TWAS hub - CTSZ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0250	7.8e-03	0.030	0.008	0.026	0.015	0.036	1.2e-04	3.0e-02	3.4e-04	5.5e-03	3.2e-05
2	GTEx	Colon Sigmoid	0.2350	0.0700	8.7e-04	0.162	NA	0.151	NA	0.142	2.3e-06	NA	5.1e-06	NA	1.1e-05
3	GTEx	Heart Atrial Appendage	0.1920	0.0650	1.7e-03	0.040	NA	0.003	NA	0.037	6.7e-03	NA	2.2e-01	NA	8.8e-03
4	GTEx	Muscle Skeletal	0.0878	0.0349	8.3e-03	0.014	NA	0.068	NA	0.067	1.3e-02	NA	3.3e-07	NA	4.0e-07
5	NTR	Blood	0.0218	0.0090	8.8e-03	0.000	0.007	-0.001	0.006	0.000	2.3e-01	2.2e-03	5.9e-01	3.5e-03	4.5e-01
6	YFS	Blood	0.0942	0.0185	5.6e-17	0.072	0.063	0.085	0.091	0.083	2.0e-22	6.2e-20	1.9e-26	4.5e-28	9.9e-26
7	TCGA	Breast Invasive Carcinoma	0.0126	0.0065	2.5e-03	0.019	0.013	0.009	NA	0.014	6.6e-05	8.7e-04	5.4e-03	NA	5.2e-04
8	TCGA	Brain Lower Grade Glioma	0.0373	0.0196	3.2e-04	0.011	0.011	0.001	NA	0.002	1.9e-02	1.7e-02	2.1e-01	NA	1.7e-01
9	TCGA	Uterine Corpus Endometrial Carcinoma	0.1440	0.0770	6.3e-03	0.041	0.082	0.032	NA	0.046	2.7e-02	2.7e-03	4.5e-02	NA	2.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Blood Platelet Count	10.6	123.0	404.0	12.8	0.0	0.7	-5.1	1.4	10.0	-13.4	-15.2	-20.1
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	10.0	-2.7	3.2	2.4	2.7	2.4	0.4	3.0	2.3	0.5
Medication: Ibuprofen	3.4	4.1	7.9	-2.6	1.7	2.6	2.2	0.5	0.8	2.2	2.8	1.4
Osteoporosis (self-reported)	3.2	4.0	6.7	-2.0	2.6	2.4	2.5	1.6	1.0	1.9	2.3	1.0
HbA1C	2.9	3.2	5.7	2.3	-1.7	-2.4	-1.8	1.9	-0.5	-1.7	-2.2	-0.7
Supplements: Zinc	2.9	3.1	7.4	1.3	-1.6	-2.4	-2.7	-2.3	2.0	-0.6	-1.1	0.1
Primary Biliary Cirrhosis	2.8	4.0	7.4	2.7	-1.6	-1.4	-2.2	0.5	0.4	-2.5	-2.7	-2.3
Qualifications: CSEs or equivalent	2.8	3.7	7.4	2.2	-2.2	-2.3	-2.7	-1.7	0.8	-2.2	-1.3	0.4
Blood clot in the leg (DVT)	2.8	3.6	6.9	2.3	-1.0	-2.1	-1.9	-1.0	1.3	-1.9	-2.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	6.2	-2.4	1.8	2.5	2.1	0.2	0.8	2.1	2.3	0.8
Hypertension (Self-reported)	2.6	7.2	24.5	-1.5	0.5	2.5	1.0	-2.3	1.0	-0.1	4.9	4.9
Fluid intelligence score	2.5	5.2	7.7	-2.4	2.5	2.4	2.4	2.1	-2.0	2.0	2.8	1.8
Qualifications: A levels/AS levels or equivalent	2.5	5.6	14.8	-3.6	2.3	1.9	1.6	1.5	-0.6	3.8	2.4	1.7
Supplements: Vitamin C	2.5	3.0	9.1	1.3	-2.2	-1.1	-3.0	-2.4	1.7	-0.9	-0.6	0.0
High blood pressure	2.4	6.8	24.0	-1.3	-0.0	2.0	0.5	-3.0	1.2	-0.1	4.6	4.9
Diastolic blood pressure, automated reading	2.3	7.0	22.5	-1.9	1.3	2.9	1.1	-1.5	1.7	0.6	4.7	4.5
Supplements: Calcium	2.3	2.5	6.9	-1.0	2.6	2.0	1.5	0.6	2.6	0.7	1.0	-0.6
Alzheimer’s Disease (in mother)	2.1	2.4	5.6	-1.6	2.4	1.8	1.9	1.5	0.3	1.6	1.4	-0.1
Systolic Blood Pressure	2.1	10.6	35.0	-2.2	1.7	3.8	1.4	-2.6	1.3	0.1	5.9	5.2
Falls in the last year	2.1	2.9	9.0	1.6	0.4	1.4	0.3	-0.1	2.3	-2.3	-1.2	-3.0
Average weekly beer plus cider intake	2.1	3.0	7.0	1.9	-1.4	-1.5	-1.7	-1.1	-0.1	-1.7	-2.7	-2.3
Age started oral contraceptive pill	2.1	2.6	7.1	-1.4	2.7	2.6	1.3	0.8	0.7	1.2	1.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	5.2	2.1	-0.7	-2.0	-1.7	-1.0	1.0	-1.7	-2.3	-1.6
Verbal and Numeric Reasoning (VNR)	2.0	4.8	11.2	-2.1	3.4	1.7	2.2	2.4	-2.3	2.1	2.0	1.0
Cardiovascular Disease	2.0	6.5	22.1	-1.5	0.3	2.3	1.4	-2.8	1.2	-0.0	4.7	4.2
Current tobacco smoking	2.0	3.2	6.2	2.1	1.5	-0.6	-1.1	-0.8	2.3	-2.1	-2.1	-2.5
Heart attack	2.0	2.6	7.7	0.9	1.8	1.7	1.1	-0.3	2.8	-1.8	0.4	-1.9
Vascular/heart problems diagnosed by doctor	2.0	5.3	18.1	0.7	-0.1	-1.8	-0.5	2.5	-1.1	0.6	-4.3	-4.2
Medication: Ramipril	1.9	2.5	10.6	-0.6	3.3	1.8	1.1	-1.0	1.5	-0.2	1.7	0.7
Heart attack/myocardial infarction (self-reported)	1.9	2.4	6.7	0.7	1.9	1.9	1.1	-0.2	2.6	-1.6	0.6	-1.8
Coronary Artery Disease (CAD)	1.8	2.2	4.8	2.1	-0.6	-1.8	-0.7	-1.7	-0.4	-2.2	-1.6	-0.6
Health satisfaction	1.8	2.3	6.6	-1.2	2.6	2.2	1.0	-1.1	2.2	0.7	0.5	-0.3
Back pain experienced in last month	1.8	2.6	5.3	1.4	0.3	1.2	-2.2	-1.6	2.0	-2.3	-0.7	-1.5
Townsend deprivation index at recruitment	1.7	2.3	5.0	1.5	0.4	-0.3	-0.3	-1.9	1.6	-1.7	-2.2	-2.2
Hair/balding pattern: Pattern 2	1.7	2.2	12.1	-0.7	3.5	1.6	1.2	0.9	1.2	0.5	0.7	-0.6
Mouth/teeth dental problems	1.7	2.6	6.3	-1.7	2.3	2.5	1.4	0.9	0.2	1.8	0.9	-1.1
Mouth/teeth dental problems: Dentures	1.7	2.8	5.6	1.7	-2.4	-1.7	-1.9	-2.1	0.4	-2.1	-1.0	0.2
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.3	1.0	-2.7	-1.1	-2.1	-0.8	0.7	-0.5	-1.4	-0.8
Angina (self-reported)	1.7	2.3	6.5	-1.4	1.1	2.5	2.0	0.0	0.3	0.5	2.3	1.0
Number of full sisters	1.7	2.0	5.1	1.7	-1.5	-0.8	-0.3	-2.3	0.7	-2.1	-1.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	6.6	-0.3	-0.5	0.7	-0.7	-2.6	2.5	-0.2	0.9	1.1
Smoking status: Current	1.7	2.7	4.2	2.0	1.4	-0.8	-1.4	-0.8	2.0	-2.0	-1.8	-1.9
Systolic blood pressure, automated reading	1.6	4.6	16.0	-1.1	1.5	1.9	-0.2	-1.6	1.0	0.2	4.0	3.8
Severe depression (siblings)	1.6	1.8	4.1	-1.6	1.9	0.8	1.1	-0.2	-0.1	2.0	1.6	1.3
Qualifications: None of the above	1.6	3.4	6.5	2.3	-2.5	-1.7	-1.9	-1.5	-0.5	-2.5	-1.8	-0.4
Worrier / anxious feelings	1.6	3.0	9.3	-2.0	1.1	3.0	2.3	0.6	1.1	1.0	2.2	0.5
Birth weight of first child	1.6	2.9	6.9	1.3	-2.6	-2.1	-2.1	-2.3	-0.7	-1.1	-1.0	0.7
Medication: Blood pressure	1.6	2.9	11.8	-0.7	1.1	1.0	0.8	-0.3	0.2	-0.3	3.2	3.4
Medication: Blood pressure	1.6	3.0	7.8	-0.6	1.7	2.8	0.4	-1.5	1.7	-0.7	2.6	1.7
High cholesterol (Self-reported)	1.6	2.8	9.4	-1.2	1.1	0.9	0.2	-1.4	0.9	0.7	3.1	3.1
HDL Cholesterol	1.5	2.4	5.7	2.2	-1.1	-1.3	-2.4	0.3	0.4	-2.4	-1.5	-0.6
Angina	1.5	1.9	5.6	-1.3	0.9	2.4	2.0	-0.0	0.2	0.4	2.1	0.8
Medication: Atenolol	1.5	1.9	7.2	-0.7	0.7	1.0	0.3	1.5	-0.9	0.1	2.2	2.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.7	-1.9	0.3	0.8	1.9	-0.2	-1.3	1.9	1.0	1.2
Arm predicted mass (right)	1.5	7.7	15.7	3.2	-1.8	-2.7	-4.0	-3.6	2.4	-3.1	-2.1	-0.2
Whole body fat-free mass	1.5	8.5	15.9	3.3	-1.2	-2.4	-4.0	-4.0	3.1	-3.3	-2.5	-0.8
Number of self-reported non-cancer illnesses	1.5	2.6	6.5	-0.3	0.7	1.3	0.3	-2.2	2.5	-0.5	2.3	2.0
Basal metabolic rate	1.5	8.0	16.2	3.2	-1.1	-2.3	-3.8	-4.0	3.1	-3.2	-2.3	-0.7
Arm predicted mass (left)	1.5	7.5	15.3	2.9	-1.9	-2.4	-3.9	-3.8	2.8	-2.9	-2.0	-0.1
Diabetes (mother)	1.4	1.8	4.8	1.2	-2.2	-1.1	-1.7	-1.0	-1.3	-1.3	-1.2	-0.0
Trunk fat-free mass	1.4	8.3	17.4	3.1	-1.6	-2.4	-3.9	-4.2	3.0	-3.1	-2.2	-0.4
Trunk predicted mass	1.4	8.2	16.2	3.2	-1.5	-2.4	-3.9	-4.0	3.1	-3.2	-2.2	-0.5
Arm fat-free mass (right)	1.4	7.2	14.1	3.0	-1.8	-2.7	-3.8	-3.7	2.4	-2.8	-2.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	7.2	-0.7	-0.7	-0.2	1.3	1.7	-2.7	1.0	1.0	0.5
Leg fat-free mass (right)	1.4	7.3	13.2	3.0	-0.2	-1.8	-3.6	-3.5	3.4	-2.9	-2.6	-1.3
Medication for cholesterol	1.4	2.1	5.0	-0.4	-2.2	-1.4	0.0	1.8	-2.2	1.2	-1.4	-0.6
Whole body water mass	1.4	8.1	15.2	3.2	-1.2	-2.3	-3.8	-3.9	3.0	-3.2	-2.5	-0.8
Leg predicted mass (right)	1.4	7.4	12.8	3.1	-0.2	-1.8	-3.6	-3.5	3.4	-3.0	-2.6	-1.3
Intelligence (Savage-Jansen 2018)	1.3	4.1	10.2	-2.1	3.2	1.8	1.6	2.2	-2.0	2.5	1.2	-0.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	4.6	-1.7	0.7	0.8	1.6	0.4	-0.2	2.1	1.4	0.4
Leg fat-free mass (left)	1.3	7.0	12.2	3.1	-0.5	-2.0	-3.4	-3.5	3.1	-3.0	-2.5	-1.1
Serious illness, injury or assault to yourself	1.3	1.6	4.0	-1.1	0.7	1.8	2.0	1.1	1.6	1.0	0.5	-0.8
Medication: Levothyroxine sodium	1.3	2.2	4.3	-1.3	1.0	1.4	1.0	1.6	-1.4	0.9	2.1	2.1
Leg predicted mass (left)	1.3	6.8	12.4	3.0	-0.5	-1.9	-3.3	-3.5	3.1	-2.9	-2.4	-1.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.7	0.6	-0.0	0.4	0.2	-1.0	2.3	-0.4	-1.6	-2.4
Weight	1.3	6.6	13.3	3.0	-1.0	-2.5	-3.4	-3.6	2.3	-2.9	-2.1	-0.1
Hair/balding pattern: Pattern 3	1.3	2.0	4.0	0.9	-1.9	-1.6	-2.0	-1.1	-0.3	-1.1	0.5	2.0
Depression (self-reported)	1.3	1.6	2.7	1.1	-1.3	-0.9	-1.2	-1.2	1.4	-0.8	-1.6	-1.7
Average weekly red wine intake	1.3	1.8	7.3	-1.1	2.7	1.4	0.9	1.4	0.3	0.8	1.6	0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	6.6	-0.2	-2.2	-2.1	-0.0	-0.3	-1.1	0.7	1.1	2.6
Osteoarthritis (self-reported)	1.3	1.7	4.3	1.6	0.8	-0.5	-1.3	-0.3	0.6	-1.3	-1.9	-2.1
Financial situation satisfaction	1.3	1.6	7.2	-0.7	0.0	0.4	-0.1	-2.4	2.7	0.7	0.4	0.5
Ever smoked	1.3	2.2	4.9	1.6	0.4	-1.3	-2.2	-1.6	1.9	-2.0	-0.4	0.4
Arm fat-free mass (left)	1.3	6.4	12.6	2.8	-1.5	-2.2	-3.5	-3.6	2.6	-2.7	-1.8	-0.1
Ulcerative Colitis	1.2	1.7	7.9	1.7	0.1	-2.8	-0.4	-0.9	-0.1	-1.1	-1.5	0.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	6.7	1.9	1.4	-2.6	-1.4	-0.5	-0.5	-1.4	-1.8	0.0
Number of full brothers	1.2	1.5	4.5	1.4	-0.4	0.2	-0.8	0.7	1.1	-2.1	-1.2	-1.6
Qualifications: College or University degree	1.2	3.8	8.2	-2.6	1.9	1.4	1.7	1.4	-1.7	2.9	1.9	1.5
Average weekly champagne plus white wine intake	1.2	1.7	4.2	1.1	-2.0	-0.8	-1.2	-2.0	0.9	-1.4	-0.8	-0.5
Pack years of smoking	1.2	1.7	3.2	1.8	0.2	-0.9	-1.7	-0.1	0.7	-1.5	-1.7	-1.7
Ulcerative Colitis (UC)	1.1	2.0	8.4	0.9	-1.1	-2.9	-1.1	-1.4	-1.3	-0.1	-1.3	1.2
Triglycerides	1.1	1.9	6.9	-2.1	-0.1	0.9	1.9	0.6	-0.4	2.6	0.8	0.2
Average weekly spirits intake	1.1	1.4	4.0	1.7	-0.2	-0.3	-1.7	-0.3	0.3	-2.0	-1.3	-0.9
Trunk fat mass	1.1	4.7	10.5	2.7	-0.7	-2.4	-2.7	-3.2	1.4	-2.7	-1.5	0.4
Illnesses of siblings	1.1	1.6	6.9	-1.8	0.9	0.1	1.5	-0.1	-0.7	2.6	0.6	0.4
Number of live births	1.1	1.6	5.7	0.8	-1.7	-1.2	-1.4	-1.2	2.4	-0.4	-0.3	-0.2
Medication: Cholesterol lowering	1.1	1.7	4.5	0.9	-0.2	-0.4	-0.7	-1.7	1.0	-1.7	1.5	2.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	8.0	-0.2	0.2	0.0	-0.3	0.9	-0.3	1.2	-2.3	-2.8
Medication for pain relief, constipation, heartburn	1.1	1.9	5.1	0.3	-1.3	-2.1	-1.2	1.4	-2.3	0.3	-1.2	0.5
Leg fat mass (right)	1.1	4.3	8.4	2.6	-1.4	-2.9	-2.7	-2.5	0.4	-2.2	-1.6	0.5
Overall health rating	1.1	2.3	4.3	-1.4	1.7	2.0	1.6	-0.9	1.1	0.8	2.1	1.4
Loneliness, isolation	1.1	1.6	4.5	1.2	-0.0	0.2	-1.5	-1.5	2.1	-1.4	-0.5	-1.3
Qualifications: nursing, teaching	1.1	1.7	6.4	-1.2	2.5	1.4	1.8	0.6	0.2	1.0	0.7	-0.5
Mother’s age at death	1.1	1.4	3.1	-1.2	1.4	0.2	1.8	0.4	-1.1	1.1	1.2	1.5
Medication: Lisinopril	1.1	1.4	4.8	-0.5	-0.7	-0.1	0.7	-0.6	-2.1	0.1	1.3	2.2
Risk taking	1.1	1.6	3.7	1.7	-1.1	-1.4	-0.3	-0.2	0.4	-1.4	-1.9	-1.7
Leg fat mass (left)	1.1	4.4	8.4	2.6	-1.2	-2.8	-2.9	-2.6	0.5	-2.3	-1.6	0.5
Bipolar Disorder (2011)	1.0	1.0	3.7	-0.1	-1.8	-1.0	1.1	0.0	-1.9	0.0	0.0	0.0
LDL Cholesterol	1.0	1.6	3.8	1.0	-1.0	-0.8	-1.9	-1.1	1.5	-0.7	-1.5	-1.3
Pack years adult smoking proportion	1.0	1.6	3.4	1.6	0.3	-0.4	-1.5	-0.1	1.3	-1.4	-1.4	-1.8
Taking other prescription medications	1.0	1.5	4.7	-0.9	1.6	1.8	2.2	0.1	0.5	0.8	1.1	0.2
Past tobacco smoking	1.0	1.8	4.0	-1.5	0.2	1.4	2.0	1.8	-0.4	1.8	0.2	-0.8
Financial difficulties in last 2 years	1.0	1.3	4.1	0.8	-1.1	-0.4	-0.5	-2.0	1.8	-1.0	-1.0	-0.6
Hip circumference	1.0	4.5	7.5	2.7	-0.1	-2.2	-2.5	-1.9	2.4	-2.4	-2.3	-0.9
Eye problems/disorders: Glaucoma	1.0	1.2	5.3	-1.1	0.9	0.8	0.8	2.3	0.1	1.6	0.2	0.2
Pain experienced in last month	1.0	1.7	4.0	-1.9	0.5	1.5	1.0	1.2	-0.3	2.0	1.4	0.7
Reaction Time	0.9	1.7	6.6	-1.8	0.2	0.8	2.6	0.0	-0.6	2.2	0.3	0.1
Blood White Count	0.9	6.8	21.6	2.2	-4.1	-4.6	-2.2	-0.3	-2.6	-1.1	-2.0	1.2
Height	0.9	16.9	55.8	3.3	-0.8	-0.3	-3.8	-7.5	6.8	-4.9	-0.2	-0.3
Number of treatments/medications taken	0.9	1.6	5.6	-0.6	1.3	1.6	0.7	-0.7	0.9	0.2	2.4	1.7
Medication: Co-codamol	0.9	1.1	2.0	-1.3	0.1	1.2	1.4	0.7	-0.3	1.0	1.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.0	0.2	1.2	1.2	0.4	0.2	1.3	-0.4	-0.8	-2.2
Age when periods started (menarche)	0.9	2.2	9.4	0.6	-0.5	0.9	-0.6	-3.1	2.4	-1.6	0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	4.5	0.3	-0.4	0.5	-0.3	-1.3	2.1	-0.4	-0.4	-1.3
Sitting height	0.9	6.6	22.2	2.2	-1.2	-0.5	-2.4	-4.7	3.6	-3.4	-0.6	-0.0
Medication: Simvastatin	0.9	1.3	4.6	-0.2	1.1	0.5	0.3	-1.4	-0.6	-0.6	1.7	2.1
Prospective memory result	0.9	1.2	3.3	1.2	-1.0	-0.4	-0.2	-0.1	1.6	-1.0	-0.9	-1.8
Standing height	0.9	9.3	34.0	2.3	-1.4	-0.2	-3.0	-5.8	4.4	-3.7	-0.3	-0.0
Worry too long after embarrassment	0.9	1.6	3.9	-1.4	1.2	1.2	0.7	0.3	-0.6	1.1	2.0	1.7
Neck or shoulder pain in last month	0.9	1.2	2.7	1.5	-0.1	0.1	-1.0	-0.6	1.0	-1.6	-1.2	-1.5
Medication: Omeprazole	0.9	1.1	4.1	-0.1	1.3	1.4	0.0	-1.0	2.0	-0.1	0.4	-0.9
Mean time to correctly identify matches	0.9	1.7	5.0	-1.6	1.0	0.5	2.2	0.4	-1.3	2.1	0.4	0.4
Whole body fat mass	0.9	3.9	8.5	2.5	-0.6	-2.2	-2.5	-2.9	1.3	-2.4	-1.4	0.4
Knee pain experienced in last month	0.9	1.5	3.5	1.2	-1.7	-1.9	-0.9	-1.4	-0.3	-0.7	-1.3	-0.5
Illnesses of siblings: Diabetes	0.9	1.1	3.3	1.0	0.3	-0.1	-1.0	0.5	-0.2	-1.2	-1.5	-1.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	5.3	-0.7	1.0	1.0	-0.3	-1.0	2.3	0.5	0.9	0.3
Long-standing illness, disability or infirmity	0.9	1.4	3.7	-0.8	1.9	1.6	1.0	-0.1	1.1	0.4	1.4	1.1
Friendships satisfaction	0.9	1.1	4.4	-0.7	1.1	1.3	0.3	-0.6	2.1	0.7	-0.4	-1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.3	-1.3	1.5	0.9	1.0	0.3	-0.7	1.3	1.5	1.0
Leg fat percentage (left)	0.9	3.3	8.5	2.2	-1.1	-2.9	-2.4	-1.7	-0.7	-1.9	-1.1	1.1
Bipolar Disorder (2018)	0.8	1.2	6.1	0.2	-0.7	-0.5	-0.4	-2.5	-0.8	-0.3	0.5	1.7
Ovarian Cancer	0.8	1.1	4.3	0.5	0.7	0.5	1.0	-0.7	1.2	-0.5	-1.2	-2.1
Prostate Cancer	0.8	1.2	3.8	-0.1	-1.5	-0.6	-1.5	-1.3	-2.0	0.1	-0.4	0.3
Crohns Disease (2012)	0.8	1.3	2.8	-1.3	1.1	0.6	1.7	0.9	-0.3	1.3	1.2	1.2
Fasting Glucose	0.8	1.0	3.8	0.9	-0.1	-1.3	-2.0	0.4	-0.8	-0.3	-1.2	-0.4
Blood Red Count	0.8	8.0	27.8	-3.2	0.2	-0.4	1.3	1.1	-1.9	3.5	3.9	5.3
Heel T-Score	0.8	6.6	18.6	3.0	0.4	-3.3	-1.8	0.8	0.4	-1.7	-4.3	-3.7
BMI	0.8	4.4	11.9	2.9	-0.5	-3.4	-2.6	-1.3	-0.4	-2.2	-2.2	0.4
Smoking Status	0.8	2.0	3.7	1.6	-0.4	-1.7	-1.5	-1.9	0.8	-1.7	-1.5	-0.7
Hearing difficulty/problems: Yes	0.8	1.2	6.4	-0.6	0.7	-0.0	2.5	-1.3	-1.0	0.5	-0.1	-0.2
Stomach or abdominal pain in last month	0.8	0.9	2.3	0.7	-0.9	-0.9	-1.0	-0.7	-1.0	-0.5	-1.5	-1.0
Waist circumference	0.8	2.9	5.7	2.1	-0.7	-2.2	-2.4	-1.9	1.3	-1.8	-1.1	0.9
Diabetes (self-reported)	0.8	1.2	2.8	1.0	0.8	-1.7	-1.5	-1.1	-0.3	-0.9	-0.7	1.1
Pulse rate	0.8	1.3	4.5	-0.1	2.1	0.7	0.9	1.9	-1.5	0.1	-0.0	-0.7
Medication: Lansoprazole	0.8	0.9	3.6	-0.5	1.9	1.2	0.7	0.0	1.5	0.3	0.5	-0.4
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	-1.4	-1.9	1.5	1.1	-1.5	0.4	1.3	1.6	1.3
Pulse wave reflection index	0.8	1.0	2.8	0.5	-0.5	0.6	-1.3	-1.5	1.7	-1.2	0.2	-0.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.2	1.4	-1.3	-0.1	-0.6	-0.4	0.9	-1.5	-0.6	-0.8
Leg fat percentage (right)	0.8	3.0	8.2	2.2	-1.2	-2.9	-2.0	-1.6	-0.7	-1.9	-1.0	1.1
Medication: Atorvastatin	0.8	1.0	4.6	-0.8	-0.0	0.4	-0.3	0.2	2.1	0.7	1.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	0.4	0.9	1.2	0.0	-1.4	1.6	-0.5	-0.3	-1.2
Crohns Disease (2017)	0.7	1.5	3.3	-1.4	-0.2	0.6	1.2	0.6	-1.1	1.3	1.8	1.8
Chronotype (morning person)	0.7	1.7	5.6	1.7	-0.7	-1.4	-2.4	-0.0	0.7	-1.6	0.3	1.2
Relative age of first facial hair	0.7	1.4	3.3	-1.8	-0.6	0.8	0.2	1.0	0.5	1.8	1.7	1.0
Ever had hysterectomy (womb removed)	0.7	0.7	2.0	-1.3	0.8	1.4	0.2	-0.8	0.6	0.9	0.7	-0.3
Medication: Metformin	0.7	1.0	2.8	0.3	1.3	-1.4	-0.9	-1.7	-0.2	-0.0	-0.1	1.4
Trunk fat percentage	0.7	2.6	4.7	2.1	-0.4	-2.0	-1.9	-2.2	0.7	-2.1	-1.0	0.6
Hand grip strength (right)	0.7	1.9	5.7	1.2	-2.4	-0.9	-0.9	-2.2	0.5	-1.6	-0.6	0.6
High blood pressure (mother)	0.7	1.0	2.7	-0.2	1.0	1.4	-0.1	-0.3	0.6	-0.8	1.7	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.8	0.8	1.1	0.6	-0.0	-0.4	1.9	-1.1	-0.6	-1.4
Had menopause	0.7	0.9	5.1	-0.2	2.2	0.9	0.7	-0.1	1.0	0.2	0.4	-0.8
Forced vital capacity (FVC)	0.7	2.8	4.3	1.7	-2.1	-1.3	-1.6	-1.4	0.3	-2.0	-1.9	-2.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.0	1.6	-1.7	-1.1	-1.0	-1.4	-0.0	-1.9	-1.9	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.3	1.6	-1.0	-0.7	-1.0	-1.7	0.4	-2.0	-1.7	-2.1
Arm fat mass (right)	0.7	2.7	4.6	2.1	-0.1	-1.8	-1.9	-2.1	1.5	-1.9	-1.8	-0.3
Length of working week for main job	0.7	0.8	2.6	0.6	-0.3	-0.9	-0.0	-1.1	0.7	-0.1	-1.6	-1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.0	-0.6	-1.7	-0.2	-0.8	-0.6	0.0	0.7	1.0	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	4.2	-0.3	0.6	1.1	0.6	2.0	-0.1	0.3	-0.2	-1.1
Eye problems/disorders: None of the above	0.7	0.8	2.5	1.1	-0.4	-0.5	-1.2	-1.1	-0.4	-1.6	-0.5	0.0
Pulse rate, automated reading	0.7	2.2	5.9	-0.7	2.2	0.9	2.3	2.4	-1.0	1.1	-0.1	-0.5
Suffer from ‘nerves’	0.7	1.1	3.3	0.3	-0.6	1.0	-0.1	-1.5	1.8	-1.5	0.7	0.1
Leg pain on walking	0.7	0.8	2.5	-1.2	0.6	0.7	0.5	1.1	-0.9	1.6	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.7	1.5	-1.1	-1.0	-1.3	0.3	-0.5	-1.3	-1.5	-1.9
Arm fat mass (left)	0.7	3.0	5.2	2.2	-0.2	-2.0	-2.1	-2.3	1.3	-1.9	-1.8	-0.3
Guilty feelings	0.7	1.0	3.2	-0.7	0.4	1.5	1.3	1.8	0.2	0.5	1.0	-0.5
Medication: Bendroflumethiazide	0.7	1.1	3.8	-0.6	0.7	1.3	-0.0	-0.7	-0.3	-0.2	1.8	1.9
Illnesses of father: High blood pressure	0.7	0.8	1.9	-0.6	0.7	1.3	0.1	-1.1	0.4	-0.3	1.3	1.4
Unable to work because of sickness or disability	0.7	0.9	3.8	-0.3	0.7	1.0	1.1	-0.5	1.9	0.4	-0.4	-1.1
Commuting to job workplace: Cycle	0.7	0.9	2.5	0.1	-1.1	-1.6	-0.1	-1.3	-1.2	0.5	-0.2	0.8
Alcohol drinker status: Previous	0.7	0.8	3.6	0.1	-0.6	-0.5	-0.7	-0.2	-1.1	0.0	0.9	1.9
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	-1.0	-0.8	0.4	-0.6	-1.7	1.0	0.6	1.7	1.7
Schizophrenia vs Biploar Disorder	0.6	0.9	4.3	-1.0	-0.0	0.6	0.6	2.1	-0.7	1.1	0.1	0.2
Body Mass Index (BMI) (2010)	0.6	0.8	2.7	1.1	-1.0	-1.6	-1.1	-0.3	-0.2	-0.6	-0.8	0.3
Mean Putamen Volume	0.6	0.7	1.9	-1.1	-0.7	1.4	0.7	0.8	0.3	0.9	0.7	0.1
Lupus	0.6	1.0	2.7	-0.8	-1.3	-0.5	-0.2	-0.9	-1.3	0.6	0.2	1.6
Rheumatoid Arthritis	0.6	0.8	2.7	0.4	1.5	0.8	1.6	0.6	-0.2	-0.6	-0.2	-0.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.8	0.6	1.0	0.2	-0.5	0.2	0.8	-0.5	-1.1	-1.9
Vitamin and mineral supplements	0.6	0.8	2.6	-0.4	1.1	0.6	1.5	1.6	-0.5	-0.0	0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.9	-0.2	0.5	0.2	-0.8	-0.8	-0.7	0.1	1.3	1.7
Body mass index (BMI)	0.6	2.6	6.1	2.2	-0.4	-2.5	-2.1	-1.2	0.4	-1.4	-2.1	-0.2
Time employed in main current job	0.6	0.7	1.5	-0.8	0.9	1.2	0.9	1.1	-0.5	0.6	0.9	0.2
Alcohol intake versus 10 years previously	0.6	0.9	5.0	0.1	-2.2	-0.4	-0.5	-1.4	-0.1	-0.2	-0.4	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	0.0	-0.7	1.0	-0.8	-1.3	1.4	-0.8	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	0.8	-0.1	-1.4	-0.1	0.9	-1.1	-0.5	-1.3	-0.1
Birth weight	0.6	1.3	3.0	1.1	-0.6	-0.4	-1.7	-1.1	-1.5	-1.5	-0.9	-0.8
High blood pressure (siblings)	0.6	0.8	3.3	0.8	-0.3	0.7	-0.2	0.3	1.1	-1.8	1.0	0.7
Body fat percentage	0.6	2.6	5.0	2.1	-0.3	-2.2	-1.9	-2.0	0.2	-2.0	-1.0	0.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.3	0.9	-1.5	-0.8	-0.8	-1.4	1.0	-0.7	-1.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	-0.2	-1.2	-0.2	0.2	-1.0	0.3	-0.2	1.0	1.5
Age at first live birth	0.6	1.1	2.2	-1.3	0.4	1.3	1.4	-1.5	0.8	1.2	0.7	0.4
Emphysema/chronic bronchitis	0.6	0.7	2.3	-0.7	-1.2	0.3	-0.9	-0.3	1.5	0.7	0.4	0.6
Comparative height size at age 10	0.6	3.3	11.8	1.7	-1.3	-0.9	-2.5	-3.4	1.4	-1.9	-0.7	-0.0
Chest pain or discomfort	0.6	0.9	2.6	-0.6	-0.9	1.6	0.8	-1.1	0.9	0.2	1.2	-0.2
Illnesses of father: Heart disease	0.6	0.8	1.9	1.3	1.0	-0.6	-0.9	0.4	1.0	-1.4	-0.4	-0.7
Medication: Gliclazide	0.6	0.7	2.3	0.0	1.1	-1.5	-0.8	-1.0	0.5	0.4	-0.3	0.7
Wears glasses or contact lenses	0.6	0.7	2.4	-0.0	0.7	-0.8	-0.1	1.2	-0.4	0.4	0.9	1.6
Ever taken oral contraceptive pill	0.6	0.6	2.2	0.4	-1.2	-0.8	-0.6	-1.5	0.6	-0.3	-0.6	-0.4
Commuting to job workplace: Public transport	0.6	0.7	2.7	0.3	1.7	0.9	-0.1	-0.7	0.7	-0.5	-0.7	-1.1
Ever depressed for a whole week	0.6	0.7	2.3	-0.7	-1.1	1.3	1.5	-0.1	0.6	0.3	0.5	-0.3
Myopia	0.6	0.9	2.6	-0.6	0.4	0.7	1.1	-1.2	0.1	0.0	1.6	1.4
Heart disease (siblings)	0.6	0.7	2.2	1.2	-0.1	0.3	-1.0	0.2	-0.1	-1.5	-0.7	-1.1
Depression (Nagel 2018)	0.5	0.7	3.0	0.5	0.9	-0.2	-0.1	0.5	1.0	-0.2	-1.2	-1.7
Worry (Nagel 2018)	0.5	1.0	2.6	-0.5	-0.6	0.8	1.6	-0.4	0.1	-0.4	1.5	1.5
Alzheimer’s Disease (in father)	0.5	0.5	2.1	0.3	-0.3	-1.4	-0.6	-0.8	-0.6	0.0	0.3	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	3.7	-0.2	-1.1	-1.5	-0.3	-0.9	-1.3	0.5	0.3	1.9
Maternal smoking around birth	0.5	0.7	2.5	-0.1	-1.6	-0.4	0.1	-0.7	0.5	0.6	-1.4	-0.6
Had other major operations	0.5	0.6	2.3	-0.3	1.5	1.2	-0.4	-0.2	0.7	-0.1	0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.5	1.6	-0.1	-2.1	-0.3	0.9	-0.1	-1.1	-1.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.1	-0.4	0.4	1.1	1.8	0.2	0.3	0.2	0.3	-0.7
Impedance of arm (right)	0.5	2.5	8.4	-1.5	1.7	2.9	2.1	0.3	0.8	0.5	1.8	-0.5
Arm fat percentage (right)	0.5	1.8	3.7	1.9	0.5	-1.7	-1.6	-1.4	0.7	-1.6	-1.4	-0.2
Happiness	0.5	0.6	1.3	-0.9	1.1	0.5	0.1	-1.1	0.5	0.9	0.4	0.4
Loud music exposure frequency	0.5	0.6	1.9	0.7	0.4	-0.8	-1.4	-0.0	0.6	-0.2	-1.0	-0.8
Gout (self-reported)	0.5	0.7	1.5	0.9	0.1	-0.9	-0.8	-1.2	-0.7	-0.9	-1.1	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.8	3.7	1.4	-1.1	-0.5	-1.1	-1.9	0.9	-1.9	-1.1	-1.6
Shortness of breath walking on level ground	0.5	0.6	2.7	0.2	-0.4	0.6	-1.4	0.1	1.6	-0.3	0.3	0.3
Medication: Seretide 50 evohaler	0.5	0.6	3.7	-0.4	0.4	0.7	0.6	-0.5	1.9	0.2	0.6	0.1
Heart disease (mother)	0.5	0.6	2.2	0.3	-0.5	0.1	-0.5	-1.2	1.5	-0.7	-0.4	-0.6
Medication: Aspirin	0.5	0.6	1.5	0.3	0.8	1.0	0.8	-0.2	1.2	-0.9	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	0.4	1.2	0.2	-1.2	-0.4	1.1	-0.5	-0.4	-0.5
Smoking status: Previous	0.5	0.8	1.3	0.5	-0.7	-0.9	-1.1	-1.1	-0.9	-0.9	0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.9	1.2	-0.1	-0.3	-0.5	-1.2	0.7	-1.7	-1.5	-0.8
Arm fat percentage (left)	0.5	2.0	4.2	2.0	0.4	-1.8	-1.6	-1.4	0.5	-1.7	-1.6	-0.2
Ever had bowel cancer screening	0.5	0.6	1.6	1.1	1.0	-0.3	0.1	-1.1	0.6	-1.3	-0.4	-0.3
Diabetes diagnosed by doctor	0.5	0.8	2.2	0.8	1.5	-1.4	-0.8	-0.1	-0.2	-0.7	-0.5	0.9
Number of operations (self-reported)	0.5	0.7	2.8	-0.1	0.6	0.6	0.2	-1.7	1.4	-0.4	0.6	-0.0
Irritability	0.5	0.9	2.9	-0.5	1.7	1.6	1.2	0.2	-0.1	-0.1	0.5	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.0	1.0	-0.6	-0.5	-0.1	-0.8	0.5	-1.4	-0.6	-0.1
Age at First Birth	0.4	0.6	1.3	-0.6	0.9	0.8	0.4	-1.1	1.0	0.6	0.9	0.3
Waist Hip Ratio (WHR)	0.4	1.9	8.1	-0.8	-1.1	0.5	0.3	-1.4	-0.3	0.3	2.1	2.9
Neuroticism	0.4	1.0	3.1	-0.8	0.3	1.3	0.7	-1.1	0.5	-0.1	1.8	1.5
Medication for hormone replacement therapy	0.4	0.4	1.6	0.4	1.3	-0.4	-0.6	-0.3	1.0	-0.4	0.1	0.5
Diabetes (father)	0.4	0.5	3.3	0.1	0.2	-0.1	0.7	-0.2	1.8	-0.5	-0.4	-0.3
Impedance of leg (right)	0.4	2.2	6.7	-1.2	-1.8	0.8	1.2	-0.3	-1.3	0.2	2.6	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.2	1.5	0.3	-1.8	0.0	0.7	0.2	-1.1	-0.9	-0.2
Supplements: Glucosamine	0.4	0.6	1.8	0.7	-0.8	-1.0	-1.0	-1.3	0.2	-0.4	0.0	0.2
Impedance of leg (left)	0.4	1.9	6.6	-1.1	-1.5	0.9	0.7	-0.4	-0.9	0.0	2.6	2.1
Number of incorrect matches in round	0.4	0.6	1.2	0.5	-0.9	-1.1	-0.7	-0.6	-0.9	0.0	-1.1	-0.6
Illnesses of mother	0.4	0.5	1.2	-0.4	-0.3	-0.6	0.3	1.1	-1.0	0.9	-0.5	-0.2
Impedance of arm (left)	0.4	1.9	5.6	-1.4	1.3	2.4	2.1	0.3	0.2	0.4	1.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.6	-1.0	-0.1	0.8	-0.2	-1.0	0.7	0.7	0.8
Medication: Paracetamol	0.4	0.6	2.7	0.4	-0.5	-0.7	-1.1	-1.6	0.3	0.1	-0.7	-0.4
Medication: Amlodipine	0.4	0.6	2.0	0.9	0.3	-0.2	-1.4	-1.0	-0.0	-1.1	-0.4	0.5
Comparative body size at age 10	0.4	1.2	4.9	-0.6	1.0	-0.2	1.1	2.2	-1.0	1.4	0.3	-0.3
Pulse wave peak to peak time	0.4	0.4	1.0	0.1	0.5	-1.0	0.6	0.9	-1.0	0.7	-0.1	0.4
Migraine (self-reported)	0.4	0.5	2.7	0.3	-0.5	-0.2	0.3	-1.7	0.0	-0.6	0.7	0.8
Alcohol intake frequency.	0.4	1.0	2.3	-1.3	-0.8	0.8	1.5	0.1	-0.6	1.5	0.9	0.7
Family relationship satisfaction	0.4	0.5	1.8	-0.1	-0.5	0.1	0.2	-1.4	1.3	0.0	-0.6	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.7	0.2	-0.5	0.0	0.2	1.6	-1.0	-0.3	0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	1.1	-0.1	-0.2	-0.4	0.8	0.7	-1.3	-0.4	-0.1
Commuting to job workplace: Walk	0.4	0.4	1.3	-0.2	-0.4	0.2	-0.0	-1.1	0.7	0.0	-0.7	-1.1
Eye problems/disorders: Cataract	0.4	0.5	2.0	0.0	-0.2	-0.0	0.5	0.4	-0.4	0.1	-1.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.6	0.1	-0.6	0.6	-0.1	-1.3	1.1	-0.1	0.2	-0.4
Hearing aid user	0.4	0.4	1.3	0.5	-0.9	-0.9	0.6	0.6	-1.1	-0.2	-0.2	0.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.6	0.5	0.5	-0.1	0.0	0.5	-1.6	-0.6	-0.0	0.2
Impedance of whole body	0.4	2.0	6.2	-1.5	-0.1	2.1	1.8	0.1	-0.5	0.3	2.5	1.1
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	0.1	-1.2	-0.7	0.3	-0.6	-1.4	0.4	0.6	1.5
Neuroticism (Nagel 2018)	0.3	0.8	2.6	-0.6	-0.4	0.5	0.3	-1.0	0.3	-0.1	1.6	1.5
Schizophrenia (2018)	0.3	0.6	1.3	-0.1	-1.1	-0.4	0.9	1.0	-1.2	0.7	0.3	0.6
Major Depression (MDD)	0.3	0.4	1.5	-0.8	0.1	-0.1	-0.1	0.1	0.2	1.2	1.0	0.8
Schizophrenia (2014)	0.3	0.6	1.4	-0.0	-1.1	-0.8	0.5	0.4	-1.2	0.7	0.4	1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	0.2	-0.3	-1.0	-0.2	0.3	0.5	-0.0	-0.0	1.1
Hypothyroidism (self reported)	0.3	0.8	2.3	-0.7	0.9	1.3	1.5	0.4	-0.4	0.6	0.9	0.5
Respiratory disease	0.3	0.7	1.6	-1.0	-0.8	0.6	0.1	-0.0	0.1	1.2	1.2	1.3
Hand grip strength (left)	0.3	0.9	3.4	0.8	-1.1	-0.1	-0.7	-1.8	0.2	-1.2	-0.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.4	-0.4	0.4	0.1	-0.9	-0.0	0.1	1.3	1.0
Fed-up feelings	0.3	0.5	1.6	-0.3	-1.2	-0.4	0.1	-1.3	0.8	0.2	0.6	0.5
Multivitamins +/- minerals	0.3	0.4	1.5	-0.5	-0.2	0.8	-0.3	-1.2	0.9	0.4	0.2	-0.4
Nervous feelings	0.3	0.6	1.5	-0.0	-0.7	0.4	0.3	1.2	-0.3	-0.7	1.0	1.2
Allergy	0.3	0.7	2.7	0.3	0.7	-0.7	-0.9	1.2	-1.6	-0.1	0.2	0.7
Father’s age at death	0.3	0.4	1.8	0.2	0.6	-0.5	-0.5	0.7	-1.3	-0.3	-0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-1.0	-0.3	1.1	0.2	-0.1	1.0	0.8	0.7	-0.1
Noisy workplace	0.3	0.3	1.3	0.3	-0.3	-0.7	-0.4	-0.3	-0.2	0.1	-1.1	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.6	-0.1	-0.9	-0.3	-0.7	-1.3	-0.0	-0.0	-0.1	0.5
Asthma	0.3	0.5	1.0	-0.7	-0.7	0.2	1.0	0.0	0.9	1.0	0.7	0.6
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.4	-0.6	0.6	0.3	0.4	1.0	0.3	0.7	-0.2
Glaucoma (self-reported)	0.3	0.4	2.5	-0.2	-0.1	-0.3	0.2	1.6	0.1	0.8	-0.4	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	-0.7	0.2	1.2	0.5	-0.0	-0.3	0.4	1.3	1.1
Exposure to tobacco smoke outside home	0.3	0.4	1.0	0.5	-0.7	-1.0	-0.6	0.5	-0.5	-0.2	-0.7	-0.3
Had major operations	0.3	0.3	1.1	0.1	-0.2	-0.0	1.1	-0.9	0.9	-0.2	-0.1	-0.3
Age at last live birth	0.3	0.5	2.9	-0.5	-0.1	-0.3	0.4	-1.7	0.4	0.6	0.2	0.6
Breast cancer (self-reported)	0.3	0.4	1.4	0.7	-0.1	-0.7	0.1	-0.0	-1.2	-0.5	-0.9	-0.4
Medication: Aspirin	0.3	0.5	1.5	0.5	0.5	0.6	0.7	-0.2	1.2	-0.9	0.6	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	-0.4	0.1	0.6	0.0	1.0	-0.9	0.6	-0.2	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	0.0	0.6	0.4	1.0	1.2	-0.4	-0.1	0.3	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.6	0.6	-0.6	0.4	0.4	0.6	-0.1	-1.1	-0.8
Cholesterol lowering medication	0.3	0.5	1.3	-0.5	0.4	0.7	0.6	-1.0	0.3	0.3	1.1	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.4	-0.0	0.2	0.2	1.2	-1.0	0.4	0.7	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.5	-0.0	1.2	0.3	0.6	-0.0	0.2	-0.1	0.8	0.1
Breast Cancer	0.2	0.6	2.8	0.3	0.1	0.6	-0.6	0.2	0.3	-0.7	-1.1	-1.7
Neuroticism (2016)	0.2	0.2	0.6	0.4	-0.7	-0.2	0.4	0.7	0.5	-0.8	0.0	-0.0
Lung FEV1/FVC ratio	0.2	0.9	1.8	1.3	0.3	-0.8	0.3	-0.6	-0.8	-1.1	-1.3	-1.1
Lung FVC	0.2	0.9	2.2	0.6	-0.8	-1.0	-0.3	1.3	-1.5	-0.3	-1.1	-1.1
Hair Pigment	0.2	4.8	16.3	-1.2	-3.7	-0.4	0.3	-4.0	2.5	0.7	0.7	2.2
Sensitivity / hurt feelings	0.2	0.4	1.4	0.4	-1.2	-0.6	-0.2	-1.0	-0.3	-0.6	-0.1	0.6
Average weekly fortified wine intake	0.2	0.3	0.8	0.3	0.9	-0.1	0.1	0.6	-0.1	-0.1	-0.8	-0.8
Relative age voice broke	0.2	0.4	1.6	-1.0	-0.7	-0.3	-0.0	-0.0	0.4	1.2	0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.2	-0.3	0.8	1.1	0.4	-0.3	0.4	0.1	0.1	-0.8
Alcohol usually taken with meals	0.2	0.3	0.7	0.6	0.5	-0.3	-0.8	0.7	0.2	-0.8	-0.2	0.0
Pain all over the body in last month	0.2	0.2	0.8	-0.4	-0.1	-0.3	0.9	-0.4	0.3	0.4	0.2	0.3
Lung cancer (father)	0.2	0.2	0.8	-0.3	0.2	0.3	0.3	-0.5	0.9	0.6	0.7	0.0
Tense / ‘highly strung’	0.2	0.3	1.2	0.7	-0.4	0.1	-0.2	-1.0	-0.1	-1.1	-0.1	0.2
Peak expiratory flow (PEF)	0.2	0.4	1.8	0.7	-0.5	-0.3	-0.2	-0.4	0.0	-1.3	-0.8	-0.6
Number of children fathered	0.2	0.2	1.0	-0.1	-1.0	-0.4	-0.9	-0.2	0.1	0.1	-0.1	0.3
Medication: Allopurinol	0.2	0.2	1.7	0.0	1.3	0.3	0.3	-0.2	-0.4	-0.3	0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.6	-0.2	-0.1	-0.6	0.5	-0.3	0.9	-0.5	0.4
Mood swings	0.2	0.3	1.9	0.0	-0.3	0.2	-0.2	-0.5	1.4	-0.1	0.0	-0.5
Asthma (self-reported)	0.2	0.4	0.9	-0.5	-0.9	-0.1	0.8	-0.1	0.6	0.8	0.7	0.8
Miserableness	0.2	0.4	1.0	-0.5	0.2	0.9	-0.4	-0.9	1.0	0.1	0.3	-0.4
Medication: Paracetamol	0.2	0.4	1.7	0.2	-0.6	-0.2	-0.5	-1.3	0.8	0.3	-0.1	-0.3
Alcohol drinker status: Never	0.2	0.3	0.8	-0.2	-0.3	0.7	-0.5	0.9	-0.6	0.2	0.4	-0.6
Blood Eosinophil Count	0.1	0.9	3.5	0.4	-1.9	-0.7	0.1	-0.6	-0.3	-0.6	0.8	1.7
Allergy or Eczema	0.1	0.4	1.0	0.5	1.0	0.5	-0.4	0.5	-0.3	-0.5	-0.2	-0.9
Tanning	0.1	1.6	5.0	0.9	1.7	0.4	0.0	-0.3	2.2	-0.7	-0.8	-2.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.3	0.2	0.1	-0.5	-0.2	0.6	-0.6	0.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.5	-0.1	0.3	0.1	-0.4	0.0	0.7	0.0	-0.3	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.3	-0.5	-0.5	-0.5	0.1	-0.1	0.1	-0.7	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.1	0.5	-0.5	0.4	-0.7	-0.6	-0.2	-0.3	-0.1
Neuroticism score	0.1	0.3	1.0	-0.1	-0.4	0.7	0.3	-0.5	0.6	-0.3	1.0	0.5
Breastfed as a baby	0.1	0.2	0.4	-0.1	-0.3	0.1	-0.6	-0.5	-0.2	-0.2	0.6	0.5
Headache pain in last month	0.1	0.2	0.6	0.1	-0.4	0.8	0.1	0.6	0.5	-0.5	0.5	0.3
Mineral and other dietary supplements	0.1	0.1	0.8	-0.2	-0.9	0.2	-0.4	-0.0	-0.1	-0.1	0.1	0.3

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