Best TWAS P=1.72e-22 · Best GWAS P=1.76e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | UBE2E3 | 0.09 | 0.00 | lasso | 3 | 0.01 | 1.6e-01 | -9.5 | -9.0 | 3.3e-19 | 0.89 | 0.03 | 0.78 | FALSE |
| 2 | GTEx | Brain Hippocampus | FTH1P20 | 0.18 | 0.02 | lasso | 6 | 0.00 | 4.3e-01 | -8.7 | 8.3 | 1.4e-16 | -0.78 | 0.04 | 0.48 | FALSE |
| 3 | GTEx | Esophagus Mucosa | UBE2E3 | 0.07 | 0.02 | enet | 22 | 0.06 | 7.9e-05 | 3.9 | -6.9 | 6.2e-12 | 0.52 | 0.14 | 0.77 | FALSE |
| 4 | GTEx | Esophagus Muscularis | UBE2E3 | 0.10 | 0.09 | lasso | 3 | 0.08 | 2.2e-05 | -9.4 | -9.2 | 5.4e-20 | 0.83 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | UBE2E3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 6.4e-03 | -9.5 | -9.8 | 1.7e-22 | 0.99 | 0.01 | 0.98 | TRUE |
| 6 | GTEx | Ovary | UBE2E3 | 0.25 | 0.09 | lasso | 8 | 0.10 | 1.5e-03 | 6.4 | -6.8 | 1.0e-11 | 0.62 | 0.08 | 0.55 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | UBE2E3 | 0.25 | 0.06 | enet | 39 | 0.12 | 2.5e-07 | -7.1 | -8.3 | 1.3e-16 | 0.64 | 0.03 | 0.97 | FALSE |
| 8 | NTR | Blood | UBE2E3 | 0.02 | 0.00 | bslmm | 446 | 0.00 | 1.1e-02 | -9.4 | -7.5 | 6.9e-14 | 0.62 | 0.02 | 0.93 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBE2E3 | 0.02 | 0.00 | blup | 61 | 0.01 | 1.1e-02 | 5.2 | -9.3 | 1.5e-20 | 0.79 | 0.02 | 0.76 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2E3 | 0.04 | 0.02 | blup | 61 | 0.02 | 1.4e-03 | -9.5 | -9.6 | 9.4e-22 | 0.89 | 0.01 | 0.90 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBE2E3 | 0.05 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -9.5 | -9.3 | 1.5e-20 | 0.92 | 0.01 | 0.98 | FALSE |