TWAS
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Models
Genes
Traits
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Traits
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Blood Red Count
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chr5:38,148,794-39,670,061
Best TWAS P=3.82e-13 · Best GWAS P=1.43e-16 conditioned to 8.11e-10
38.2M
38.4M
38.6M
38.8M
39M
39.2M
39.4M
39.6M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Cells Transformed fibroblasts
OSMR
0.15
0.01
enet
16
0.06
3.1e-05
-7.4
7.3
3.8e-13
-0.31
0.48
0.12
TRUE
5
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
DAB2
0.04
0.01
enet
9
0.02
3.3e-03
-4.1
-5.5
5.2e-08
0.03
0.01
0.53
TRUE
1
GTEx
Adipose Subcutaneous
OSMR
0.12
0.06
lasso
3
0.05
4.8e-05
-6.6
7.1
1.1e-12
-0.43
0.34
0.55
FALSE
2
GTEx
Artery Aorta
OSMR
0.12
0.05
enet
31
0.06
3.5e-04
-6.9
6.3
3.4e-10
-0.43
0.13
0.52
FALSE
4
METSIM
Adipose
OSMR
0.03
0.00
blup
479
0.01
1.1e-02
-6.9
5.6
2.1e-08
-0.58
0.16
0.49
FALSE