4	0.8	0.0	0.9
Lung FVC	0.1	0.3	0.4	-0.6	0.5
Medication for hormone replacement therapy	0.1	0.1	0.1	0.3	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.1	-0.4
High blood pressure	0.1	0.3	0.4	-0.7	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	0.3
Supplements: Glucosamine	0.1	0.1	0.1	-0.3	0.4
Medication: Atenolol	0.1	0.1	0.2	-0.4	0.1
Sitting height	0.1	0.9	1.5	-1.2	0.5
Had other major operations	0.1	0.1	0.2	0.2	-0.5
Mouth/teeth dental problems	0.1	0.1	0.2	-0.4	0.1
Impedance of arm (right)	0.1	0.3	0.6	0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.0	0.4
Birth weight	0.1	0.2	0.2	0.4	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.5
Comparative body size at age 10	0.1	0.2	0.2	0.4	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.3	0.5	-0.1	0.7
Neck or shoulder pain in last month	0.1	0.2	0.2	0.4	-0.5
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	0.1
Age at last live birth	0.1	0.1	0.2	-0.4	0.3
Knee pain experienced in last month	0.1	0.1	0.2	0.4	-0.3
Hypertension (Self-reported)	0.1	0.2	0.3	-0.5	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.1	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.3	0.4
Leg fat percentage (left)	0.1	0.2	0.4	-0.6	-0.1
Pain experienced in last month	0.1	0.2	0.2	-0.5	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.2	0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.2	0.2
Neuroticism (2016)	0.0	0.1	0.1	-0.1	0.4
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.4	0.0
Smoking Status	0.0	0.0	0.0	-0.1	-0.0
Hair Pigment	0.0	1.2	1.3	1.2	1.0
Hand grip strength (left)	0.0	0.1	0.1	-0.3	0.2
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	0.0
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	-0.2	0.3
Alcohol usually taken with meals	0.0	0.0	0.0	-0.1	-0.0
Father’s age at death	0.0	0.0	0.0	-0.1	0.1
Happiness	0.0	0.0	0.0	-0.1	0.0
Medication: Lansoprazole	0.0	0.0	0.1	-0.1	0.2
Impedance of arm (left)	0.0	0.2	0.3	0.5	0.2
Birth weight of first child	0.0	0.1	0.1	0.2	0.3
Medication: Amlodipine	0.0	0.1	0.1	-0.1	-0.3
Leg fat percentage (right)	0.0	0.1	0.3	-0.5	0.1
Alcohol intake frequency.	0.0	0.1	0.1	0.3	0.4
Illnesses of father: Heart disease	0.0	0.1	0.1	0.2	-0.3
Friendships satisfaction	0.0	0.0	0.0	0.0	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	0.2	0.0
Medication: Blood pressure	0.0	0.1	0.1	-0.2	0.3
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	0.2
Average weekly beer plus cider intake	0.0	0.1	0.1	0.2	-0.3

Hub : Genes

ELF1

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Trait associations