Best TWAS P=4.68e-10 · Best GWAS P=2.64e-13 conditioned to 4.79e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AP3B2 | 0.16 | 0.10 | bslmm | 236 | 0.09 | 2.1e-11 | 5.1 | 5.5 | 4.5e-08 | 0.06 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | RP11-152F13.3 | 0.13 | 0.08 | enet | 8 | 0.11 | 2.9e-06 | 5.2 | -5.4 | 7.7e-08 | 0.00 | 0.26 | 0.64 | FALSE |
| 3 | GTEx | Esophagus Mucosa | EFTUD1 | 0.09 | 0.06 | enet | 10 | 0.08 | 9.0e-06 | 5.2 | 5.7 | 1.1e-08 | -0.04 | 0.21 | 0.74 | FALSE |
| 4 | GTEx | Muscle Skeletal | RP11-152F13.3 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | 2.6 | -5.3 | 1.4e-07 | -0.03 | 0.13 | 0.11 | FALSE |
| 5 | GTEx | Testis | EFTUD1 | 0.35 | 0.13 | enet | 17 | 0.21 | 1.2e-09 | 4.6 | 5.4 | 5.4e-08 | -0.10 | 0.80 | 0.19 | FALSE |
| 6 | GTEx | Thyroid | GOLGA6L9 | 0.12 | 0.02 | lasso | 4 | 0.01 | 6.5e-02 | 5.0 | 5.2 | 2.1e-07 | -0.01 | 0.00 | 0.89 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RP11-152F13.3 | 0.48 | 0.26 | bslmm | 179 | 0.42 | 1.1e-57 | 1.7 | -5.5 | 3.3e-08 | 0.08 | 0.97 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOLGA6L10 | 0.03 | 0.02 | blup | 21 | 0.02 | 3.5e-05 | 4.0 | -5.5 | 3.6e-08 | -0.02 | 0.01 | 0.88 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EFTUD1 | 0.06 | 0.02 | blup | 96 | 0.06 | 7.3e-07 | -4.4 | 6.2 | 4.7e-10 | -0.08 | 0.26 | 0.68 | TRUE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AP3B2 | 0.46 | 0.24 | enet | 16 | 0.30 | 2.2e-17 | 4.7 | 5.2 | 2.1e-07 | 0.01 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | EFTUD1 | 0.05 | 0.02 | blup | 95 | 0.02 | 2.1e-02 | 4.5 | 6.0 | 2.6e-09 | -0.07 | 0.06 | 0.14 | FALSE |