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chr1:15,119,708-18,132,937

Best TWAS P=5.29e-23 · Best GWAS P=1.42e-25 conditioned to 0.0038

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
74	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPB7	0.08	0.04	lasso	3	0.06	8.0e-08	9.1	-9.9	5.3e-23	-0.82	0.06	0.94	TRUE
38	GTEx	Pancreas	CASP9	0.26	0.16	lasso	8	0.17	1.6e-07	-7.2	7.6	3.8e-14	0.05	0.98	0.00	TRUE
48	GTEx	Testis	CROCC	0.18	0.03	lasso	4	0.04	1.0e-02	5.2	-6.3	3.8e-10	-0.05	0.03	0.74	TRUE
18	GTEx	Cells Transformed fibroblasts	HSPB7	0.10	0.10	lasso	3	0.07	2.9e-06	8.9	-9.3	1.2e-20	-0.73	0.38	0.59	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCNKB	0.03	0.03	lasso	2	0.01	1.1e-02	9.1	8.7	2.5e-18	0.75	0.04	0.04	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	CLCNKA	0.16	0.18	enet	15	0.21	1.4e-26	7.0	-7.5	6.1e-14	-0.64	1.00	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	FAM131C	0.09	0.08	enet	13	0.06	4.3e-08	6.1	-7.5	6.9e-14	-0.58	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	HSPB7	0.18	0.16	lasso	11	0.15	3.1e-18	-5.8	-7.4	1.3e-13	-0.61	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CASP9	0.05	0.05	blup	52	0.06	6.7e-06	-6.6	7.2	6.6e-13	0.03	0.02	0.98	FALSE
50	GTEx	Thyroid	HSPB7	0.17	0.12	lasso	6	0.15	9.8e-12	-5.8	-7.1	9.3e-13	-0.60	1.00	0.00	FALSE
27	GTEx	Heart Left Ventricle	CASP9	0.22	0.13	enet	30	0.21	2.3e-11	-7.1	7.1	1.2e-12	0.04	1.00	0.00	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	HSPB7	0.18	0.18	lasso	9	0.20	2.2e-25	-5.7	-7.1	1.2e-12	-0.57	1.00	0.00	FALSE
25	GTEx	Heart Atrial Appendage	CASP9	0.25	0.21	enet	16	0.25	2.1e-11	-7.1	7.1	1.3e-12	0.04	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue	CASP9	0.14	0.15	lasso	11	0.14	7.2e-08	-7.1	7.0	1.7e-12	0.03	0.99	0.00	FALSE
36	GTEx	Nerve Tibial	CASP9	0.09	0.09	lasso	12	0.03	1.6e-03	-7.1	7.1	1.7e-12	0.02	0.94	0.00	FALSE
85	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SPEN	0.18	0.03	blup	71	0.00	3.7e-01	7.9	-7.0	1.8e-12	-0.62	0.01	0.56	FALSE
37	GTEx	Ovary	CASP9	0.33	0.07	lasso	7	0.06	1.4e-02	-7.0	7.0	1.9e-12	0.11	0.15	0.18	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM131C	0.11	0.09	lasso	4	0.06	1.8e-03	7.0	-7.0	1.9e-12	-0.60	0.03	0.20	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	CASP9	0.20	0.18	blup	52	0.20	1.2e-20	-7.0	7.0	3.5e-12	0.02	0.01	0.99	FALSE
24	GTEx	Esophagus Muscularis	CASP9	0.16	0.15	lasso	5	0.14	6.7e-09	-7.0	6.9	3.9e-12	0.02	1.00	0.00	FALSE
9	GTEx	Artery Coronary	CASP9	0.15	0.12	lasso	11	0.04	1.8e-02	-6.3	6.9	4.7e-12	0.04	0.40	0.03	FALSE
6	GTEx	Adipose Subcutaneous	CASP9	0.11	0.12	enet	17	0.11	2.9e-09	-7.0	6.9	5.0e-12	0.01	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	CASP9	0.21	-0.01	enet	40	0.01	1.1e-01	-7.0	6.9	5.2e-12	0.25	0.28	0.19	FALSE
45	GTEx	Spleen	CASP9	0.34	0.24	lasso	4	0.22	3.0e-06	-6.7	6.8	1.3e-11	0.03	0.72	0.02	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASP9	0.03	0.04	blup	52	0.04	1.4e-05	5.3	6.8	1.3e-11	0.04	0.07	0.88	FALSE
34	GTEx	Muscle Skeletal	CASP9	0.07	0.05	lasso	5	0.07	4.5e-07	5.2	6.8	1.4e-11	0.05	0.98	0.00	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	CLCNKA	0.09	0.11	lasso	4	0.10	9.2e-10	7.0	-6.7	1.5e-11	-0.60	0.97	0.03	FALSE
49	GTEx	Testis	DNAJC16	0.20	0.03	enet	24	0.04	6.0e-03	-6.1	6.7	1.7e-11	0.12	0.23	0.04	FALSE
83	The Cancer Genome Atlas	Soft Tissue Sarcoma	CASP9	0.05	0.02	blup	52	0.02	1.2e-02	5.3	6.6	3.2e-11	0.04	0.02	0.67	FALSE
39	GTEx	Prostate	CASP9	0.30	0.03	lasso	14	0.03	6.3e-02	-7.0	6.6	3.4e-11	0.05	0.18	0.05	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	RP11-169K16.7	0.07	0.07	lasso	6	0.06	1.4e-08	-7.1	6.6	3.7e-11	0.48	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Male)	CASP9	0.09	0.03	lasso	4	0.04	4.9e-02	-6.6	6.6	3.9e-11	0.03	0.08	0.05	FALSE
22	GTEx	Esophagus Mucosa	CASP9	0.17	0.10	enet	25	0.16	1.0e-10	-7.1	6.6	3.9e-11	0.02	1.00	0.00	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CASP9	0.16	0.12	lasso	15	0.09	1.3e-03	5.3	6.5	9.9e-11	0.05	0.13	0.11	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLCNKA	0.21	0.14	blup	63	0.18	5.2e-07	-5.7	-6.5	9.9e-11	-0.54	0.67	0.15	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CASP9	0.09	0.06	enet	19	0.08	2.6e-05	5.3	6.5	1.0e-10	0.05	0.06	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CASP9	0.09	0.07	lasso	2	0.07	2.3e-09	-7.0	-6.4	1.2e-10	-0.02	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLCNKA	0.02	0.02	blup	63	0.01	2.2e-02	7.0	-6.4	1.4e-10	-0.60	0.08	0.29	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	CASP9	0.14	0.13	lasso	3	0.15	8.8e-15	5.3	6.4	1.4e-10	0.05	0.92	0.08	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCNKA	0.06	0.02	blup	62	0.03	9.8e-03	-4.4	6.4	1.7e-10	0.56	0.05	0.12	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM131C	0.21	0.14	lasso	10	0.16	2.0e-19	6.1	-6.4	1.8e-10	-0.53	1.00	0.00	FALSE
28	GTEx	Liver	CASP9	0.46	0.19	lasso	9	0.22	1.1e-06	-7.1	6.3	2.3e-10	0.00	0.52	0.03	FALSE
31	GTEx	Lung	CASP9	0.16	0.10	enet	28	0.11	4.9e-09	-7.0	6.3	2.8e-10	-0.03	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-169K16.9	0.09	0.04	lasso	3	0.03	1.6e-03	-5.0	6.2	4.3e-10	0.41	0.36	0.02	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP13A2	0.11	0.04	blup	54	0.08	3.4e-05	5.0	6.1	8.4e-10	0.05	0.02	0.92	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	DNAJC16	0.07	0.02	bslmm	516	0.03	3.0e-05	5.3	6.1	1.2e-09	0.07	0.90	0.00	FALSE
52	GTEx	Uterus	CASP9	0.48	0.19	lasso	7	0.22	2.5e-05	-7.0	6.0	1.9e-09	-0.01	0.49	0.03	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	SDHB	0.03	0.02	blup	99	0.02	1.3e-03	-4.5	6.0	2.7e-09	0.04	0.06	0.71	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CASP9	0.06	0.04	blup	51	0.05	7.3e-06	5.6	5.9	3.0e-09	0.02	0.14	0.78	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CASP9	0.12	0.02	blup	52	0.05	3.6e-03	5.3	5.9	4.0e-09	0.03	0.03	0.55	FALSE
54	GTEx	Whole Blood	MST1L	0.08	0.02	enet	12	0.04	6.3e-05	-4.1	-5.9	4.8e-09	0.00	0.15	0.83	FALSE
30	GTEx	Lung	MFAP2	0.09	0.08	enet	19	0.06	1.3e-05	-4.9	5.8	6.3e-09	0.03	0.19	0.79	FALSE
42	GTEx	Skin Sun Exposed Lower leg	CROCC	0.19	0.13	enet	30	0.21	3.4e-17	-4.1	-5.8	6.7e-09	-0.04	0.88	0.11	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	MST1L	0.31	0.10	lasso	6	0.14	2.2e-05	-5.4	-5.8	7.1e-09	0.00	0.08	0.88	FALSE
55	METSIM	Adipose	PLEKHM2	0.06	0.06	lasso	6	0.06	6.3e-10	-6.3	5.8	7.4e-09	0.03	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	CROCC	0.14	0.08	enet	18	0.14	9.5e-10	-4.7	-5.7	9.8e-09	-0.03	0.02	0.98	FALSE
53	GTEx	Whole Blood	MST1P2	0.05	0.02	enet	14	0.04	1.8e-04	-3.7	5.7	1.0e-08	0.14	0.05	0.92	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	DNAJC16	0.09	0.07	lasso	2	0.06	1.4e-06	5.4	5.7	1.0e-08	0.05	0.82	0.16	FALSE
29	GTEx	Liver	MST1P2	0.20	0.14	lasso	4	0.10	7.6e-04	5.2	5.7	1.1e-08	0.02	0.06	0.66	FALSE
47	GTEx	Stomach	NBPF1	0.09	0.01	lasso	2	0.00	4.0e-01	-5.5	-5.7	1.1e-08	-0.05	0.07	0.13	FALSE
84	The Cancer Genome Atlas	Soft Tissue Sarcoma	SDHB	0.06	0.03	blup	99	0.02	2.1e-02	-5.4	5.7	1.1e-08	0.02	0.04	0.40	FALSE
8	GTEx	Artery Aorta	CASP9	0.13	0.02	lasso	5	0.03	1.4e-02	5.4	5.7	1.3e-08	0.06	0.20	0.27	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM131C	0.17	0.06	enet	26	0.10	6.0e-12	-5.3	-5.6	2.2e-08	-0.50	0.93	0.07	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MST1P9	0.04	0.02	lasso	5	0.02	1.0e-03	-5.4	-5.6	2.2e-08	0.00	0.00	0.97	FALSE
33	GTEx	Muscle Skeletal	PADI2	0.03	0.03	lasso	2	0.03	4.6e-04	-5.4	-5.6	2.7e-08	-0.02	0.02	0.97	FALSE
32	GTEx	Muscle Skeletal	PLEKHM2	0.08	0.06	lasso	2	0.04	2.1e-04	-6.1	5.5	3.7e-08	0.03	0.66	0.02	FALSE
23	GTEx	Esophagus Mucosa	NBPF1	0.17	0.09	enet	27	0.12	1.5e-08	-5.5	-5.5	3.8e-08	-0.02	0.41	0.59	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	MST1P9	0.13	0.09	lasso	6	0.11	3.3e-11	5.1	-5.5	4.0e-08	-0.02	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CASP9	0.03	0.02	enet	10	0.01	2.2e-02	5.3	5.5	4.1e-08	0.05	0.13	0.31	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCNKA	0.22	0.28	lasso	10	0.28	7.8e-30	-5.7	5.5	4.1e-08	0.48	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	HSPB7	0.34	0.42	enet	15	0.46	6.7e-49	-5.9	-5.5	4.7e-08	-0.50	1.00	0.00	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	NBPF1	0.08	0.02	lasso	3	0.00	2.8e-01	-4.8	-5.4	7.6e-08	-0.04	0.16	0.20	FALSE
46	GTEx	Stomach	CASP9	0.24	0.06	enet	14	0.11	9.4e-06	-7.0	5.4	8.1e-08	-0.04	0.95	0.00	FALSE
7	GTEx	Adrenal Gland	CROCC	0.16	0.00	lasso	3	0.00	2.1e-01	-4.1	-5.3	9.5e-08	-0.04	0.03	0.66	FALSE
35	GTEx	Nerve Tibial	MFAP2	0.09	0.06	lasso	3	0.07	9.7e-06	5.0	5.3	9.6e-08	0.02	0.19	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP13A2	0.08	0.06	lasso	5	0.08	6.9e-10	5.1	5.3	1.4e-07	0.02	0.19	0.81	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	MST1P2	0.14	0.03	lasso	4	0.01	5.0e-02	5.1	5.3	1.4e-07	0.03	0.09	0.38	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	AGMAT	0.07	0.07	lasso	2	0.07	5.4e-08	5.3	5.3	1.4e-07	0.06	0.98	0.01	FALSE
17	GTEx	Cells Transformed fibroblasts	CASP9	0.23	0.14	lasso	10	0.14	1.5e-10	5.3	5.2	1.5e-07	0.06	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CROCC	0.18	0.15	enet	24	0.19	2.9e-15	-3.7	-5.2	1.6e-07	-0.03	0.96	0.03	FALSE
43	GTEx	Skin Sun Exposed Lower leg	NBPF1	0.14	0.04	lasso	7	0.05	2.9e-05	-3.7	-5.2	1.6e-07	-0.03	0.95	0.04	FALSE
51	GTEx	Thyroid	MST1P2	0.18	0.11	lasso	9	0.13	2.7e-10	5.1	5.2	1.6e-07	0.00	0.16	0.83	FALSE
10	GTEx	Artery Tibial	MFAP2	0.15	0.06	enet	20	0.07	2.3e-06	-4.7	5.2	1.7e-07	0.04	0.30	0.68	FALSE
26	GTEx	Heart Atrial Appendage	MST1P2	0.20	0.09	lasso	4	0.09	6.7e-05	-4.5	5.2	1.7e-07	0.04	0.15	0.74	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	NBPF1	0.39	0.08	enet	47	0.18	4.0e-22	-2.4	-5.2	2.0e-07	-0.01	1.00	0.00	FALSE
11	GTEx	Artery Tibial	MST1L	0.21	0.08	lasso	6	0.12	5.0e-10	-3.7	-5.2	2.2e-07	-0.02	0.40	0.59	FALSE
12	GTEx	Brain Cerebellum	MST1L	0.21	0.13	lasso	2	0.09	1.7e-03	5.2	-5.2	2.2e-07	-0.04	0.07	0.53	FALSE
44	GTEx	Small Intestine Terminal Ileum	CROCC	0.32	0.07	lasso	14	0.18	7.9e-05	-4.1	-5.2	2.2e-07	-0.04	0.04	0.58	FALSE
63	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CROCC	0.09	0.04	lasso	4	0.06	1.3e-05	-4.1	-5.2	2.5e-07	-0.02	0.03	0.95	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP13A2	0.05	0.00	enet	1	0.01	1.6e-02	-5.1	5.1	2.8e-07	0.01	0.01	0.38	FALSE