Best TWAS P=2.79e-27 · Best GWAS P=2.82e-37 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MAX | 0.15 | 0.16 | lasso | 2 | 0.16 | 1.2e-18 | -11.2 | 10.8 | 2.8e-27 | -0.55 | 1.00 | 0.00 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | SPTB | 0.06 | 0.05 | bslmm | 528 | 0.05 | 9.5e-07 | -1.3 | 7.2 | 6.0e-13 | -0.30 | 0.84 | 0.07 | FALSE |
3 | GTEx | Adipose Subcutaneous | RAB15 | 0.48 | 0.07 | enet | 82 | 0.18 | 5.7e-15 | -2.2 | -5.6 | 1.8e-08 | 0.35 | 1.00 | 0.00 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | MTHFD1 | 0.27 | 0.10 | lasso | 3 | 0.14 | 1.3e-04 | -5.1 | 5.3 | 1.3e-07 | -0.02 | 0.18 | 0.31 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | MTHFD1 | 0.20 | 0.03 | lasso | 6 | 0.09 | 5.6e-04 | -2.6 | -6.9 | 4.2e-12 | 0.00 | 0.02 | 0.84 | TRUE |
6 | GTEx | Cells Transformed fibroblasts | RAB15 | 0.64 | 0.08 | enet | 41 | 0.33 | 1.3e-25 | -5.7 | -7.0 | 1.9e-12 | 0.46 | 1.00 | 0.00 | FALSE |
7 | GTEx | Colon Transverse | MTHFD1 | 0.20 | 0.01 | enet | 49 | 0.02 | 6.2e-02 | -3.3 | 6.2 | 4.9e-10 | -0.20 | 0.20 | 0.14 | TRUE |
8 | GTEx | Esophagus Mucosa | MTHFD1 | 0.09 | 0.00 | enet | 25 | 0.02 | 3.2e-02 | 5.9 | 5.6 | 2.2e-08 | -0.06 | 0.10 | 0.07 | FALSE |
9 | GTEx | Esophagus Muscularis | RAB15 | 0.35 | 0.06 | enet | 23 | 0.17 | 1.2e-10 | -5.7 | -5.1 | 2.8e-07 | 0.56 | 0.84 | 0.16 | TRUE |
10 | GTEx | Heart Left Ventricle | SYNE2 | 0.20 | 0.14 | lasso | 5 | 0.09 | 1.6e-05 | 5.4 | -5.6 | 1.7e-08 | -0.03 | 0.27 | 0.70 | FALSE |
11 | GTEx | Muscle Skeletal | FNTB | 0.05 | 0.02 | lasso | 6 | 0.01 | 5.8e-02 | -9.9 | 9.2 | 3.0e-20 | -0.53 | 0.25 | 0.46 | FALSE |
12 | GTEx | Nerve Tibial | RAB15 | 0.35 | 0.15 | enet | 68 | 0.18 | 4.7e-13 | -8.2 | -8.0 | 9.2e-16 | 0.43 | 1.00 | 0.00 | FALSE |
13 | GTEx | Nerve Tibial | CTD-2555O16.4 | 0.09 | 0.06 | lasso | 6 | 0.04 | 7.7e-04 | 6.9 | 5.3 | 1.3e-07 | 0.02 | 0.07 | 0.80 | FALSE |
14 | GTEx | Ovary | CTD-2555O16.2 | 0.23 | 0.10 | enet | 26 | 0.18 | 2.7e-05 | -2.1 | 7.4 | 1.1e-13 | 0.02 | 0.07 | 0.83 | FALSE |
15 | GTEx | Pituitary | RAB15 | 0.32 | 0.03 | enet | 16 | 0.10 | 1.9e-03 | -10.8 | -9.6 | 5.4e-22 | 0.63 | 0.15 | 0.48 | TRUE |
16 | GTEx | Testis | RAB15 | 0.23 | 0.16 | lasso | 5 | 0.13 | 2.8e-06 | -5.7 | -6.2 | 4.5e-10 | 0.59 | 0.18 | 0.74 | FALSE |
17 | GTEx | Testis | PPP1R36 | 0.29 | 0.25 | enet | 17 | 0.28 | 1.1e-12 | 3.6 | -6.2 | 5.7e-10 | 0.36 | 1.00 | 0.00 | FALSE |
18 | GTEx | Thyroid | RAB15 | 0.26 | 0.04 | enet | 52 | 0.08 | 1.5e-06 | -5.7 | -7.0 | 2.1e-12 | 0.41 | 0.90 | 0.08 | TRUE |
19 | GTEx | Whole Blood | RAB15 | 0.34 | 0.03 | lasso | 6 | 0.05 | 2.8e-05 | -2.2 | -6.6 | 5.7e-11 | 0.34 | 0.68 | 0.06 | FALSE |
20 | METSIM | Adipose | ESR2 | 0.03 | 0.02 | enet | 8 | 0.03 | 2.5e-05 | 6.2 | -6.4 | 1.2e-10 | -0.09 | 0.64 | 0.30 | FALSE |
21 | METSIM | Adipose | RAB15 | 0.10 | 0.04 | enet | 22 | 0.08 | 3.8e-12 | -9.2 | -7.8 | 4.4e-15 | 0.56 | 1.00 | 0.00 | FALSE |
22 | NTR | Blood | ESR2 | 0.03 | 0.01 | bslmm | 507 | 0.01 | 5.5e-04 | 5.1 | 6.7 | 1.6e-11 | 0.06 | 0.00 | 1.00 | FALSE |
23 | NTR | Blood | SYNE2 | 0.08 | 0.08 | lasso | 5 | 0.08 | 9.9e-25 | 6.2 | -6.9 | 4.3e-12 | -0.04 | 1.00 | 0.00 | TRUE |
24 | YFS | Blood | MAX | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.8e-06 | -10.2 | 10.3 | 7.6e-25 | -0.66 | 0.68 | 0.26 | FALSE |
25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FNTB | 0.10 | 0.03 | blup | 107 | 0.07 | 7.9e-07 | -2.1 | 5.4 | 6.4e-08 | -0.36 | 0.84 | 0.02 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FNTB | 0.02 | 0.03 | enet | 8 | 0.03 | 2.0e-07 | -3.5 | 5.5 | 3.3e-08 | -0.43 | 0.98 | 0.01 | FALSE |
27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB15 | 0.02 | 0.01 | blup | 49 | 0.02 | 6.7e-05 | -3.6 | -6.4 | 1.2e-10 | 0.57 | 0.36 | 0.36 | FALSE |
28 | The Cancer Genome Atlas | Esophageal Carcinoma | FNTB | 0.09 | 0.05 | lasso | 3 | 0.04 | 2.6e-02 | -8.6 | 6.9 | 5.3e-12 | -0.61 | 0.06 | 0.22 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ESR2 | 0.04 | 0.01 | blup | 88 | 0.03 | 1.1e-04 | 6.9 | 7.1 | 8.8e-13 | 0.04 | 0.04 | 0.94 | TRUE |
30 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FNTB | 0.06 | 0.02 | blup | 106 | 0.04 | 3.7e-05 | -1.7 | 7.9 | 3.0e-15 | -0.51 | 0.16 | 0.37 | FALSE |
31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAB15 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.8e-02 | -8.1 | -6.8 | 1.3e-11 | 0.59 | 0.05 | 0.64 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ESR2 | 0.11 | 0.03 | blup | 88 | 0.06 | 6.9e-07 | -11.1 | 10.6 | 3.7e-26 | 0.02 | 0.00 | 0.99 | TRUE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB15 | 0.14 | 0.07 | enet | 15 | 0.09 | 5.5e-10 | -8.2 | -7.9 | 4.1e-15 | 0.56 | 0.66 | 0.34 | FALSE |
34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAB15 | 0.04 | 0.05 | blup | 49 | 0.06 | 2.5e-07 | -3.6 | -6.6 | 4.9e-11 | 0.62 | 0.44 | 0.53 | FALSE |
35 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB15 | 0.04 | 0.01 | enet | 5 | 0.03 | 1.9e-04 | -12.3 | -9.6 | 6.3e-22 | 0.82 | 0.00 | 0.97 | TRUE |
36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ESR2 | 0.02 | 0.00 | blup | 88 | 0.01 | 2.1e-02 | -11.1 | 9.2 | 2.7e-20 | -0.01 | 0.01 | 0.88 | FALSE |
37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB15 | 0.04 | 0.00 | blup | 49 | 0.01 | 6.9e-02 | -8.2 | -6.7 | 1.7e-11 | 0.51 | 0.11 | 0.11 | FALSE |
38 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FNTB | 0.05 | 0.04 | blup | 107 | 0.03 | 6.5e-03 | -2.0 | 6.1 | 1.4e-09 | -0.51 | 0.22 | 0.15 | FALSE |
39 | The Cancer Genome Atlas | Thyroid Carcinoma | ESR2 | 0.05 | 0.05 | lasso | 3 | 0.05 | 9.6e-06 | 6.2 | 6.4 | 1.9e-10 | 0.04 | 0.28 | 0.64 | FALSE |
40 | The Cancer Genome Atlas | Thyroid Carcinoma | FNTB | 0.14 | 0.06 | enet | 18 | 0.14 | 1.4e-13 | -1.7 | 5.9 | 2.7e-09 | -0.47 | 0.99 | 0.01 | FALSE |