Best TWAS P=1.15e-14 · Best GWAS P=5.9e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 9 | GTEx | Nerve Tibial | AL132989.1 | 0.19 | 0.16 | lasso | 5 | 0.15 | 1.6e-10 | -7.75 | -7.7 | 1.1e-14 | 1.00 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Artery Tibial | AL132989.1 | 0.05 | 0.05 | lasso | 1 | 0.01 | 2.4e-02 | -7.69 | -7.7 | 1.5e-14 | 0.99 | 0.02 | 0.98 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | AL132989.1 | 0.10 | 0.06 | enet | 13 | 0.05 | 4.6e-05 | -7.68 | -7.6 | 3.8e-14 | 0.87 | 0.03 | 0.97 | FALSE |
| 13 | GTEx | Testis | AL132989.1 | 0.12 | 0.07 | enet | 10 | 0.08 | 2.9e-04 | -7.44 | -7.4 | 1.1e-13 | 0.98 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | AL132989.1 | 0.10 | 0.10 | lasso | 4 | 0.10 | 8.7e-06 | -7.75 | -7.4 | 1.4e-13 | 0.91 | 0.02 | 0.96 | FALSE |
| 14 | GTEx | Thyroid | AL132989.1 | 0.10 | 0.06 | lasso | 4 | 0.05 | 6.3e-05 | -6.88 | -7.4 | 1.6e-13 | 0.98 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Esophagus Muscularis | AL132989.1 | 0.08 | 0.09 | lasso | 3 | 0.07 | 3.6e-05 | -6.88 | -7.2 | 8.6e-13 | 0.97 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | AL132989.1 | 0.31 | 0.08 | lasso | 4 | 0.10 | 4.1e-04 | -7.75 | -7.1 | 1.0e-12 | 0.91 | 0.02 | 0.96 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | AL132989.1 | 0.07 | 0.03 | enet | 8 | 0.04 | 9.6e-04 | -7.63 | -7.0 | 2.9e-12 | 0.94 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | AL132989.1 | 0.10 | 0.07 | enet | 18 | 0.07 | 2.4e-06 | -7.59 | -6.6 | 3.4e-11 | 0.82 | 0.03 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | ARID4A | 0.03 | 0.02 | lasso | 2 | 0.02 | 2.1e-03 | -6.31 | 6.4 | 1.6e-10 | -0.78 | 0.01 | 0.57 | FALSE |
| 7 | GTEx | Esophagus Mucosa | AL132989.1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 5.6e-04 | -6.56 | -6.3 | 2.8e-10 | 0.88 | 0.03 | 0.95 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | HNRNPCP1 | 0.10 | 0.04 | enet | 8 | 0.02 | 4.6e-03 | -4.03 | 6.3 | 3.3e-10 | -0.77 | 0.05 | 0.92 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | C14orf37 | 0.15 | 0.00 | enet | 19 | 0.00 | 2.0e-01 | -7.71 | 5.5 | 2.9e-08 | -0.74 | 0.04 | 0.76 | FALSE |
| 15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C14orf37 | 0.04 | 0.00 | blup | 167 | 0.02 | 6.9e-03 | -7.14 | 5.5 | 4.0e-08 | -0.83 | 0.02 | 0.76 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | AL132989.1 | 0.03 | 0.00 | enet | 12 | -0.01 | 6.8e-01 | -0.45 | -5.3 | 8.8e-08 | 0.61 | 0.03 | 0.33 | FALSE |