Best TWAS P=2.56e-28 · Best GWAS P=5.19e-30 conditioned to 0.234
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Colon Adenocarcinoma | HOXD3 | 0.13 | 0.07 | lasso | 4 | 0.05 | 8.4e-04 | -8.3 | -8.6 | 1.2e-17 | 0.44 | 0.02 | 0.61 | FALSE |
| 2 | The Cancer Genome Atlas | Colon Adenocarcinoma | HOXD9 | 0.06 | 0.04 | blup | 53 | 0.02 | 2.0e-02 | -9.8 | -9.6 | 5.5e-22 | 0.58 | 0.06 | 0.54 | TRUE |
| 3 | The Cancer Genome Atlas | Esophageal Carcinoma | HOXD12 | 0.21 | 0.05 | blup | 48 | 0.13 | 6.3e-05 | 1.7 | -5.4 | 5.4e-08 | 0.35 | 0.02 | 0.28 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXD11 | 0.03 | 0.02 | enet | 7 | 0.03 | 5.8e-04 | 4.7 | -8.7 | 3.7e-18 | 0.74 | 0.02 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HOXD10 | 0.06 | 0.03 | enet | 6 | 0.03 | 5.6e-03 | -11.4 | -10.6 | 3.6e-26 | 0.88 | 0.00 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HOXD9 | 0.05 | 0.02 | blup | 54 | 0.03 | 6.1e-03 | -9.6 | -11.0 | 2.6e-28 | 0.58 | 0.01 | 0.75 | TRUE |