[Hub]/) : Traits : Blood Red Count :

chr1:11,170,131-13,176,463

Best TWAS P=6e-13 · Best GWAS P=4.03e-13 conditioned to 0.0957

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells EBV-transformed lymphocytes MTHFR 0.33 0.12 lasso 6 0.09 7.9e-04 5.4 5.4 5.6e-08 0.81 0.32 0.29 FALSE
2 GTEx Cells Transformed fibroblasts CLCN6 0.08 0.02 enet 17 0.05 1.6e-04 7.0 6.6 3.4e-11 0.75 0.01 0.98 FALSE
3 GTEx Skin Not Sun Exposed Suprapubic CLCN6 0.12 0.03 lasso 3 0.04 3.3e-03 5.7 6.9 3.9e-12 0.81 0.02 0.94 FALSE
4 GTEx Skin Sun Exposed Lower leg CLCN6 0.08 0.00 lasso 3 0.01 7.9e-02 2.6 5.6 1.8e-08 0.65 0.03 0.66 FALSE
5 GTEx Spleen CLCN6 0.21 0.10 lasso 3 0.06 1.3e-02 5.4 5.8 8.8e-09 0.87 0.04 0.70 FALSE
6 NTR Blood CLCN6 0.01 0.01 lasso 2 0.01 3.0e-04 5.2 5.3 1.1e-07 0.76 0.40 0.51 FALSE
7 YFS Blood DHRS3 0.02 0.02 lasso 3 0.01 3.5e-05 -5.9 5.6 2.2e-08 0.01 0.00 1.00 TRUE
8 The Cancer Genome Atlas Breast Invasive Carcinoma CLCN6 0.06 0.06 blup 104 0.06 5.0e-12 4.4 6.3 3.4e-10 0.74 0.33 0.67 FALSE
9 The Cancer Genome Atlas Colon Adenocarcinoma CLCN6 0.14 0.05 blup 104 0.09 1.2e-05 7.3 7.1 1.5e-12 0.81 0.01 0.98 FALSE
10 The Cancer Genome Atlas Colon Adenocarcinoma MTHFR 0.07 0.01 blup 92 0.04 2.9e-03 3.7 5.3 1.1e-07 0.74 0.04 0.47 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CLCN6 0.04 0.06 lasso 2 0.05 1.1e-06 4.4 5.2 2.7e-07 0.69 0.09 0.90 FALSE
12 The Cancer Genome Atlas Lung Adenocarcinoma CLCN6 0.06 0.04 blup 104 0.04 5.2e-06 7.0 7.2 6.0e-13 0.90 0.01 0.99 TRUE
13 The Cancer Genome Atlas Prostate Adenocarcinoma CLCN6 0.10 0.07 blup 104 0.07 3.9e-08 4.3 5.4 7.5e-08 0.58 0.19 0.80 FALSE
14 The Cancer Genome Atlas Stomach Adenocarcinoma CLCN6 0.07 0.04 blup 104 0.05 2.4e-04 7.3 6.3 3.8e-10 0.93 0.01 0.99 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma CLCN6 0.08 0.02 blup 104 0.05 2.5e-05 4.8 7.1 1.3e-12 0.64 0.18 0.80 FALSE