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chr14:63,623,678-66,266,677

Best TWAS P=2.79e-27 · Best GWAS P=2.82e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAX	0.15	0.16	lasso	2	0.16	1.2e-18	-11.2	10.8	2.8e-27	-0.55	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ESR2	0.11	0.03	blup	88	0.06	6.9e-07	-11.1	10.6	3.7e-26	0.02	0.00	0.99	TRUE
15	GTEx	Pituitary	RAB15	0.32	0.03	enet	16	0.10	1.9e-03	-10.8	-9.6	5.4e-22	0.63	0.15	0.48	TRUE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB15	0.04	0.01	enet	5	0.03	1.9e-04	-12.3	-9.6	6.3e-22	0.82	0.00	0.97	TRUE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ESR2	0.04	0.01	blup	88	0.03	1.1e-04	6.9	7.1	8.8e-13	0.04	0.04	0.94	TRUE
18	GTEx	Thyroid	RAB15	0.26	0.04	enet	52	0.08	1.5e-06	-5.7	-7.0	2.1e-12	0.41	0.90	0.08	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	MTHFD1	0.20	0.03	lasso	6	0.09	5.6e-04	-2.6	-6.9	4.2e-12	0.00	0.02	0.84	TRUE
23	NTR	Blood	SYNE2	0.08	0.08	lasso	5	0.08	9.9e-25	6.2	-6.9	4.3e-12	-0.04	1.00	0.00	TRUE
7	GTEx	Colon Transverse	MTHFD1	0.20	0.01	enet	49	0.02	6.2e-02	-3.3	6.2	4.9e-10	-0.20	0.20	0.14	TRUE
9	GTEx	Esophagus Muscularis	RAB15	0.35	0.06	enet	23	0.17	1.2e-10	-5.7	-5.1	2.8e-07	0.56	0.84	0.16	TRUE
24	YFS	Blood	MAX	0.04	0.02	lasso	4	0.02	2.8e-06	-10.2	10.3	7.6e-25	-0.66	0.68	0.26	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ESR2	0.02	0.00	blup	88	0.01	2.1e-02	-11.1	9.2	2.7e-20	-0.01	0.01	0.88	FALSE
11	GTEx	Muscle Skeletal	FNTB	0.05	0.02	lasso	6	0.01	5.8e-02	-9.9	9.2	3.0e-20	-0.53	0.25	0.46	FALSE
12	GTEx	Nerve Tibial	RAB15	0.35	0.15	enet	68	0.18	4.7e-13	-8.2	-8.0	9.2e-16	0.43	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNTB	0.06	0.02	blup	106	0.04	3.7e-05	-1.7	7.9	3.0e-15	-0.51	0.16	0.37	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB15	0.14	0.07	enet	15	0.09	5.5e-10	-8.2	-7.9	4.1e-15	0.56	0.66	0.34	FALSE
21	METSIM	Adipose	RAB15	0.10	0.04	enet	22	0.08	3.8e-12	-9.2	-7.8	4.4e-15	0.56	1.00	0.00	FALSE
14	GTEx	Ovary	CTD-2555O16.2	0.23	0.10	enet	26	0.18	2.7e-05	-2.1	7.4	1.1e-13	0.02	0.07	0.83	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SPTB	0.06	0.05	bslmm	528	0.05	9.5e-07	-1.3	7.2	6.0e-13	-0.30	0.84	0.07	FALSE
6	GTEx	Cells Transformed fibroblasts	RAB15	0.64	0.08	enet	41	0.33	1.3e-25	-5.7	-7.0	1.9e-12	0.46	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	FNTB	0.09	0.05	lasso	3	0.04	2.6e-02	-8.6	6.9	5.3e-12	-0.61	0.06	0.22	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB15	0.03	0.00	blup	49	0.01	1.8e-02	-8.1	-6.8	1.3e-11	0.59	0.05	0.64	FALSE
22	NTR	Blood	ESR2	0.03	0.01	bslmm	507	0.01	5.5e-04	5.1	6.7	1.6e-11	0.06	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB15	0.04	0.00	blup	49	0.01	6.9e-02	-8.2	-6.7	1.7e-11	0.51	0.11	0.11	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB15	0.04	0.05	blup	49	0.06	2.5e-07	-3.6	-6.6	4.9e-11	0.62	0.44	0.53	FALSE
19	GTEx	Whole Blood	RAB15	0.34	0.03	lasso	6	0.05	2.8e-05	-2.2	-6.6	5.7e-11	0.34	0.68	0.06	FALSE
20	METSIM	Adipose	ESR2	0.03	0.02	enet	8	0.03	2.5e-05	6.2	-6.4	1.2e-10	-0.09	0.64	0.30	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB15	0.02	0.01	blup	49	0.02	6.7e-05	-3.6	-6.4	1.2e-10	0.57	0.36	0.36	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	ESR2	0.05	0.05	lasso	3	0.05	9.6e-06	6.2	6.4	1.9e-10	0.04	0.28	0.64	FALSE
16	GTEx	Testis	RAB15	0.23	0.16	lasso	5	0.13	2.8e-06	-5.7	-6.2	4.5e-10	0.59	0.18	0.74	FALSE
17	GTEx	Testis	PPP1R36	0.29	0.25	enet	17	0.28	1.1e-12	3.6	-6.2	5.7e-10	0.36	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	FNTB	0.05	0.04	blup	107	0.03	6.5e-03	-2.0	6.1	1.4e-09	-0.51	0.22	0.15	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	FNTB	0.14	0.06	enet	18	0.14	1.4e-13	-1.7	5.9	2.7e-09	-0.47	0.99	0.01	FALSE
10	GTEx	Heart Left Ventricle	SYNE2	0.20	0.14	lasso	5	0.09	1.6e-05	5.4	-5.6	1.7e-08	-0.03	0.27	0.70	FALSE
3	GTEx	Adipose Subcutaneous	RAB15	0.48	0.07	enet	82	0.18	5.7e-15	-2.2	-5.6	1.8e-08	0.35	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	MTHFD1	0.09	0.00	enet	25	0.02	3.2e-02	5.9	5.6	2.2e-08	-0.06	0.10	0.07	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	FNTB	0.02	0.03	enet	8	0.03	2.0e-07	-3.5	5.5	3.3e-08	-0.43	0.98	0.01	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FNTB	0.10	0.03	blup	107	0.07	7.9e-07	-2.1	5.4	6.4e-08	-0.36	0.84	0.02	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	MTHFD1	0.27	0.10	lasso	3	0.14	1.3e-04	-5.1	5.3	1.3e-07	-0.02	0.18	0.31	FALSE
13	GTEx	Nerve Tibial	CTD-2555O16.4	0.09	0.06	lasso	6	0.04	7.7e-04	6.9	5.3	1.3e-07	0.02	0.07	0.80	FALSE