TWAS hub - MRPS31

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0526	0.0151	3.9e-10	0.025	0.033	0.019	0.032	0.028	1.1e-08	6.5e-11	6.4e-07	9.3e-11	1.1e-09
2	TCGA	Uterine Corpus Endometrial Carcinoma	0.3450	0.1350	1.8e-04	0.129	0.158	0.145	NA	0.153	1.9e-04	3.7e-05	7.6e-05	NA	4.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	10.4	80.2	158.8	-12.6	1.3
Blood Platelet Count	4.6	53.1	105.0	-10.2	1.1
Hayfever, allergic rhinitis or eczema	4.2	9.0	11.1	-3.3	2.6
Allergy	4.0	9.1	13.8	3.7	-2.1
Mouth/teeth dental problems: Mouth ulcers	3.9	6.3	12.3	-3.5	0.5
Breastfed as a baby	3.7	4.5	7.5	1.3	2.7
Blood Red Count	3.6	35.0	61.2	-7.8	3.0
Allergy or Eczema	3.6	9.6	10.0	-3.2	3.0
Severe depression (siblings)	3.5	4.0	5.5	-1.5	-2.4
Supplements: Glucosamine	3.2	4.1	7.1	1.1	2.7
Heart attack/myocardial infarction (self-reported)	3.1	4.0	4.4	2.1	1.9
Pulse rate, automated reading	3.0	9.8	18.9	-4.3	0.8
Mineral and other dietary supplements	2.9	3.9	7.2	-0.8	-2.7
Coronary Artery Disease (CAD)	2.6	3.1	3.9	2.0	1.5
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.8	0.4	2.4
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	5.3	-2.3	-1.0
HbA1C	2.5	2.8	5.4	2.3	0.4
Rheumatoid Arthritis	2.5	3.4	5.7	-2.4	1.1
Type 2 Diabetes (T2D) (2012)	2.5	2.9	5.2	2.3	-0.8
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.9	-2.2	-1.0
Illnesses of father: Heart disease	2.5	3.5	6.6	-0.7	2.6
Supplements: Fish oil (including cod liver oil)	2.4	3.2	6.3	-0.2	2.5
Mouth/teeth dental problems	2.3	3.5	4.2	2.0	-1.7
Heart attack	2.3	3.0	3.8	1.9	1.5
Illnesses of father: High blood pressure	2.3	2.9	5.6	-2.4	-0.4
Alzheimer’s Disease (including proxy)	2.2	3.2	5.3	-2.3	-1.1
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	4.7	2.2	2.0
Lung FEV1/FVC ratio	2.1	10.5	16.2	4.0	-2.2
Leg fat-free mass (left)	2.1	11.0	22.0	4.7	-0.1
Leg predicted mass (left)	2.1	10.9	21.7	4.7	-0.1
Medication: Cholesterol lowering	2.1	3.3	4.2	1.5	2.1
Supplements: Zinc	2.0	2.2	3.3	-1.8	-1.0
Relative age voice broke	2.0	3.0	5.7	-2.4	0.5
Falls in the last year	2.0	2.7	3.0	-1.5	-1.7
Exposure to tobacco smoke at home	2.0	2.3	2.5	1.6	-1.5
Comparative height size at age 10	2.0	10.8	19.6	4.4	1.4
Number of full sisters	2.0	2.4	4.2	-0.7	-2.1
Medication: Omeprazole	1.9	2.3	4.2	-2.1	-0.7
Leg fat-free mass (right)	1.9	10.3	20.3	4.5	0.4
Leg predicted mass (right)	1.9	10.2	20.3	4.5	0.3
Fractured/broken bones in last 5 years	1.9	2.4	4.5	2.1	-0.5
Alzheimer’s Disease (in mother)	1.8	2.1	3.9	-2.0	-0.6
Prostate Cancer	1.8	2.5	4.8	-2.2	0.4
Ever had bowel cancer screening	1.8	2.1	3.8	0.7	1.9
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.7	-0.7	1.9
Ulcerative Colitis (UC)	1.7	3.3	5.6	-2.4	-1.0
Major Depression (MDD)	1.7	2.0	2.1	1.4	-1.4
Medication: Simvastatin	1.7	2.5	5.1	2.3	0.1
Weight	1.7	8.3	16.6	4.1	-0.1
Hip circumference	1.7	7.1	14.0	3.7	-0.5
Prospective memory result	1.7	2.1	3.9	-2.0	0.5
Number of children fathered	1.7	1.9	3.0	1.7	0.9
Pulse wave peak to peak time	1.7	2.0	3.9	2.0	0.2
Financial situation satisfaction	1.7	2.1	4.1	2.0	-0.1
Heart disease (siblings)	1.7	2.0	3.4	0.8	1.8
Ovarian Cancer	1.6	2.1	3.5	1.9	-0.8
Height	1.6	31.0	56.0	7.5	2.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.2	-1.2	1.5
Qualifications: CSEs or equivalent	1.6	2.1	3.4	1.8	0.9
Leg pain on walking	1.6	2.0	3.8	-0.4	2.0
Number of self-reported non-cancer illnesses	1.6	2.8	3.0	-1.7	1.6
Basal metabolic rate	1.6	8.9	17.9	4.2	-0.1
Hypothyroidism (self reported)	1.5	3.5	5.0	1.4	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	9.4	3.1	0.2
Whole body fat-free mass	1.5	8.4	16.9	4.1	-0.1
Neuroticism (2016)	1.4	2.0	3.2	0.9	1.8
Medication for hormone replacement therapy	1.4	1.6	2.9	0.6	1.7
Time employed in main current job	1.4	1.6	3.1	0.3	-1.8
Medication: Amlodipine	1.4	2.0	3.9	0.2	2.0
Emphysema/chronic bronchitis	1.4	1.5	1.6	1.3	-1.2
Whole body water mass	1.4	8.1	16.2	4.0	0.0
Commuting to job workplace: Public transport	1.4	1.7	3.2	0.5	-1.8
High cholesterol (Self-reported)	1.4	2.6	2.8	1.7	1.5
Bipolar Disorder (2011)	1.3	1.2	2.4	1.6	-0.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.5	1.6	0.6
Medication: Levothyroxine sodium	1.3	2.1	2.4	1.4	1.5
Impedance of leg (left)	1.3	6.1	12.2	-3.5	0.3
Number of live births	1.3	1.8	3.0	-1.7	-0.8
Pulse rate	1.3	2.2	4.3	-2.1	-0.2
Standing height	1.3	12.5	23.7	4.9	1.1
Eye problems/disorders: Cataract	1.3	1.5	2.3	-1.5	0.8
Medication for cholesterol	1.3	1.9	3.5	-0.5	-1.9
Osteoarthritis (self-reported)	1.3	1.7	3.3	-0.4	1.8
Ever taken oral contraceptive pill	1.3	1.5	2.9	-1.7	0.0
Diastolic blood pressure, automated reading	1.3	4.2	7.8	-2.8	0.8
Arm predicted mass (left)	1.3	6.5	12.8	3.6	-0.5
Trunk fat-free mass	1.2	7.1	14.2	3.8	-0.0
Worrier / anxious feelings	1.2	2.3	3.6	1.0	1.9
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	7.7	2.8	0.8
Illnesses of mother	1.2	1.5	2.9	-0.4	-1.7
Arm fat mass (right)	1.2	5.0	9.6	3.1	-0.6
Trunk predicted mass	1.2	7.0	13.9	3.7	-0.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.8	-0.3	1.7
Qualifications: nursing, teaching	1.2	1.9	3.3	0.7	1.8
Arm fat mass (left)	1.2	4.9	9.7	3.1	-0.3
Average weekly champagne plus white wine intake	1.2	1.6	1.7	1.3	1.2
Arm fat-free mass (left)	1.2	6.2	11.7	3.4	-0.8
Body Mass Index (BMI) (2010)	1.1	1.5	2.4	1.5	0.8
High blood pressure (mother)	1.1	1.6	1.9	1.1	1.4
Medication: Lansoprazole	1.1	1.3	1.9	0.8	-1.4
Pulse wave reflection index	1.1	1.4	2.6	-1.6	-0.4
Gout (self-reported)	1.1	1.5	2.8	-1.7	-0.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.6	-1.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.0	-1.4	-0.9
Shortness of breath walking on level ground	1.1	1.3	2.6	-1.6	-0.1
Heart disease (mother)	1.1	1.4	2.6	1.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.5	2.1	-0.1
Age at First Birth	1.0	1.4	1.7	-1.1	1.3
Ulcerative Colitis	1.0	1.5	2.4	-1.6	-0.7
BMI	1.0	5.6	11.1	3.3	-0.4
Impedance of leg (right)	1.0	4.9	9.4	-3.1	-0.6
Trunk fat mass	1.0	4.3	8.6	2.9	0.1
Waist circumference	1.0	3.7	6.9	2.6	-0.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.5	-0.8	-1.2
Whole body fat mass	1.0	4.3	8.5	2.9	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.1	0.2	1.4
Fasting Glucose	0.9	1.1	2.0	1.4	-0.5
Cardiovascular Disease	0.9	2.9	3.4	-1.8	1.6
Medication: Metformin	0.9	1.2	2.4	1.6	0.2
Hand grip strength (right)	0.9	2.3	4.4	2.1	0.5
Townsend deprivation index at recruitment	0.9	1.3	1.3	1.1	-1.1
Stomach or abdominal pain in last month	0.9	1.1	2.2	-0.2	1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.9	-0.4	1.4
Medication: Atenolol	0.9	1.1	1.5	-1.2	0.8
Nervous feelings	0.9	1.7	2.6	-0.9	1.6
Had other major operations	0.9	1.1	1.2	1.1	1.0
Pain all over the body in last month	0.9	1.0	1.7	-0.6	1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.5	-0.9	1.2
Arm fat percentage (right)	0.9	3.6	6.5	2.5	-0.8
Peak expiratory flow (PEF)	0.9	2.0	3.1	1.8	0.9
Glaucoma (self-reported)	0.9	1.0	2.1	1.4	0.1
Arm predicted mass (right)	0.9	4.4	8.4	2.9	-0.6
Had major operations	0.9	1.0	1.4	-1.2	0.7
Medication: Aspirin	0.9	1.2	2.2	1.5	0.5
Supplements: Vitamin C	0.9	1.1	1.5	-0.9	1.2
Guilty feelings	0.9	1.3	2.3	-0.5	1.5
Eye problems/disorders: Glaucoma	0.9	1.1	2.2	1.5	-0.0
Depression (Nagel 2018)	0.8	1.2	1.6	-1.3	0.8
Lupus	0.8	1.3	1.7	0.9	-1.3
Neuroticism	0.8	2.0	3.9	0.3	2.0
Pulse wave Arterial Stiffness index	0.8	0.9	1.9	-1.4	-0.2
Blood clot in the leg (DVT)	0.8	1.0	2.1	-1.4	-0.1
Arm fat-free mass (right)	0.8	4.3	8.4	2.9	-0.4
Angina (self-reported)	0.8	1.0	1.9	0.2	1.4
Medication: Allopurinol	0.8	1.1	1.5	-1.2	-0.8
Leg fat mass (right)	0.8	2.9	4.8	2.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.2	1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.2	1.8	0.5
Medication: Aspirin	0.8	1.1	2.2	1.5	0.1
Mother’s age at death	0.8	1.0	1.6	1.3	0.7
Average weekly beer plus cider intake	0.8	1.1	2.0	-0.4	-1.4
Depressed Affect (Nagel 2018)	0.7	1.5	2.9	0.4	1.7
Neuroticism (Nagel 2018)	0.7	1.7	3.4	0.1	1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	-1.2	-0.6
Reaction Time	0.7	1.3	1.4	1.1	1.2
Waist Hip Ratio (WHR)	0.7	3.2	5.2	-2.3	-1.1
Average weekly spirits intake	0.7	0.9	1.7	-0.2	1.3
Angina	0.7	1.0	1.8	0.4	1.3
Medication: Co-codamol	0.7	0.8	1.3	0.5	1.1
Diabetes (father)	0.7	0.8	1.1	-0.7	-1.1
Age when periods started (menarche)	0.7	1.8	2.9	1.7	-0.8
Forced vital capacity (FVC)	0.7	2.8	4.3	2.1	1.2
Happiness	0.7	0.8	1.6	1.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.0	0.2	1.4
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-0.2	-1.4
Mean time to correctly identify matches	0.7	1.4	2.4	1.5	0.6
Arm fat percentage (left)	0.7	2.7	5.0	2.2	-0.6
Average weekly red wine intake	0.7	1.1	1.3	0.9	1.1
Mood swings	0.7	1.3	1.7	1.0	1.3
Breast cancer (self-reported)	0.7	0.8	1.0	0.8	-1.0
Hearing aid user	0.7	0.8	0.9	1.0	-0.8
Supplements: Calcium	0.7	0.7	1.4	1.2	-0.2
Bipolar Disorder (2018)	0.6	0.9	1.3	0.7	-1.2
Alzheimer’s Disease (in father)	0.6	0.6	0.6	-0.8	-0.8
Irritable Bowel Disease (IBD)	0.6	1.5	2.1	-1.4	-1.0
LDL Cholesterol	0.6	0.9	1.8	-0.2	1.3
Primary Biliary Cirrhosis	0.6	0.9	1.3	1.2	0.6
Triglycerides	0.6	1.1	1.3	1.1	0.9
Respiratory disease	0.6	1.3	2.1	-0.6	1.5
Pack years adult smoking proportion	0.6	0.9	1.5	-1.2	0.6
Trunk fat percentage	0.6	2.4	4.9	2.2	0.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	1.2	0.2
Mouth/teeth dental problems: Dentures	0.6	0.9	1.6	0.6	1.3
Forced vital capacity (FVC), Best measure	0.6	2.3	4.2	2.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	0.8	-0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-1.2	0.2
Friendships satisfaction	0.6	0.8	1.2	1.1	0.6
Number of operations (self-reported)	0.6	0.9	1.6	1.3	-0.3
Ever depressed for a whole week	0.6	0.7	1.2	-0.4	-1.1
Cholesterol lowering medication	0.6	0.9	1.8	1.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	-1.2	0.2
Pack years of smoking	0.6	0.9	1.7	-1.3	0.4
Leg fat mass (left)	0.6	2.5	4.6	2.1	-0.7
Breast Cancer	0.5	1.2	2.1	-0.6	1.5
Systolic blood pressure, automated reading	0.5	1.5	3.0	0.2	1.7
Diabetes (mother)	0.5	0.6	0.9	-0.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	0.0	-1.5
Sitting height	0.5	3.7	6.7	2.6	0.9
Body mass index (BMI)	0.5	2.3	4.0	2.0	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-1.1	0.3
Headache pain in last month	0.5	0.9	1.2	-1.1	-0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-0.1	-1.2
Body fat percentage	0.5	2.1	4.0	2.0	-0.4
Eye problems/disorders: None of the above	0.5	0.6	0.6	0.8	-0.7
Knee pain experienced in last month	0.5	0.7	1.4	-0.1	-1.2
Age started oral contraceptive pill	0.5	0.6	1.1	-0.3	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.7	1.6	0.0
Systolic Blood Pressure	0.4	2.0	2.9	-1.1	1.7
Hand grip strength (left)	0.4	1.1	1.3	0.9	1.2
Hearing difficulty/problems: Yes	0.4	0.6	0.7	0.8	-0.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.4	0.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.6	-0.8	0.4
Maternal smoking around birth	0.4	0.5	1.0	0.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	-0.6	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.1	0.4	-1.1
Hair/balding pattern: Pattern 2	0.4	0.4	0.7	-0.8	0.5
Noisy workplace	0.4	0.5	0.8	-0.9	0.4
Asthma	0.4	0.8	0.8	-0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	-0.6	0.8
Depression (self-reported)	0.4	0.5	1.0	-0.1	-1.0
Hair/balding pattern: Pattern 4	0.4	0.9	1.1	1.0	-0.9
Birth weight of first child	0.4	0.8	1.2	-1.1	-0.6
Loud music exposure frequency	0.4	0.5	0.7	0.4	-0.9
Birth weight	0.4	1.0	1.1	1.0	-0.9
Qualifications: College or University degree	0.4	1.2	1.4	-1.0	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.6	0.6	0.8
Medication: Blood pressure	0.4	0.7	1.3	-0.3	1.1
Hypertension (Self-reported)	0.4	1.2	1.5	-1.0	1.2
Medication: Gliclazide	0.4	0.4	0.4	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.9	-0.5
Medication: Blood pressure	0.4	0.8	1.1	-0.7	1.1
Alcohol drinker status: Never	0.4	0.5	0.5	-0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.1	0.5	-1.5
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.9	0.1
Worry (Nagel 2018)	0.3	0.7	0.8	-0.7	0.9
Mean Putamen Volume	0.3	0.4	0.7	-0.9	-0.2
Lung FVC	0.3	1.5	2.9	0.4	1.7
Tanning	0.3	4.2	8.2	0.3	2.9
Sensitivity / hurt feelings	0.3	0.5	0.7	0.5	0.9
Average weekly fortified wine intake	0.3	0.4	0.8	0.2	0.9
Taking other prescription medications	0.3	0.5	1.0	-0.1	1.0
High blood pressure	0.3	0.9	1.5	-0.5	1.2
Alcohol usually taken with meals	0.3	0.5	0.8	-0.9	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.8	-0.2
Qualifications: None of the above	0.3	0.7	0.8	0.7	-0.9
Illnesses of siblings	0.3	0.4	0.7	-0.8	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	0.9	0.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	-0.7	0.5
Tense / ‘highly strung’	0.3	0.4	0.5	0.6	-0.7
Worry too long after embarrassment	0.3	0.5	0.6	0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.4	-0.8
Medication: Ibuprofen	0.3	0.4	0.4	-0.6	0.7
Chest pain or discomfort	0.3	0.5	1.0	1.0	0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.1	-0.9
Asthma (self-reported)	0.3	0.5	0.7	-0.9	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.9	-0.1
Medication: Atorvastatin	0.3	0.3	0.4	0.5	0.7
Irritability	0.3	0.4	0.9	-0.1	-0.9
Myopia	0.3	0.4	0.8	-0.1	-0.9
Impedance of whole body	0.3	1.7	3.1	-1.8	0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.3	-0.9
Crohns Disease (2017)	0.2	0.3	0.5	0.4	-0.7
Crohns Disease (2012)	0.2	0.4	0.8	0.0	-0.9
HDL Cholesterol	0.2	0.3	0.3	0.5	0.5
Heel T-Score	0.2	1.6	3.1	0.3	-1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.5	0.5
Multivitamins +/- minerals	0.2	0.2	0.4	-0.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.0	0.7
Neuroticism score	0.2	0.4	0.8	0.3	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.3	-0.5	-0.5
Hair/balding pattern: Pattern 3	0.2	0.2	0.3	0.6	-0.4
Lung cancer (father)	0.2	0.2	0.5	-0.7	-0.1
Length of working week for main job	0.2	0.2	0.4	0.1	-0.7
Leg fat percentage (right)	0.2	0.9	1.3	0.7	-1.1
Age at first live birth	0.2	0.4	0.7	0.2	0.9
Health satisfaction	0.2	0.3	0.5	-0.4	0.7
Migraine (self-reported)	0.2	0.2	0.4	-0.7	-0.1
Overall health rating	0.2	0.4	0.8	-0.9	0.2
Smoking status: Previous	0.2	0.2	0.4	0.1	-0.7
Loneliness, isolation	0.2	0.3	0.6	0.4	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.2	0.5	-0.5
Miserableness	0.2	0.3	0.5	0.3	0.7
Medication: Lisinopril	0.2	0.2	0.4	0.2	-0.6
Risk taking	0.2	0.3	0.5	0.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.0	0.7
Schizophrenia (2014)	0.1	0.2	0.3	0.3	-0.6
Smoking Status	0.1	0.1	0.2	0.5	-0.1
Chronotype (morning person)	0.1	0.2	0.2	-0.5	0.3
Number of treatments/medications taken	0.1	0.2	0.2	-0.3	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.5	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	-0.3	0.5
Vitamin and mineral supplements	0.1	0.1	0.2	0.5	0.0
Fed-up feelings	0.1	0.1	0.2	-0.4	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	0.4
Number of incorrect matches in round	0.1	0.2	0.3	0.6	-0.4
Past tobacco smoking	0.1	0.2	0.2	-0.3	0.5
Had menopause	0.1	0.1	0.2	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.4	-0.6
Financial difficulties in last 2 years	0.1	0.1	0.2	0.2	0.4
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	-0.5
Medication: Ramipril	0.1	0.1	0.2	-0.2	-0.5
Fluid intelligence score	0.1	0.2	0.4	0.3	0.6
Impedance of arm (left)	0.1	0.5	0.9	-0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	-0.5
Medication: Paracetamol	0.1	0.2	0.4	0.1	0.7
High blood pressure (siblings)	0.1	0.2	0.3	-0.4	0.5
Comparative body size at age 10	0.1	0.1	0.2	0.5	0.3
Number of full brothers	0.1	0.1	0.2	0.4	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.2	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.1	-0.5
Alcohol intake frequency.	0.1	0.1	0.2	-0.3	-0.5
Suffer from ‘nerves’	0.1	0.2	0.2	0.4	0.5
Age at last live birth	0.1	0.2	0.2	0.4	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.1	0.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.0	0.5
Back pain experienced in last month	0.1	0.2	0.3	0.3	-0.6
Smoking status: Current	0.1	0.1	0.2	0.4	-0.2
Medication: Paracetamol	0.1	0.2	0.2	-0.4	-0.4
Leg fat percentage (left)	0.1	0.2	0.2	0.4	-0.5
Pain experienced in last month	0.1	0.1	0.1	0.3	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.3	0.3
Schizophrenia (2018)	0.0	0.0	0.0	-0.1	-0.2
Blood White Count	0.0	0.1	0.2	-0.5	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.1
Hair Pigment	0.0	0.4	0.5	0.7	-0.6
Relative age of first facial hair	0.0	0.0	0.1	0.3	0.0
Current tobacco smoking	0.0	0.0	0.1	-0.3	-0.1
Impedance of arm (right)	0.0	0.1	0.1	-0.0	0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.2	-0.1
Father’s age at death	0.0	0.0	0.1	0.2	0.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.2	-0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	-0.2
Family relationship satisfaction	0.0	0.0	0.1	0.3	-0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.2	0.2
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.1	-0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.2	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	-0.1
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.2	0.1
Ever smoked	0.0	0.1	0.1	-0.3	0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	0.3	0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.2	-0.3

Hub : Genes

MRPS31

Models

Trait associations