TWAS
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Usage
Models
Genes
Traits
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Traits
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Blood Red Count
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chr5:40,018,216-41,529,448
Best TWAS P=4.01e-10 · Best GWAS P=1.15e-10 conditioned to 0.0257
40M
40.2M
40.4M
40.6M
40.8M
41M
41.2M
41.4M
41.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
PRKAA1
0.02
0.02
blup
51
0.01
1.9e-02
6.0
-6.2
4.0e-10
-0.83
0.01
0.94
TRUE
4
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
TTC33
0.05
0.04
blup
47
0.03
1.9e-02
4.7
5.7
1.1e-08
0.88
0.03
0.58
FALSE
2
GTEx
Artery Tibial
TTC33
0.08
0.08
lasso
2
0.06
1.1e-05
5.6
5.6
2.8e-08
0.88
0.10
0.89
FALSE
1
CommonMind
Brain Pre-frontal Cortex
LOC100506548
0.10
0.10
lasso
6
0.11
7.4e-13
5.2
-5.2
1.7e-07
-0.76
0.68
0.32
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
RPL37
0.04
0.06
lasso
1
0.06
1.1e-07
5.1
5.1
2.9e-07
0.67
0.19
0.81
FALSE