Best TWAS P=3.82e-13 · Best GWAS P=1.43e-16 conditioned to 8.11e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | OSMR | 0.12 | 0.06 | lasso | 3 | 0.05 | 4.8e-05 | -6.6 | 7.1 | 1.1e-12 | -0.43 | 0.34 | 0.55 | FALSE |
| 2 | GTEx | Artery Aorta | OSMR | 0.12 | 0.05 | enet | 31 | 0.06 | 3.5e-04 | -6.9 | 6.3 | 3.4e-10 | -0.43 | 0.13 | 0.52 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | OSMR | 0.15 | 0.01 | enet | 16 | 0.06 | 3.1e-05 | -7.4 | 7.3 | 3.8e-13 | -0.31 | 0.48 | 0.12 | TRUE |
| 4 | METSIM | Adipose | OSMR | 0.03 | 0.00 | blup | 479 | 0.01 | 1.1e-02 | -6.9 | 5.6 | 2.1e-08 | -0.58 | 0.16 | 0.49 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DAB2 | 0.04 | 0.01 | enet | 9 | 0.02 | 3.3e-03 | -4.1 | -5.5 | 5.2e-08 | 0.03 | 0.01 | 0.53 | TRUE |