TWAS hub - DHRS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0233	0.0095	0.0022	0.018	0.006	0.011	0.009	0.013	1.1e-06	0.00440	0.00011	0.00049	3.5e-05
2	TCGA	Uterine Corpus Endometrial Carcinoma	0.2830	0.1020	0.0039	0.005	0.103	0.018	NA	0.001	2.3e-01	0.00083	0.10000	NA	3.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Serious illness, injury or assault to yourself	10.0	12.2	13.5	-3.7	-3.3
Pulse wave reflection index	6.1	7.5	9.6	2.3	3.1
Angina	4.2	5.5	5.6	-2.3	-2.4
Angina (self-reported)	3.7	4.8	4.9	-2.2	-2.2
Alcohol drinker status: Never	3.5	4.2	7.4	0.9	2.7
Had other major operations	3.3	4.0	7.5	0.7	2.7
Blood Red Count	2.9	28.5	31.4	5.6	5.1
Taking other prescription medications	2.7	4.2	5.6	-1.7	-2.4
Mineral and other dietary supplements	2.6	3.5	5.1	1.4	2.2
Father’s age at death	2.5	3.4	6.7	-2.6	0.1
Pack years of smoking	2.5	3.7	4.7	-1.7	2.2
Pack years adult smoking proportion	2.3	3.6	5.4	-1.3	2.3
Hair/balding pattern: Pattern 2	2.3	2.9	5.8	-0.1	-2.4
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.4	-2.3	-0.3
Pulse rate	2.2	3.8	6.7	-0.9	-2.6
Family relationship satisfaction	2.2	2.7	5.1	0.6	-2.2
Type 2 Diabetes (T2D) (2018)	2.1	3.9	7.3	0.7	-2.7
Hand grip strength (right)	2.1	5.8	10.5	1.1	3.2
High cholesterol (Self-reported)	2.1	3.7	6.2	-1.2	-2.5
Commuting to job workplace: Cycle	2.1	2.5	4.8	0.4	2.2
Age when periods started (menarche)	2.0	4.7	8.9	-0.7	3.0
Peak expiratory flow (PEF)	2.0	4.6	6.5	1.7	2.5
Medication: Blood pressure	2.0	3.7	5.1	2.3	1.5
Lung cancer (father)	1.9	2.2	3.5	1.9	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	5.5	-2.4	-0.5
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.7	-1.3	-1.7
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.3	1.2	-1.8
Wears glasses or contact lenses	1.8	2.1	3.2	-1.0	-1.8
Supplements: Glucosamine	1.7	2.2	2.8	-1.3	-1.7
Handedness (chirality/laterality): Left-handed	1.7	2.0	2.9	-1.7	-1.0
Qualifications: CSEs or equivalent	1.6	2.2	3.5	1.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	2.5	1.6	1.2
Medication: Atorvastatin	1.6	2.0	2.4	-1.3	-1.6
Medication: Atenolol	1.5	1.9	3.0	1.7	1.0
Risk taking	1.5	2.3	3.6	1.0	1.9
Chronic bronchitis/emphysema (father)	1.4	1.6	3.0	-1.7	-0.5
Nervous feelings	1.4	2.6	3.7	-1.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	6.4	1.7	2.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.6	2.1	0.2
Forced vital capacity (FVC), Best measure	1.4	5.1	7.2	1.8	2.7
Illnesses of father: Heart disease	1.4	1.9	2.1	-1.3	-1.4
Number of operations (self-reported)	1.4	2.1	4.2	-2.0	-0.3
Age started oral contraceptive pill	1.4	1.8	3.1	-1.8	-0.7
Pain experienced in last month	1.4	2.3	4.6	0.2	2.2
Vitamin and mineral supplements	1.3	1.8	3.4	-0.3	1.8
Multivitamins +/- minerals	1.3	1.6	1.7	1.2	-1.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.5	-0.8	-1.6
Hair/balding pattern: Pattern 3	1.3	2.0	3.9	0.0	2.0
Medication: Lansoprazole	1.3	1.4	2.1	-1.5	-0.9
Emphysema/chronic bronchitis	1.3	1.5	1.7	-1.3	-1.1
Diabetes diagnosed by doctor	1.3	2.2	4.2	-0.4	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	1.9	1.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.7	-1.6	0.6
Hearing aid user	1.3	1.4	2.7	-1.6	-0.4
Average weekly beer plus cider intake	1.3	1.9	2.1	1.4	1.3
Ever depressed for a whole week	1.3	1.6	1.9	-1.4	-1.2
Hypothyroidism (self reported)	1.2	2.7	5.4	-2.3	-0.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.6	-1.1	-1.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.3	0.5	1.5
Medication: Amlodipine	1.2	1.7	2.2	1.5	1.1
Guilty feelings	1.2	1.8	2.7	-0.9	1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.0	-1.4	-1.1
Townsend deprivation index at recruitment	1.1	1.6	1.7	-1.3	-1.2
Maternal smoking around birth	1.1	1.6	3.3	-0.1	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	2.9	1.7	1.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.7	-1.7	-0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.9	-2.0	-0.7
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.9	-0.7	-1.4
Heart disease (siblings)	1.1	1.3	2.2	-0.6	-1.5
Bipolar Disorder (2018)	1.0	1.6	3.1	-0.3	1.8
Alzheimer’s Disease (in father)	1.0	1.0	1.8	-1.3	-0.5
Rheumatoid Arthritis	1.0	1.4	1.7	-1.1	1.3
Average weekly spirits intake	1.0	1.2	2.2	0.5	1.5
Medication: Co-codamol	1.0	1.2	1.8	-1.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	2.8	1.4	1.7
Medication: Levothyroxine sodium	1.0	1.7	3.3	-1.8	-0.3
Financial difficulties in last 2 years	1.0	1.3	2.0	0.7	1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	4.9	1.2	2.2
Medication: Ibuprofen	1.0	1.2	1.3	1.1	1.1
Medication: Aspirin	1.0	1.3	1.8	-0.8	-1.4
Average weekly red wine intake	1.0	1.5	2.9	1.7	0.3
Medication: Aspirin	1.0	1.4	2.3	-0.6	-1.5
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.4	-1.2	-0.9
Breast Cancer	0.9	2.2	2.8	-1.7	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.7	-0.6	-1.3
Illnesses of siblings	0.9	1.3	1.7	-0.9	1.3
Hip circumference	0.9	3.7	6.8	2.6	0.8
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.4	-0.6	-1.8
Illnesses of mother	0.9	1.1	2.1	-1.4	-0.3
Loud music exposure frequency	0.9	1.0	1.4	1.2	-0.7
Arm fat-free mass (right)	0.9	4.4	6.7	1.4	2.6
Worry too long after embarrassment	0.9	1.6	2.2	1.0	1.5
Chest pain or discomfort	0.9	1.3	1.9	-0.8	-1.4
Medication: Gliclazide	0.9	1.1	2.0	1.4	0.3
Myopia	0.9	1.3	1.7	-0.9	-1.3
Alzheimer’s Disease (including proxy)	0.8	1.2	1.2	-1.1	-1.1
Reaction Time	0.8	1.6	2.0	-1.1	1.4
Body Mass Index (BMI) (2010)	0.8	1.0	2.0	-1.4	-0.3
Fasting Glucose	0.8	1.0	1.0	0.9	1.0
Neuroticism (2016)	0.8	1.1	1.7	-1.3	0.8
Number of treatments/medications taken	0.8	1.4	2.1	-1.4	-0.9
Sensitivity / hurt feelings	0.8	1.4	2.1	-1.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.0	-1.4	-0.1
Sitting height	0.8	5.3	7.7	1.7	2.8
Heart attack	0.8	1.1	1.9	-0.5	1.4
Falls in the last year	0.8	1.0	1.9	-0.4	-1.4
Medication: Cholesterol lowering	0.8	1.2	1.7	-1.3	-0.9
Arm fat mass (right)	0.8	3.4	5.5	2.4	1.1
Wheeze or whistling in the chest in last year	0.8	1.3	2.5	-1.6	-0.4
Shortness of breath walking on level ground	0.8	1.0	1.8	-0.4	-1.3
Medication: Allopurinol	0.8	1.0	2.0	1.4	0.0
Mean time to correctly identify matches	0.8	1.5	3.0	-1.7	0.1
Knee pain experienced in last month	0.8	1.2	2.2	0.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.3	1.1	0.8
Whole body fat-free mass	0.8	4.5	5.3	1.9	2.3
Qualifications: nursing, teaching	0.8	1.2	2.3	-0.3	-1.5
Back pain experienced in last month	0.8	1.2	2.4	-0.0	-1.5
Illnesses of father: None of the above (group 1)	0.8	0.9	1.7	0.4	1.3
Whole body water mass	0.8	4.4	5.2	1.9	2.3
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	-1.7	0.1
Eye problems/disorders: Glaucoma	0.8	0.9	1.8	-0.2	-1.4
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	1.3	0.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.7	1.3	0.0
Mean Putamen Volume	0.7	0.9	1.5	1.2	0.5
HDL Cholesterol	0.7	1.1	1.2	-1.0	-1.1
BMI	0.7	3.9	7.2	2.7	0.7
Leg fat-free mass (left)	0.7	3.7	4.7	2.2	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.1	-1.0	-1.0
Weight	0.7	3.2	4.3	2.1	1.4
Medication: Paracetamol	0.7	1.1	1.4	0.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.6	-0.4	1.3
Pulse wave peak to peak time	0.7	0.8	1.1	0.8	-1.1
Medication: Blood pressure	0.7	1.3	2.5	-1.6	0.2
Medication: Seretide 50 evohaler	0.7	0.8	0.9	-0.8	-1.0
Arm predicted mass (right)	0.7	3.8	5.6	1.4	2.4
Pulse rate, automated reading	0.7	2.3	4.5	-0.3	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.4	0.6	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.0	1.0	0.9
Leg fat-free mass (right)	0.7	3.5	3.6	1.9	1.8
Leg predicted mass (right)	0.7	3.8	3.8	2.0	1.9
Arm fat mass (left)	0.7	3.0	5.0	2.2	1.0
Basal metabolic rate	0.7	4.0	4.2	2.1	1.9
Arm fat-free mass (left)	0.7	3.6	4.6	1.6	2.1
Fractured/broken bones in last 5 years	0.7	1.0	1.4	0.7	-1.2
Arm predicted mass (left)	0.7	3.6	4.4	1.7	2.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	1.2	0.0
Medication: Metformin	0.6	0.9	1.8	-0.1	-1.3
Severe depression (siblings)	0.6	0.7	1.2	1.1	0.4
High blood pressure (mother)	0.6	0.8	1.0	0.8	-1.0
Leg predicted mass (left)	0.6	3.3	4.2	2.0	1.6
Forced vital capacity (FVC)	0.6	2.4	3.9	0.9	2.0
Medication: Ramipril	0.6	0.8	1.0	-0.8	-1.0
Arm fat percentage (right)	0.6	2.5	4.9	2.2	0.2
Trunk fat-free mass	0.6	3.6	4.7	1.6	2.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	-0.6	1.0
Trunk predicted mass	0.6	3.7	4.9	1.6	2.2
Length of working week for main job	0.6	0.7	1.3	1.2	0.2
Blood clot in the leg (DVT)	0.6	0.7	1.3	-0.4	1.1
Whole body fat mass	0.6	2.5	4.3	2.1	0.8
Illnesses of siblings: Diabetes	0.6	0.7	0.8	0.8	-0.9
Arm fat percentage (left)	0.6	2.4	4.8	2.2	0.1
Commuting to job workplace: Walk	0.6	0.6	1.0	1.0	-0.5
Medication: Bendroflumethiazide	0.6	0.8	0.9	0.9	0.9
Cholesterol lowering medication	0.6	0.9	1.6	0.4	-1.3
Trunk fat percentage	0.5	1.9	3.8	2.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	-0.9	-0.7
Trunk fat mass	0.5	2.4	4.2	2.0	0.7
Waist circumference	0.5	2.0	3.6	1.9	0.6
Diabetes (self-reported)	0.5	0.8	1.7	-0.0	-1.3
Impedance of arm (right)	0.5	2.5	4.5	0.6	-2.1
Impedance of arm (left)	0.5	2.3	4.0	0.8	-2.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	0.0	1.1
Age at first live birth	0.5	0.9	1.7	0.1	-1.3
Age at last live birth	0.5	0.7	1.4	-1.2	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	0.8	-0.8	-0.9
Friendships satisfaction	0.5	0.7	1.3	0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	1.4	0.5
Ever taken oral contraceptive pill	0.5	0.6	1.1	0.1	-1.1
Mother’s age at death	0.5	0.6	0.8	0.9	0.7
Unable to work because of sickness or disability	0.5	0.6	0.7	-0.7	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-0.5	1.1
Alcohol drinker status: Previous	0.5	0.6	1.1	0.0	-1.1
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	0.5	1.2
Depression (Nagel 2018)	0.4	0.6	0.8	-0.9	-0.6
Worry (Nagel 2018)	0.4	0.8	1.5	-0.4	-1.2
Alzheimer’s Disease (in mother)	0.4	0.5	0.5	0.7	-0.7
Crohns Disease (2017)	0.4	0.8	1.4	-0.5	-1.2
HbA1C	0.4	0.5	0.9	-0.9	0.1
Blood Eosinophil Count	0.4	3.0	3.6	-1.9	1.5
Allergy or Eczema	0.4	1.2	2.3	-1.5	-0.2
Hand grip strength (left)	0.4	1.0	1.9	0.4	1.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.8	-0.9	-0.6
Supplements: Zinc	0.4	0.5	0.9	-0.9	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	0.7	-0.7	-0.8
Medication: Simvastatin	0.4	0.5	0.7	0.8	-0.6
Noisy workplace	0.4	0.5	0.7	0.6	0.9
Prospective memory result	0.4	0.5	0.9	0.3	-0.9
Headache pain in last month	0.4	0.7	0.8	0.8	-0.9
Glaucoma (self-reported)	0.4	0.5	0.6	0.6	-0.8
Body fat percentage	0.4	1.5	3.0	1.7	0.0
Number of full brothers	0.4	0.5	0.8	-0.4	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	0.5	0.9
Leg fat mass (right)	0.4	1.7	3.0	1.7	0.6
Number of full sisters	0.4	0.5	1.0	-0.0	1.0
Leg pain on walking	0.4	0.5	0.8	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.4	0.3	1.2
Ever had bowel cancer screening	0.4	0.4	0.5	-0.7	0.6
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.9	0.3
Osteoarthritis (self-reported)	0.4	0.6	0.6	0.7	-0.8
Smoking status: Current	0.4	0.6	1.3	1.1	0.1
Financial situation satisfaction	0.4	0.5	1.0	1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.6	-0.5	0.8
Leg fat mass (left)	0.4	1.4	2.4	1.5	0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	0.1	-1.1
Schizophrenia (2014)	0.3	0.6	1.3	0.1	1.1
Blood White Count	0.3	1.9	3.7	0.4	1.9
Hearing difficulty/problems: Yes	0.3	0.5	1.0	1.0	-0.2
Medication for hormone replacement therapy	0.3	0.4	0.7	-0.8	-0.2
Impedance of leg (right)	0.3	1.3	2.6	-0.1	-1.6
Relative age voice broke	0.3	0.5	0.7	0.8	-0.6
Stomach or abdominal pain in last month	0.3	0.4	0.8	-0.9	-0.1
Body mass index (BMI)	0.3	1.4	1.8	1.3	1.0
Qualifications: None of the above	0.3	0.7	1.0	-1.0	-0.5
Allergy	0.3	0.7	1.3	1.1	-0.3
Worrier / anxious feelings	0.3	0.7	1.3	1.1	0.1
Number of live births	0.3	0.4	0.8	-0.9	-0.3
Happiness	0.3	0.4	0.7	0.8	0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	-1.0	-0.3
Asthma	0.3	0.6	0.7	-0.8	0.7
Standing height	0.3	2.8	3.6	1.9	1.4
Exposure to tobacco smoke at home	0.3	0.4	0.6	-0.4	-0.8
Tense / ‘highly strung’	0.3	0.4	0.4	-0.7	-0.6
Leg fat percentage (right)	0.3	1.1	2.0	1.4	-0.4
Number of children fathered	0.3	0.3	0.6	0.2	0.7
Neck or shoulder pain in last month	0.3	0.4	0.7	0.8	-0.3
Overall health rating	0.3	0.7	1.5	0.0	-1.2
Asthma (self-reported)	0.3	0.6	1.1	-1.0	0.3
Miserableness	0.3	0.5	0.9	1.0	-0.3
Medication: Paracetamol	0.3	0.5	0.6	0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.0	0.9
Impedance of whole body	0.3	1.6	3.1	0.3	-1.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.7	0.9	-0.7
Schizophrenia (2018)	0.2	0.5	0.8	0.9	-0.4
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	-0.4
Ovarian Cancer	0.2	0.3	0.4	0.6	0.4
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.4	-0.6
Ulcerative Colitis	0.2	0.3	0.6	0.8	-0.2
Height	0.2	3.9	6.4	1.2	2.5
Lung FEV1/FVC ratio	0.2	1.1	2.0	1.4	0.5
Diabetes (mother)	0.2	0.2	0.3	0.6	0.4
Current tobacco smoking	0.2	0.4	0.8	0.9	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.4	-0.6	0.6
Impedance of leg (left)	0.2	0.8	1.5	-0.4	-1.2
Number of incorrect matches in round	0.2	0.4	0.7	-0.3	-0.8
Mouth/teeth dental problems	0.2	0.3	0.7	-0.0	-0.8
Pain all over the body in last month	0.2	0.3	0.4	-0.6	-0.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.1	1.0
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.7	0.1
Comparative body size at age 10	0.2	0.6	1.1	-0.2	-1.0
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.6	0.3
Medication: Omeprazole	0.2	0.2	0.3	0.4	0.5
Alcohol intake frequency.	0.2	0.5	0.6	0.6	0.8
Suffer from ‘nerves’	0.2	0.3	0.6	-0.8	-0.2
Hypertension (Self-reported)	0.2	0.5	0.9	0.3	1.0
Smoking status: Previous	0.2	0.2	0.4	-0.7	-0.1
Mood swings	0.2	0.3	0.6	0.1	0.8
Loneliness, isolation	0.2	0.3	0.6	-0.8	0.1
Osteoporosis (self-reported)	0.2	0.3	0.4	-0.3	-0.7
Medication: Lisinopril	0.2	0.3	0.5	-0.0	-0.7
Leg fat percentage (left)	0.2	0.6	1.1	1.0	-0.4
Irritability	0.2	0.3	0.4	0.4	0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.0	-0.8
Prostate Cancer	0.1	0.1	0.2	-0.3	0.4
Lupus	0.1	0.2	0.3	0.4	-0.5
Systolic Blood Pressure	0.1	0.5	0.8	0.9	-0.4
Smoking Status	0.1	0.2	0.3	0.5	-0.3
Cardiovascular Disease	0.1	0.2	0.4	0.0	-0.6
Respiratory disease	0.1	0.3	0.6	-0.8	0.1
Tanning	0.1	0.8	1.5	-1.2	0.5
Relative age of first facial hair	0.1	0.2	0.4	0.6	0.2
Systolic blood pressure, automated reading	0.1	0.3	0.4	-0.5	-0.6
Diabetes (father)	0.1	0.1	0.1	-0.3	-0.2
Average weekly fortified wine intake	0.1	0.1	0.2	0.4	-0.2
Fed-up feelings	0.1	0.2	0.3	0.2	0.6
High blood pressure	0.1	0.3	0.3	0.6	0.5
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	-0.1
Time employed in main current job	0.1	0.2	0.2	0.4	-0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.0	-0.4
Breastfed as a baby	0.1	0.2	0.3	0.5	-0.3
Birth weight of first child	0.1	0.2	0.4	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.4	-0.5
Gout (self-reported)	0.1	0.1	0.1	0.2	-0.3
High blood pressure (siblings)	0.1	0.1	0.2	0.4	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.1	-0.3
Heart disease (mother)	0.1	0.1	0.2	0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.5	-0.2
Medication for cholesterol	0.1	0.2	0.3	-0.0	0.6
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.3	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.1	-0.4
Ever smoked	0.1	0.2	0.2	0.5	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.4	-0.6	-0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.1	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.2	0.0
Age at First Birth	0.0	0.1	0.1	0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.1	0.3	0.0
LDL Cholesterol	0.0	0.1	0.1	0.1	-0.3
Triglycerides	0.0	0.1	0.1	0.1	0.3
Blood Platelet Count	0.0	0.4	0.6	-0.4	-0.8
Heel T-Score	0.0	0.1	0.2	0.4	-0.1
Waist Hip Ratio (WHR)	0.0	0.0	0.1	0.3	-0.0
Lung FVC	0.0	0.2	0.3	-0.3	0.5
Neuroticism	0.0	0.0	0.0	-0.1	0.2
Chronotype (morning person)	0.0	0.1	0.2	-0.2	-0.4
Hair Pigment	0.0	0.7	1.3	-0.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.1	0.2
Past tobacco smoking	0.0	0.0	0.0	0.1	-0.0
Had menopause	0.0	0.0	0.0	0.2	0.1
Fluid intelligence score	0.0	0.1	0.2	0.4	0.0
Neuroticism score	0.0	0.1	0.1	-0.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.2	0.1
Depression (self-reported)	0.0	0.0	0.1	-0.2	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	0.2
Birth weight	0.0	0.1	0.2	0.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.2
Health satisfaction	0.0	0.0	0.0	0.0	-0.2
Qualifications: College or University degree	0.0	0.1	0.1	0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	0.0
Migraine (self-reported)	0.0	0.0	0.0	-0.0	-0.1
Comparative height size at age 10	0.0	0.1	0.2	0.2	-0.5
Had major operations	0.0	0.0	0.0	-0.2	-0.2
Supplements: Vitamin C	0.0	0.1	0.1	0.1	-0.3
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.1	-0.2
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.3	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	0.3	-0.3
Supplements: Calcium	0.0	0.0	0.0	-0.0	0.2

Hub : Genes

DHRS3

Models

Trait associations