Hub : Genes

C18orf25

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1460	0.0580	7.1e-03	0.081	NA	0.061	NA	0.054	3.1e-05	NA	2.7e-04	NA	5.9e-04
2	GTEx	Nerve Tibial	0.1430	0.0515	2.9e-03	0.000	NA	0.026	NA	0.003	3.4e-01	NA	5.8e-03	NA	2.0e-01
3	NTR	Blood	0.0591	0.0135	1.0e-13	0.061	0.057	0.063	0.061	0.061	5.3e-19	1.1e-17	1.6e-19	8e-19	4.4e-19
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0328	0.0217	1.5e-03	0.028	0.017	0.014	NA	0.020	3.5e-04	5.0e-03	8.4e-03	NA	2.5e-03
5	TCGA	Brain Lower Grade Glioma	0.0356	0.0195	4.6e-04	0.009	0.030	0.019	NA	0.017	3.2e-02	2.3e-04	2.9e-03	NA	4.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.4	-0.3	1.0	0.1	-0.6	1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	3.4	-0.7	1.9	0.6	-0.4	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-1.0	-0.3	0.2	-0.2	-1.1
Depression (Nagel 2018)	0.2	0.3	0.5	0.4	-0.2	-0.7	0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.4	1.6	1.1	-1.5	-0.3	1.2
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.4	-1.1	-0.7	0.8	-0.3
Schizophrenia (2018)	0.4	0.9	3.0	-0.6	1.7	0.7	-0.1	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	1.1	0.2	-0.6	1.3	0.5
Worry (Nagel 2018)	0.5	1.1	1.9	1.4	-1.3	-1.1	0.7	0.3
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	0.4	-0.2	-1.0	-0.1	-0.3
Alzheimer’s Disease (in father)	2.6	2.8	7.2	-2.0	-1.0	0.9	-0.8	-2.7
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	-0.1	-1.1	-0.8	-0.2	-1.4
Crohns Disease (2017)	1.2	2.6	5.6	-0.9	2.2	0.9	-2.4	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.2	-0.7	0.7	0.6	-1.1	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.6	-0.4	0.5	-0.4	-0.5
Major Depression (MDD)	0.9	1.1	1.9	-1.0	1.4	1.3	-0.7	-0.3
Reaction Time	1.1	2.1	4.7	-1.4	-1.0	1.1	-1.1	-2.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	0.7	0.4	-0.8	-0.7	1.0
Breast Cancer	0.0	0.1	0.4	-0.1	0.0	-0.1	0.6	-0.0
Ovarian Cancer	0.7	0.9	3.1	0.7	-1.8	-0.7	0.3	-0.2
Prostate Cancer	0.4	0.5	0.9	-1.0	-0.7	0.8	-0.5	-0.6
Age at First Birth	1.1	1.6	5.0	-0.5	-1.1	0.4	-2.2	-1.2
Bipolar Disorder (2011)	0.6	0.6	1.1	-0.9	0.0	1.0	0.0	-1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.7	-0.1	-1.3	-0.3	-0.1	0.3
Coronary Artery Disease (CAD)	0.4	0.4	1.0	0.8	0.3	-1.0	0.3	0.6
Crohns Disease (2012)	0.6	0.9	3.8	0.3	1.9	-0.3	-0.1	0.8
Mean Putamen Volume	0.3	0.4	0.9	0.4	0.9	-0.7	-0.1	0.6
Fasting Glucose	1.4	1.7	4.6	-1.2	1.3	0.8	-2.1	-0.5
HbA1C	1.0	1.1	1.9	-1.4	-0.6	1.2	-1.2	0.5
HDL Cholesterol	0.3	0.4	1.0	-0.5	1.0	0.6	-0.5	-0.6
LDL Cholesterol	0.6	0.9	3.5	-0.3	1.9	0.9	0.3	-0.0
Lupus	0.5	0.7	1.2	1.0	0.1	-0.6	1.1	0.9
Neuroticism (2016)	0.0	0.1	0.2	0.5	0.1	-0.2	-0.0	0.2
Primary Biliary Cirrhosis	0.4	0.5	2.4	0.1	1.5	-0.2	0.4	0.1
Rheumatoid Arthritis	0.8	1.0	4.1	-0.2	2.0	0.2	0.6	0.8
Schizophrenia (2014)	0.2	0.4	1.6	-0.1	1.3	0.6	0.2	-0.1
Triglycerides	0.2	0.4	1.1	0.6	-0.2	-0.5	1.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.2	0.3	-0.1	0.4	-0.5
Ulcerative Colitis	0.1	0.2	0.4	0.2	0.3	-0.5	0.4	0.6
Blood Eosinophil Count	1.1	8.6	18.1	2.8	-3.5	-4.3	2.1	0.1
Blood Platelet Count	1.3	15.5	29.9	4.0	-5.5	-4.5	3.4	-0.4
Blood Red Count	14.6	140.9	213.2	-14.6	5.5	14.3	-12.2	-10.4
Blood White Count	5.1	38.0	58.1	7.5	-4.8	-7.6	5.6	4.7
Heel T-Score	0.1	0.5	1.9	0.2	-0.2	0.5	0.4	-1.4
BMI	0.6	3.6	6.9	2.1	-0.2	-2.6	1.2	2.2
Height	0.0	0.2	0.6	0.0	0.4	-0.4	0.6	0.8
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.1	0.9	0.2	0.6	-0.7
Systolic Blood Pressure	0.1	0.3	0.8	-0.7	-0.9	0.1	0.1	-0.4
Smoking Status	0.7	1.7	3.1	1.1	-0.2	-1.7	1.8	1.1
Allergy or Eczema	0.6	1.6	4.1	-0.6	-2.0	0.5	-1.0	-1.6
Cardiovascular Disease	0.2	0.6	1.4	0.4	-1.2	-0.8	0.6	0.7
Hypothyroidism (self reported)	0.2	0.4	1.6	0.2	-1.3	0.1	0.6	0.4
Respiratory disease	1.7	3.7	9.2	-1.7	-1.2	1.5	-3.0	-1.6
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.6	-1.9	-0.3	1.6	-1.6	-1.1
Lung FEV1/FVC ratio	0.4	1.9	3.5	1.2	0.8	-1.6	1.9	1.1
Lung FVC	1.3	6.6	10.9	-2.9	1.6	3.3	-2.3	-2.5
Neuroticism	0.2	0.4	1.1	-0.7	0.4	0.6	-0.4	-1.0
Chronotype (morning person)	0.8	1.9	4.8	0.2	2.2	-0.2	0.2	2.2
Hair Pigment	0.1	3.3	7.2	-1.6	2.7	1.5	-1.4	-1.7
Tanning	0.1	0.9	2.8	-0.6	-1.7	0.9	0.2	-0.7
Hand grip strength (left)	1.0	2.6	6.1	-1.3	2.5	1.4	-1.7	0.4
Number of treatments/medications taken	0.7	1.3	5.6	-0.2	-2.4	0.3	-0.7	-0.6
Average weekly spirits intake	2.2	2.7	4.9	1.8	0.9	-2.0	0.7	2.2
Sensitivity / hurt feelings	0.3	0.6	1.5	-0.4	-1.1	0.2	0.1	-1.2
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.6	-0.7	0.3	0.7	-1.3	-1.0
Hearing difficulty/problems: Yes	1.3	2.0	4.4	-1.1	1.4	1.3	-2.1	-0.7
Relative age of first facial hair	0.6	1.1	1.8	1.3	0.9	-0.9	0.7	1.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.5	-1.2	-0.8	1.0	-0.5	-1.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-0.1	1.2	0.9	-0.9	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	0.4	1.3	-0.7	-0.2	1.0
Systolic blood pressure, automated reading	0.5	1.5	5.7	0.6	-2.4	-0.8	0.5	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.0	-1.0	-1.0	0.8	-1.0	-0.5
Angina	2.1	2.8	4.7	-2.2	1.5	1.9	-1.8	-0.7
Medication for hormone replacement therapy	0.9	1.1	2.7	-0.0	1.6	0.2	-1.5	0.6
Vitamin and mineral supplements	0.2	0.3	0.9	0.7	0.4	-0.1	-0.2	1.0
Supplements: Zinc	2.4	2.6	6.0	-2.2	-0.8	1.2	-0.2	-2.4
Medication: Co-codamol	0.5	0.6	1.5	-0.7	-0.4	1.2	-0.8	-0.1
Medication: Metformin	0.7	1.0	2.0	-1.4	-0.1	1.1	-0.7	-1.1
Diabetes (father)	0.2	0.3	0.6	0.2	-0.4	-0.3	0.8	-0.7
Diabetes (mother)	0.8	1.0	2.0	-1.4	0.1	1.0	-0.2	-1.4
Severe depression (siblings)	1.2	1.3	1.9	1.4	-0.7	-1.4	1.0	1.1
Pack years adult smoking proportion	0.3	0.5	1.8	0.4	-1.3	-0.5	-0.7	-0.2
Impedance of leg (right)	0.3	1.3	2.6	-1.3	0.3	1.4	-0.4	-1.6
Leg fat-free mass (left)	0.4	1.9	3.3	1.3	0.9	-1.8	0.9	1.6
Trunk fat percentage	0.5	2.2	3.7	1.6	-0.2	-1.9	1.5	1.6
Hand grip strength (right)	0.6	1.5	2.3	-1.5	1.4	1.5	-1.0	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.8	-0.0	0.2	-0.4	-0.5
Current tobacco smoking	0.3	0.5	2.1	0.4	-1.4	-0.6	-0.1	0.3
Average weekly fortified wine intake	1.0	1.2	2.4	1.6	0.1	-1.3	-0.1	1.3
Maternal smoking around birth	1.4	2.0	3.3	1.8	-1.0	-1.6	1.1	1.4
Fed-up feelings	0.2	0.4	1.0	-0.9	0.0	0.4	-1.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.1	-0.8	-0.3	0.6	-0.2	-1.8
Relative age voice broke	0.5	0.8	3.0	0.9	1.7	-0.5	0.2	0.2
Taking other prescription medications	0.9	1.4	2.3	-0.8	-0.9	1.5	-1.1	-1.3
Age when periods started (menarche)	1.1	2.7	4.0	-1.5	2.0	2.0	-1.9	-0.3
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	6.8	-1.7	2.5	2.1	-2.6	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.6	-1.7	-0.9	1.3	0.1	-2.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	0.3	-1.2	0.0	-0.4	0.7
Qualifications: CSEs or equivalent	0.5	0.6	1.1	-0.6	-1.0	-0.5	-0.7	-1.0
Serious illness, injury or assault to yourself	0.2	0.3	0.6	0.4	0.7	0.0	-0.8	0.4
High blood pressure	0.4	1.1	1.5	1.2	-0.7	-1.2	0.7	1.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-0.5	-0.8	0.2	-0.8	-1.0
Multivitamins +/- minerals	0.1	0.2	0.8	-0.1	-0.1	-0.2	0.9	-0.1
Stomach or abdominal pain in last month	1.8	2.3	5.4	1.9	-1.0	-2.3	0.9	0.6
Supplements: Glucosamine	1.3	1.7	6.1	-0.8	-2.5	0.2	-0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.2	-1.8	-1.2	1.5	0.2	-1.6
Medication: Atenolol	0.5	0.6	1.6	0.0	-1.2	-0.2	-0.3	1.3
Medication: Levothyroxine sodium	0.8	1.4	2.1	-1.3	-0.3	1.3	-1.5	-1.1
Sitting height	0.0	0.1	0.3	0.1	-0.2	-0.6	0.1	0.5
Chronic bronchitis/emphysema (father)	0.6	0.8	2.1	0.6	-1.4	-0.3	-1.1	-0.3
High blood pressure (mother)	0.2	0.3	0.5	0.6	-0.6	-0.3	-0.1	0.7
Body mass index (BMI)	0.6	2.8	4.3	1.8	-0.8	-2.1	1.3	2.0
Impedance of leg (left)	0.2	1.2	2.1	-1.3	-0.1	1.3	-0.4	-1.5
Leg predicted mass (left)	0.4	2.0	3.6	1.4	0.9	-1.9	0.9	1.7
Trunk fat mass	0.6	2.7	4.6	1.7	-0.0	-2.1	1.5	1.9
Waist circumference	0.4	1.4	2.6	1.3	-0.2	-1.6	0.8	1.4
Number of incorrect matches in round	0.5	0.9	1.7	0.9	0.6	-1.3	1.0	0.6
Past tobacco smoking	1.1	2.0	3.5	-1.1	-1.9	1.3	-1.3	-1.4
Alcohol usually taken with meals	0.9	1.4	3.8	1.1	0.7	-0.9	0.8	2.0
Nervous feelings	0.2	0.3	0.7	0.1	-0.7	0.4	-0.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.1	-1.3	-0.4	1.1	-0.5	-2.5
Hearing difficulty/problems with background noise	0.8	1.2	2.4	-0.8	1.4	1.5	-0.4	-1.0
Hair/balding pattern: Pattern 2	1.0	1.3	3.3	-1.0	1.8	1.1	-1.0	-0.4
Had menopause	0.8	1.0	3.2	0.9	-1.8	-0.4	0.5	0.8
Had other major operations	0.2	0.2	0.9	0.1	-1.0	-0.3	0.2	0.1
Forced vital capacity (FVC)	1.2	4.8	7.1	-2.5	1.5	2.7	-1.9	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.2	-1.5	-0.6	1.5	0.0	-2.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	2.7	-1.1	-1.6	1.3	-1.4	-1.3
Qualifications: None of the above	0.1	0.2	0.5	-0.5	-0.4	0.7	-0.3	0.2
Financial difficulties in last 2 years	1.7	2.3	6.4	-1.2	0.4	0.8	-1.6	-2.5
Mouth/teeth dental problems	0.8	1.2	2.1	-1.2	-0.8	1.5	-1.1	-0.8
Heart attack	0.4	0.5	1.3	-0.3	1.1	0.2	-0.9	0.4
Allergy	1.1	2.5	4.6	1.6	0.1	-1.4	2.1	1.9
Pain all over the body in last month	1.8	1.9	3.4	-1.1	-1.5	1.3	-1.8	-1.0
Diabetes (self-reported)	0.5	0.7	2.4	-0.4	-1.5	-0.1	-0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.6	0.0	-0.7	-0.3	0.4
Medication: Ramipril	0.6	0.8	1.3	0.6	-1.0	-0.7	0.9	1.1
Medication: Simvastatin	0.3	0.4	0.8	-0.7	-0.7	0.9	-0.5	0.1
Fluid intelligence score	0.2	0.3	1.2	-0.5	0.2	0.2	-1.1	-0.4
Illnesses of siblings	0.3	0.4	0.7	0.8	0.7	-0.1	-0.2	0.8
Neuroticism score	0.9	1.8	4.1	-1.4	-0.9	1.1	-1.0	-2.0
Weight	0.5	2.5	4.2	1.6	0.0	-2.0	1.2	2.0
Impedance of arm (right)	0.2	1.0	3.2	-0.7	0.7	0.9	-0.2	-1.8
Arm fat percentage (right)	0.2	0.9	1.9	0.9	-0.5	-1.4	0.9	0.8
Trunk fat-free mass	0.3	1.6	3.6	1.2	0.6	-1.6	0.6	1.9
Hip circumference	0.6	2.5	4.6	1.8	0.0	-2.0	0.7	2.2
Time employed in main current job	1.1	1.3	2.2	-1.5	1.4	1.1	-0.7	-0.7
Alcohol intake versus 10 years previously	1.5	2.2	10.2	-0.1	-3.2	0.4	-0.3	-0.8
Father’s age at death	0.5	0.7	2.0	-0.1	1.2	0.1	-1.4	0.2
Worrier / anxious feelings	0.4	0.8	2.2	-0.5	-0.6	1.0	-1.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	5.1	0.0	-2.3	-0.3	-0.2	-0.8
Falls in the last year	1.4	1.9	4.0	0.7	-2.0	-1.9	1.3	-0.0
Hair/balding pattern: Pattern 3	0.8	1.2	4.1	-0.5	-2.0	0.1	0.8	-0.9
Number of live births	2.6	3.7	7.2	-2.1	1.7	2.7	-1.6	-1.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	5.1	-2.3	2.2	2.3	-1.1	-1.6
Pulse rate	1.6	2.7	3.9	2.0	-1.6	-1.8	1.2	1.6
Happiness	2.0	2.4	3.5	-1.8	0.4	1.7	-1.9	-1.5
Noisy workplace	0.6	0.7	1.1	0.9	-0.7	-0.6	1.1	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	-0.6	-0.2	-0.1	-0.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.8	-1.1	-1.3	1.2	-1.0	-1.2
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.4	0.9	-0.4	0.2	1.0
Asthma	1.4	2.8	6.7	-1.7	0.1	1.8	-2.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	6.1	-0.2	2.5	-0.5	-0.2	-0.1
Medication: Cholesterol lowering	0.5	0.8	1.4	0.9	-0.8	-1.0	0.5	1.2
Depression (self-reported)	1.6	1.9	4.2	-1.0	-2.1	0.4	-0.6	-2.0
Medication: Lansoprazole	2.2	2.5	4.7	-1.5	-0.7	1.4	-1.8	-2.2
Prospective memory result	0.8	1.0	1.7	-1.0	0.8	1.1	-1.3	-0.8
Lung cancer (father)	0.3	0.4	0.6	0.7	-0.4	-0.6	0.6	0.8
Illnesses of mother	0.7	0.8	3.9	-0.3	2.0	0.1	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.5	-1.2	1.9	1.3	-0.3	-1.1
Pulse wave Arterial Stiffness index	1.3	1.5	2.8	1.3	-1.2	-0.5	1.2	1.7
Impedance of arm (left)	0.2	0.8	2.3	-0.7	0.5	0.9	0.2	-1.5
Arm fat mass (right)	0.4	1.6	3.1	1.3	-0.2	-1.8	1.0	1.4
Trunk predicted mass	0.3	1.6	3.5	1.2	0.6	-1.6	0.6	1.9
Standing height	0.1	0.8	3.5	-0.1	1.9	-0.1	-0.1	0.5
Length of working week for main job	0.3	0.3	1.3	0.0	0.0	0.3	1.1	0.6
Exposure to tobacco smoke at home	0.2	0.3	1.1	-0.0	-1.1	-0.0	0.2	-0.4
Breastfed as a baby	4.6	5.7	8.2	-2.9	0.6	2.7	-2.4	-2.7
Tense / ‘highly strung’	1.0	1.6	3.2	1.6	-0.2	-1.8	1.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.6	-1.1	-1.0	0.9	-1.1	-1.9
Hair/balding pattern: Pattern 4	0.7	1.7	4.9	0.6	1.5	-0.2	1.0	2.2
Birth weight of first child	2.3	4.2	6.8	2.6	0.2	-2.0	1.9	2.6
Peak expiratory flow (PEF)	0.2	0.5	1.1	-1.1	0.8	0.7	0.4	-0.6
Pulse wave reflection index	0.2	0.3	0.8	-0.3	0.3	0.9	-0.7	0.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.4	-1.1	1.2	1.0	-1.1	-0.5
Loud music exposure frequency	0.5	0.5	2.1	-0.1	1.4	0.3	-0.7	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	0.6	-0.5	-0.9	1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.5	0.8	-0.3	0.5	-1.0
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.3	0.4
Medication: Paracetamol	0.8	1.3	5.3	0.5	-2.3	-0.9	0.1	0.4
Headache pain in last month	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.5	0.3
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	5.7	-2.3	0.7	2.4	-1.8	-2.2
Glaucoma (self-reported)	0.3	0.3	0.5	0.7	-0.4	-0.7	-0.6	-0.3
Gout (self-reported)	0.4	0.6	1.1	0.3	-0.9	-0.6	1.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.2	-0.7	-1.8	0.8	0.1	-0.7
Medication: Amlodipine	0.1	0.2	0.3	-0.4	0.1	0.4	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	-0.8	-0.7	1.4	-1.6	-0.9
Birth weight	0.3	0.7	2.0	0.6	1.4	-0.6	0.6	0.7
Chronic bronchitis/emphysema (mother)	1.1	1.2	1.7	-0.9	-0.7	1.3	-1.3	-1.2
High blood pressure (siblings)	0.2	0.2	0.9	-0.4	0.3	-0.3	-0.0	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.5	2.6	-1.2	1.6	1.2	-0.9	-1.0
Body fat percentage	0.5	1.9	3.0	1.4	-0.5	-1.7	1.4	1.4
Leg fat percentage (right)	0.5	1.7	2.3	1.3	-0.5	-1.4	1.5	1.5
Arm fat-free mass (right)	0.4	1.9	4.0	1.3	0.2	-1.7	0.9	2.0
Exposure to tobacco smoke outside home	0.8	1.1	2.5	0.9	0.4	-0.7	1.2	1.6
Comparative body size at age 10	0.2	0.7	1.4	0.6	0.6	-1.0	-0.3	1.2
Number of full brothers	0.6	0.7	2.5	0.4	0.9	0.0	0.3	1.6
Worry too long after embarrassment	0.4	0.7	0.9	-1.0	0.7	1.0	0.7	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.2	-1.5	-1.4	1.3	-0.7	-1.8
Wheeze or whistling in the chest in last year	2.0	3.5	7.4	-1.2	-1.7	1.4	-2.7	-1.9
Number of children fathered	0.8	0.9	1.8	1.2	-0.3	-1.0	0.4	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.5	-1.0	-1.4	0.6	-0.4	-1.9
Age at first live birth	2.0	3.6	6.4	2.5	-0.5	-1.8	1.7	2.3
Pulse wave peak to peak time	1.2	1.4	2.3	-1.2	1.3	0.5	-1.1	-1.5
Health satisfaction	0.6	0.8	2.6	-0.7	-1.6	0.5	-0.8	0.1
Shortness of breath walking on level ground	1.2	1.4	2.2	-1.3	-1.5	1.0	-1.2	-0.8
Qualifications: College or University degree	1.2	3.9	6.9	-2.0	0.3	1.9	-2.6	-2.2
Eye problems/disorders: None of the above	1.5	1.8	3.7	-1.6	-0.8	1.3	-0.5	-1.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	1.0	-1.0	-0.4	-0.6	0.1
Emphysema/chronic bronchitis	1.1	1.2	4.1	-0.8	2.0	0.6	-1.0	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	2.7	0.0	1.6	0.6	-0.4	0.4
Neck or shoulder pain in last month	0.4	0.6	2.7	-0.1	-1.6	0.2	-0.0	-0.2
Medication: Blood pressure	2.3	4.1	6.4	2.3	0.1	-2.5	2.1	2.1
Angina (self-reported)	2.3	3.1	4.8	-2.2	1.6	2.0	-2.0	-0.7
Migraine (self-reported)	0.7	0.8	1.5	-1.2	-0.5	1.2	-0.4	-1.0
Medication: Ibuprofen	1.2	1.4	5.8	0.1	2.4	-0.8	0.6	0.3
Medication: Allopurinol	1.5	2.0	4.8	0.8	-2.2	-1.4	1.3	-1.1
Medication: Omeprazole	0.6	0.8	1.7	0.7	-1.3	-1.0	0.8	-0.0
Medication: Seretide 50 evohaler	1.9	2.1	6.2	-1.1	-0.1	1.4	-2.5	-1.1
Mean time to correctly identify matches	0.7	1.4	2.7	-0.9	-1.2	1.2	-0.8	-1.6
Heart disease (mother)	1.5	1.8	3.4	1.5	-1.1	-1.9	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.6	1.3	-1.6	-1.1	1.5	-0.0
Whole body fat mass	0.6	2.4	4.2	1.6	-0.1	-2.1	1.3	1.8
Leg fat mass (right)	0.5	1.9	3.1	1.4	-0.4	-1.8	1.4	1.6
Arm predicted mass (right)	0.4	2.3	4.6	1.5	0.2	-1.9	0.9	2.1
Pulse rate, automated reading	0.2	0.8	1.6	1.3	-0.7	-0.6	0.7	1.1
Alcohol intake frequency.	0.1	0.3	1.2	0.2	0.5	0.4	-1.1	0.0
Comparative height size at age 10	0.6	3.1	5.6	2.0	1.0	-2.4	1.5	1.7
Number of full sisters	1.6	1.9	4.3	-1.2	0.8	1.7	-0.6	-2.1
Suffer from ‘nerves’	1.8	2.8	10.7	-0.3	-3.3	-0.2	-0.2	-1.8
Overall health rating	1.1	2.5	11.1	-0.4	-3.3	0.0	-0.6	-0.8
Chest pain or discomfort	1.1	1.6	4.7	-0.3	-2.2	0.0	-1.6	-0.7
Had major operations	0.4	0.4	1.0	-0.4	-0.3	-0.0	-0.9	-1.0
Age at last live birth	1.2	1.8	3.2	1.6	0.3	-0.9	1.5	1.8
Family relationship satisfaction	3.5	4.3	8.1	-2.3	-1.3	2.1	-1.5	-2.8
Leg pain on walking	1.1	1.3	2.2	1.2	-1.5	-1.3	0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	-0.9	-0.5	0.4	-0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.0	-0.1	-1.7	0.9	-1.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	0.2	-0.1	-0.4	1.4	0.7
Medication: Aspirin	1.0	1.3	2.9	-1.7	-1.0	1.1	0.2	-1.2
Supplements: Vitamin C	0.5	0.5	1.2	-1.1	-0.5	0.1	0.2	-1.1
Knee pain experienced in last month	0.6	1.0	1.8	1.0	-0.9	-1.3	0.8	0.9
Hypertension (Self-reported)	0.4	1.1	1.9	1.1	-0.8	-1.0	0.8	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.7	-0.7	0.5	-0.0	-1.1
Illnesses of father: Heart disease	0.2	0.3	0.9	0.2	-0.6	-0.4	1.0	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	1.9	0.8	-0.3	-1.0	0.4	1.4
Smoking status: Previous	1.2	1.8	4.6	0.6	2.1	-0.9	1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.5	0.8	1.3	-0.9	0.3	1.6
Whole body fat-free mass	0.3	1.8	3.3	1.3	0.6	-1.8	0.7	1.8
Leg fat-free mass (right)	0.3	1.6	2.9	1.3	0.7	-1.7	0.7	1.6
Arm fat percentage (left)	0.4	1.7	3.0	1.2	-0.7	-1.7	1.3	1.2
Average weekly red wine intake	4.6	6.9	7.8	2.8	-2.6	-2.4	2.8	2.5
Handedness (chirality/laterality): Left-handed	1.7	2.0	5.0	-1.2	0.1	2.2	-1.4	-1.4
Mood swings	0.8	1.5	3.4	-1.3	-1.3	0.8	0.3	-1.8
Loneliness, isolation	2.1	2.9	4.9	-2.2	0.8	1.3	-1.7	-2.1
Long-standing illness, disability or infirmity	0.2	0.2	0.5	0.6	-0.3	-0.1	-0.7	0.5
Ever had bowel cancer screening	0.1	0.1	0.2	0.2	0.4	0.0	-0.2	0.4
Diabetes diagnosed by doctor	0.3	0.5	0.9	-0.9	-0.9	0.4	-0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	0.7	-0.5	-0.5	1.4	0.6
Friendships satisfaction	1.3	1.6	3.0	-1.5	-0.1	1.0	-1.3	-1.7
Qualifications: nursing, teaching	0.6	1.0	3.8	0.5	1.9	-0.7	0.3	0.4
Commuting to job workplace: Walk	0.5	0.5	1.5	0.8	0.1	-1.2	0.5	0.5
Eye problems/disorders: Cataract	0.1	0.2	0.6	-0.3	0.8	0.1	-0.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	-0.7	-0.5	0.4	0.1	-1.2
Medication for cholesterol	0.4	0.5	1.3	0.7	0.0	-1.1	0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	0.5	-1.1	-0.8	0.2	-0.5
Back pain experienced in last month	0.1	0.2	0.7	-0.3	0.8	0.1	0.0	0.1
Mineral and other dietary supplements	0.3	0.4	0.9	-0.3	0.9	0.7	-0.2	-0.7
Breast cancer (self-reported)	0.8	1.0	3.2	-0.8	0.7	0.8	-0.3	-1.8
Asthma (self-reported)	1.4	2.8	6.9	-1.7	-0.1	1.7	-2.6	-1.1
Osteoporosis (self-reported)	0.8	1.0	2.5	1.6	0.6	-1.1	0.7	0.7
Osteoarthritis (self-reported)	0.7	0.8	1.5	1.0	-1.2	-0.7	0.9	0.7
Medication: Aspirin	2.0	2.6	5.2	-2.3	-1.0	1.8	-0.4	-1.9
Medication: Gliclazide	0.6	0.6	1.3	0.5	1.1	-0.5	0.5	1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.4	-0.6	0.5	-0.2	0.4
Smoking status: Current	0.5	0.7	2.3	0.7	-1.5	-0.8	0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.0	-1.2	2.6	1.2	-0.4	-1.2
Whole body water mass	0.3	1.9	3.7	1.4	0.6	-1.8	0.7	1.9
Leg predicted mass (right)	0.3	1.6	3.0	1.3	0.6	-1.7	0.7	1.6
Arm fat mass (left)	0.6	2.3	4.2	1.5	-0.3	-2.0	1.4	1.8
Number of self-reported non-cancer illnesses	0.8	1.3	4.1	1.1	-2.0	-0.7	0.3	0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.0	0.8	-0.1	0.5	0.8
Miserableness	1.7	3.0	6.2	-1.9	-0.6	1.5	-1.6	-2.5
Guilty feelings	2.4	3.7	5.2	-2.3	-0.5	1.8	-2.1	-2.3
Wears glasses or contact lenses	0.6	0.7	1.5	0.5	-1.0	-0.8	-1.2	0.1
Ever taken oral contraceptive pill	0.4	0.5	1.5	-0.7	-0.3	0.4	-0.5	-1.2
Hearing aid user	3.1	3.5	5.6	-2.4	0.8	2.2	-2.0	-1.4
Mother’s age at death	0.8	1.0	3.5	1.0	0.0	-0.4	1.9	0.8
Financial situation satisfaction	1.1	1.4	4.3	-0.9	-2.1	0.7	-0.0	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	0.0	1.5	0.1	-0.3	1.1
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	0.7	0.4	0.3	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	1.0	-0.3	-0.7	-0.9	0.3
Medication: Blood pressure	0.8	1.6	3.7	-1.8	-0.1	1.9	-0.8	-0.3
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.8	1.4	-1.0	-2.0	1.2	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.3	0.8	-0.8	-0.7	1.2	1.5
High cholesterol (Self-reported)	0.3	0.6	2.8	-0.1	-1.7	0.2	0.0	0.2
Medication: Bendroflumethiazide	1.5	2.2	4.9	1.2	-2.2	-1.1	1.3	1.4
Medication: Paracetamol	0.3	0.5	2.2	0.2	-1.5	-0.5	-0.2	0.1
Medication: Lisinopril	0.2	0.3	0.6	-0.4	0.8	0.2	0.5	0.5
Medication: Atorvastatin	0.7	0.8	1.5	1.1	-0.4	-1.2	0.7	0.8
Illnesses of father: High blood pressure	1.3	1.6	3.8	-1.7	0.8	2.0	-0.6	-0.6
Alcohol drinker status: Never	1.0	1.2	2.9	-1.1	-0.2	1.7	-1.1	-0.8
Ever smoked	0.8	1.4	4.2	0.4	2.1	-0.5	0.6	1.4
Basal metabolic rate	0.3	1.9	3.3	1.3	0.5	-1.8	0.9	1.8
Leg fat percentage (left)	0.6	2.0	2.8	1.4	-0.7	-1.6	1.5	1.7
Arm fat-free mass (left)	0.3	1.6	3.4	1.1	0.4	-1.6	0.6	1.9
Number of operations (self-reported)	0.8	1.3	2.9	-0.5	1.7	0.1	-1.7	-0.4
Average weekly beer plus cider intake	0.3	0.5	1.6	0.4	-1.3	-0.5	0.5	-0.4
Irritability	0.4	0.6	1.6	0.1	-1.2	-0.3	1.2	-0.2
Risk taking	0.5	0.8	1.8	-0.9	0.8	0.6	-0.5	-1.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	-1.3	-1.0	0.8	-0.7	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.9	0.6	0.2	-0.5	-0.3	1.4
Age started oral contraceptive pill	0.2	0.3	1.2	0.0	1.1	0.3	-0.3	0.3
Diastolic blood pressure, automated reading	1.6	4.9	7.3	2.3	-2.0	-2.7	2.4	1.3
Ever depressed for a whole week	2.1	2.5	4.1	-1.9	-0.9	1.8	-0.9	-2.0
Unable to work because of sickness or disability	1.1	1.4	3.0	0.5	-1.4	-0.7	1.7	-1.1
Commuting to job workplace: Cycle	3.0	3.6	9.8	-2.3	-0.1	1.5	-0.7	-3.1
Myopia	2.0	2.9	4.4	-2.0	2.1	1.8	-1.2	-1.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.4	-1.4	0.8	1.7	-1.1	-1.8
Cholesterol lowering medication	0.2	0.4	0.7	-0.4	-0.2	0.9	-0.7	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.8	0.1	-1.0	0.6	0.4
Pain experienced in last month	0.3	0.5	2.2	-0.1	1.5	0.1	0.5	-0.3
Supplements: Calcium	1.0	1.1	2.3	0.9	-0.9	-1.2	1.5	-0.0
Basal cell carcinoma (self-reported)	7.9	9.3	11.7	-3.4	3.1	3.0	-3.3	-2.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.4	0.8	0.3	-0.9	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	0.5	-0.1	-0.7	0.8	0.7
Heart disease (siblings)	0.7	0.8	1.9	-0.5	1.1	0.4	1.4	-0.8
Alcohol drinker status: Previous	0.9	1.0	2.7	-0.7	0.8	0.8	-1.7	-0.9
Pack years of smoking	0.6	0.9	3.2	0.6	-1.8	-0.7	-0.7	0.1
Impedance of whole body	0.2	1.2	2.9	-1.2	0.3	1.3	-0.2	-1.7
Leg fat mass (left)	0.6	2.2	3.6	1.4	-0.4	-1.9	1.5	1.7
Arm predicted mass (left)	0.3	1.7	3.6	1.3	0.2	-1.7	0.7	1.9