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chr2:26,883,355-29,792,216

Best TWAS P=2.94e-22 · Best GWAS P=2.39e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	9.41	9.7	2.9e-22	0.96	0.00	0.98	TRUE
87	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	7.92	9.1	5.7e-20	0.61	0.00	0.85	TRUE
83	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRMT61B	0.13	0.12	enet	14	0.13	2.7e-08	7.44	8.1	6.2e-16	-0.06	0.02	0.98	TRUE
18	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	8.73	9.2	3.4e-20	0.81	0.03	0.25	FALSE
39	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	-0.53	9.1	7.5e-20	0.79	0.17	0.22	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	9.26	8.6	5.6e-18	0.92	0.01	0.84	FALSE
41	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	8.07	8.2	2.1e-16	0.53	0.97	0.03	FALSE
10	GTEx	Artery Coronary	TRMT61B	0.21	0.16	lasso	3	0.17	2.8e-06	7.66	8.0	9.1e-16	-0.05	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	PPP1CB	0.05	0.02	blup	39	0.03	4.7e-03	7.22	-8.0	9.3e-16	0.05	0.04	0.82	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	8.63	7.9	2.0e-15	0.49	0.00	1.00	FALSE
8	GTEx	Adrenal Gland	PPP1CB	0.16	0.07	lasso	6	0.07	1.6e-03	7.42	-7.9	2.3e-15	0.06	0.03	0.92	FALSE
43	GTEx	Thyroid	PPP1CB	0.07	0.00	enet	7	0.00	3.4e-01	7.66	-7.9	2.8e-15	0.06	0.02	0.94	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPDYA	0.05	0.03	blup	49	0.05	6.0e-03	7.14	7.9	4.0e-15	-0.05	0.02	0.67	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRMT61B	0.12	0.15	lasso	4	0.16	1.7e-17	7.50	7.8	4.8e-15	-0.05	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	TRMT61B	0.35	0.22	lasso	3	0.22	2.1e-07	7.66	7.8	5.6e-15	-0.06	0.01	0.98	FALSE
14	GTEx	Brain Frontal Cortex BA9	TRMT61B	0.39	0.24	lasso	8	0.17	3.5e-05	7.50	7.8	6.3e-15	-0.07	0.02	0.97	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRMT61B	0.12	0.18	lasso	4	0.18	1.8e-10	7.52	7.8	7.2e-15	-0.06	0.01	0.99	FALSE
12	GTEx	Brain Caudate basal ganglia	TRMT61B	0.22	0.01	enet	5	0.04	2.5e-02	7.66	7.8	8.6e-15	-0.05	0.02	0.94	FALSE
15	GTEx	Brain Frontal Cortex BA9	PPP1CB	0.27	0.14	lasso	5	0.12	4.3e-04	7.14	-7.8	8.7e-15	0.05	0.04	0.86	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUPT7L	0.03	0.04	blup	29	0.03	7.2e-05	5.83	7.8	8.7e-15	0.77	0.08	0.83	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRMT61B	0.17	0.29	enet	17	0.32	9.9e-37	7.66	7.7	1.1e-14	-0.06	0.01	0.99	FALSE
29	GTEx	Lung	TRMT61B	0.20	0.24	lasso	9	0.24	4.2e-18	7.44	7.7	1.7e-14	-0.05	0.03	0.97	FALSE
90	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRMT61B	0.26	0.15	lasso	7	0.14	1.0e-04	7.66	7.6	2.2e-14	-0.06	0.01	0.92	FALSE
7	GTEx	Adrenal Gland	TRMT61B	0.30	0.27	enet	17	0.23	9.6e-09	7.50	7.6	2.3e-14	-0.06	0.01	0.99	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	TRMT61B	0.15	0.11	lasso	8	0.10	3.7e-13	7.52	7.6	2.7e-14	-0.05	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	TRMT61B	0.31	0.33	lasso	13	0.31	1.1e-16	7.50	7.6	2.8e-14	-0.06	0.02	0.98	FALSE
36	GTEx	Skin Sun Exposed Lower leg	TRMT61B	0.12	0.17	lasso	4	0.16	8.4e-13	7.49	7.6	2.9e-14	-0.06	0.02	0.98	FALSE
5	GTEx	Adipose Subcutaneous	TRMT61B	0.21	0.24	lasso	5	0.22	2.7e-18	7.50	7.6	3.2e-14	-0.05	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRMT61B	0.14	0.17	lasso	2	0.16	1.9e-13	7.50	7.6	3.2e-14	-0.06	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPP1CB	0.09	0.13	lasso	4	0.12	9.7e-13	7.50	-7.6	3.3e-14	0.05	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	TRMT61B	0.29	0.37	lasso	4	0.38	1.5e-38	7.50	7.6	3.4e-14	-0.05	0.01	0.99	FALSE
23	GTEx	Colon Transverse	TRMT61B	0.15	0.12	lasso	5	0.10	1.1e-05	7.50	7.5	4.4e-14	-0.05	0.01	0.99	FALSE
27	GTEx	Heart Atrial Appendage	TRMT61B	0.38	0.27	lasso	4	0.24	5.5e-11	7.50	7.5	4.9e-14	-0.05	0.02	0.98	FALSE
42	GTEx	Thyroid	TRMT61B	0.18	0.23	lasso	6	0.22	1.0e-16	7.50	7.5	4.9e-14	-0.05	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRMT61B	0.10	0.17	lasso	2	0.17	1.2e-33	7.50	7.5	4.9e-14	-0.05	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRMT61B	0.30	0.30	enet	18	0.30	2.6e-12	7.50	7.5	5.0e-14	-0.04	0.01	0.99	FALSE
45	METSIM	Adipose	PPP1CB	0.07	0.08	lasso	3	0.08	1.1e-11	-7.36	-7.5	5.1e-14	0.05	0.05	0.95	FALSE
73	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRMT61B	0.08	0.09	lasso	1	0.07	3.4e-04	7.52	7.5	5.6e-14	-0.05	0.01	0.95	FALSE
26	GTEx	Esophagus Muscularis	TRMT61B	0.27	0.34	lasso	3	0.33	1.0e-20	7.50	7.5	5.7e-14	-0.05	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	TRMT61B	0.20	0.23	lasso	7	0.22	6.1e-13	7.66	7.5	5.8e-14	-0.07	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPP1CB	0.03	0.03	lasso	4	0.03	5.6e-04	7.50	-7.5	5.9e-14	0.05	0.01	0.90	FALSE
21	GTEx	Cells Transformed fibroblasts	TRMT61B	0.36	0.46	lasso	6	0.46	2.8e-38	7.50	7.5	6.0e-14	-0.05	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUPT7L	0.01	0.01	blup	29	0.01	1.3e-02	3.96	7.5	6.1e-14	0.82	0.03	0.76	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	TRMT61B	0.09	0.11	blup	43	0.11	1.5e-12	7.44	7.5	6.2e-14	-0.06	0.01	0.99	FALSE
28	GTEx	Heart Left Ventricle	TRMT61B	0.21	0.17	lasso	3	0.15	1.9e-08	7.50	7.5	6.4e-14	-0.05	0.02	0.98	FALSE
16	GTEx	Brain Putamen basal ganglia	TRMT61B	0.27	0.12	enet	11	0.20	1.3e-05	7.50	7.5	7.1e-14	-0.03	0.03	0.96	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	TRMT61B	0.20	0.13	lasso	5	0.12	7.3e-07	7.49	7.5	7.8e-14	-0.05	0.02	0.98	FALSE
40	GTEx	Testis	TRMT61B	0.32	0.28	lasso	3	0.27	2.7e-12	7.50	7.5	7.8e-14	-0.05	0.02	0.98	FALSE
22	GTEx	Colon Sigmoid	TRMT61B	0.31	0.14	lasso	6	0.16	1.8e-06	6.75	7.5	8.8e-14	-0.04	0.03	0.96	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRMT61B	0.14	0.14	lasso	6	0.13	3.7e-09	7.44	7.5	8.8e-14	-0.05	0.02	0.98	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	TRMT61B	0.41	0.33	lasso	10	0.31	8.2e-12	7.14	7.5	9.3e-14	-0.04	0.02	0.98	FALSE
25	GTEx	Esophagus Mucosa	TRMT61B	0.18	0.22	lasso	3	0.22	1.7e-14	7.50	7.4	9.4e-14	-0.05	0.02	0.98	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TRMT61B	0.26	0.35	lasso	4	0.35	1.2e-43	7.44	7.4	1.0e-13	-0.05	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61B	0.10	0.17	lasso	3	0.16	1.6e-17	7.44	7.4	1.0e-13	-0.05	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61B	0.20	0.31	lasso	4	0.31	4.8e-33	7.42	7.4	1.0e-13	-0.05	0.02	0.98	FALSE
11	GTEx	Artery Tibial	TRMT61B	0.29	0.27	lasso	4	0.28	1.1e-21	7.49	7.4	1.2e-13	-0.04	0.02	0.98	FALSE
37	GTEx	Spleen	TRMT61B	0.48	0.39	lasso	6	0.36	3.0e-10	7.14	7.4	1.3e-13	-0.04	0.03	0.96	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRMT61B	0.24	0.38	enet	16	0.38	8.3e-46	7.52	7.4	1.3e-13	-0.05	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1CB	0.11	0.06	lasso	7	0.10	2.4e-10	-7.39	-7.4	1.4e-13	0.07	0.04	0.96	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP1CB	0.04	0.04	lasso	1	0.03	9.8e-05	-7.38	-7.4	1.6e-13	0.04	0.04	0.93	FALSE
9	GTEx	Artery Aorta	TRMT61B	0.26	0.29	enet	16	0.29	4.0e-16	7.50	7.4	1.7e-13	-0.05	0.02	0.98	FALSE
33	GTEx	Pancreas	TRMT61B	0.17	0.14	lasso	2	0.12	7.5e-06	-7.25	7.4	1.7e-13	-0.06	0.04	0.96	FALSE
17	GTEx	Breast Mammary Tissue	TRMT61B	0.32	0.17	lasso	7	0.20	8.2e-11	7.42	7.3	2.7e-13	-0.04	0.02	0.98	FALSE
31	GTEx	Muscle Skeletal	TRMT61B	0.16	0.14	enet	17	0.14	1.1e-13	7.42	7.3	4.1e-13	-0.05	0.02	0.98	FALSE
32	GTEx	Nerve Tibial	TRMT61B	0.15	0.16	lasso	5	0.13	1.4e-09	7.14	7.2	5.2e-13	-0.05	0.03	0.97	FALSE
44	GTEx	Thyroid	AC097724.3	0.07	0.03	lasso	4	0.03	4.1e-03	-7.33	-7.1	1.1e-12	0.04	0.04	0.91	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-6.23	7.1	1.2e-12	0.34	0.04	0.26	FALSE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRMT61B	0.14	0.16	blup	43	0.16	2.4e-08	7.44	7.1	1.7e-12	-0.06	0.02	0.98	FALSE
38	GTEx	Stomach	TRMT61B	0.32	0.24	lasso	5	0.26	9.7e-13	7.49	7.0	2.2e-12	-0.05	0.02	0.98	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	TRMT61B	0.40	0.28	enet	34	0.18	1.3e-06	7.50	7.0	2.5e-12	-0.07	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRMT61B	0.13	0.14	enet	11	0.15	5.5e-11	7.50	7.0	3.3e-12	-0.03	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Rectum Adenocarcinoma	PPP1CB	0.14	0.05	lasso	2	0.05	2.8e-02	7.14	-6.9	6.2e-12	0.03	0.01	0.36	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	8.07	6.9	6.5e-12	0.40	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRMT61B	0.20	0.12	enet	12	0.18	3.2e-08	7.66	6.7	1.7e-11	-0.03	0.02	0.98	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	SLC4A1AP	0.08	0.08	lasso	6	0.07	7.4e-10	6.17	-6.7	2.7e-11	-0.56	0.99	0.01	FALSE
30	GTEx	Muscle Skeletal	SLC4A1AP	0.04	0.02	lasso	4	0.01	1.5e-02	5.60	-6.6	4.6e-11	-0.51	0.12	0.30	FALSE
51	YFS	Blood	MRPL33	0.02	0.01	blup	385	0.01	6.4e-05	8.37	-6.6	4.7e-11	-0.68	0.85	0.12	FALSE
46	METSIM	Adipose	TRMT61B	0.06	0.08	enet	12	0.09	8.5e-13	7.66	6.6	5.0e-11	-0.06	0.01	0.99	FALSE
52	YFS	Blood	PPP1CB	0.07	0.10	enet	17	0.12	9.2e-36	-7.36	-6.4	1.3e-10	0.01	0.05	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PPP1CB	0.12	0.08	blup	574	0.10	3.3e-12	6.58	-6.4	1.6e-10	0.01	0.06	0.94	FALSE
50	YFS	Blood	GPN1	0.04	0.04	lasso	2	0.03	2.7e-11	6.11	-6.3	2.8e-10	-0.59	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SUPT7L	0.03	0.02	blup	303	0.02	1.4e-03	5.83	6.2	5.8e-10	0.78	0.02	0.94	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SUPT7L	0.05	0.05	enet	3	0.04	2.4e-03	6.11	5.9	2.8e-09	0.58	0.11	0.30	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1CB	0.04	0.02	blup	39	0.02	1.6e-04	6.58	-5.9	3.0e-09	0.02	0.14	0.34	FALSE
34	GTEx	Pituitary	TRMT61B	0.28	0.11	enet	28	0.10	1.9e-03	7.42	5.9	4.3e-09	0.01	0.03	0.93	FALSE
20	GTEx	Cells Transformed fibroblasts	PPM1G	0.06	0.00	lasso	4	0.01	3.2e-02	-1.21	5.5	2.9e-08	0.69	0.12	0.55	FALSE
13	GTEx	Brain Cerebellum	TRMT61B	0.26	0.00	lasso	6	0.00	4.1e-01	6.75	5.4	5.1e-08	-0.01	0.04	0.43	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC4A1AP	0.09	0.07	lasso	7	0.06	7.2e-08	6.03	-5.4	6.5e-08	-0.57	0.99	0.01	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CGREF1	0.11	0.03	blup	37	0.02	2.6e-02	2.85	5.3	1.0e-07	0.33	0.00	0.04	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	PPP1CB	0.13	0.04	lasso	5	0.08	1.4e-10	6.58	-5.2	1.5e-07	0.04	0.08	0.92	FALSE