Best TWAS P=1.66e-11 · Best GWAS P=2.76e-12 conditioned to 0.00883
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Prostate | EIF2S2P3 | 0.21 | 0.05 | lasso | 4 | 0.11 | 1.1e-03 | 5.1 | 5.8 | 5.2e-09 | -0.61 | 0.07 | 0.18 | FALSE |
| 2 | GTEx | Spleen | EIF2S2P3 | 0.32 | 0.04 | enet | 15 | 0.11 | 1.2e-03 | 5.5 | 6.3 | 2.1e-10 | -0.75 | 0.04 | 0.63 | FALSE |
| 3 | GTEx | Testis | HHEX | 0.11 | 0.02 | enet | 8 | 0.00 | 4.2e-01 | 6.3 | 6.7 | 1.7e-11 | -0.81 | 0.05 | 0.52 | TRUE |
| 4 | GTEx | Thyroid | EIF2S2P3 | 0.15 | 0.14 | lasso | 2 | 0.14 | 6.2e-11 | 5.1 | 5.3 | 1.1e-07 | -0.62 | 0.99 | 0.01 | FALSE |
| 5 | NTR | Blood | KIF11 | 0.11 | 0.10 | lasso | 8 | 0.10 | 3.0e-29 | -6.3 | 6.5 | 6.8e-11 | -0.74 | 0.11 | 0.89 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | EIF2S2P3 | 0.05 | 0.01 | bslmm | 378 | 0.03 | 2.7e-04 | -3.5 | 5.3 | 1.1e-07 | -0.42 | 0.08 | 0.41 | FALSE |
| 7 | YFS | Blood | HHEX | 0.09 | 0.04 | lasso | 9 | 0.08 | 2.3e-25 | 6.3 | 6.0 | 2.6e-09 | -0.74 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HHEX | 0.03 | 0.00 | blup | 28 | 0.02 | 1.4e-03 | 5.4 | 6.3 | 2.5e-10 | -0.69 | 0.01 | 0.07 | FALSE |