Best TWAS P=1.55e-11 · Best GWAS P=1.17e-07 conditioned to 0.0909
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DAP | 0.25 | 0.09 | enet | 24 | 0.24 | 2.2e-19 | 4.6 | -6.2 | 6.7e-10 | 0.55 | 0.10 | 0.88 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | DAP | 0.21 | 0.07 | enet | 26 | 0.09 | 1.4e-05 | 4.6 | -6.1 | 1.1e-09 | 0.59 | 0.06 | 0.89 | FALSE |
| 3 | GTEx | Artery Aorta | DAP | 0.28 | 0.13 | enet | 42 | 0.19 | 9.6e-11 | 4.5 | -6.7 | 1.6e-11 | 0.58 | 0.03 | 0.96 | TRUE |
| 4 | GTEx | Artery Tibial | DAP | 0.31 | 0.07 | enet | 28 | 0.20 | 2.8e-15 | 4.6 | -6.1 | 8.3e-10 | 0.52 | 0.08 | 0.90 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | DAP | 0.34 | 0.14 | lasso | 8 | 0.26 | 6.5e-09 | 4.5 | -6.3 | 3.8e-10 | 0.55 | 0.04 | 0.94 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | DAP | 0.31 | 0.19 | lasso | 5 | 0.26 | 1.4e-19 | 4.0 | -6.3 | 3.9e-10 | 0.63 | 0.39 | 0.51 | FALSE |
| 7 | GTEx | Colon Transverse | DAP | 0.35 | 0.16 | lasso | 6 | 0.18 | 4.5e-09 | 4.6 | -6.3 | 2.9e-10 | 0.64 | 0.04 | 0.94 | FALSE |
| 8 | GTEx | Esophagus Mucosa | DAP | 0.16 | 0.05 | enet | 16 | 0.18 | 3.8e-12 | -5.3 | -6.6 | 5.3e-11 | 0.76 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Esophagus Muscularis | DAP | 0.27 | 0.15 | lasso | 8 | 0.24 | 5.6e-15 | 4.6 | -6.7 | 2.8e-11 | 0.70 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | DAP | 0.26 | 0.08 | lasso | 4 | 0.17 | 4.0e-08 | -5.3 | -6.5 | 1.0e-10 | 0.79 | 0.01 | 0.98 | FALSE |
| 11 | GTEx | Lung | DAP | 0.32 | 0.21 | lasso | 3 | 0.26 | 1.2e-19 | -5.3 | -6.3 | 2.3e-10 | 0.89 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Nerve Tibial | DAP | 0.40 | 0.11 | enet | 47 | 0.34 | 3.2e-25 | 4.6 | -6.2 | 7.1e-10 | 0.62 | 0.03 | 0.96 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | DAP | 0.21 | 0.11 | lasso | 5 | 0.16 | 3.9e-13 | 4.6 | -6.2 | 6.0e-10 | 0.60 | 0.10 | 0.88 | FALSE |
| 14 | GTEx | Testis | DAP | 0.28 | 0.00 | enet | 26 | 0.13 | 1.6e-06 | 4.2 | -5.5 | 3.7e-08 | 0.37 | 0.08 | 0.54 | FALSE |
| 15 | METSIM | Adipose | DAP | 0.13 | 0.03 | bslmm | 662 | 0.06 | 1.7e-09 | -5.3 | -6.0 | 1.4e-09 | 0.79 | 0.00 | 1.00 | FALSE |
| 16 | NTR | Blood | DAP | 0.03 | 0.01 | enet | 19 | 0.02 | 2.2e-06 | 4.5 | -5.8 | 8.1e-09 | 0.64 | 0.04 | 0.95 | FALSE |
| 17 | YFS | Blood | DAP | 0.35 | 0.19 | lasso | 8 | 0.27 | 1.3e-88 | -5.3 | -6.2 | 7.5e-10 | 0.84 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DAP | 0.06 | 0.04 | enet | 13 | 0.05 | 1.2e-10 | 4.5 | -6.2 | 5.9e-10 | 0.51 | 0.13 | 0.83 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | DAP | 0.03 | 0.02 | lasso | 3 | 0.02 | 6.0e-03 | 2.9 | -5.3 | 1.2e-07 | 0.55 | 0.08 | 0.76 | FALSE |