TWAS hub - OSMR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1240	0.0400	0.00039	0.055	NA	0.051	NA	0.051	2.6e-05	NA	4.8e-05	NA	4.8e-05
2	GTEx	Artery Aorta	0.1200	0.0400	0.00076	0.047	NA	0.059	NA	0.044	1.4e-03	NA	3.5e-04	NA	1.8e-03
3	GTEx	Cells Transformed fibroblasts	0.1480	0.0480	0.00042	0.015	NA	0.059	NA	0.055	2.6e-02	NA	3.1e-05	NA	5.7e-05
4	METSIM	Adipose	0.0337	0.0144	0.00520	0.004	0.010	0.007	0.009	0.002	6.9e-02	0.011	2.8e-02	0.015	1.6e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0384	0.0200	0.00660	-0.002	0.005	-0.002	NA	0.001	8.5e-01	0.071	9.5e-01	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Mean Putamen Volume	6.6	7.6	13.3	-3.5	-3.6	-2.5	-2.1	-1.4
Blood Red Count	4.0	38.7	52.7	7.1	6.3	7.3	5.6	4.4
Ulcerative Colitis (UC)	3.5	6.5	16.6	2.2	4.1	2.2	-0.3	2.4
Number of operations (self-reported)	3.4	5.0	7.8	-2.5	-2.6	-2.8	-2.0	-0.2
Average weekly beer plus cider intake	3.3	4.8	8.3	2.7	2.9	2.0	1.8	1.0
Type 2 Diabetes (T2D) (2012)	3.1	3.6	6.2	0.5	2.5	1.4	1.7	2.5
Relative age of first facial hair	2.8	5.8	10.6	3.3	2.3	1.9	1.6	2.6
Townsend deprivation index at recruitment	2.8	4.0	10.0	3.2	0.4	2.6	1.3	1.0
Had major operations	2.6	3.0	6.8	-2.0	-1.7	-1.2	-2.6	-0.1
Ever had bowel cancer screening	2.6	3.1	4.7	-2.1	-1.9	-1.5	-2.2	-0.7
Qualifications: A levels/AS levels or equivalent	2.5	5.5	9.1	-2.2	-2.0	-3.0	-2.6	-1.8
Blood Platelet Count	2.3	26.4	40.2	6.3	4.3	5.8	5.0	3.9
Ulcerative Colitis	2.2	3.2	10.0	1.6	3.2	1.2	0.4	1.3
Time employed in main current job	2.2	2.5	5.0	1.4	2.2	1.4	1.1	1.5
Alcohol intake frequency.	2.2	5.2	8.5	2.8	2.2	2.3	2.9	0.3
Chronotype (morning person)	2.1	4.8	9.7	-2.5	-2.0	-3.1	-1.3	-1.6
Medication: Co-codamol	2.1	2.4	5.2	-0.8	-1.8	-1.7	-0.4	-2.3
Handedness (chirality/laterality): Left-handed	2.1	2.5	4.4	-1.1	-2.1	-1.5	-1.8	-1.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.1	0.8	2.8	1.2	-0.5	1.1
Mood swings	2.0	3.6	6.0	2.2	2.5	2.2	0.5	1.5
Friendships satisfaction	2.0	2.5	5.1	1.9	2.3	1.3	1.3	0.6
Ever smoked	2.0	3.6	5.9	1.6	1.2	2.0	1.9	2.4
Pack years of smoking	2.0	2.9	5.1	2.3	0.8	2.3	1.3	1.3
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	3.1	1.6	1.6	1.2	1.8	0.4
Falls in the last year	1.8	2.5	4.8	-1.7	-1.5	-1.4	-2.2	0.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	6.2	-0.2	-1.6	-1.4	-0.7	-2.5
Intelligence (Savage-Jansen 2018)	1.7	5.3	8.5	-2.8	-2.4	-2.1	-2.9	0.8
Noisy workplace	1.7	2.1	4.7	1.1	2.2	1.0	1.8	0.8
Ever depressed for a whole week	1.7	2.1	5.1	1.7	1.0	0.4	2.3	1.2
Rheumatoid Arthritis	1.6	2.2	3.7	-1.2	-1.4	-1.8	-0.9	-1.9
Mouth/teeth dental problems: Dentures	1.6	2.7	3.9	-1.9	-0.7	-2.0	-1.5	-1.8
Number of full brothers	1.6	2.1	3.7	1.1	1.8	1.1	1.9	1.0
Number of full sisters	1.6	2.0	4.3	2.1	0.6	1.4	1.8	0.6
Crohns Disease (2012)	1.5	2.4	5.4	-1.7	-1.2	-1.4	-2.3	-0.5
Supplements: Glucosamine	1.5	2.0	4.4	-0.1	-2.0	-0.8	0.9	-2.1
Pulse wave Arterial Stiffness index	1.5	1.7	2.6	-0.3	1.6	1.6	1.1	1.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.6	1.6	1.9	1.2	0.9	0.7
Pack years adult smoking proportion	1.4	2.2	4.3	1.9	0.5	2.1	1.3	0.9
Mouth/teeth dental problems	1.4	2.1	4.9	1.8	0.8	1.0	2.2	0.9
Tense / ‘highly strung’	1.4	2.3	5.3	1.6	1.3	0.7	2.3	1.3
Birth weight of first child	1.4	2.6	7.0	-0.9	-0.2	-1.1	-2.6	-2.0
Loud music exposure frequency	1.4	1.6	4.4	2.1	1.3	0.8	0.9	0.6
Pulse wave peak to peak time	1.4	1.6	2.3	0.4	-1.5	-1.5	-1.3	-1.3
Shortness of breath walking on level ground	1.4	1.6	3.8	1.3	2.0	0.0	0.9	1.4
Breast cancer (self-reported)	1.4	1.6	2.5	-1.6	-1.6	-1.4	-1.1	-0.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.9	1.1	1.4	2.0	-0.4	0.8
Age started oral contraceptive pill	1.4	1.8	3.2	-1.5	-1.6	-1.8	-0.8	0.0
Basal cell carcinoma (self-reported)	1.4	1.7	5.9	0.2	1.4	0.8	0.2	2.4
Medication for hormone replacement therapy	1.3	1.4	3.4	1.4	-0.6	0.9	1.8	-0.9
Happiness	1.3	1.6	6.6	1.0	2.6	0.5	-0.1	-0.3
Medication: Lansoprazole	1.3	1.4	2.8	1.1	1.7	0.4	1.7	0.4
Eye problems/disorders: None of the above	1.3	1.5	2.7	1.1	1.6	0.4	1.6	-1.0
Medication: Allopurinol	1.3	1.7	5.8	-1.3	-2.4	-0.9	0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	2.7	-1.3	-1.6	-1.4	-1.2	-1.4
Schizophrenia vs Biploar Disorder	1.2	1.6	2.7	-1.5	-1.7	-1.2	-0.8	-0.9
Vitamin and mineral supplements	1.2	1.6	4.5	0.5	2.1	1.1	0.4	1.3
Sitting height	1.2	8.4	34.7	-2.0	-0.7	-1.7	-5.9	-0.1
Prospective memory result	1.2	1.4	4.0	2.0	1.1	0.8	1.1	0.4
Glaucoma (self-reported)	1.2	1.4	4.2	-0.5	-2.1	-0.2	-1.5	-0.4
Medication: Seretide 50 evohaler	1.2	1.3	3.3	-0.3	-1.8	-1.5	-0.2	-0.9
Chest pain or discomfort	1.2	1.7	4.9	1.2	1.3	0.8	0.2	2.2
Diabetes diagnosed by doctor	1.2	2.0	4.7	-1.2	-1.2	-1.6	-0.3	-2.2
Qualifications: nursing, teaching	1.2	1.8	2.6	-1.5	-1.6	-1.4	-1.4	-0.3
Mineral and other dietary supplements	1.2	1.6	7.3	0.1	2.7	0.6	-0.5	0.2
Financial situation satisfaction	1.2	1.5	2.7	0.9	1.2	1.6	0.9	1.4
Supplements: Calcium	1.2	1.3	3.7	-0.7	-1.9	-0.9	-0.6	-1.0
Bipolar Disorder (2011)	1.1	1.1	4.0	0.5	2.0	0.4	0.8	0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.5	1.6	0.4	-0.7	1.3	-1.4
Diabetes (self-reported)	1.1	1.8	4.8	-1.2	-0.8	-1.4	-0.2	-2.2
Age at first live birth	1.1	1.9	3.0	-1.7	-1.7	-1.3	-1.3	-0.4
Arm fat percentage (left)	1.1	4.5	8.7	-2.1	-2.9	-2.5	-1.2	-1.4
Eye problems/disorders: Cataract	1.1	1.3	4.1	-2.0	-0.7	-1.2	-0.7	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.3	2.7	-1.6	-0.1	-1.3	-1.3	-0.6
Average weekly champagne plus white wine intake	1.1	1.5	2.9	-1.0	-1.0	-1.1	-1.7	-1.0
Eye problems/disorders: Glaucoma	1.1	1.3	4.0	-0.5	-2.0	-0.1	-1.6	0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	5.6	0.2	-2.4	0.3	1.1	0.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	5.9	1.0	-0.3	0.8	2.4	-1.8
Hearing difficulty/problems with background noise	1.0	1.5	3.7	0.4	1.8	-0.2	0.8	1.9
Allergy	1.0	2.2	5.2	-1.5	-0.5	-1.3	-2.3	1.4
Breastfed as a baby	1.0	1.2	2.5	0.7	1.6	-0.4	1.6	0.8
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.8	-0.6	-0.8	-1.3	-0.5	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.8	0.4	2.0	1.2	-0.2	1.0
Emphysema/chronic bronchitis	1.0	1.2	2.6	1.6	1.1	0.7	1.0	0.7
Neck or shoulder pain in last month	1.0	1.4	4.1	0.8	2.0	0.7	-1.3	0.4
Family relationship satisfaction	1.0	1.3	2.6	1.4	1.6	0.7	0.9	0.8
Leg pain on walking	1.0	1.2	2.3	1.5	0.0	1.5	0.2	1.2
Lupus	0.9	1.4	2.8	-0.9	-1.7	-1.5	-0.2	-1.1
Respiratory disease	0.9	2.0	4.7	2.2	0.9	1.7	1.2	-0.4
Diabetes (father)	0.9	1.1	2.1	1.4	0.7	0.9	1.4	-0.4
Impedance of leg (right)	0.9	4.4	9.0	1.4	3.0	2.8	0.4	1.6
Trunk fat percentage	0.9	3.5	6.6	-1.8	-2.6	-2.1	-1.7	-0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.7	-0.2	1.2	0.9	-1.6	-0.5
Heart attack	0.9	1.1	2.6	0.9	0.7	-0.8	1.6	-1.0
Arm fat percentage (right)	0.9	3.4	5.8	-1.8	-2.4	-2.4	-1.2	-0.9
Hair/balding pattern: Pattern 3	0.9	1.4	4.0	-1.0	-1.3	-2.0	0.1	-0.3
Blood clot in the leg (DVT)	0.9	1.1	2.9	-1.7	-0.2	-0.4	-1.6	0.2
Headache pain in last month	0.9	1.6	4.3	0.6	2.1	1.3	0.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.4	-1.0	0.1	-0.7	-2.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.4	-1.9	-0.4	-0.3	-1.5	0.2
Irritable Bowel Disease (IBD)	0.8	2.0	4.9	0.4	2.2	0.6	-1.5	1.5
Coronary Artery Disease (CAD)	0.8	1.0	2.2	1.5	1.1	1.0	-0.4	0.8
Taking other prescription medications	0.8	1.2	2.0	-1.4	-1.0	-0.9	-1.0	1.1
Impedance of arm (left)	0.8	3.6	5.5	-2.3	-2.2	-1.8	-1.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	-0.3	-0.0	0.5	-1.4	1.7
Mean time to correctly identify matches	0.8	1.5	3.6	1.8	-0.2	0.8	1.9	0.1
Comparative height size at age 10	0.8	4.1	12.0	1.4	1.4	1.3	-1.8	3.5
Hearing aid user	0.8	0.9	1.5	-1.2	-0.9	-0.8	-1.1	-0.0
Medication: Atorvastatin	0.8	1.0	3.7	0.0	-0.9	-0.1	1.9	-0.8
Cholesterol lowering medication	0.8	1.2	1.6	-1.2	-1.3	-1.2	0.4	1.2
Bipolar Disorder or Schizophrenia	0.7	1.7	3.3	1.4	0.8	0.8	1.8	1.4
Reaction Time	0.7	1.3	3.9	2.0	-0.1	1.1	1.1	-0.5
Allergy or Eczema	0.7	1.8	5.8	0.9	0.1	1.1	2.4	-1.0
Lung FEV1/FVC ratio	0.7	3.7	11.6	1.2	1.4	1.9	3.4	0.4
Medication: Metformin	0.7	1.0	4.1	-0.3	-0.2	-0.7	0.1	-2.0
Average weekly fortified wine intake	0.7	0.9	2.9	0.0	1.0	-0.6	-1.7	0.4
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.7	1.0	1.4	1.1	0.1
Multivitamins +/- minerals	0.7	0.9	2.8	0.2	-1.7	-0.4	0.7	-0.9
Medication: Levothyroxine sodium	0.7	1.1	2.6	-1.3	-1.6	-0.8	-0.8	-0.4
Past tobacco smoking	0.7	1.2	2.5	-0.7	-0.0	-0.9	-1.5	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.1	-0.6	0.8	0.9	-1.8	-1.7
Fluid intelligence score	0.7	1.4	3.1	-1.4	-1.8	-1.4	-0.2	0.4
Illnesses of siblings	0.7	1.0	1.4	-1.1	-0.8	-1.1	-0.8	-1.2
Hip circumference	0.7	2.9	5.2	-1.0	-2.3	-2.2	-1.6	-1.1
Father’s age at death	0.7	1.0	2.2	-1.1	-1.5	-1.0	0.4	0.3
Medication: Cholesterol lowering	0.7	1.1	4.0	0.9	0.4	0.5	2.0	-0.4
Exposure to tobacco smoke at home	0.7	0.8	1.5	1.1	-0.9	0.4	1.2	0.5
Pulse wave reflection index	0.7	0.8	1.9	-0.0	1.4	1.4	0.2	0.6
Gout (self-reported)	0.7	1.0	3.2	-0.8	-1.8	-0.8	-0.1	0.5
Migraine (self-reported)	0.7	0.9	3.2	0.8	0.7	0.5	0.2	1.8
Pulse rate, automated reading	0.7	2.3	6.7	-0.7	-0.6	-1.9	0.6	-2.6
Illnesses of siblings: Diabetes	0.7	0.9	3.1	0.9	0.1	0.6	1.7	0.2
Loneliness, isolation	0.7	1.0	3.5	-0.1	1.2	0.2	1.9	0.0
Osteoarthritis (self-reported)	0.7	0.9	3.2	-0.8	-0.5	-1.8	-0.4	0.4
Medication: Gliclazide	0.7	0.8	2.5	-0.4	1.0	-0.4	-0.4	-1.6
Alcohol drinker status: Previous	0.7	0.8	1.4	-0.4	-1.0	-0.6	-1.2	-0.9
Crohns Disease (2017)	0.6	1.3	3.8	-1.4	-0.4	-0.8	-2.0	-0.1
Waist Hip Ratio (WHR)	0.6	2.5	5.6	-0.7	1.9	1.4	1.1	2.4
Neuroticism	0.6	1.5	3.8	0.9	0.7	1.1	2.0	1.0
Age when periods started (menarche)	0.6	1.4	2.1	-1.4	-1.5	-1.4	-0.2	-1.0
Trunk fat mass	0.6	2.5	4.8	-1.2	-2.2	-1.7	-1.8	-0.5
Number of incorrect matches in round	0.6	0.9	3.9	0.7	0.2	0.4	2.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.9	0.9	0.8	1.7	-0.0	-0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	-1.2	-0.6	-0.9	-1.1	0.1
Neuroticism score	0.6	1.3	1.5	1.2	1.1	1.2	1.2	0.9
Alcohol intake versus 10 years previously	0.6	0.9	3.6	-0.2	0.8	-0.5	-0.3	-1.9
Depression (self-reported)	0.6	0.8	3.0	0.6	0.4	0.5	1.7	-0.0
Arm fat mass (right)	0.6	2.3	3.9	-1.3	-1.8	-2.0	-1.5	-0.8
Qualifications: College or University degree	0.6	1.8	5.2	-1.4	-0.3	-1.3	-2.3	-0.4
Suffer from ‘nerves’	0.6	0.9	2.3	0.8	1.2	1.5	-0.0	0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	2.8	-0.1	0.5	0.5	0.0	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	0.3	1.2	0.5	1.1	0.6
Smoking status: Previous	0.6	0.8	1.7	0.5	-1.1	0.3	1.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.1	-0.5	-1.1	-0.7	-1.4	-1.4
Arm fat mass (left)	0.6	2.3	3.8	-1.4	-2.0	-1.9	-1.2	-0.7
Wears glasses or contact lenses	0.6	0.7	1.4	-0.8	-1.2	-0.8	-0.6	0.6
Mother’s age at death	0.6	0.7	2.7	0.7	0.2	0.1	-0.6	1.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	0.9	0.4	1.4	-0.7	0.1
Illnesses of father: High blood pressure	0.6	0.8	2.5	-1.6	-0.7	-0.7	-0.4	-0.7
Irritability	0.6	1.1	4.1	0.7	0.5	0.6	0.5	2.0
Myopia	0.6	0.9	1.4	1.2	1.2	1.1	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	0.8	0.7	-0.7	1.3	-0.8
Bipolar Disorder (2018)	0.5	0.8	1.6	0.8	0.5	1.1	1.2	0.7
Major Depression (MDD)	0.5	0.6	2.6	0.4	-0.5	1.6	0.2	0.4
Fasting Glucose	0.5	0.6	1.4	0.9	-0.1	1.2	0.8	0.5
HbA1C	0.5	0.5	2.0	1.4	0.6	0.3	0.4	-0.3
Number of treatments/medications taken	0.5	1.0	1.4	-0.9	-1.2	-1.1	-0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.4	0.2	0.6	1.0	-0.9	-1.8
High blood pressure	0.5	1.5	5.8	-0.3	1.1	0.4	0.5	2.4
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	-0.2	-0.8	0.1	-0.5	-1.4
Impedance of leg (left)	0.5	2.7	6.7	0.9	2.6	2.0	0.4	1.2
Alcohol usually taken with meals	0.5	0.7	1.9	0.2	1.4	0.8	0.5	0.9
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	0.1	0.9	1.2	0.4	0.8
Qualifications: None of the above	0.5	1.0	1.9	1.4	-0.0	1.0	1.4	-0.6
Impedance of arm (right)	0.5	2.4	4.1	-2.0	-1.2	-1.7	-1.9	0.1
Pulse rate	0.5	0.8	2.4	0.5	0.9	-0.6	0.4	-1.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.9	-0.4	-0.3	-0.6	-1.7	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.6	-1.0	-1.9	-0.1	0.8	0.1
Body fat percentage	0.5	2.0	4.2	-1.3	-2.1	-1.6	-1.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	0.1	-0.2	0.8	-1.0	-1.2
High cholesterol (Self-reported)	0.5	0.8	3.8	-0.0	-0.2	-0.1	1.9	0.6
Schizophrenia (2018)	0.4	0.9	1.7	1.1	0.6	0.2	1.3	1.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	0.3	1.0	1.2	0.1	0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	-0.9	-1.4	-1.1	-0.0	0.9
Breast Cancer	0.4	0.9	2.7	0.5	-0.7	-0.9	1.6	-0.5
Schizophrenia (2014)	0.4	0.9	2.4	0.8	0.4	0.5	1.1	1.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	0.8	-0.4	1.1	0.0	0.3
Severe depression (siblings)	0.4	0.4	1.1	0.3	0.6	1.1	-0.6	0.4
Financial difficulties in last 2 years	0.4	0.5	1.0	0.1	-0.3	1.0	0.9	0.9
Pain all over the body in last month	0.4	0.4	1.5	0.5	-1.2	-0.1	0.5	0.1
Medication: Ramipril	0.4	0.6	1.6	-0.0	0.5	-0.2	1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.5	0.6	1.3	0.7	-0.2
Peak expiratory flow (PEF)	0.4	1.0	2.3	-0.9	-0.2	-1.1	-0.6	-1.5
Medication: Paracetamol	0.4	0.7	1.7	-0.9	-0.8	-1.3	0.2	0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.6	0.5	-0.0	-0.6	1.3	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	1.8	0.7	0.7	1.3	-0.6	0.1
Medication: Blood pressure	0.4	0.7	1.8	0.3	-0.2	0.6	1.3	1.2
Heart disease (mother)	0.4	0.5	1.1	-1.0	-0.9	-0.1	-0.5	0.3
Whole body fat mass	0.4	1.7	2.8	-0.9	-1.7	-1.6	-1.5	-0.5
Hypertension (Self-reported)	0.4	1.2	4.5	-0.6	1.0	0.2	-0.1	2.1
Illnesses of father: Heart disease	0.4	0.6	1.7	1.3	0.5	0.5	0.4	0.8
Medication: Aspirin	0.4	0.5	1.4	0.1	0.3	-0.6	1.2	0.8
Number of self-reported non-cancer illnesses	0.4	0.6	1.0	-0.9	0.4	-0.9	0.6	1.0
Commuting to job workplace: Public transport	0.4	0.5	1.4	-0.3	-0.5	0.0	-0.8	-1.2
Medication: Blood pressure	0.4	0.8	2.1	-1.4	0.3	-0.4	-1.4	-0.0
Medication: Lisinopril	0.4	0.5	1.1	0.6	1.0	0.8	0.0	-0.5
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.6	-0.9	-0.4	-0.7	-0.6
Pain experienced in last month	0.4	0.6	1.1	-0.3	-0.7	-0.7	1.0	-1.1
Neuroticism (Nagel 2018)	0.3	0.6	1.4	0.6	0.3	1.2	0.2	1.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	-0.2	0.4	1.1	-0.2	0.8
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.7	-0.3	0.2	1.0	-0.8
Blood White Count	0.3	2.1	7.0	1.1	-0.3	1.4	2.6	0.4
Heel T-Score	0.3	2.1	4.2	1.0	2.0	1.0	-1.8	-0.9
BMI	0.3	1.6	4.3	-1.2	-2.1	-1.1	-0.9	-0.6
Height	0.3	4.8	21.3	-0.1	1.0	-0.8	-4.6	1.1
Smoking Status	0.3	0.7	2.5	0.6	-0.2	0.5	1.6	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.5	-0.9	-1.2	-0.4	1.0	0.2
Hand grip strength (left)	0.3	0.8	1.7	0.6	0.9	0.9	-1.3	0.7
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.6	0.5	-1.0	-0.1	0.9
Hand grip strength (right)	0.3	0.8	1.9	0.2	1.4	0.6	-1.3	-0.1
Maternal smoking around birth	0.3	0.4	0.9	0.7	-0.4	-0.4	0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.6	-0.0	0.7	0.9	-0.6
Relative age voice broke	0.3	0.4	1.2	0.2	0.6	0.0	-0.7	1.1
Stomach or abdominal pain in last month	0.3	0.3	0.9	-0.9	-0.2	-0.2	-0.9	-0.1
Body mass index (BMI)	0.3	1.1	2.2	-0.8	-1.5	-1.4	-0.3	-0.7
Waist circumference	0.3	1.0	2.0	-1.1	-1.4	-1.1	-0.6	0.1
Nervous feelings	0.3	0.6	1.5	1.2	1.2	-0.0	0.5	0.1
Had menopause	0.3	0.3	1.1	0.4	-0.3	0.4	1.1	-0.0
Had other major operations	0.3	0.3	1.1	0.0	-0.0	-1.1	0.8	-0.2
Medication: Simvastatin	0.3	0.4	1.5	-0.2	-0.7	-0.2	1.2	0.3
Number of live births	0.3	0.4	1.3	-0.1	1.1	0.6	0.2	-0.3
Asthma	0.3	0.7	2.3	1.5	0.0	0.9	0.3	-0.5
Standing height	0.3	2.8	10.4	0.6	0.4	0.7	-3.2	1.7
Medication: Amlodipine	0.3	0.5	1.1	-0.9	0.5	-0.3	-1.0	-0.2
Birth weight	0.3	0.6	1.5	0.5	1.2	0.3	-0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.0	0.6	0.6	-0.8	-0.6
Health satisfaction	0.3	0.4	1.4	0.3	1.2	0.1	0.2	-0.4
Medication: Omeprazole	0.3	0.4	0.7	-0.9	-0.1	-0.5	-0.9	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	-0.2	0.6	-0.4	0.1	1.0
Medication: Aspirin	0.3	0.3	0.9	0.1	0.2	-0.6	0.9	0.7
Leg fat-free mass (right)	0.3	1.8	3.6	-0.2	-1.6	-1.6	-1.9	-0.5
Medication for cholesterol	0.3	0.4	1.3	0.2	0.4	0.5	-1.1	0.4
Back pain experienced in last month	0.3	0.5	1.1	0.8	-0.4	0.7	1.0	0.4
Asthma (self-reported)	0.3	0.6	2.0	1.4	0.0	1.0	0.4	-0.2
Smoking status: Current	0.3	0.5	1.5	0.1	0.6	-0.1	0.7	-1.2
Leg predicted mass (right)	0.3	1.6	3.3	-0.2	-1.6	-1.5	-1.8	-0.3
Guilty feelings	0.3	0.5	2.1	0.6	-0.0	1.5	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.4	0.2	-0.5	-1.0	0.8
Medication: Bendroflumethiazide	0.3	0.5	1.8	-1.3	-0.3	-0.6	-0.6	0.1
Medication: Paracetamol	0.3	0.5	1.6	-0.7	-0.1	-0.7	0.3	1.3
Risk taking	0.3	0.4	1.7	-0.1	-0.2	0.2	-0.3	-1.3
Diastolic blood pressure, automated reading	0.3	1.0	2.0	0.9	1.4	0.8	0.6	1.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.6	0.2	-1.0	-0.1	-0.5	-1.6
Arm predicted mass (left)	0.3	1.4	2.3	1.5	0.9	0.9	-1.0	1.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.6	0.5	0.5	0.6	0.3	1.2
Worry (Nagel 2018)	0.2	0.4	0.7	0.5	0.6	0.9	0.8	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.2	0.8	0.3	-0.1	0.4
Ovarian Cancer	0.2	0.3	0.5	0.1	-0.5	-0.7	0.4	-0.7
Age at First Birth	0.2	0.3	0.7	-0.9	-0.4	0.2	-0.6	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.9	0.3	0.6	0.3	0.2
Tanning	0.2	1.9	7.7	0.7	0.2	1.1	0.5	2.8
Average weekly spirits intake	0.2	0.3	1.1	-0.5	0.0	-0.3	-0.3	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.8	-0.9	-0.3	-0.0	-0.5	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	-0.0	0.9	-0.6	0.2	-0.2
Angina	0.2	0.2	0.6	-0.1	0.3	0.8	-0.5	0.4
Leg fat-free mass (left)	0.2	1.3	3.4	0.0	-1.3	-1.1	-1.8	-0.2
Current tobacco smoking	0.2	0.4	1.3	-0.1	0.3	-0.3	0.5	-1.1
Fed-up feelings	0.2	0.4	0.9	0.9	0.6	0.0	0.7	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.8	-0.4	0.2	-0.2	-0.3	0.9
Medication: Atenolol	0.2	0.2	0.8	-0.1	-0.1	0.9	0.4	-0.4
Leg predicted mass (left)	0.2	1.3	3.1	0.1	-1.4	-1.1	-1.8	-0.3
Weight	0.2	1.0	2.7	-0.3	-1.2	-0.9	-1.6	0.2
Trunk fat-free mass	0.2	1.3	2.0	1.4	0.8	0.9	-1.1	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.2	0.2	0.5	-0.6	-1.0
Illnesses of mother	0.2	0.3	0.6	-0.1	0.3	-0.8	-0.7	-0.4
Trunk predicted mass	0.2	1.3	2.0	1.4	0.8	0.9	-1.1	1.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-0.5	0.7	0.1	-1.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	0.2	0.7	-0.2	0.1	-0.8
High blood pressure (siblings)	0.2	0.3	0.6	-0.8	-0.5	0.2	-0.7	0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	3.8	0.5	-0.2	0.3	-1.9	0.1
Arm fat-free mass (right)	0.2	0.8	1.6	1.2	0.1	0.7	-1.3	0.7
Number of children fathered	0.2	0.3	0.8	-0.7	0.2	0.2	0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.4	0.3	0.7	-0.4	-0.7
Knee pain experienced in last month	0.2	0.4	1.3	-0.1	0.0	0.2	-0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.8	1.3	-0.3	0.7	-0.3	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.3	-0.3	-0.7	-0.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.8	-0.1	0.3	-0.4	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.6	0.4	0.6	0.3	-0.5
Alcohol drinker status: Never	0.2	0.2	0.8	0.9	0.3	0.3	-0.2	-0.1
Arm fat-free mass (left)	0.2	0.9	1.7	1.3	0.5	0.6	-0.9	1.2
Unable to work because of sickness or disability	0.2	0.3	1.3	-0.3	-0.1	0.0	-1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.6	0.4	-0.6	-0.0	0.3
Heart disease (siblings)	0.2	0.2	0.8	0.3	0.2	0.2	-0.5	0.9
Depression (Nagel 2018)	0.1	0.2	0.5	-0.5	-0.7	-0.1	-0.1	-0.4
HDL Cholesterol	0.1	0.2	0.5	-0.7	0.1	-0.1	0.5	0.6
LDL Cholesterol	0.1	0.1	0.3	-0.0	-0.1	0.5	0.1	0.5
Neuroticism (2016)	0.1	0.2	0.7	-0.5	-0.9	0.2	0.1	0.1
Triglycerides	0.1	0.2	0.5	0.7	0.2	0.3	-0.4	-0.0
Blood Eosinophil Count	0.1	1.1	2.5	1.6	-0.0	0.5	1.5	-0.5
Cardiovascular Disease	0.1	0.4	0.9	-0.1	0.3	0.5	0.7	0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.3	-0.1	-0.1	0.1	-0.9
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.1	-0.1	0.6	-0.2	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.5	0.0	0.3	-0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	-0.1	-0.8	-0.0	0.2	0.0
Systolic blood pressure, automated reading	0.1	0.3	1.1	-0.6	-0.1	-1.1	0.0	0.5
Supplements: Zinc	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.4	0.3
Diabetes (mother)	0.1	0.2	0.7	0.1	0.8	0.2	-0.0	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.5	-0.3	0.2	0.4	-0.5
High blood pressure (mother)	0.1	0.1	0.4	0.1	0.6	0.3	0.1	0.1
Forced vital capacity (FVC)	0.1	0.6	1.7	0.8	0.6	0.3	-1.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.1	0.5	0.3	-0.7	-0.5
Lung cancer (father)	0.1	0.1	0.2	0.4	0.3	-0.1	0.5	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.5	0.3	0.6	-0.8	-0.4
Comparative body size at age 10	0.1	0.1	0.5	0.3	0.7	-0.3	-0.2	0.1
Worry too long after embarrassment	0.1	0.2	0.5	0.2	-0.7	0.4	-0.2	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.3	-0.4	-0.4	-0.2	-0.8
Angina (self-reported)	0.1	0.1	0.3	-0.2	0.3	0.6	-0.4	0.3
Leg fat mass (right)	0.1	0.3	0.5	0.2	-0.7	-0.7	-0.3	-0.4
Arm predicted mass (right)	0.1	0.6	1.1	1.1	0.0	0.7	-1.0	0.6
Age at last live birth	0.1	0.1	0.3	0.1	-0.5	-0.3	-0.2	-0.3
Supplements: Vitamin C	0.1	0.1	0.4	0.3	0.1	0.0	-0.3	-0.6
Whole body fat-free mass	0.1	0.7	1.9	0.9	0.0	0.2	-1.4	0.9
Average weekly red wine intake	0.1	0.2	0.3	-0.6	0.3	0.4	-0.6	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	-0.1	-0.2	-0.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	0.0	0.5	0.4	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.0	0.5	-0.6	0.3	-0.1
Whole body water mass	0.1	0.7	1.8	0.9	-0.0	0.1	-1.3	0.9
Miserableness	0.1	0.2	0.6	0.1	0.2	0.4	-0.3	0.8
Basal metabolic rate	0.1	0.7	2.4	0.6	-0.3	-0.2	-1.5	0.6
Leg fat percentage (left)	0.1	0.2	0.4	-0.1	-0.6	-0.7	0.3	-0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.3	-0.1	0.4	0.6	0.5
Impedance of whole body	0.1	0.3	0.9	-0.8	-0.2	-0.1	-0.9	0.1
Leg fat mass (left)	0.1	0.5	1.1	-0.1	-0.9	-1.1	-0.3	-0.6
Prostate Cancer	0.0	0.1	0.2	-0.0	0.2	-0.2	0.2	-0.4
Systolic Blood Pressure	0.0	0.2	0.3	-0.6	-0.2	-0.4	0.6	0.3
Lung FVC	0.0	0.2	0.5	-0.3	0.6	-0.7	-0.2	-0.1
Hair Pigment	0.0	0.9	1.9	1.1	0.4	1.0	0.5	-1.4
Worrier / anxious feelings	0.0	0.1	0.2	0.4	0.1	0.2	0.4	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.0	-0.2	0.3	-0.1
Length of working week for main job	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.1	-0.4
Leg fat percentage (right)	0.0	0.1	0.1	0.3	-0.3	-0.1	0.4	0.2
Medication: Ibuprofen	0.0	0.0	0.1	0.2	-0.1	0.0	0.3	-0.3
Overall health rating	0.0	0.1	0.2	-0.4	-0.3	-0.2	-0.3	-0.0

Hub : Genes

OSMR

Models

Trait associations