Best TWAS P=8.9e-12 · Best GWAS P=8.12e-20 conditioned to 2.26e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | NELFCD | 0.29 | 0.20 | lasso | 3 | 0.23 | 2.8e-12 | -4.5 | 5.2 | 2.3e-07 | 0.10 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | NELFCD | 0.47 | 0.29 | lasso | 8 | 0.35 | 2.8e-27 | -4.6 | 6.0 | 2.0e-09 | 0.22 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | NELFCD | 0.45 | 0.14 | lasso | 9 | 0.18 | 3.4e-07 | -4.6 | 5.7 | 1.3e-08 | 0.12 | 0.96 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Mucosa | STX16-NPEPL1 | 0.13 | 0.05 | lasso | 5 | 0.03 | 2.8e-03 | -4.8 | -5.3 | 9.1e-08 | 0.04 | 0.38 | 0.07 | TRUE |
| 5 | GTEx | Lung | NELFCD | 0.22 | 0.22 | lasso | 2 | 0.21 | 5.0e-16 | -4.7 | 5.1 | 2.7e-07 | 0.11 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Pancreas | NELFCD | 0.17 | 0.03 | lasso | 3 | 0.07 | 5.7e-04 | -4.7 | 5.4 | 7.5e-08 | 0.10 | 0.45 | 0.07 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | NELFCD | 0.28 | 0.21 | lasso | 7 | 0.22 | 1.1e-17 | -4.7 | 5.2 | 1.7e-07 | 0.11 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Testis | NELFCD | 0.53 | 0.51 | lasso | 3 | 0.51 | 4.2e-26 | 5.1 | 5.7 | 1.2e-08 | 0.57 | 1.00 | 0.00 | FALSE |
| 9 | METSIM | Adipose | NELFCD | 0.25 | 0.21 | bslmm | 540 | 0.23 | 1.0e-33 | -4.7 | 5.3 | 1.2e-07 | 0.16 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TH1L | 0.05 | 0.04 | lasso | 3 | 0.02 | 5.4e-03 | 5.2 | 5.8 | 7.8e-09 | 0.57 | 0.04 | 0.08 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TH1L | 0.04 | 0.01 | enet | 10 | 0.03 | 3.7e-07 | -4.5 | 6.0 | 1.9e-09 | 0.37 | 0.63 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TH1L | 0.18 | 0.02 | blup | 46 | 0.04 | 2.9e-03 | -4.5 | 6.3 | 3.8e-10 | 0.38 | 0.01 | 0.27 | FALSE |
| 13 | The Cancer Genome Atlas | Esophageal Carcinoma | TH1L | 0.19 | 0.16 | blup | 46 | 0.19 | 8.9e-07 | -3.7 | 5.2 | 2.5e-07 | 0.07 | 0.82 | 0.01 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TH1L | 0.10 | 0.06 | blup | 46 | 0.08 | 3.3e-09 | -4.7 | 5.1 | 2.8e-07 | 0.34 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TH1L | 0.12 | 0.06 | enet | 11 | 0.12 | 7.1e-14 | -4.6 | 5.3 | 1.2e-07 | 0.34 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TH1L | 0.14 | 0.06 | blup | 46 | 0.11 | 5.4e-07 | -4.7 | 6.8 | 8.9e-12 | 0.44 | 0.15 | 0.59 | TRUE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TH1L | 0.12 | 0.02 | enet | 20 | 0.06 | 3.6e-07 | -6.1 | 5.2 | 2.4e-07 | 0.17 | 0.43 | 0.02 | FALSE |
| 18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TH1L | 0.07 | 0.00 | blup | 46 | 0.02 | 2.8e-02 | -4.7 | 5.8 | 5.9e-09 | 0.28 | 0.03 | 0.07 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TH1L | 0.16 | 0.00 | enet | 14 | 0.08 | 3.4e-04 | -4.6 | 6.3 | 2.8e-10 | 0.40 | 0.04 | 0.13 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TH1L | 0.32 | 0.12 | blup | 47 | 0.27 | 1.8e-28 | 5.1 | 6.8 | 1.2e-11 | 0.50 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | TH1L | 0.20 | 0.03 | blup | 47 | 0.04 | 2.4e-02 | -4.7 | 5.4 | 6.9e-08 | 0.28 | 0.02 | 0.06 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | TH1L | 0.21 | 0.08 | blup | 46 | 0.11 | 5.4e-11 | 5.1 | 5.2 | 1.6e-07 | 0.41 | 0.99 | 0.01 | FALSE |
| 23 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | CTSZ | 0.14 | 0.04 | blup | 49 | 0.08 | 2.7e-03 | -4.6 | 5.3 | 1.3e-07 | 0.06 | 0.04 | 0.04 | FALSE |