Hub : Genes

HNRNPCP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.180 0.063 0.00240 0.072 NA 0.053 NA 0.074 0.00015 NA 0.0010 NA 0.00011
2 GTEx Breast Mammary Tissue (Male) 0.198 0.105 0.03800 -0.001 NA -0.002 NA -0.007 0.35000 NA 0.3700 NA 0.50000
3 GTEx Breast Mammary Tissue (Female) 0.132 0.093 0.11000 0.009 NA -0.009 NA 0.010 0.17000 NA 0.7700 NA 0.15000
4 GTEx Skin Sun Exposed Lower leg 0.102 0.036 0.00038 0.039 NA 0.023 NA 0.023 0.00032 NA 0.0046 NA 0.00490

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 1.1 -1.0 0.5 0.0 -0.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 -0.3 0.3 0.0 -0.7
Depressed Affect (Nagel 2018) 0.8 1.6 4.3 -2.1 -0.5 0.0 -1.4
Depression (Nagel 2018) 1.5 2.3 7.3 -2.7 -0.4 0.0 -1.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.5 0.0 1.2 0.0 0.3
Neuroticism (Nagel 2018) 0.5 1.2 4.6 -2.2 -0.5 0.0 -0.1
Schizophrenia (2018) 0.1 0.2 0.5 0.5 0.0 0.0 -0.7
Schizophrenia vs Biploar Disorder 1.0 1.3 3.9 0.6 -1.0 0.0 -2.0
Worry (Nagel 2018) 0.6 1.3 3.6 -1.9 -0.0 0.0 1.3
Alzheimer’s Disease (in mother) 1.1 1.3 3.4 1.3 1.9 0.0 0.1
Alzheimer’s Disease (in father) 1.4 1.6 5.4 -0.2 -0.9 0.0 -2.3
Alzheimer’s Disease (including proxy) 1.0 1.4 5.5 -0.0 0.3 0.0 -2.3
Crohns Disease (2017) 0.1 0.1 0.4 -0.4 -0.2 0.0 0.6
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 -0.7 -0.6 0.0 0.1
Ulcerative Colitis (UC) 0.2 0.4 1.1 -1.1 -0.3 0.0 -0.5
Major Depression (MDD) 0.2 0.2 0.7 -0.1 0.8 0.0 0.6
Reaction Time 0.4 0.7 1.3 -1.1 0.7 0.0 -1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.6 -1.3 -0.1 0.0 -0.7
Breast Cancer 0.2 0.5 1.6 -0.0 0.6 0.0 1.3
Ovarian Cancer 0.1 0.1 0.2 0.5 -0.4 0.0 -0.4
Prostate Cancer 0.9 1.2 4.9 -0.1 -0.2 0.0 2.2
Age at First Birth 0.6 0.9 1.9 -1.3 1.4 0.0 -0.1
Bipolar Disorder (2011) 1.0 0.9 3.5 -1.9 0.2 0.0 -0.5
Body Mass Index (BMI) (2010) 0.4 0.6 1.5 0.8 -0.2 0.0 -1.2
Coronary Artery Disease (CAD) 0.5 0.5 1.4 -1.2 0.4 0.0 -0.7
Crohns Disease (2012) 0.1 0.2 0.7 -0.1 -0.9 0.0 0.4
Mean Putamen Volume 1.5 1.7 5.7 -2.4 -0.8 0.0 -0.7
Fasting Glucose 0.3 0.3 1.1 -1.0 -0.2 0.0 0.5
HbA1C 0.7 0.8 2.6 0.0 0.7 0.0 1.6
HDL Cholesterol 0.2 0.4 1.2 0.1 1.1 0.0 0.5
LDL Cholesterol 0.6 1.0 3.2 0.1 -1.8 0.0 0.9
Lupus 1.1 1.7 4.6 2.1 1.3 0.0 0.8
Neuroticism (2016) 2.0 2.9 9.2 -0.9 1.3 0.0 3.0
Primary Biliary Cirrhosis 0.5 0.7 1.9 -0.6 -0.6 0.0 1.4
Rheumatoid Arthritis 2.1 2.9 6.5 2.2 0.6 0.0 2.5
Schizophrenia (2014) 0.2 0.3 0.9 -0.1 0.6 0.0 -1.0
Triglycerides 0.3 0.5 1.2 -0.1 -1.1 0.0 -0.9
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.3 0.4 1.1 0.0 -0.5
Ulcerative Colitis 0.1 0.1 0.2 -0.5 -0.3 0.0 -0.1
Blood Eosinophil Count 0.4 2.8 7.2 0.2 -2.0 0.0 -2.7
Blood Platelet Count 0.1 1.7 5.2 1.3 0.1 0.0 -2.3
Blood Red Count 1.2 11.2 39.5 -1.2 2.0 0.0 6.3
Blood White Count 0.2 1.3 2.9 0.8 -1.7 0.0 -1.2
Heel T-Score 0.3 2.5 9.7 -0.7 -0.0 0.0 -3.1
BMI 0.3 1.8 4.0 -1.4 -2.0 0.0 -1.2
Height 0.2 4.3 8.2 -1.0 2.9 0.0 2.8
Waist Hip Ratio (WHR) 1.3 5.7 19.7 1.7 0.2 0.0 -4.4
Systolic Blood Pressure 0.4 1.9 5.2 -2.3 1.3 0.0 -0.8
Smoking Status 0.3 0.7 1.5 1.2 -0.5 0.0 -1.0
Allergy or Eczema 0.4 1.1 2.6 0.4 1.6 0.0 1.3
Cardiovascular Disease 0.1 0.2 0.6 0.5 -0.8 0.0 -0.1
Hypothyroidism (self reported) 0.8 1.9 3.4 1.6 1.3 0.0 1.8
Respiratory disease 0.9 2.0 6.0 -2.5 -1.3 0.0 0.3
Type 2 Diabetes (T2D) (2018) 1.0 1.9 6.2 -1.1 -2.5 0.0 0.2
Lung FEV1/FVC ratio 0.0 0.0 0.0 -0.0 0.2 0.0 0.1
Lung FVC 0.4 1.8 6.7 2.6 0.2 0.0 -0.7
Neuroticism 0.7 1.6 5.4 -2.3 -0.4 0.0 1.0
Chronotype (morning person) 0.1 0.3 0.9 0.3 -1.0 0.0 -0.5
Hair Pigment 0.0 0.4 0.6 0.8 0.5 0.0 0.7
Tanning 0.2 2.6 9.8 0.7 0.2 0.0 -3.1
Hand grip strength (left) 0.2 0.5 1.0 -0.1 -1.0 0.0 -0.9
Number of treatments/medications taken 0.5 0.9 2.8 -1.7 -0.5 0.0 0.7
Average weekly spirits intake 0.2 0.3 1.0 0.4 -0.1 0.0 1.0
Sensitivity / hurt feelings 0.1 0.2 0.6 0.0 0.5 0.0 0.8
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.3 -1.6 0.0 0.0 -1.8
Hearing difficulty/problems: Yes 0.4 0.6 1.6 0.7 0.6 0.0 -1.3
Relative age of first facial hair 0.6 1.2 3.9 2.0 -0.6 0.0 -0.7
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 1.2 0.9 0.0 0.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.8 0.7 0.0 0.0 -1.7
Ever had hysterectomy (womb removed) 0.8 0.9 2.4 0.9 -1.6 0.0 0.6
Systolic blood pressure, automated reading 0.5 1.4 4.2 -2.0 1.1 0.0 -0.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 1.2 -1.4 0.0 0.3
Angina 0.3 0.3 1.4 1.2 -0.1 0.0 0.1
Medication for hormone replacement therapy 0.8 0.9 2.4 1.0 1.5 0.0 -0.1
Vitamin and mineral supplements 0.2 0.3 1.3 -0.1 -0.2 0.0 -1.1
Supplements: Zinc 0.8 0.8 2.6 0.8 1.6 0.0 0.1
Medication: Co-codamol 0.5 0.6 0.9 1.0 0.6 0.0 -1.0
Medication: Metformin 0.9 1.2 4.7 -0.3 -2.2 0.0 -0.2
Diabetes (father) 0.1 0.1 0.4 -0.6 0.1 0.0 0.4
Diabetes (mother) 0.5 0.6 2.2 -0.3 -1.5 0.0 0.1
Severe depression (siblings) 0.1 0.2 0.4 0.6 0.4 0.0 -0.1
Pack years adult smoking proportion 0.4 0.6 1.3 0.8 1.2 0.0 0.5
Impedance of leg (right) 0.6 3.1 7.6 2.0 2.7 0.0 0.9
Leg fat-free mass (left) 0.5 2.5 5.7 -2.0 -2.4 0.0 0.8
Trunk fat percentage 0.2 0.8 1.8 -1.1 -1.4 0.0 0.3
Hand grip strength (right) 0.1 0.4 0.9 -0.6 -0.6 0.0 -1.0
Townsend deprivation index at recruitment 1.0 1.4 3.9 0.9 -1.0 0.0 -2.0
Current tobacco smoking 0.4 0.6 2.2 1.5 -0.2 0.0 0.4
Average weekly fortified wine intake 0.4 0.5 1.6 1.3 0.4 0.0 0.5
Maternal smoking around birth 1.6 2.4 5.3 2.3 1.3 0.0 -1.6
Fed-up feelings 0.1 0.2 0.6 0.2 0.4 0.0 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.7 -1.3 -1.0 0.0 0.1
Relative age voice broke 0.1 0.1 0.2 0.4 -0.3 0.0 -0.3
Taking other prescription medications 0.1 0.2 0.3 -0.6 -0.6 0.0 0.0
Age when periods started (menarche) 1.2 2.8 7.6 0.5 -1.8 0.0 -2.8
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.5 -1.2 -0.8 0.0 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.7 0.5 0.9 0.0 0.5
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.7 1.1 1.9 0.0 -1.4
Qualifications: CSEs or equivalent 0.5 0.7 2.4 0.2 0.5 0.0 -1.6
Serious illness, injury or assault to yourself 0.4 0.5 1.3 0.2 -0.9 0.0 -1.1
High blood pressure 0.3 0.8 1.4 -1.0 -1.2 0.0 -0.8
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.2 0.0 1.5 0.0 1.2
Multivitamins +/- minerals 0.3 0.4 0.9 -0.6 -0.9 0.0 0.6
Stomach or abdominal pain in last month 1.0 1.3 4.7 -0.4 -0.4 0.0 -2.2
Supplements: Glucosamine 1.6 2.1 5.3 0.4 2.3 0.0 1.7
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 9.5 1.1 3.1 0.0 -0.1
Medication: Atenolol 0.0 0.0 0.0 0.1 -0.2 0.0 0.0
Medication: Levothyroxine sodium 0.1 0.2 0.7 0.2 -0.8 0.0 0.4
Sitting height 0.1 1.0 3.2 -0.8 -0.6 0.0 1.8
Chronic bronchitis/emphysema (father) 2.7 3.2 12.5 0.5 -0.3 0.0 3.5
High blood pressure (mother) 0.4 0.6 1.0 1.0 0.9 0.0 0.7
Body mass index (BMI) 0.4 1.8 4.2 -1.4 -2.0 0.0 -1.1
Impedance of leg (left) 0.7 3.2 9.3 1.8 3.1 0.0 0.6
Leg predicted mass (left) 0.5 2.5 5.8 -1.9 -2.4 0.0 0.7
Trunk fat mass 0.3 1.5 3.0 -1.7 -1.7 0.0 0.3
Waist circumference 0.7 2.4 4.1 -1.5 -1.8 0.0 -2.0
Number of incorrect matches in round 0.6 1.1 3.1 1.0 1.8 0.0 -0.3
Past tobacco smoking 0.1 0.2 0.4 -0.6 -0.3 0.0 0.6
Alcohol usually taken with meals 0.9 1.4 2.8 -0.4 1.7 0.0 1.6
Nervous feelings 0.6 1.1 3.6 -1.9 0.0 0.0 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 8.0 -2.8 -0.2 0.0 -0.1
Hearing difficulty/problems with background noise 0.2 0.4 0.9 -0.4 -0.9 0.0 -0.7
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 1.0 0.0 0.0 -0.4
Had menopause 0.1 0.2 0.3 -0.5 0.4 0.0 -0.5
Had other major operations 1.6 2.0 6.3 0.1 2.5 0.0 1.2
Forced vital capacity (FVC) 0.3 1.2 3.8 2.0 0.0 0.0 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.3 0.2 0.5 0.0 0.0
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.8 1.5 2.2 0.0 0.5
Qualifications: None of the above 0.1 0.2 0.6 0.8 -0.3 0.0 -0.1
Financial difficulties in last 2 years 0.4 0.6 1.7 1.3 0.4 0.0 -0.7
Mouth/teeth dental problems 0.5 0.8 2.2 -1.5 0.8 0.0 -0.7
Heart attack 0.8 1.0 2.4 1.6 1.2 0.0 -0.4
Allergy 0.3 0.7 1.2 0.6 -1.0 0.0 -1.1
Pain all over the body in last month 0.4 0.5 1.4 0.6 0.3 0.0 -1.2
Diabetes (self-reported) 1.4 2.1 5.1 -1.0 -2.3 0.0 -1.5
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.1 -0.0 0.0 0.0 0.3
Medication: Ramipril 0.1 0.1 0.3 0.4 0.6 0.0 -0.2
Medication: Simvastatin 0.2 0.3 0.8 0.7 0.1 0.0 -0.9
Fluid intelligence score 0.1 0.3 0.6 -0.7 -0.1 0.0 0.7
Illnesses of siblings 0.3 0.4 1.4 0.4 -0.0 0.0 1.2
Neuroticism score 0.8 1.6 4.9 -2.2 -0.7 0.0 1.0
Weight 0.4 1.7 4.0 -2.0 -1.7 0.0 0.1
Impedance of arm (right) 0.2 1.0 2.1 1.0 0.9 0.0 1.5
Arm fat percentage (right) 0.3 1.1 2.6 -1.3 -1.6 0.0 -0.4
Trunk fat-free mass 0.3 1.7 4.9 -2.2 -1.4 0.0 0.3
Hip circumference 0.6 2.5 5.0 -2.2 -1.5 0.0 1.6
Time employed in main current job 0.9 1.1 4.2 -0.4 0.2 0.0 2.0
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.5 0.2 0.0 0.9
Father’s age at death 1.6 2.1 6.3 -2.5 -1.5 0.0 -0.2
Worrier / anxious feelings 0.7 1.2 3.1 -1.8 0.8 0.0 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.2 0.2 0.2 0.0 1.1
Falls in the last year 1.0 1.3 3.5 0.4 1.9 0.0 1.3
Hair/balding pattern: Pattern 3 0.7 1.0 2.6 -1.6 1.2 0.0 -0.4
Number of live births 0.5 0.7 2.6 0.3 0.4 0.0 -1.6
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.6 1.6 0.3 0.0 0.9
Pulse rate 0.3 0.5 1.9 0.4 -0.0 0.0 1.4
Happiness 0.6 0.7 2.4 -0.5 1.6 0.0 0.3
Noisy workplace 0.9 1.1 2.4 1.6 -1.3 0.0 -0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.1 1.0 1.0 0.0 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.1 -0.7 1.1 0.0 -0.7
Mouth/teeth dental problems: Dentures 0.2 0.3 1.1 1.0 -0.5 0.0 -0.2
Asthma 0.4 0.8 2.1 -1.5 -0.8 0.0 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.6 0.1 0.6 0.0 1.3
Medication: Cholesterol lowering 0.4 0.6 2.3 -0.1 0.1 0.0 -1.5
Depression (self-reported) 0.4 0.4 1.2 -0.8 0.1 0.0 -1.1
Medication: Lansoprazole 0.8 0.9 1.9 1.4 0.6 0.0 -1.1
Prospective memory result 0.7 0.9 2.9 1.7 -0.4 0.0 -0.7
Lung cancer (father) 0.4 0.5 1.3 0.7 -0.5 0.0 1.2
Illnesses of mother 0.5 0.6 1.8 0.1 -1.4 0.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.9 2.0 0.2 0.0 -0.1
Pulse wave Arterial Stiffness index 0.9 1.0 1.7 -1.1 -1.1 0.0 -1.3
Impedance of arm (left) 0.2 1.0 3.2 0.7 0.5 0.0 1.8
Arm fat mass (right) 0.4 1.8 3.7 -1.9 -1.9 0.0 -0.1
Trunk predicted mass 0.3 1.7 5.0 -2.2 -1.4 0.0 0.4
Standing height 0.2 2.3 6.6 -1.6 0.3 0.0 2.6
Length of working week for main job 0.2 0.2 0.8 0.9 0.1 0.0 0.4
Exposure to tobacco smoke at home 2.1 2.4 8.6 0.7 -0.7 0.0 -2.9
Breastfed as a baby 0.5 0.6 1.4 -0.1 1.1 0.0 1.2
Tense / ‘highly strung’ 1.0 1.7 4.1 -2.0 0.9 0.0 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.2 0.2 0.0 -0.8
Hair/balding pattern: Pattern 4 0.4 1.0 3.1 -0.4 0.9 0.0 1.8
Birth weight of first child 1.0 1.9 3.6 -1.4 -1.5 0.0 -1.9
Peak expiratory flow (PEF) 0.1 0.1 0.5 0.2 -0.7 0.0 -0.0
Pulse wave reflection index 1.2 1.5 2.6 -1.6 -1.6 0.0 -0.9
Ever highly irritable/argumentative for 2 days 1.6 1.9 3.5 1.5 1.4 0.0 1.9
Loud music exposure frequency 0.6 0.6 1.0 -0.8 0.9 0.0 -1.0
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.2 0.2 0.5 0.0 2.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 1.2 0.0 0.0 -0.0
Blood clot in the leg (DVT) 1.0 1.3 4.7 -0.4 0.5 0.0 2.2
Medication: Paracetamol 0.2 0.3 0.9 -0.6 -1.0 0.0 0.3
Headache pain in last month 0.9 1.6 5.4 0.5 -1.0 0.0 2.3
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.8 -1.1 0.1 0.0 1.7
Glaucoma (self-reported) 0.4 0.4 1.5 -0.5 1.2 0.0 -0.2
Gout (self-reported) 0.3 0.5 0.9 0.9 0.5 0.0 0.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 0.8 0.2 0.0 0.7
Medication: Amlodipine 0.0 0.0 0.1 0.1 -0.2 0.0 -0.3
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 0.7 0.0 0.0 -0.0
Birth weight 0.4 0.9 1.5 -1.0 -1.1 0.0 -1.2
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 0.0 0.2 0.0 0.6
High blood pressure (siblings) 0.2 0.3 0.5 -0.7 0.4 0.0 -0.7
Forced vital capacity (FVC), Best measure 0.3 1.2 4.7 2.2 0.1 0.0 -0.0
Body fat percentage 0.2 0.8 1.6 -1.2 -1.3 0.0 -0.2
Leg fat percentage (right) 0.0 0.2 0.3 -0.6 -0.3 0.0 -0.5
Arm fat-free mass (right) 0.5 2.4 5.5 -2.3 -2.0 0.0 0.1
Exposure to tobacco smoke outside home 0.7 1.0 2.2 1.5 -1.1 0.0 -0.7
Comparative body size at age 10 0.3 0.9 3.2 0.5 -1.8 0.0 -0.5
Number of full brothers 0.4 0.5 1.4 0.5 0.6 0.0 -1.2
Worry too long after embarrassment 1.7 2.9 9.1 -3.0 -1.6 0.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.7 -0.2 -0.3 0.0 -1.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 -0.1 0.2 0.0 0.9
Number of children fathered 1.4 1.6 3.5 -0.4 -1.9 0.0 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 0.3 0.8 0.0 -0.7
Age at first live birth 1.1 2.0 4.5 -1.8 -0.7 0.0 2.1
Pulse wave peak to peak time 1.2 1.4 2.4 1.2 1.4 0.0 1.5
Health satisfaction 0.4 0.5 1.2 -0.2 -1.1 0.0 1.0
Shortness of breath walking on level ground 0.0 0.0 0.1 0.1 0.2 0.0 -0.3
Qualifications: College or University degree 0.1 0.4 0.9 -0.7 0.2 0.0 1.0
Eye problems/disorders: None of the above 0.8 0.9 1.7 1.3 -0.8 0.0 -1.1
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.3 -0.3 -1.1 0.0 0.1
Emphysema/chronic bronchitis 0.9 1.0 3.3 -1.8 -0.4 0.0 -0.7
Medication for pain relief, constipation, heartburn 0.5 0.8 1.4 1.0 0.8 0.0 1.2
Neck or shoulder pain in last month 0.3 0.4 1.1 0.0 1.0 0.0 0.8
Medication: Blood pressure 1.3 2.3 7.5 0.6 -1.1 0.0 -2.7
Angina (self-reported) 0.2 0.3 1.0 1.0 -0.4 0.0 -0.3
Migraine (self-reported) 0.6 0.8 2.9 0.3 0.3 0.0 1.7
Medication: Ibuprofen 0.1 0.2 0.7 -0.1 0.1 0.0 0.8
Medication: Allopurinol 0.2 0.3 1.0 1.0 0.3 0.0 0.1
Medication: Omeprazole 1.9 2.3 6.0 -2.5 -1.1 0.0 -1.4
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.0 -0.1 0.0 -0.6
Mean time to correctly identify matches 0.4 0.7 1.2 -0.9 0.9 0.0 -1.1
Heart disease (mother) 0.4 0.5 2.0 -0.1 1.4 0.0 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.2 -1.5 -0.0 0.0 -0.7
Whole body fat mass 0.3 1.3 3.0 -1.7 -1.5 0.0 0.2
Leg fat mass (right) 0.2 0.8 1.6 -1.3 -1.2 0.0 -0.1
Arm predicted mass (right) 0.4 2.1 5.1 -2.3 -1.8 0.0 0.3
Pulse rate, automated reading 0.3 1.1 2.0 1.4 0.7 0.0 1.4
Alcohol intake frequency. 0.9 2.2 7.1 0.5 -2.7 0.0 1.2
Comparative height size at age 10 0.2 1.1 3.8 -1.9 0.2 0.0 0.7
Number of full sisters 1.3 1.6 4.2 0.9 -2.0 0.0 -1.2
Suffer from ‘nerves’ 0.4 0.7 2.4 -0.5 0.3 0.0 1.6
Overall health rating 0.2 0.5 1.7 -0.4 -0.3 0.0 1.3
Chest pain or discomfort 1.0 1.4 4.3 -1.1 0.4 0.0 2.1
Had major operations 0.0 0.0 0.1 0.3 0.1 0.0 0.3
Age at last live birth 0.2 0.4 1.2 -0.1 -0.5 0.0 1.1
Family relationship satisfaction 0.6 0.7 2.4 -1.6 0.6 0.0 -0.0
Leg pain on walking 0.5 0.6 2.0 0.7 -0.0 0.0 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 -0.2 0.4 0.0 -1.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.3 -0.3 -0.5 0.0 1.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 0.2 -0.1 0.0 0.6
Medication: Aspirin 0.2 0.3 1.3 -0.1 -0.1 0.0 -1.1
Supplements: Vitamin C 0.2 0.2 0.4 -0.4 0.6 0.0 0.5
Knee pain experienced in last month 0.3 0.4 1.1 -0.4 0.6 0.0 1.1
Hypertension (Self-reported) 0.2 0.7 1.2 -0.8 -0.9 0.0 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.4 -0.1 0.0 0.0
Illnesses of father: Heart disease 0.2 0.3 0.8 -0.9 -0.0 0.0 0.6
Illnesses of siblings: Diabetes 0.7 0.8 1.9 -1.1 -0.5 0.0 -1.4
Smoking status: Previous 0.6 0.8 3.3 0.3 0.1 0.0 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 -0.1 0.2 0.0 0.9
Whole body fat-free mass 0.4 2.0 4.8 -2.2 -1.8 0.0 0.3
Leg fat-free mass (right) 0.5 2.4 5.3 -2.0 -2.3 0.0 0.5
Arm fat percentage (left) 0.3 1.4 3.6 -1.4 -1.9 0.0 -0.2
Average weekly red wine intake 0.6 0.9 2.6 -1.0 0.1 0.0 -1.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.3 -0.3 -0.2 0.0 -1.2
Mood swings 1.2 2.2 4.1 -2.0 -1.3 0.0 -1.7
Loneliness, isolation 2.3 3.1 6.6 -2.6 -1.7 0.0 -1.7
Long-standing illness, disability or infirmity 0.5 0.7 1.6 -0.2 -1.3 0.0 -1.1
Ever had bowel cancer screening 0.6 0.7 1.8 -1.0 0.1 0.0 -1.4
Diabetes diagnosed by doctor 1.1 1.7 3.9 -0.9 -2.0 0.0 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 3.0 -0.9 1.0 0.0 -1.7
Friendships satisfaction 0.1 0.1 0.3 0.1 0.2 0.0 -0.6
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.7 0.2 0.0 0.7
Commuting to job workplace: Walk 0.2 0.3 0.5 0.7 0.6 0.0 0.4
Eye problems/disorders: Cataract 0.4 0.5 1.3 -1.1 0.5 0.0 0.7
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.0 -0.3 0.0 -0.0
Medication for cholesterol 0.2 0.4 1.4 -0.2 -1.2 0.0 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.7 -1.3 -1.3 0.0 -0.9
Back pain experienced in last month 0.0 0.1 0.1 -0.3 -0.3 0.0 -0.1
Mineral and other dietary supplements 1.2 1.7 3.8 0.1 -1.9 0.0 -1.7
Breast cancer (self-reported) 0.4 0.5 0.9 -0.6 -0.8 0.0 0.9
Asthma (self-reported) 0.6 1.1 2.9 -1.7 -1.1 0.0 0.5
Osteoporosis (self-reported) 0.3 0.4 0.8 -0.9 -0.2 0.0 -0.8
Osteoarthritis (self-reported) 0.3 0.4 1.2 -0.4 1.1 0.0 0.4
Medication: Aspirin 0.2 0.3 1.0 -0.4 0.2 0.0 -1.0
Medication: Gliclazide 0.1 0.1 0.2 0.0 -0.2 0.0 0.5
Illnesses of father: None of the above (group 1) 1.0 1.2 4.5 0.5 0.3 0.0 -2.1
Smoking status: Current 0.4 0.6 2.2 1.5 -0.3 0.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.0 1.7 0.8 0.0 -0.5
Whole body water mass 0.4 2.1 5.1 -2.3 -1.8 0.0 0.2
Leg predicted mass (right) 0.4 2.4 5.5 -1.9 -2.3 0.0 0.5
Arm fat mass (left) 0.5 1.9 4.2 -1.9 -2.1 0.0 -0.1
Number of self-reported non-cancer illnesses 0.2 0.4 1.2 -1.1 -0.4 0.0 0.2
Average weekly champagne plus white wine intake 1.3 1.8 2.9 1.7 1.3 0.0 1.7
Miserableness 0.2 0.4 1.2 -0.2 0.5 0.0 -1.1
Guilty feelings 0.6 0.9 3.0 1.7 -0.6 0.0 -0.6
Wears glasses or contact lenses 0.1 0.1 0.4 -0.6 -0.2 0.0 -0.3
Ever taken oral contraceptive pill 3.2 3.6 7.2 2.6 2.7 0.0 -0.4
Hearing aid user 1.4 1.6 3.9 0.3 -1.5 0.0 -2.0
Mother’s age at death 1.4 1.7 6.9 -2.6 0.1 0.0 0.1
Financial situation satisfaction 0.1 0.1 0.5 0.1 0.7 0.0 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.1 0.4 0.2 0.0 -1.4
Commuting to job workplace: Public transport 0.6 0.7 1.3 0.5 1.1 0.0 -1.1
Eye problems/disorders: Glaucoma 0.6 0.7 2.7 -1.6 0.4 0.0 0.1
Medication: Blood pressure 0.5 0.9 2.8 -1.7 0.2 0.0 0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.8 -0.9 -0.8 0.0 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.1 2.2 -0.6 1.5 0.0 1.4
High cholesterol (Self-reported) 1.1 1.9 6.2 2.5 0.7 0.0 -0.9
Medication: Bendroflumethiazide 0.1 0.2 0.3 -0.6 0.5 0.0 -0.2
Medication: Paracetamol 0.1 0.2 0.5 -0.5 -0.7 0.0 -0.2
Medication: Lisinopril 0.8 1.0 2.5 -1.2 -0.4 0.0 -1.6
Medication: Atorvastatin 1.1 1.3 2.0 1.3 1.4 0.0 -1.3
Illnesses of father: High blood pressure 1.1 1.3 2.3 1.5 0.9 0.0 1.5
Alcohol drinker status: Never 0.7 0.8 2.2 0.9 -1.5 0.0 -0.5
Ever smoked 0.0 0.1 0.1 0.4 0.3 0.0 0.3
Basal metabolic rate 0.4 2.2 4.7 -2.2 -2.0 0.0 0.3
Leg fat percentage (left) 0.1 0.3 0.6 -0.6 -0.2 0.0 -0.8
Arm fat-free mass (left) 0.4 1.9 4.7 -2.2 -1.6 0.0 -0.4
Number of operations (self-reported) 0.5 0.8 1.5 0.7 1.2 0.0 1.1
Average weekly beer plus cider intake 1.0 1.4 4.3 -0.2 1.1 0.0 -2.1
Irritability 0.5 0.9 2.5 -1.6 -1.0 0.0 0.3
Risk taking 1.4 2.0 5.7 1.3 0.8 0.0 -2.4
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.8 -0.8 -0.3 0.0 -2.2
Fractured/broken bones in last 5 years 0.3 0.3 1.3 0.1 -0.2 0.0 1.1
Age started oral contraceptive pill 0.5 0.6 1.3 -1.0 -0.3 0.0 1.1
Diastolic blood pressure, automated reading 0.3 1.0 2.0 -1.1 0.9 0.0 1.4
Ever depressed for a whole week 1.3 1.6 3.6 1.4 1.9 0.0 -1.0
Unable to work because of sickness or disability 0.1 0.1 0.3 0.2 0.0 0.0 0.5
Commuting to job workplace: Cycle 0.2 0.2 0.4 0.2 0.6 0.0 0.6
Myopia 0.9 1.3 2.8 -1.5 0.3 0.0 -1.7
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.4 0.2 0.6 0.0 0.5
Cholesterol lowering medication 0.6 0.9 2.6 1.0 0.5 0.0 -1.6
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 5.8 -2.4 -1.2 0.0 -1.6
Pain experienced in last month 0.0 0.1 0.2 -0.2 -0.2 0.0 0.4
Supplements: Calcium 0.3 0.3 0.8 0.6 -0.9 0.0 0.2
Basal cell carcinoma (self-reported) 0.9 1.1 2.5 -1.6 1.1 0.0 0.8
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.5 1.6 1.4 0.0 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 5.4 -0.7 0.5 0.0 2.3
Heart disease (siblings) 1.0 1.3 3.2 1.8 -0.3 0.0 -1.4
Alcohol drinker status: Previous 0.8 1.0 3.3 0.7 -1.8 0.0 0.2
Pack years of smoking 0.2 0.4 1.3 0.3 1.1 0.0 0.2
Impedance of whole body 0.3 1.8 3.0 1.3 1.7 0.0 1.6
Leg fat mass (left) 0.2 0.8 1.9 -1.4 -1.2 0.0 -0.2
Arm predicted mass (left) 0.4 2.0 5.5 -2.3 -1.6 0.0 -0.1