TWAS
hub
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Models
Genes
Traits
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Traits
:
Blood Red Count
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chr2:42,296,221-44,307,450
Best TWAS P=3.19e-11 · Best GWAS P=1.08e-17 conditioned to 7.06e-16
42.5M
43M
43.5M
44M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
ABCG5
0.05
0.04
blup
75
0.02
1.6e-03
6.21
-6.6
3.2e-11
0.05
0.02
0.97
TRUE
2
GTEx
Testis
HAAO
0.30
0.08
lasso
6
0.12
5.0e-06
-1.11
6.1
1.3e-09
-0.03
0.76
0.02
TRUE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
PLEKHH2
0.07
0.00
blup
127
0.03
3.2e-04
-0.87
-5.6
1.6e-08
-0.01
0.09
0.33
FALSE
1
GTEx
Stomach
AC010883.5
0.16
0.07
lasso
6
0.07
2.4e-04
5.45
-5.5
4.8e-08
0.10
0.33
0.03
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
ABCG5
0.03
0.01
blup
75
0.02
3.0e-03
4.17
-5.4
6.1e-08
0.03
0.10
0.48
FALSE