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chr17:6,652,789-9,227,278

Best TWAS P=5.35e-22 · Best GWAS P=1.57e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
50	ROSMAP	Brain Pre-frontal Cortex	PFAS	0.08	0.02	enet	10	0.03	4.4e-05	8.9	9.6	5.4e-22	0.05	0.31	0.66	TRUE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYB5D1	0.04	0.03	blup	40	0.02	1.6e-02	7.4	-9.0	1.6e-19	-0.54	0.02	0.43	TRUE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFAS	0.02	0.01	blup	54	0.01	8.1e-03	8.9	9.0	3.1e-19	0.01	0.00	0.90	TRUE
99	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	-5.7	-7.4	1.3e-13	0.00	0.00	0.99	TRUE
24	GTEx	Lung	CNTROB	0.15	0.06	enet	28	0.07	9.5e-06	5.9	-7.2	7.3e-13	-0.45	0.64	0.03	TRUE
49	ROSMAP	Brain Pre-frontal Cortex	KCNAB3	0.07	0.08	enet	15	0.08	1.5e-10	5.6	-6.0	2.1e-09	-0.72	1.00	0.00	TRUE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf68	0.05	0.00	blup	59	0.03	3.3e-04	4.1	6.0	2.5e-09	0.03	0.01	0.93	TRUE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNF222	0.02	0.02	lasso	2	0.02	3.2e-04	-6.2	-5.7	1.3e-08	0.01	0.09	0.66	TRUE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	AURKB	0.02	0.01	blup	49	0.01	2.9e-03	1.4	5.7	1.4e-08	0.07	0.00	0.63	TRUE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EFNB3	0.03	0.00	blup	36	0.01	7.2e-02	4.1	-5.4	7.0e-08	-0.09	0.02	0.07	TRUE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC25A35	0.02	0.01	blup	50	0.01	6.7e-03	7.7	9.2	3.6e-20	-0.01	0.01	0.58	FALSE
53	YFS	Blood	CYB5D1	0.28	0.19	bslmm	488	0.24	5.9e-79	6.7	-8.7	2.3e-18	-0.48	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	PFAS	0.07	0.06	enet	11	0.07	1.1e-07	7.5	8.6	6.8e-18	0.04	0.28	0.71	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	KDM6B	0.07	0.05	lasso	4	0.04	2.7e-06	7.4	-8.6	9.3e-18	-0.49	0.78	0.19	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFAS	0.02	0.01	lasso	3	0.01	9.7e-03	8.9	8.5	2.3e-17	0.04	0.00	0.99	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PFAS	0.10	0.09	lasso	4	0.10	8.9e-13	6.8	8.5	2.7e-17	0.04	0.43	0.57	FALSE
31	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	-5.1	-8.4	3.2e-17	-0.30	0.08	0.35	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	PFAS	0.04	0.03	blup	54	0.04	4.0e-05	6.6	8.4	6.5e-17	0.00	0.10	0.80	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PFAS	0.04	0.04	blup	50	0.03	6.7e-03	6.5	8.3	9.5e-17	0.00	0.05	0.52	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFAS	0.05	0.06	enet	6	0.03	1.5e-04	8.0	8.3	1.5e-16	0.02	0.53	0.34	FALSE
16	GTEx	Cells Transformed fibroblasts	PFAS	0.13	0.05	lasso	6	0.07	4.1e-06	8.9	8.2	3.1e-16	-0.03	0.47	0.50	FALSE
18	GTEx	Colon Transverse	LSMD1	0.28	0.12	lasso	5	0.19	3.3e-09	7.4	8.1	3.9e-16	0.43	0.98	0.00	FALSE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RANGRF	0.05	0.01	blup	46	0.02	4.0e-03	6.7	8.1	3.9e-16	0.03	0.10	0.04	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RP11-849F2.9	0.13	0.00	enet	34	0.02	1.1e-02	8.9	7.9	2.4e-15	0.29	0.11	0.32	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	CYB5D1	0.05	0.03	blup	40	0.03	1.9e-04	7.4	-7.9	2.9e-15	-0.36	0.06	0.06	FALSE
32	GTEx	Pancreas	KCNAB3	0.16	0.07	enet	14	0.12	1.0e-05	5.5	-7.8	5.6e-15	-0.70	0.83	0.04	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFAS	0.03	0.02	blup	54	0.03	1.3e-04	6.6	7.7	1.4e-14	0.00	0.07	0.87	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	KCNAB3	0.02	0.01	blup	53	0.02	5.4e-03	5.7	-7.6	3.4e-14	-0.82	0.03	0.90	FALSE
30	GTEx	Pancreas	CNTROB	0.14	0.06	lasso	8	0.03	1.5e-02	6.7	-7.5	4.6e-14	-0.76	0.23	0.42	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	KCNAB3	0.03	0.01	blup	52	0.02	4.7e-03	-6.1	-7.5	5.2e-14	-0.83	0.02	0.74	FALSE
35	GTEx	Skin Sun Exposed Lower leg	AC135178.1	0.23	0.14	enet	10	0.15	3.4e-12	-6.5	-7.5	6.2e-14	-0.01	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	CNTROB	0.14	0.07	blup	50	0.10	4.8e-10	6.5	-7.4	9.8e-14	-0.62	0.97	0.03	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	CYB5D1	0.14	0.12	lasso	1	0.10	1.7e-06	7.4	-7.4	1.4e-13	-0.29	0.94	0.00	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	VAMP2	0.06	0.00	blup	47	0.02	2.1e-02	5.9	7.3	3.6e-13	0.05	0.02	0.62	FALSE
42	METSIM	Adipose	AC135178.1	0.17	0.12	enet	19	0.14	7.4e-20	-6.5	-7.2	6.6e-13	0.05	1.00	0.00	FALSE
37	GTEx	Spleen	CNTROB	0.22	0.04	enet	19	0.03	7.4e-02	5.7	-7.2	8.3e-13	-0.57	0.14	0.26	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC284023	0.09	0.01	blup	55	0.03	5.5e-04	6.9	7.1	1.2e-12	0.41	0.02	0.34	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	GUCY2D	0.09	0.13	enet	8	0.13	3.0e-12	6.6	-7.1	1.3e-12	-0.66	0.00	1.00	FALSE
27	GTEx	Nerve Tibial	CNTROB	0.17	0.09	enet	14	0.13	9.7e-10	6.3	-7.1	1.6e-12	-0.75	0.95	0.05	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYB5D1	0.07	0.02	enet	14	0.02	5.5e-03	7.4	-7.0	2.6e-12	-0.07	0.04	0.03	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	GUCY2D	0.05	0.02	blup	50	0.03	1.1e-06	6.3	-7.0	3.0e-12	-0.41	0.01	0.98	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM88	0.06	0.00	enet	10	0.01	6.5e-02	7.5	7.0	3.1e-12	0.22	0.01	0.08	FALSE
17	GTEx	Cells Transformed fibroblasts	AC135178.1	0.31	0.14	lasso	5	0.13	8.4e-10	-6.7	-6.9	4.1e-12	-0.02	1.00	0.00	FALSE
26	GTEx	Muscle Skeletal	AC135178.1	0.20	0.08	lasso	5	0.14	2.8e-13	4.7	-6.9	5.5e-12	-0.03	1.00	0.00	FALSE
9	GTEx	Artery Tibial	AC135178.1	0.20	0.15	lasso	3	0.20	2.1e-15	4.7	-6.8	1.4e-11	-0.03	1.00	0.00	FALSE
39	GTEx	Testis	RP11-849F2.5	0.45	0.40	lasso	5	0.40	2.6e-19	-6.5	-6.7	1.6e-11	-0.01	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	GUCY2D	0.02	0.00	blup	47	0.01	1.8e-02	6.3	-6.7	1.9e-11	-0.65	0.00	0.96	FALSE
54	YFS	Blood	KDM6B	0.07	0.04	enet	34	0.04	1.1e-13	7.4	-6.7	2.0e-11	-0.28	1.00	0.00	FALSE
14	GTEx	Brain Cortex	AC135178.1	0.26	0.19	lasso	2	0.21	1.5e-06	6.7	-6.7	2.2e-11	-0.03	0.28	0.05	FALSE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100128288	0.12	0.06	lasso	4	0.10	6.8e-05	4.8	-6.7	2.9e-11	-0.03	0.11	0.17	FALSE
29	GTEx	Nerve Tibial	AC135178.1	0.12	0.06	lasso	2	0.05	1.6e-04	-6.5	-6.6	4.5e-11	0.00	0.98	0.00	FALSE
7	GTEx	Artery Tibial	KDM6B	0.14	0.02	enet	22	0.03	1.4e-03	8.3	-6.5	6.5e-11	-0.24	0.26	0.05	FALSE
12	GTEx	Brain Cerebellum	KCNAB3	0.34	0.33	lasso	7	0.34	6.8e-11	5.7	-6.5	1.0e-10	-0.72	0.96	0.04	FALSE
93	The Cancer Genome Atlas	Stomach Adenocarcinoma	GUCY2D	0.06	0.04	blup	50	0.04	8.9e-04	5.6	-6.4	1.4e-10	-0.65	0.02	0.92	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	TRAPPC1	0.12	0.02	lasso	4	0.05	2.6e-05	3.7	-6.4	1.5e-10	-0.45	0.18	0.38	FALSE
5	GTEx	Adipose Subcutaneous	KCNAB3	0.09	0.08	lasso	3	0.05	5.8e-05	5.5	-6.4	1.9e-10	-0.72	0.97	0.02	FALSE
11	GTEx	Brain Cerebellar Hemisphere	KCNAB3	0.54	0.35	lasso	9	0.30	1.9e-08	5.7	-6.3	2.2e-10	-0.70	0.90	0.07	FALSE
44	METSIM	Adipose	KRBA2	0.17	0.13	lasso	5	0.15	7.1e-22	4.8	-6.3	2.2e-10	-0.03	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	KCNAB3	0.17	0.11	lasso	8	0.09	3.1e-07	5.7	-6.3	2.9e-10	-0.71	1.00	0.00	FALSE
43	METSIM	Adipose	ARHGEF15	0.06	0.00	blup	449	0.02	3.1e-04	-2.6	6.3	3.5e-10	0.23	0.07	0.17	FALSE
19	GTEx	Colon Transverse	AC135178.1	0.18	0.03	lasso	7	0.03	1.1e-02	-6.6	-6.2	4.5e-10	-0.02	0.35	0.03	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100128288	0.05	0.05	enet	4	0.05	6.1e-06	4.8	-6.2	5.9e-10	-0.02	0.89	0.01	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	GUCY2D	0.06	0.08	enet	5	0.09	9.5e-10	5.5	-6.2	6.3e-10	-0.73	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCNAB3	0.03	0.01	blup	52	0.03	7.0e-04	5.6	-6.1	8.4e-10	-0.66	0.13	0.25	FALSE
45	METSIM	Adipose	TMEM88	0.09	0.02	bslmm	500	0.03	4.6e-05	3.7	6.1	9.1e-10	0.25	0.62	0.04	FALSE
101	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GUCY2D	0.17	0.13	enet	7	0.18	9.7e-06	5.5	-6.1	9.3e-10	-0.68	0.02	0.97	FALSE
20	GTEx	Colon Transverse	RP11-849F2.8	0.18	0.12	enet	25	0.10	2.5e-05	6.1	-6.1	1.0e-09	-0.03	0.91	0.01	FALSE
23	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	-5.1	-6.1	1.1e-09	-0.13	0.36	0.03	FALSE
8	GTEx	Artery Tibial	CNTROB	0.16	0.16	lasso	5	0.15	5.2e-12	5.7	-6.0	1.5e-09	-0.69	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHD3	0.03	0.00	blup	62	0.03	6.0e-04	6.6	6.0	1.6e-09	0.75	0.02	0.60	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	GUCY2D	0.05	0.09	lasso	1	0.08	7.4e-11	6.0	-6.0	2.6e-09	-0.55	1.00	0.00	FALSE
22	GTEx	Esophagus Muscularis	CNTROB	0.10	0.04	lasso	4	0.02	1.6e-02	5.7	-5.8	5.4e-09	-0.73	0.08	0.72	FALSE
33	GTEx	Prostate	AC113189.5	0.43	0.02	lasso	5	0.01	2.0e-01	-4.2	5.8	5.9e-09	0.21	0.06	0.06	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	VAMP2	0.03	0.02	blup	47	0.01	2.9e-02	4.4	-5.8	5.9e-09	-0.05	0.13	0.21	FALSE
10	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	-5.8	-5.8	6.1e-09	-0.03	0.76	0.01	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GUCY2D	0.14	0.04	lasso	2	0.04	9.5e-03	5.4	-5.8	6.9e-09	-0.57	0.02	0.21	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	CNTROB	0.11	0.09	lasso	3	0.09	1.2e-05	5.7	-5.7	9.7e-09	-0.69	0.82	0.03	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	FXR2	0.04	0.03	lasso	1	0.02	1.8e-03	-5.7	-5.7	1.2e-08	-0.01	0.01	0.90	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	2.7	5.7	1.5e-08	-0.02	0.01	0.40	FALSE
6	GTEx	Adipose Subcutaneous	LSMD1	0.21	0.10	enet	29	0.13	6.6e-11	7.4	5.7	1.6e-08	0.17	0.99	0.00	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	SHBG	0.04	0.01	blup	60	0.03	5.4e-04	6.3	5.7	1.6e-08	0.12	0.01	0.46	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CNTROB	0.05	0.01	blup	504	0.01	5.3e-03	5.9	-5.6	1.7e-08	-0.59	0.48	0.24	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC25A35	0.09	0.06	enet	12	0.11	3.9e-11	6.4	5.6	1.7e-08	-0.01	0.01	0.99	FALSE
25	GTEx	Lung	KCNAB3	0.14	0.05	lasso	4	0.04	2.9e-04	5.5	-5.6	2.1e-08	-0.72	0.99	0.00	FALSE
38	GTEx	Testis	CYB5D1	0.37	0.12	lasso	4	0.12	4.2e-06	6.7	5.6	2.1e-08	0.45	0.94	0.04	FALSE
21	GTEx	Esophagus Mucosa	KCNAB3	0.20	0.12	lasso	9	0.08	3.1e-06	5.6	-5.6	2.2e-08	-0.72	0.96	0.03	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	KRBA2	0.04	0.00	blup	48	0.02	5.4e-03	4.8	-5.6	2.3e-08	-0.04	0.02	0.05	FALSE
92	The Cancer Genome Atlas	Soft Tissue Sarcoma	PFAS	0.10	0.05	blup	54	0.03	6.2e-03	6.5	5.6	2.4e-08	-0.04	0.05	0.33	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	VAMP2	0.16	0.02	enet	10	0.03	2.8e-02	5.1	-5.6	2.5e-08	-0.03	0.04	0.11	FALSE
55	YFS	Blood	MYH10	0.03	0.00	blup	508	0.01	1.1e-03	3.5	-5.5	2.9e-08	0.07	0.11	0.02	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	VAMP2	0.06	0.05	lasso	1	0.04	3.1e-05	5.5	-5.5	3.6e-08	-0.05	0.51	0.02	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf59	0.04	0.01	blup	50	0.03	6.5e-04	2.1	5.4	5.8e-08	0.05	0.05	0.86	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	AC135178.1	0.26	0.27	lasso	3	0.28	2.1e-35	4.7	-5.4	7.4e-08	-0.03	1.00	0.00	FALSE
41	GTEx	Thyroid	KCNAB3	0.15	0.14	enet	16	0.12	1.6e-09	5.5	-5.3	9.0e-08	-0.73	1.00	0.00	FALSE
52	YFS	Blood	CNTROB	0.02	0.01	bslmm	487	0.01	5.6e-05	5.7	-5.3	1.0e-07	-0.66	0.80	0.13	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LOC284023	0.10	0.07	bslmm	506	0.07	1.1e-08	3.6	5.3	1.3e-07	0.40	0.97	0.03	FALSE
15	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	-1.9	-5.2	1.8e-07	-0.04	1.00	0.00	FALSE
40	GTEx	Thyroid	CNTROB	0.12	0.08	lasso	2	0.06	1.9e-05	5.7	-5.2	1.9e-07	-0.69	0.96	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100128288	0.32	0.32	lasso	2	0.31	1.2e-38	4.7	-5.2	2.0e-07	-0.03	1.00	0.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	CNTROB	0.09	0.11	enet	27	0.09	5.2e-12	5.5	-5.2	2.1e-07	-0.65	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	AC135178.1	0.54	0.40	lasso	6	0.38	3.0e-12	4.8	-5.2	2.5e-07	0.02	1.00	0.00	FALSE