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chr20:56,567,724-58,262,841

Best TWAS P=8.9e-12 · Best GWAS P=8.12e-20 conditioned to 2.26e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TH1L	0.14	0.06	blup	46	0.11	5.4e-07	-4.7	6.8	8.9e-12	0.44	0.15	0.59	TRUE
4	GTEx	Esophagus Mucosa	STX16-NPEPL1	0.13	0.05	lasso	5	0.03	2.8e-03	-4.8	-5.3	9.1e-08	0.04	0.38	0.07	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	TH1L	0.32	0.12	blup	47	0.27	1.8e-28	5.1	6.8	1.2e-11	0.50	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TH1L	0.16	0.00	enet	14	0.08	3.4e-04	-4.6	6.3	2.8e-10	0.40	0.04	0.13	FALSE
12	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TH1L	0.18	0.02	blup	46	0.04	2.9e-03	-4.5	6.3	3.8e-10	0.38	0.01	0.27	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	TH1L	0.04	0.01	enet	10	0.03	3.7e-07	-4.5	6.0	1.9e-09	0.37	0.63	0.04	FALSE
2	GTEx	Cells Transformed fibroblasts	NELFCD	0.47	0.29	lasso	8	0.35	2.8e-27	-4.6	6.0	2.0e-09	0.22	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TH1L	0.07	0.00	blup	46	0.02	2.8e-02	-4.7	5.8	5.9e-09	0.28	0.03	0.07	FALSE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TH1L	0.05	0.04	lasso	3	0.02	5.4e-03	5.2	5.8	7.8e-09	0.57	0.04	0.08	FALSE
8	GTEx	Testis	NELFCD	0.53	0.51	lasso	3	0.51	4.2e-26	5.1	5.7	1.2e-08	0.57	1.00	0.00	FALSE
3	GTEx	Esophagus Gastroesophageal Junction	NELFCD	0.45	0.14	lasso	9	0.18	3.4e-07	-4.6	5.7	1.3e-08	0.12	0.96	0.00	FALSE
21	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TH1L	0.20	0.03	blup	47	0.04	2.4e-02	-4.7	5.4	6.9e-08	0.28	0.02	0.06	FALSE
6	GTEx	Pancreas	NELFCD	0.17	0.03	lasso	3	0.07	5.7e-04	-4.7	5.4	7.5e-08	0.10	0.45	0.07	FALSE
9	METSIM	Adipose	NELFCD	0.25	0.21	bslmm	540	0.23	1.0e-33	-4.7	5.3	1.2e-07	0.16	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TH1L	0.12	0.06	enet	11	0.12	7.1e-14	-4.6	5.3	1.2e-07	0.34	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSZ	0.14	0.04	blup	49	0.08	2.7e-03	-4.6	5.3	1.3e-07	0.06	0.04	0.04	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	TH1L	0.21	0.08	blup	46	0.11	5.4e-11	5.1	5.2	1.6e-07	0.41	0.99	0.01	FALSE
7	GTEx	Skin Sun Exposed Lower leg	NELFCD	0.28	0.21	lasso	7	0.22	1.1e-17	-4.7	5.2	1.7e-07	0.11	1.00	0.00	FALSE
1	GTEx	Adipose Visceral Omentum	NELFCD	0.29	0.20	lasso	3	0.23	2.8e-12	-4.5	5.2	2.3e-07	0.10	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	TH1L	0.12	0.02	enet	20	0.06	3.6e-07	-6.1	5.2	2.4e-07	0.17	0.43	0.02	FALSE
13	The Cancer Genome Atlas	Esophageal Carcinoma	TH1L	0.19	0.16	blup	46	0.19	8.9e-07	-3.7	5.2	2.5e-07	0.07	0.82	0.01	FALSE
5	GTEx	Lung	NELFCD	0.22	0.22	lasso	2	0.21	5.0e-16	-4.7	5.1	2.7e-07	0.11	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TH1L	0.10	0.06	blup	46	0.08	3.3e-09	-4.7	5.1	2.8e-07	0.34	1.00	0.00	FALSE