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chr17:4,108,648-5,575,563

Best TWAS P=8.08e-10 · Best GWAS P=4.5e-09 conditioned to 0.842

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CHRNE	0.47	0.50	enet	29	0.54	1.5e-51	5.5	6.0	1.9e-09	0.88	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	CHRNE	0.29	0.27	lasso	3	0.22	7.0e-12	5.5	5.6	2.6e-08	0.81	0.02	0.98	FALSE
3	GTEx	Adrenal Gland	CHRNE	0.25	0.33	lasso	4	0.30	3.3e-11	5.5	5.8	7.1e-09	0.81	0.01	0.99	FALSE
4	GTEx	Artery Aorta	CHRNE	0.32	0.28	enet	13	0.31	1.7e-17	5.8	5.8	5.2e-09	0.84	0.01	0.99	FALSE
5	GTEx	Artery Coronary	CHRNE	0.50	0.38	lasso	6	0.37	3.0e-13	5.5	5.8	7.7e-09	0.81	0.02	0.98	FALSE
6	GTEx	Artery Tibial	CHRNE	0.40	0.38	lasso	4	0.45	2.8e-38	5.5	5.7	1.5e-08	0.83	0.03	0.97	FALSE
7	GTEx	Brain Putamen basal ganglia	CHRNE	0.30	0.03	lasso	8	0.07	1.2e-02	5.3	5.1	2.8e-07	0.72	0.07	0.74	FALSE
8	GTEx	Breast Mammary Tissue	CHRNE	0.36	0.31	lasso	4	0.29	1.6e-15	5.5	5.8	7.2e-09	0.79	0.02	0.98	FALSE
9	GTEx	Breast Mammary Tissue (Female)	CHRNE	0.41	0.30	lasso	9	0.30	1.7e-09	5.4	5.6	1.7e-08	0.79	0.04	0.96	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	CHRNE	0.15	0.19	lasso	4	0.21	1.7e-07	5.5	5.7	1.4e-08	0.83	0.02	0.96	FALSE
11	GTEx	Cells Transformed fibroblasts	CHRNE	0.43	0.42	enet	23	0.49	2.9e-41	5.6	6.0	1.9e-09	0.89	0.02	0.98	FALSE
12	GTEx	Colon Sigmoid	CHRNE	0.32	0.26	lasso	4	0.26	1.0e-09	5.5	5.7	1.0e-08	0.81	0.02	0.98	FALSE
13	GTEx	Esophagus Mucosa	CHRNE	0.11	0.07	enet	19	0.07	2.5e-05	5.5	6.0	2.5e-09	0.75	0.02	0.98	FALSE
14	GTEx	Esophagus Muscularis	CHRNE	0.39	0.43	enet	11	0.46	2.4e-30	5.5	5.9	4.2e-09	0.86	0.02	0.98	FALSE
15	GTEx	Lung	CHRNE	0.33	0.28	enet	45	0.24	1.7e-18	5.8	5.5	3.6e-08	0.79	0.01	0.99	FALSE
16	GTEx	Lung	RP5-1050D4.2	0.10	0.02	lasso	4	0.01	3.6e-02	5.6	5.6	2.7e-08	0.81	0.03	0.95	FALSE
17	GTEx	Nerve Tibial	CHRNE	0.42	0.41	lasso	9	0.42	1.2e-31	5.8	6.0	2.5e-09	0.88	0.01	0.99	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	CHRNE	0.19	0.25	lasso	2	0.23	1.1e-12	5.8	5.8	6.3e-09	0.82	0.01	0.99	FALSE
19	GTEx	Skin Sun Exposed Lower leg	CHRNE	0.20	0.27	lasso	4	0.25	7.9e-21	5.8	5.9	2.8e-09	0.86	0.01	0.99	FALSE
20	GTEx	Spleen	CHRNE	0.26	0.26	lasso	2	0.22	2.9e-06	5.5	5.5	4.8e-08	0.78	0.03	0.88	FALSE
21	GTEx	Stomach	CHRNE	0.20	0.16	enet	12	0.14	2.0e-07	5.8	5.5	5.1e-08	0.86	0.01	0.99	FALSE
22	GTEx	Thyroid	CHRNE	0.36	0.39	lasso	10	0.40	8.4e-33	5.5	5.8	9.1e-09	0.82	0.02	0.98	FALSE
23	GTEx	Whole Blood	CHRNE	0.09	0.05	lasso	4	0.06	6.1e-06	5.9	6.0	2.1e-09	0.95	0.01	0.99	FALSE
24	METSIM	Adipose	CHRNE	0.08	0.09	lasso	5	0.10	7.1e-15	5.8	6.0	2.5e-09	0.92	0.01	0.99	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	CHRNE	0.33	0.28	enet	26	0.32	2.9e-42	5.6	5.3	1.0e-07	0.82	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNE	0.15	0.28	enet	9	0.29	1.3e-60	5.5	5.8	6.8e-09	0.83	0.02	0.97	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNE	0.14	0.19	lasso	5	0.18	1.9e-09	5.5	5.6	1.8e-08	0.82	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	CHRNE	0.25	0.29	lasso	6	0.30	5.4e-18	5.8	5.7	1.1e-08	0.78	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	CHRNE	0.22	0.03	lasso	7	0.07	2.9e-03	5.8	6.1	8.1e-10	0.94	0.01	0.93	TRUE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	CHRNE	0.12	0.08	lasso	5	0.06	5.9e-03	5.8	6.0	1.9e-09	0.87	0.01	0.93	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNE	0.19	0.15	blup	41	0.19	6.2e-21	5.8	5.9	4.4e-09	0.78	0.01	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNE	0.17	0.20	enet	15	0.20	3.3e-22	5.5	5.6	2.6e-08	0.84	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHRNE	0.10	0.06	blup	41	0.07	1.1e-04	5.4	5.8	5.1e-09	0.83	0.01	0.95	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNE	0.10	0.10	blup	41	0.12	3.7e-13	5.8	6.0	1.6e-09	0.87	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	C17orf107	0.06	0.03	blup	40	0.04	3.0e-05	5.9	5.4	6.5e-08	0.85	0.01	0.98	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNE	0.14	0.22	lasso	7	0.23	2.0e-26	5.6	6.0	2.6e-09	0.91	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHRNE	0.15	0.18	lasso	4	0.18	2.1e-19	5.5	5.6	2.2e-08	0.84	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHRNE	0.39	0.35	lasso	7	0.36	6.8e-16	5.5	6.1	1.4e-09	0.93	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNE	0.04	0.04	lasso	4	0.05	1.0e-05	5.8	5.8	6.1e-09	0.82	0.01	0.98	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIF1C	0.08	0.07	blup	55	0.07	1.2e-07	4.6	5.2	2.2e-07	0.82	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHRNE	0.08	0.09	lasso	1	0.08	3.0e-05	5.5	5.5	3.1e-08	0.82	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CHRNE	0.37	0.19	lasso	5	0.17	2.4e-05	5.8	5.9	4.6e-09	0.81	0.01	0.96	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNE	0.24	0.28	lasso	4	0.28	1.7e-20	5.5	5.6	2.3e-08	0.82	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHRNE	0.09	0.04	blup	41	0.05	1.1e-02	5.8	5.8	5.7e-09	0.89	0.01	0.79	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNE	0.11	0.15	enet	9	0.15	1.0e-14	5.6	5.6	1.9e-08	0.87	0.02	0.98	FALSE