Best TWAS P=1.53e-30 · Best GWAS P=5.12e-57 conditioned to 2.46e-71
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C5orf55 | 0.21 | 0.06 | enet | 16 | 0.16 | 2.5e-19 | -3.16 | 6.8 | 1.1e-11 | -0.11 | 0.02 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PP7080 | 0.12 | 0.04 | lasso | 4 | 0.07 | 9.9e-09 | 8.01 | 5.7 | 9.5e-09 | 0.00 | 0.74 | 0.05 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | SLC12A7 | 0.05 | 0.01 | blup | 398 | 0.02 | 2.9e-03 | 9.32 | -7.8 | 4.6e-15 | 0.04 | 0.06 | 0.08 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | SLC12A7 | 0.17 | 0.07 | enet | 6 | 0.11 | 2.1e-09 | 11.03 | 11.2 | 5.0e-29 | -0.02 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | EXOC3 | 0.13 | 0.06 | lasso | 3 | 0.04 | 6.4e-04 | 9.11 | -8.6 | 9.8e-18 | 0.15 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Adipose Subcutaneous | C5orf55 | 0.29 | 0.16 | enet | 41 | 0.23 | 1.8e-18 | 9.11 | 7.0 | 2.3e-12 | -0.10 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Adipose Visceral Omentum | C5orf55 | 0.23 | 0.07 | lasso | 6 | 0.11 | 1.8e-06 | 8.95 | 9.0 | 2.4e-19 | -0.10 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Artery Aorta | EXOC3 | 0.27 | 0.12 | lasso | 5 | 0.10 | 2.9e-06 | 9.00 | -8.3 | 9.3e-17 | 0.18 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Artery Aorta | C5orf55 | 0.20 | 0.06 | lasso | 5 | 0.09 | 7.0e-06 | 9.00 | 7.6 | 2.4e-14 | -0.15 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Artery Tibial | BRD9 | 0.11 | 0.00 | enet | 7 | 0.00 | 3.0e-01 | -0.86 | -7.1 | 1.2e-12 | -0.18 | 0.05 | 0.10 | FALSE |
| 11 | GTEx | Artery Tibial | EXOC3 | 0.27 | 0.05 | lasso | 3 | 0.14 | 1.9e-11 | 9.00 | -6.8 | 1.4e-11 | 0.14 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Artery Tibial | C5orf55 | 0.08 | 0.00 | enet | 4 | 0.00 | 1.6e-01 | 7.70 | 9.3 | 2.0e-20 | -0.12 | 0.01 | 0.98 | FALSE |
| 13 | GTEx | Brain Cerebellar Hemisphere | EXOC3 | 0.25 | 0.06 | lasso | 4 | 0.08 | 3.8e-03 | 5.92 | -7.7 | 1.4e-14 | 0.12 | 0.01 | 0.94 | FALSE |
| 14 | GTEx | Brain Cerebellum | SLC9A3 | 0.48 | 0.25 | lasso | 3 | 0.34 | 6.2e-11 | -5.24 | -7.5 | 4.7e-14 | 0.03 | 0.05 | 0.95 | FALSE |
| 15 | GTEx | Brain Frontal Cortex BA9 | SLC9A3 | 0.41 | 0.27 | lasso | 6 | 0.32 | 2.5e-09 | -5.24 | -6.1 | 9.8e-10 | -0.01 | 0.25 | 0.25 | FALSE |
| 16 | GTEx | Brain Hippocampus | EXOC3 | 0.34 | 0.00 | lasso | 7 | 0.07 | 1.0e-02 | -2.58 | -5.4 | 7.4e-08 | 0.17 | 0.02 | 0.53 | FALSE |
| 17 | GTEx | Brain Hypothalamus | EXOC3 | 0.31 | 0.22 | lasso | 6 | 0.22 | 5.6e-06 | 9.00 | -9.0 | 1.6e-19 | 0.12 | 0.00 | 0.99 | FALSE |
| 18 | GTEx | Breast Mammary Tissue (Female) | EXOC3 | 0.02 | 0.01 | lasso | 3 | 0.00 | 3.8e-01 | 8.95 | -8.9 | 4.1e-19 | 0.09 | 0.02 | 0.35 | FALSE |
| 19 | GTEx | Cells Transformed fibroblasts | SLC12A7 | 0.16 | 0.04 | lasso | 3 | 0.04 | 3.9e-04 | 11.52 | -10.5 | 5.7e-26 | 0.04 | 0.39 | 0.02 | FALSE |
| 20 | GTEx | Cells Transformed fibroblasts | EXOC3 | 0.16 | 0.05 | lasso | 8 | 0.08 | 1.7e-06 | 9.00 | -6.9 | 4.6e-12 | 0.13 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Cells Transformed fibroblasts | C5orf55 | 0.41 | 0.22 | enet | 24 | 0.27 | 2.4e-20 | -3.16 | 6.0 | 2.1e-09 | -0.14 | 0.35 | 0.65 | FALSE |
| 22 | GTEx | Colon Sigmoid | EXOC3 | 0.38 | 0.11 | lasso | 7 | 0.24 | 5.7e-09 | -2.35 | -6.2 | 6.2e-10 | 0.14 | 0.01 | 0.98 | FALSE |
| 23 | GTEx | Colon Transverse | EXOC3 | 0.35 | 0.08 | lasso | 6 | 0.18 | 8.4e-09 | -3.16 | -6.1 | 1.4e-09 | 0.13 | 0.01 | 0.99 | FALSE |
| 24 | GTEx | Colon Transverse | C5orf55 | 0.17 | 0.07 | lasso | 6 | 0.09 | 4.8e-05 | 9.00 | 9.4 | 5.5e-21 | -0.15 | 0.00 | 1.00 | TRUE |
| 25 | GTEx | Esophagus Gastroesophageal Junction | C5orf55 | 0.23 | 0.04 | lasso | 6 | 0.06 | 2.6e-03 | 8.95 | 9.1 | 8.3e-20 | -0.14 | 0.00 | 0.98 | FALSE |
| 26 | GTEx | Esophagus Mucosa | EXOC3 | 0.13 | 0.04 | enet | 12 | 0.06 | 1.4e-04 | -6.48 | -7.8 | 7.6e-15 | 0.13 | 0.09 | 0.90 | FALSE |
| 27 | GTEx | Esophagus Mucosa | CTD-2228K2.5 | 0.08 | 0.04 | lasso | 3 | 0.02 | 2.5e-02 | 9.00 | 8.8 | 1.3e-18 | -0.16 | 0.01 | 0.94 | FALSE |
| 28 | GTEx | Esophagus Muscularis | EXOC3 | 0.20 | 0.16 | lasso | 4 | 0.20 | 2.3e-12 | 9.00 | -8.1 | 7.9e-16 | 0.15 | 0.00 | 1.00 | FALSE |
| 29 | GTEx | Esophagus Muscularis | C5orf55 | 0.19 | 0.08 | lasso | 6 | 0.08 | 1.4e-05 | 6.16 | 7.5 | 4.5e-14 | -0.14 | 0.01 | 0.99 | FALSE |
| 30 | GTEx | Heart Atrial Appendage | EXOC3 | 0.23 | 0.00 | lasso | 5 | 0.04 | 7.7e-03 | -3.16 | -7.1 | 1.4e-12 | 0.11 | 0.02 | 0.80 | FALSE |
| 31 | GTEx | Heart Atrial Appendage | C5orf55 | 0.13 | 0.12 | lasso | 5 | 0.09 | 6.5e-05 | 9.11 | 8.8 | 1.9e-18 | -0.17 | 0.00 | 0.99 | FALSE |
| 32 | GTEx | Heart Left Ventricle | C5orf55 | 0.19 | 0.08 | lasso | 4 | 0.12 | 6.1e-07 | -3.16 | 7.1 | 1.0e-12 | -0.14 | 0.00 | 0.99 | FALSE |
| 33 | GTEx | Lung | SLC12A7 | 0.26 | 0.12 | enet | 14 | 0.12 | 2.0e-09 | 11.03 | 10.9 | 1.8e-27 | -0.04 | 0.99 | 0.00 | FALSE |
| 34 | GTEx | Lung | EXOC3 | 0.09 | 0.06 | lasso | 2 | 0.09 | 3.5e-07 | 9.11 | -7.7 | 1.6e-14 | 0.15 | 0.00 | 1.00 | FALSE |
| 35 | GTEx | Lung | C5orf55 | 0.15 | 0.02 | lasso | 5 | 0.07 | 4.1e-06 | 7.71 | 7.2 | 5.3e-13 | -0.12 | 0.01 | 0.99 | FALSE |
| 36 | GTEx | Nerve Tibial | C5orf55 | 0.34 | 0.13 | enet | 21 | 0.20 | 2.6e-14 | 9.11 | 6.8 | 7.9e-12 | -0.15 | 0.00 | 1.00 | FALSE |
| 37 | GTEx | Pancreas | EXOC3 | 0.15 | 0.09 | lasso | 4 | 0.14 | 2.0e-06 | 9.00 | -6.4 | 1.3e-10 | 0.17 | 0.00 | 0.99 | FALSE |
| 38 | GTEx | Prostate | EXOC3 | 0.23 | 0.13 | lasso | 14 | 0.06 | 1.1e-02 | 1.13 | -5.3 | 1.3e-07 | 0.16 | 0.03 | 0.87 | FALSE |
| 39 | GTEx | Skin Not Sun Exposed Suprapubic | C5orf55 | 0.22 | 0.02 | lasso | 6 | 0.04 | 3.2e-03 | -3.16 | 5.5 | 3.1e-08 | -0.12 | 0.08 | 0.74 | FALSE |
| 40 | GTEx | Skin Sun Exposed Lower leg | NKD2 | 0.13 | 0.09 | lasso | 4 | 0.09 | 3.1e-08 | -5.80 | -5.5 | 4.8e-08 | -0.05 | 1.00 | 0.00 | FALSE |
| 41 | GTEx | Spleen | EXOC3 | 0.40 | 0.31 | enet | 5 | 0.32 | 5.6e-09 | 9.11 | -8.4 | 3.1e-17 | 0.17 | 0.00 | 1.00 | FALSE |
| 42 | GTEx | Stomach | C5orf55 | 0.13 | 0.02 | lasso | 3 | 0.02 | 3.5e-02 | 6.16 | 7.3 | 2.7e-13 | -0.13 | 0.01 | 0.93 | FALSE |
| 43 | GTEx | Testis | EXOC3 | 0.42 | 0.33 | enet | 26 | 0.34 | 5.6e-16 | -6.92 | -6.5 | 1.1e-10 | 0.11 | 0.92 | 0.08 | FALSE |
| 44 | GTEx | Testis | C5orf55 | 0.19 | 0.05 | enet | 6 | 0.12 | 6.8e-06 | -0.93 | 5.5 | 4.9e-08 | -0.13 | 0.03 | 0.95 | FALSE |
| 45 | GTEx | Thyroid | C5orf55 | 0.26 | 0.14 | lasso | 4 | 0.14 | 3.9e-11 | 9.11 | 7.7 | 1.6e-14 | -0.16 | 0.00 | 1.00 | FALSE |
| 46 | GTEx | Whole Blood | SLC12A7 | 0.40 | 0.19 | enet | 10 | 0.25 | 1.7e-22 | 9.76 | 11.4 | 2.4e-30 | -0.02 | 1.00 | 0.00 | FALSE |
| 47 | GTEx | Whole Blood | EXOC3 | 0.08 | 0.10 | enet | 7 | 0.10 | 1.2e-09 | 9.11 | -8.6 | 8.4e-18 | 0.18 | 0.00 | 1.00 | FALSE |
| 48 | METSIM | Adipose | C5orf55 | 0.13 | 0.10 | lasso | 8 | 0.10 | 1.1e-14 | 9.11 | 8.3 | 1.4e-16 | -0.15 | 0.00 | 1.00 | FALSE |
| 49 | METSIM | Adipose | EXOC3 | 0.20 | 0.20 | lasso | 5 | 0.22 | 4.0e-33 | 7.84 | -8.9 | 8.1e-19 | 0.14 | 0.06 | 0.94 | FALSE |
| 50 | METSIM | Adipose | SLC12A7 | 0.16 | 0.14 | lasso | 2 | 0.13 | 3.7e-19 | 11.52 | 11.5 | 1.5e-30 | -0.03 | 1.00 | 0.00 | TRUE |
| 51 | METSIM | Adipose | ZDHHC11B | 0.07 | 0.00 | enet | 45 | 0.02 | 4.1e-04 | -2.34 | -6.8 | 8.1e-12 | 0.01 | 0.02 | 0.62 | FALSE |
| 52 | ROSMAP | Brain Pre-frontal Cortex | NKD2 | 0.17 | 0.16 | enet | 14 | 0.19 | 3.5e-24 | 4.67 | -5.6 | 2.0e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 53 | ROSMAP | Brain Pre-frontal Cortex | EXOC3 | 0.40 | 0.32 | enet | 19 | 0.36 | 5.3e-49 | 7.84 | -7.0 | 1.8e-12 | 0.12 | 0.99 | 0.01 | FALSE |
| 54 | YFS | Blood | SLC12A7 | 0.02 | 0.01 | enet | 23 | 0.02 | 6.0e-07 | 9.76 | 10.4 | 3.3e-25 | 0.11 | 0.99 | 0.00 | FALSE |
| 55 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C5orf55 | 0.07 | 0.03 | blup | 55 | 0.03 | 1.5e-03 | -2.73 | 5.5 | 3.7e-08 | -0.13 | 0.06 | 0.80 | FALSE |
| 56 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOC3 | 0.03 | 0.02 | blup | 66 | 0.01 | 5.7e-04 | -3.16 | -5.6 | 2.2e-08 | 0.07 | 0.03 | 0.42 | FALSE |
| 57 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC25845 | 0.03 | 0.03 | lasso | 2 | 0.03 | 1.0e-06 | 7.84 | 8.1 | 6.5e-16 | -0.14 | 0.55 | 0.41 | FALSE |
| 58 | The Cancer Genome Atlas | Glioblastoma Multiforme | EXOC3 | 0.33 | 0.03 | blup | 66 | 0.08 | 1.5e-03 | -6.48 | -5.5 | 4.6e-08 | 0.11 | 0.03 | 0.12 | FALSE |
| 59 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C5orf55 | 0.08 | 0.04 | enet | 10 | 0.06 | 9.4e-08 | -2.73 | 5.4 | 6.8e-08 | -0.13 | 0.08 | 0.92 | FALSE |
| 60 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AHRR | 0.10 | 0.01 | blup | 100 | 0.05 | 2.4e-06 | 0.96 | 6.3 | 3.7e-10 | -0.07 | 0.11 | 0.13 | FALSE |
| 61 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C5orf55 | 0.12 | 0.10 | enet | 11 | 0.12 | 5.5e-13 | 7.70 | 7.9 | 3.0e-15 | -0.13 | 0.02 | 0.98 | FALSE |
| 62 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC25845 | 0.06 | 0.05 | lasso | 5 | 0.06 | 2.5e-07 | -6.89 | 8.9 | 7.2e-19 | -0.12 | 0.04 | 0.96 | FALSE |
| 63 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC9A3 | 0.04 | 0.02 | blup | 63 | 0.02 | 9.4e-04 | 9.11 | 8.6 | 9.5e-18 | -0.19 | 0.00 | 0.97 | FALSE |
| 64 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C5orf55 | 0.13 | 0.09 | blup | 57 | 0.11 | 5.5e-07 | -2.73 | 5.5 | 3.0e-08 | -0.12 | 0.02 | 0.98 | FALSE |
| 65 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EXOC3 | 0.10 | 0.00 | blup | 68 | 0.01 | 1.1e-01 | 5.92 | -6.0 | 1.4e-09 | 0.00 | 0.02 | 0.15 | FALSE |
| 66 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EXOC3 | 0.08 | 0.07 | enet | 7 | 0.09 | 1.6e-10 | 7.84 | -7.4 | 1.8e-13 | 0.09 | 0.20 | 0.80 | FALSE |
| 67 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC25845 | 0.04 | 0.00 | enet | 9 | 0.01 | 2.5e-02 | -6.92 | 6.1 | 1.3e-09 | -0.03 | 0.06 | 0.09 | FALSE |
| 68 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C5orf55 | 0.10 | 0.01 | blup | 57 | 0.05 | 2.7e-03 | 6.94 | 8.1 | 4.4e-16 | -0.14 | 0.01 | 0.79 | FALSE |
| 69 | The Cancer Genome Atlas | Lung Adenocarcinoma | C5orf55 | 0.11 | 0.03 | lasso | 4 | 0.05 | 5.8e-07 | -2.73 | 6.8 | 8.7e-12 | -0.11 | 0.03 | 0.97 | FALSE |
| 70 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC25845 | 0.03 | 0.04 | lasso | 1 | 0.03 | 4.2e-04 | 8.95 | 8.9 | 3.6e-19 | -0.09 | 0.01 | 0.97 | FALSE |
| 71 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOC25845 | 0.07 | 0.02 | blup | 52 | 0.04 | 8.2e-04 | 8.95 | 9.0 | 2.3e-19 | -0.10 | 0.01 | 0.76 | FALSE |
| 72 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EXOC3 | 0.15 | 0.01 | blup | 68 | 0.06 | 1.7e-03 | 8.95 | -8.2 | 2.8e-16 | 0.13 | 0.00 | 0.90 | FALSE |
| 73 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC25845 | 0.08 | 0.09 | enet | 10 | 0.10 | 1.1e-10 | -6.38 | 7.3 | 2.6e-13 | -0.13 | 0.91 | 0.09 | FALSE |
| 74 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C5orf55 | 0.16 | 0.06 | lasso | 3 | 0.08 | 3.0e-06 | 9.11 | 7.8 | 8.0e-15 | -0.16 | 0.00 | 1.00 | FALSE |
| 75 | The Cancer Genome Atlas | Thyroid Carcinoma | C5orf55 | 0.19 | 0.14 | blup | 57 | 0.25 | 6.2e-24 | -3.16 | 5.8 | 5.1e-09 | -0.12 | 0.08 | 0.92 | FALSE |
| 76 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC25845 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.6e-03 | 8.01 | 8.4 | 3.4e-17 | -0.04 | 0.05 | 0.33 | FALSE |