[Hub]/) : Traits : Blood Red Count :

chr1:15,119,708-18,132,937

Best TWAS P=5.29e-23 · Best GWAS P=1.42e-25 conditioned to 0.0038

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATP13A2 0.08 0.06 lasso 5 0.08 6.9e-10 5.1 5.3 1.4e-07 0.02 0.19 0.81 FALSE
2 CommonMind Brain Pre-frontal Cortex CASP9 0.09 0.07 lasso 2 0.07 2.3e-09 -7.0 -6.4 1.2e-10 -0.02 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex FAM131C 0.21 0.14 lasso 10 0.16 2.0e-19 6.1 -6.4 1.8e-10 -0.53 1.00 0.00 FALSE
4 CommonMind Brain Pre-frontal Cortex HSPB7 0.18 0.16 lasso 11 0.15 3.1e-18 -5.8 -7.4 1.3e-13 -0.61 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous CROCC 0.18 0.15 enet 24 0.19 2.9e-15 -3.7 -5.2 1.6e-07 -0.03 0.96 0.03 FALSE
6 GTEx Adipose Subcutaneous CASP9 0.11 0.12 enet 17 0.11 2.9e-09 -7.0 6.9 5.0e-12 0.01 1.00 0.00 FALSE
7 GTEx Adrenal Gland CROCC 0.16 0.00 lasso 3 0.00 2.1e-01 -4.1 -5.3 9.5e-08 -0.04 0.03 0.66 FALSE
8 GTEx Artery Aorta CASP9 0.13 0.02 lasso 5 0.03 1.4e-02 5.4 5.7 1.3e-08 0.06 0.20 0.27 FALSE
9 GTEx Artery Coronary CASP9 0.15 0.12 lasso 11 0.04 1.8e-02 -6.3 6.9 4.7e-12 0.04 0.40 0.03 FALSE
10 GTEx Artery Tibial MFAP2 0.15 0.06 enet 20 0.07 2.3e-06 -4.7 5.2 1.7e-07 0.04 0.30 0.68 FALSE
11 GTEx Artery Tibial MST1L 0.21 0.08 lasso 6 0.12 5.0e-10 -3.7 -5.2 2.2e-07 -0.02 0.40 0.59 FALSE
12 GTEx Brain Cerebellum MST1L 0.21 0.13 lasso 2 0.09 1.7e-03 5.2 -5.2 2.2e-07 -0.04 0.07 0.53 FALSE
13 GTEx Breast Mammary Tissue CASP9 0.14 0.15 lasso 11 0.14 7.2e-08 -7.1 7.0 1.7e-12 0.03 0.99 0.00 FALSE
14 GTEx Breast Mammary Tissue (Male) CASP9 0.09 0.03 lasso 4 0.04 4.9e-02 -6.6 6.6 3.9e-11 0.03 0.08 0.05 FALSE
15 GTEx Breast Mammary Tissue (Female) CASP9 0.16 0.12 lasso 15 0.09 1.3e-03 5.3 6.5 9.9e-11 0.05 0.13 0.11 FALSE
16 GTEx Cells EBV-transformed lymphocytes MST1L 0.31 0.10 lasso 6 0.14 2.2e-05 -5.4 -5.8 7.1e-09 0.00 0.08 0.88 FALSE
17 GTEx Cells Transformed fibroblasts CASP9 0.23 0.14 lasso 10 0.14 1.5e-10 5.3 5.2 1.5e-07 0.06 1.00 0.00 FALSE
18 GTEx Cells Transformed fibroblasts HSPB7 0.10 0.10 lasso 3 0.07 2.9e-06 8.9 -9.3 1.2e-20 -0.73 0.38 0.59 FALSE
19 GTEx Cells Transformed fibroblasts RP11-169K16.9 0.09 0.04 lasso 3 0.03 1.6e-03 -5.0 6.2 4.3e-10 0.41 0.36 0.02 FALSE
20 GTEx Colon Sigmoid CASP9 0.21 -0.01 enet 40 0.01 1.1e-01 -7.0 6.9 5.2e-12 0.25 0.28 0.19 FALSE
21 GTEx Esophagus Mucosa CROCC 0.14 0.08 enet 18 0.14 9.5e-10 -4.7 -5.7 9.8e-09 -0.03 0.02 0.98 FALSE
22 GTEx Esophagus Mucosa CASP9 0.17 0.10 enet 25 0.16 1.0e-10 -7.1 6.6 3.9e-11 0.02 1.00 0.00 FALSE
23 GTEx Esophagus Mucosa NBPF1 0.17 0.09 enet 27 0.12 1.5e-08 -5.5 -5.5 3.8e-08 -0.02 0.41 0.59 FALSE
24 GTEx Esophagus Muscularis CASP9 0.16 0.15 lasso 5 0.14 6.7e-09 -7.0 6.9 3.9e-12 0.02 1.00 0.00 FALSE
25 GTEx Heart Atrial Appendage CASP9 0.25 0.21 enet 16 0.25 2.1e-11 -7.1 7.1 1.3e-12 0.04 1.00 0.00 FALSE
26 GTEx Heart Atrial Appendage MST1P2 0.20 0.09 lasso 4 0.09 6.7e-05 -4.5 5.2 1.7e-07 0.04 0.15 0.74 FALSE
27 GTEx Heart Left Ventricle CASP9 0.22 0.13 enet 30 0.21 2.3e-11 -7.1 7.1 1.2e-12 0.04 1.00 0.00 FALSE
28 GTEx Liver CASP9 0.46 0.19 lasso 9 0.22 1.1e-06 -7.1 6.3 2.3e-10 0.00 0.52 0.03 FALSE
29 GTEx Liver MST1P2 0.20 0.14 lasso 4 0.10 7.6e-04 5.2 5.7 1.1e-08 0.02 0.06 0.66 FALSE
30 GTEx Lung MFAP2 0.09 0.08 enet 19 0.06 1.3e-05 -4.9 5.8 6.3e-09 0.03 0.19 0.79 FALSE
31 GTEx Lung CASP9 0.16 0.10 enet 28 0.11 4.9e-09 -7.0 6.3 2.8e-10 -0.03 1.00 0.00 FALSE
32 GTEx Muscle Skeletal PLEKHM2 0.08 0.06 lasso 2 0.04 2.1e-04 -6.1 5.5 3.7e-08 0.03 0.66 0.02 FALSE
33 GTEx Muscle Skeletal PADI2 0.03 0.03 lasso 2 0.03 4.6e-04 -5.4 -5.6 2.7e-08 -0.02 0.02 0.97 FALSE
34 GTEx Muscle Skeletal CASP9 0.07 0.05 lasso 5 0.07 4.5e-07 5.2 6.8 1.4e-11 0.05 0.98 0.00 FALSE
35 GTEx Nerve Tibial MFAP2 0.09 0.06 lasso 3 0.07 9.7e-06 5.0 5.3 9.6e-08 0.02 0.19 0.80 FALSE
36 GTEx Nerve Tibial CASP9 0.09 0.09 lasso 12 0.03 1.6e-03 -7.1 7.1 1.7e-12 0.02 0.94 0.00 FALSE
37 GTEx Ovary CASP9 0.33 0.07 lasso 7 0.06 1.4e-02 -7.0 7.0 1.9e-12 0.11 0.15 0.18 FALSE
38 GTEx Pancreas CASP9 0.26 0.16 lasso 8 0.17 1.6e-07 -7.2 7.6 3.8e-14 0.05 0.98 0.00 TRUE
39 GTEx Prostate CASP9 0.30 0.03 lasso 14 0.03 6.3e-02 -7.0 6.6 3.4e-11 0.05 0.18 0.05 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic MST1P2 0.14 0.03 lasso 4 0.01 5.0e-02 5.1 5.3 1.4e-07 0.03 0.09 0.38 FALSE
41 GTEx Skin Not Sun Exposed Suprapubic NBPF1 0.08 0.02 lasso 3 0.00 2.8e-01 -4.8 -5.4 7.6e-08 -0.04 0.16 0.20 FALSE
42 GTEx Skin Sun Exposed Lower leg CROCC 0.19 0.13 enet 30 0.21 3.4e-17 -4.1 -5.8 6.7e-09 -0.04 0.88 0.11 FALSE
43 GTEx Skin Sun Exposed Lower leg NBPF1 0.14 0.04 lasso 7 0.05 2.9e-05 -3.7 -5.2 1.6e-07 -0.03 0.95 0.04 FALSE
44 GTEx Small Intestine Terminal Ileum CROCC 0.32 0.07 lasso 14 0.18 7.9e-05 -4.1 -5.2 2.2e-07 -0.04 0.04 0.58 FALSE
45 GTEx Spleen CASP9 0.34 0.24 lasso 4 0.22 3.0e-06 -6.7 6.8 1.3e-11 0.03 0.72 0.02 FALSE
46 GTEx Stomach CASP9 0.24 0.06 enet 14 0.11 9.4e-06 -7.0 5.4 8.1e-08 -0.04 0.95 0.00 FALSE
47 GTEx Stomach NBPF1 0.09 0.01 lasso 2 0.00 4.0e-01 -5.5 -5.7 1.1e-08 -0.05 0.07 0.13 FALSE
48 GTEx Testis CROCC 0.18 0.03 lasso 4 0.04 1.0e-02 5.2 -6.3 3.8e-10 -0.05 0.03 0.74 TRUE
49 GTEx Testis DNAJC16 0.20 0.03 enet 24 0.04 6.0e-03 -6.1 6.7 1.7e-11 0.12 0.23 0.04 FALSE
50 GTEx Thyroid HSPB7 0.17 0.12 lasso 6 0.15 9.8e-12 -5.8 -7.1 9.3e-13 -0.60 1.00 0.00 FALSE
51 GTEx Thyroid MST1P2 0.18 0.11 lasso 9 0.13 2.7e-10 5.1 5.2 1.6e-07 0.00 0.16 0.83 FALSE
52 GTEx Uterus CASP9 0.48 0.19 lasso 7 0.22 2.5e-05 -7.0 6.0 1.9e-09 -0.01 0.49 0.03 FALSE
53 GTEx Whole Blood MST1P2 0.05 0.02 enet 14 0.04 1.8e-04 -3.7 5.7 1.0e-08 0.14 0.05 0.92 FALSE
54 GTEx Whole Blood MST1L 0.08 0.02 enet 12 0.04 6.3e-05 -4.1 -5.9 4.8e-09 0.00 0.15 0.83 FALSE
55 METSIM Adipose PLEKHM2 0.06 0.06 lasso 6 0.06 6.3e-10 -6.3 5.8 7.4e-09 0.03 1.00 0.00 FALSE
56 ROSMAP Brain Pre-frontal Cortex DNAJC16 0.07 0.02 bslmm 516 0.03 3.0e-05 5.3 6.1 1.2e-09 0.07 0.90 0.00 FALSE
57 ROSMAP Brain Pre-frontal Cortex HSPB7 0.18 0.18 lasso 9 0.20 2.2e-25 -5.7 -7.1 1.2e-12 -0.57 1.00 0.00 FALSE
58 ROSMAP Brain Pre-frontal Cortex FAM131C 0.09 0.08 enet 13 0.06 4.3e-08 6.1 -7.5 6.9e-14 -0.58 1.00 0.00 FALSE
59 ROSMAP Brain Pre-frontal Cortex CLCNKA 0.16 0.18 enet 15 0.21 1.4e-26 7.0 -7.5 6.1e-14 -0.64 1.00 0.00 FALSE
60 ROSMAP Brain Pre-frontal Cortex NBPF1 0.39 0.08 enet 47 0.18 4.0e-22 -2.4 -5.2 2.0e-07 -0.01 1.00 0.00 FALSE
61 ROSMAP Brain Pre-frontal Cortex RP11-169K16.7 0.07 0.07 lasso 6 0.06 1.4e-08 -7.1 6.6 3.7e-11 0.48 1.00 0.00 FALSE
62 The Cancer Genome Atlas Bladder Urothelial Carcinoma CASP9 0.05 0.05 blup 52 0.06 6.7e-06 -6.6 7.2 6.6e-13 0.03 0.02 0.98 FALSE
63 The Cancer Genome Atlas Bladder Urothelial Carcinoma CROCC 0.09 0.04 lasso 4 0.06 1.3e-05 -4.1 -5.2 2.5e-07 -0.02 0.03 0.95 FALSE
64 The Cancer Genome Atlas Breast Invasive Carcinoma ATP13A2 0.05 0.00 enet 1 0.01 1.6e-02 -5.1 5.1 2.8e-07 0.01 0.01 0.38 FALSE
65 The Cancer Genome Atlas Colon Adenocarcinoma ATP13A2 0.11 0.04 blup 54 0.08 3.4e-05 5.0 6.1 8.4e-10 0.05 0.02 0.92 FALSE
66 The Cancer Genome Atlas Colon Adenocarcinoma CLCNKA 0.06 0.02 blup 62 0.03 9.8e-03 -4.4 6.4 1.7e-10 0.56 0.05 0.12 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CASP9 0.06 0.04 blup 51 0.05 7.3e-06 5.6 5.9 3.0e-09 0.02 0.14 0.78 FALSE
68 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CASP9 0.09 0.06 enet 19 0.08 2.6e-05 5.3 6.5 1.0e-10 0.05 0.06 0.93 FALSE
69 The Cancer Genome Atlas Brain Lower Grade Glioma AGMAT 0.07 0.07 lasso 2 0.07 5.4e-08 5.3 5.3 1.4e-07 0.06 0.98 0.01 FALSE
70 The Cancer Genome Atlas Brain Lower Grade Glioma CASP9 0.03 0.04 blup 52 0.04 1.4e-05 5.3 6.8 1.3e-11 0.04 0.07 0.88 FALSE
71 The Cancer Genome Atlas Brain Lower Grade Glioma CLCNKA 0.02 0.02 blup 63 0.01 2.2e-02 7.0 -6.4 1.4e-10 -0.60 0.08 0.29 FALSE
72 The Cancer Genome Atlas Brain Lower Grade Glioma FAM131C 0.17 0.06 enet 26 0.10 6.0e-12 -5.3 -5.6 2.2e-08 -0.50 0.93 0.07 FALSE
73 The Cancer Genome Atlas Brain Lower Grade Glioma SDHB 0.03 0.02 blup 99 0.02 1.3e-03 -4.5 6.0 2.7e-09 0.04 0.06 0.71 FALSE
74 The Cancer Genome Atlas Lung Adenocarcinoma HSPB7 0.08 0.04 lasso 3 0.06 8.0e-08 9.1 -9.9 5.3e-23 -0.82 0.06 0.94 TRUE
75 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CASP9 0.03 0.02 enet 10 0.01 2.2e-02 5.3 5.5 4.1e-08 0.05 0.13 0.31 FALSE
76 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MST1P9 0.04 0.02 lasso 5 0.02 1.0e-03 -5.4 -5.6 2.2e-08 0.00 0.00 0.97 FALSE
77 The Cancer Genome Atlas Pancreatic Adenocarcinoma CASP9 0.12 0.02 blup 52 0.05 3.6e-03 5.3 5.9 4.0e-09 0.03 0.03 0.55 FALSE
78 The Cancer Genome Atlas Pancreatic Adenocarcinoma FAM131C 0.11 0.09 lasso 4 0.06 1.8e-03 7.0 -7.0 1.9e-12 -0.60 0.03 0.20 FALSE
79 The Cancer Genome Atlas Prostate Adenocarcinoma CASP9 0.20 0.18 blup 52 0.20 1.2e-20 -7.0 7.0 3.5e-12 0.02 0.01 0.99 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma CLCNKA 0.22 0.28 lasso 10 0.28 7.8e-30 -5.7 5.5 4.1e-08 0.48 1.00 0.00 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma CLCNKB 0.03 0.03 lasso 2 0.01 1.1e-02 9.1 8.7 2.5e-18 0.75 0.04 0.04 FALSE
82 The Cancer Genome Atlas Prostate Adenocarcinoma MST1P9 0.13 0.09 lasso 6 0.11 3.3e-11 5.1 -5.5 4.0e-08 -0.02 0.01 0.99 FALSE
83 The Cancer Genome Atlas Soft Tissue Sarcoma CASP9 0.05 0.02 blup 52 0.02 1.2e-02 5.3 6.6 3.2e-11 0.04 0.02 0.67 FALSE
84 The Cancer Genome Atlas Soft Tissue Sarcoma SDHB 0.06 0.03 blup 99 0.02 2.1e-02 -5.4 5.7 1.1e-08 0.02 0.04 0.40 FALSE
85 The Cancer Genome Atlas Skin Cutaneous Melanoma SPEN 0.18 0.03 blup 71 0.00 3.7e-01 7.9 -7.0 1.8e-12 -0.62 0.01 0.56 FALSE
86 The Cancer Genome Atlas Testicular Germ Cell Tumors CLCNKA 0.21 0.14 blup 63 0.18 5.2e-07 -5.7 -6.5 9.9e-11 -0.54 0.67 0.15 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma CASP9 0.14 0.13 lasso 3 0.15 8.8e-15 5.3 6.4 1.4e-10 0.05 0.92 0.08 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma CLCNKA 0.09 0.11 lasso 4 0.10 9.2e-10 7.0 -6.7 1.5e-11 -0.60 0.97 0.03 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma DNAJC16 0.09 0.07 lasso 2 0.06 1.4e-06 5.4 5.7 1.0e-08 0.05 0.82 0.16 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma HSPB7 0.34 0.42 enet 15 0.46 6.7e-49 -5.9 -5.5 4.7e-08 -0.50 1.00 0.00 FALSE