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chr5:12,225-1,803,901

Best TWAS P=1.53e-30 · Best GWAS P=5.12e-57 conditioned to 2.46e-71

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
50	METSIM	Adipose	SLC12A7	0.16	0.14	lasso	2	0.13	3.7e-19	11.52	11.5	1.5e-30	-0.03	1.00	0.00	TRUE
24	GTEx	Colon Transverse	C5orf55	0.17	0.07	lasso	6	0.09	4.8e-05	9.00	9.4	5.5e-21	-0.15	0.00	1.00	TRUE
46	GTEx	Whole Blood	SLC12A7	0.40	0.19	enet	10	0.25	1.7e-22	9.76	11.4	2.4e-30	-0.02	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	SLC12A7	0.17	0.07	enet	6	0.11	2.1e-09	11.03	11.2	5.0e-29	-0.02	1.00	0.00	FALSE
33	GTEx	Lung	SLC12A7	0.26	0.12	enet	14	0.12	2.0e-09	11.03	10.9	1.8e-27	-0.04	0.99	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	SLC12A7	0.16	0.04	lasso	3	0.04	3.9e-04	11.52	-10.5	5.7e-26	0.04	0.39	0.02	FALSE
54	YFS	Blood	SLC12A7	0.02	0.01	enet	23	0.02	6.0e-07	9.76	10.4	3.3e-25	0.11	0.99	0.00	FALSE
12	GTEx	Artery Tibial	C5orf55	0.08	0.00	enet	4	0.00	1.6e-01	7.70	9.3	2.0e-20	-0.12	0.01	0.98	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	C5orf55	0.23	0.04	lasso	6	0.06	2.6e-03	8.95	9.1	8.3e-20	-0.14	0.00	0.98	FALSE
17	GTEx	Brain Hypothalamus	EXOC3	0.31	0.22	lasso	6	0.22	5.6e-06	9.00	-9.0	1.6e-19	0.12	0.00	0.99	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC25845	0.07	0.02	blup	52	0.04	8.2e-04	8.95	9.0	2.3e-19	-0.10	0.01	0.76	FALSE
7	GTEx	Adipose Visceral Omentum	C5orf55	0.23	0.07	lasso	6	0.11	1.8e-06	8.95	9.0	2.4e-19	-0.10	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC25845	0.03	0.04	lasso	1	0.03	4.2e-04	8.95	8.9	3.6e-19	-0.09	0.01	0.97	FALSE
18	GTEx	Breast Mammary Tissue (Female)	EXOC3	0.02	0.01	lasso	3	0.00	3.8e-01	8.95	-8.9	4.1e-19	0.09	0.02	0.35	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC25845	0.06	0.05	lasso	5	0.06	2.5e-07	-6.89	8.9	7.2e-19	-0.12	0.04	0.96	FALSE
49	METSIM	Adipose	EXOC3	0.20	0.20	lasso	5	0.22	4.0e-33	7.84	-8.9	8.1e-19	0.14	0.06	0.94	FALSE
27	GTEx	Esophagus Mucosa	CTD-2228K2.5	0.08	0.04	lasso	3	0.02	2.5e-02	9.00	8.8	1.3e-18	-0.16	0.01	0.94	FALSE
31	GTEx	Heart Atrial Appendage	C5orf55	0.13	0.12	lasso	5	0.09	6.5e-05	9.11	8.8	1.9e-18	-0.17	0.00	0.99	FALSE
47	GTEx	Whole Blood	EXOC3	0.08	0.10	enet	7	0.10	1.2e-09	9.11	-8.6	8.4e-18	0.18	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC9A3	0.04	0.02	blup	63	0.02	9.4e-04	9.11	8.6	9.5e-18	-0.19	0.00	0.97	FALSE
5	GTEx	Adipose Subcutaneous	EXOC3	0.13	0.06	lasso	3	0.04	6.4e-04	9.11	-8.6	9.8e-18	0.15	0.00	1.00	FALSE
41	GTEx	Spleen	EXOC3	0.40	0.31	enet	5	0.32	5.6e-09	9.11	-8.4	3.1e-17	0.17	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	LOC25845	0.04	0.04	lasso	3	0.02	1.6e-03	8.01	8.4	3.4e-17	-0.04	0.05	0.33	FALSE
8	GTEx	Artery Aorta	EXOC3	0.27	0.12	lasso	5	0.10	2.9e-06	9.00	-8.3	9.3e-17	0.18	0.00	1.00	FALSE
48	METSIM	Adipose	C5orf55	0.13	0.10	lasso	8	0.10	1.1e-14	9.11	8.3	1.4e-16	-0.15	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EXOC3	0.15	0.01	blup	68	0.06	1.7e-03	8.95	-8.2	2.8e-16	0.13	0.00	0.90	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C5orf55	0.10	0.01	blup	57	0.05	2.7e-03	6.94	8.1	4.4e-16	-0.14	0.01	0.79	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC25845	0.03	0.03	lasso	2	0.03	1.0e-06	7.84	8.1	6.5e-16	-0.14	0.55	0.41	FALSE
28	GTEx	Esophagus Muscularis	EXOC3	0.20	0.16	lasso	4	0.20	2.3e-12	9.00	-8.1	7.9e-16	0.15	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C5orf55	0.12	0.10	enet	11	0.12	5.5e-13	7.70	7.9	3.0e-15	-0.13	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC12A7	0.05	0.01	blup	398	0.02	2.9e-03	9.32	-7.8	4.6e-15	0.04	0.06	0.08	FALSE
26	GTEx	Esophagus Mucosa	EXOC3	0.13	0.04	enet	12	0.06	1.4e-04	-6.48	-7.8	7.6e-15	0.13	0.09	0.90	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	C5orf55	0.16	0.06	lasso	3	0.08	3.0e-06	9.11	7.8	8.0e-15	-0.16	0.00	1.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	EXOC3	0.25	0.06	lasso	4	0.08	3.8e-03	5.92	-7.7	1.4e-14	0.12	0.01	0.94	FALSE
34	GTEx	Lung	EXOC3	0.09	0.06	lasso	2	0.09	3.5e-07	9.11	-7.7	1.6e-14	0.15	0.00	1.00	FALSE
45	GTEx	Thyroid	C5orf55	0.26	0.14	lasso	4	0.14	3.9e-11	9.11	7.7	1.6e-14	-0.16	0.00	1.00	FALSE
9	GTEx	Artery Aorta	C5orf55	0.20	0.06	lasso	5	0.09	7.0e-06	9.00	7.6	2.4e-14	-0.15	0.00	1.00	FALSE
29	GTEx	Esophagus Muscularis	C5orf55	0.19	0.08	lasso	6	0.08	1.4e-05	6.16	7.5	4.5e-14	-0.14	0.01	0.99	FALSE
14	GTEx	Brain Cerebellum	SLC9A3	0.48	0.25	lasso	3	0.34	6.2e-11	-5.24	-7.5	4.7e-14	0.03	0.05	0.95	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	EXOC3	0.08	0.07	enet	7	0.09	1.6e-10	7.84	-7.4	1.8e-13	0.09	0.20	0.80	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC25845	0.08	0.09	enet	10	0.10	1.1e-10	-6.38	7.3	2.6e-13	-0.13	0.91	0.09	FALSE
42	GTEx	Stomach	C5orf55	0.13	0.02	lasso	3	0.02	3.5e-02	6.16	7.3	2.7e-13	-0.13	0.01	0.93	FALSE
35	GTEx	Lung	C5orf55	0.15	0.02	lasso	5	0.07	4.1e-06	7.71	7.2	5.3e-13	-0.12	0.01	0.99	FALSE
32	GTEx	Heart Left Ventricle	C5orf55	0.19	0.08	lasso	4	0.12	6.1e-07	-3.16	7.1	1.0e-12	-0.14	0.00	0.99	FALSE
10	GTEx	Artery Tibial	BRD9	0.11	0.00	enet	7	0.00	3.0e-01	-0.86	-7.1	1.2e-12	-0.18	0.05	0.10	FALSE
30	GTEx	Heart Atrial Appendage	EXOC3	0.23	0.00	lasso	5	0.04	7.7e-03	-3.16	-7.1	1.4e-12	0.11	0.02	0.80	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	EXOC3	0.40	0.32	enet	19	0.36	5.3e-49	7.84	-7.0	1.8e-12	0.12	0.99	0.01	FALSE
6	GTEx	Adipose Subcutaneous	C5orf55	0.29	0.16	enet	41	0.23	1.8e-18	9.11	7.0	2.3e-12	-0.10	0.00	1.00	FALSE
20	GTEx	Cells Transformed fibroblasts	EXOC3	0.16	0.05	lasso	8	0.08	1.7e-06	9.00	-6.9	4.6e-12	0.13	0.00	1.00	FALSE
36	GTEx	Nerve Tibial	C5orf55	0.34	0.13	enet	21	0.20	2.6e-14	9.11	6.8	7.9e-12	-0.15	0.00	1.00	FALSE
51	METSIM	Adipose	ZDHHC11B	0.07	0.00	enet	45	0.02	4.1e-04	-2.34	-6.8	8.1e-12	0.01	0.02	0.62	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	C5orf55	0.11	0.03	lasso	4	0.05	5.8e-07	-2.73	6.8	8.7e-12	-0.11	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C5orf55	0.21	0.06	enet	16	0.16	2.5e-19	-3.16	6.8	1.1e-11	-0.11	0.02	0.98	FALSE
11	GTEx	Artery Tibial	EXOC3	0.27	0.05	lasso	3	0.14	1.9e-11	9.00	-6.8	1.4e-11	0.14	0.00	1.00	FALSE
43	GTEx	Testis	EXOC3	0.42	0.33	enet	26	0.34	5.6e-16	-6.92	-6.5	1.1e-10	0.11	0.92	0.08	FALSE
37	GTEx	Pancreas	EXOC3	0.15	0.09	lasso	4	0.14	2.0e-06	9.00	-6.4	1.3e-10	0.17	0.00	0.99	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHRR	0.10	0.01	blup	100	0.05	2.4e-06	0.96	6.3	3.7e-10	-0.07	0.11	0.13	FALSE
22	GTEx	Colon Sigmoid	EXOC3	0.38	0.11	lasso	7	0.24	5.7e-09	-2.35	-6.2	6.2e-10	0.14	0.01	0.98	FALSE
15	GTEx	Brain Frontal Cortex BA9	SLC9A3	0.41	0.27	lasso	6	0.32	2.5e-09	-5.24	-6.1	9.8e-10	-0.01	0.25	0.25	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC25845	0.04	0.00	enet	9	0.01	2.5e-02	-6.92	6.1	1.3e-09	-0.03	0.06	0.09	FALSE
23	GTEx	Colon Transverse	EXOC3	0.35	0.08	lasso	6	0.18	8.4e-09	-3.16	-6.1	1.4e-09	0.13	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EXOC3	0.10	0.00	blup	68	0.01	1.1e-01	5.92	-6.0	1.4e-09	0.00	0.02	0.15	FALSE
21	GTEx	Cells Transformed fibroblasts	C5orf55	0.41	0.22	enet	24	0.27	2.4e-20	-3.16	6.0	2.1e-09	-0.14	0.35	0.65	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf55	0.19	0.14	blup	57	0.25	6.2e-24	-3.16	5.8	5.1e-09	-0.12	0.08	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PP7080	0.12	0.04	lasso	4	0.07	9.9e-09	8.01	5.7	9.5e-09	0.00	0.74	0.05	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	NKD2	0.17	0.16	enet	14	0.19	3.5e-24	4.67	-5.6	2.0e-08	-0.02	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOC3	0.03	0.02	blup	66	0.01	5.7e-04	-3.16	-5.6	2.2e-08	0.07	0.03	0.42	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C5orf55	0.13	0.09	blup	57	0.11	5.5e-07	-2.73	5.5	3.0e-08	-0.12	0.02	0.98	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	C5orf55	0.22	0.02	lasso	6	0.04	3.2e-03	-3.16	5.5	3.1e-08	-0.12	0.08	0.74	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C5orf55	0.07	0.03	blup	55	0.03	1.5e-03	-2.73	5.5	3.7e-08	-0.13	0.06	0.80	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	EXOC3	0.33	0.03	blup	66	0.08	1.5e-03	-6.48	-5.5	4.6e-08	0.11	0.03	0.12	FALSE
40	GTEx	Skin Sun Exposed Lower leg	NKD2	0.13	0.09	lasso	4	0.09	3.1e-08	-5.80	-5.5	4.8e-08	-0.05	1.00	0.00	FALSE
44	GTEx	Testis	C5orf55	0.19	0.05	enet	6	0.12	6.8e-06	-0.93	5.5	4.9e-08	-0.13	0.03	0.95	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C5orf55	0.08	0.04	enet	10	0.06	9.4e-08	-2.73	5.4	6.8e-08	-0.13	0.08	0.92	FALSE
16	GTEx	Brain Hippocampus	EXOC3	0.34	0.00	lasso	7	0.07	1.0e-02	-2.58	-5.4	7.4e-08	0.17	0.02	0.53	FALSE
38	GTEx	Prostate	EXOC3	0.23	0.13	lasso	14	0.06	1.1e-02	1.13	-5.3	1.3e-07	0.16	0.03	0.87	FALSE