Hub : Traits :

Respiratory disease

850 significantly associated models · 194 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	7686056	11137778	5	3	8.6e-12	2.0e-11	2.5e-01	97	ENO1 KIF1B RERE
2	1	151055670	153103772	7	11	5.4e-13	2.1e-14	0.0e+00	-5360	FLG HRNR LINGO4 S100A11 SMCP
3	1	166702558	168182443	1	1	2.2e-17	2.0e-17	1.0e+00	100	CD247
4	1	172311679	173713130	2	1	8.7e-08	3.6e-08	3.1e-09	-16	TNFSF4
5	1	202317696	203743653	2	1	1.4e-09	1.2e-09	1.0e+00	100	MYBPH
6	2	102118712	104027106	6	8	7.2e-74	8.3e-60	NaN	NaN	IL18R1 IL1R1 IL1RL1 SLC9A2
7	2	202952678	204788156	4	1	5.4e-09	1.0e-07	3.6e-01	97	CARF
8	2	241941773	243048760	8	2	5.3e-29	8.2e-28	4.9e-01	100	AC093642.3 D2HGDH
9	3	32339493	33825021	1	1	2.5e-08	9.1e-16	1.7e-09	44	GLB1
10	3	127097277	128821807	2	1	5.0e-10	3.9e-09	3.0e-01	97	EEFSEC
11	3	195477791	197083723	2	2	5.1e-08	2.5e-09	1.6e-03	72	NRROS SDHAP1
12	4	38097478	39643536	4	1	2.3e-16	2.8e-17	3.1e-03	88	TLR1
13	4	122377715	124935698	2	5	4.5e-21	2.9e-17	1.0e+00	100	KIAA1109 SPATA5
14	5	35608310	36124514	1	1	2.2e-09	6.4e-10	1.0e+00	100	IL7R
15	5	109381583	111527482	4	8	5.4e-18	4.0e-40	NaN	NaN	CAMK4 SLC25A46 TSLP WDR36
16	5	130588008	132900729	15	7	1.1e-25	8.7e-30	NaN	NaN	AC034220.3 KIF3A P4HA2-AS1 SLC22A5
17	5	139232299	140784895	4	1	1.9e-07	5.4e-07	3.7e-01	97	SLC4A9
18	5	140789933	142230251	1	1	3.2e-13	6.3e-14	4.0e-03	85	NDFIP1
19	5	156131251	157697754	1	1	1.5e-09	6.1e-08	4.0e-01	98	ADAM19
20	6	34528785	35987507	3	1	4.9e-10	2.7e-10	6.7e-02	92	ZNF76
21	6	63596112	64978456	2	1	5.0e-09	1.0e-08	1.9e-01	95	PTP4A1
22	6	89941356	91704536	1	2	8.3e-19	7.5e-26	1.2e-05	83	BACH2
23	6	134905567	136516257	2	2	8.1e-10	4.1e-08	6.5e-01	99	AHI1
24	7	27623776	28468319	1	1	1.3e-11	2.3e-17	8.0e-08	60	JAZF1
25	9	4934896	7345375	6	3	2.7e-27	3.8e-64	9.4e-28	58	GLDC KIAA1432 RANBP6
26	10	5238196	7317647	2	2	3.4e-08	2.5e-09	1.0e+00	100	FBXO18 PRKCQ
27	10	74879374	76266883	1	1	1.2e-07	8.2e-07	6.5e-03	70	RP11-574K11.5
28	10	93657148	95151622	3	1	1.7e-11	2.8e-12	8.8e-03	86	HHEX
29	11	36068766	36732916	1	1	1.9e-07	3.5e-09	7.0e-05	55	PRR5L
30	11	60549966	62346131	7	1	7.5e-14	1.4e-13	2.1e-01	97	FADS3
31	11	64645119	66035608	1	1	1.9e-07	5.1e-09	4.0e-06	38	FAM89B
32	11	75678647	77069746	1	1	1.9e-27	1.1e-48	4.2e-24	52	LRRC32
33	12	55601472	58677299	13	4	2.8e-19	1.3e-26	2.6e-03	92	GPR182 KIF5A RPS26 STAT6
34	13	99047988	100728229	2	3	6.3e-13	2.1e-19	2.4e-03	89	DOCK9-AS2 UBAC2
35	14	92733536	93401178	1	1	1.1e-07	5.9e-06	2.0e-02	74	RIN3
36	15	40884719	42468786	2	1	6.2e-08	4.2e-08	1.7e-01	94	RTF1
37	15	66662107	68789191	4	4	8.6e-39	5.5e-47	4.4e-04	94	IQCH SMAD3
38	16	10325245	12138068	6	3	3.8e-19	2.3e-27	7.7e-06	83	CLEC16A RMI2 RP11-396B14.2
39	16	26526350	28065536	4	1	6.1e-18	5.1e-16	1.9e-06	66	IL4R
40	16	88241380	89617518	1	1	2.8e-07	2.8e-07	3.1e-05	34	TRAPPC2L
41	17	29800656	31275580	1	1	6.8e-08	6.3e-05	6.6e-01	99	RHOT1
42	17	36710513	39502398	24	9	1.0e-60	2.1e-58	NaN	NaN	CASC3 GSDMB KRT222 MED1 MED24 ORMDL3 PGAP3
43	17	42413481	43570226	5	1	5.3e-09	1.8e-08	2.2e-03	70	LOC644172
44	17	46888301	48347817	2	1	7.5e-13	9.9e-15	2.2e-03	84	ZNF652
45	17	61805401	63197920	1	1	2.8e-08	8.1e-08	1.0e+00	100	DDX5
46	17	80790388	81051007	1	1	3.8e-09	2.9e-05	1.0e-02	62	METRNL
47	19	45037368	45550407	1	1	1.1e-08	2.5e-08	4.4e-03	74	CBLC
48	19	45585167	46994833	3	1	1.0e-08	3.4e-09	1.0e+00	100	DMWD
49	20	61576647	62912463	6	1	3.2e-09	3.3e-08	6.6e-01	99	SLC2A4RG
50	21	39849553	41254456	1	1	2.3e-07	1.7e-07	1.0e+00	100	PSMG1
51	22	41071659	42917154	13	1	4.9e-10	7.2e-10	2.0e-01	96	PHF5A

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	1.40	2	0	0.0	0.00	1.0e+00	LINGO4 STAT6
Depressed Affect (Nagel 2018)	1.12	2	0	0.0	0.00	1.0e+00	PHF5A RERE
Depression (Nagel 2018)	1.27	1	0	0.0	0.00	1.0e+00	ENO1
Intelligence (Savage-Jansen 2018)	0.97	4	3	6.7	0.74	2.6e-01	FADS3 PSMG1 RPS26 SLC4A9
Neuroticism (Nagel 2018)	1.08	1	0	0.0	0.00	1.0e+00	PHF5A
Schizophrenia (2018)	1.23	1	0	0.0	0.00	1.0e+00	STAT6
Alzheimer’s Disease (in father)	0.92	1	0	0.0	0.00	1.0e+00	CARF
Alzheimer’s Disease (including proxy)	1.05	1	0	0.0	0.00	1.0e+00	CARF
Crohns Disease (2017)	5.45	18	11	24.4	-0.15	4.8e-01	AC034220.3 BACH2 FADS3 GSDMB KIAA1109 LRRC32 MED24 METRNL NDFIP1 ORMDL3 P4HA2-AS1 PGAP3 PHF5A RP11-574K11.5 SLC22A5 SLC2A4RG SMAD3 TNFSF4
Irritable Bowel Disease (IBD)	5.22	18	12	26.7	-0.02	9.2e-01	AC034220.3 BACH2 CASC3 GSDMB HHEX KIAA1109 LINGO4 LRRC32 MED24 NDFIP1 ORMDL3 P4HA2-AS1 PGAP3 RMI2 RP11-574K11.5 SLC22A5 SLC2A4RG SMAD3
Ulcerative Colitis (UC)	2.96	9	3	6.7	-0.07	8.1e-01	CASC3 GSDMB KIAA1109 LRRC32 MED24 ORMDL3 PGAP3 SLC2A4RG SMAD3
Verbal and Numeric Reasoning (VNR)	1.02	3	0	0.0	0.00	1.0e+00	FADS3 RPS26 SLC4A9
Breast Cancer	1.36	4	3	6.7	0.65	2.3e-01	KIF1B P4HA2-AS1 SLC22A5 TLR1
Prostate Cancer	1.57	1	1	2.2	0.00	1.0e+00	EEFSEC
Body Mass Index (BMI) (2010)	1.10	1	0	0.0	0.00	1.0e+00	SMAD3
Coronary Artery Disease (CAD)	1.56	1	1	2.2	0.00	1.0e+00	CARF
Crohns Disease (2012)	4.32	9	6	13.3	-0.13	6.8e-01	AC034220.3 FADS3 LRRC32 NDFIP1 P4HA2-AS1 PGAP3 SLC22A5 SLC2A4RG SMAD3
Fasting Glucose	1.31	1	1	2.2	0.00	1.0e+00	FADS3
HDL Cholesterol	2.42	6	5	11.1	-0.59	2.2e-01	FADS3 GSDMB KIF5A MED1 ORMDL3 PGAP3
LDL Cholesterol	1.49	1	1	2.2	0.00	1.0e+00	FADS3
Lupus	1.75	3	1	2.2	0.00	1.0e+00	GSDMB ORMDL3 ZNF76
Primary Biliary Cirrhosis	2.58	6	4	8.9	0.12	8.0e-01	GSDMB IL7R MED1 ORMDL3 PGAP3 RMI2
Rheumatoid Arthritis	2.00	1	0	0.0	0.00	1.0e+00	NRROS
Schizophrenia (2014)	1.05	2	0	0.0	0.00	1.0e+00	RERE STAT6
Triglycerides	1.77	2	2	4.4	0.00	1.0e+00	FADS3 KIF5A
Type 2 Diabetes (T2D) (2012)	1.57	2	1	2.2	0.00	1.0e+00	HHEX JAZF1
Ulcerative Colitis	2.70	5	1	2.2	-0.05	9.2e-01	GSDMB KIAA1109 ORMDL3 PGAP3 SLC2A4RG
Blood Eosinophil Count	24.08	55	50	111.1	0.89	5.2e-27	AC034220.3 AC093642.3 AHI1 BACH2 CAMK4 CARF CASC3 CBLC CD247 CLEC16A D2HGDH DMWD DOCK9-AS2 FADS3 FBXO18 GLDC GPR182 GSDMB HHEX IL18R1 IL1R1 IL1RL1 IL4R IL7R IQCH KIAA1109 KIAA1432 KIF1B KIF3A KRT222 LRRC32 MED24 NDFIP1 NRROS ORMDL3 P4HA2-AS1 PHF5A PRKCQ RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RPS26 RTF1 SLC22A5 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 TSLP UBAC2 WDR36 ZNF652
Blood Platelet Count	2.05	23	20	44.4	0.12	5.4e-01	AC034220.3 CARF DMWD EEFSEC ENO1 FADS3 GSDMB KIAA1109 KIF1B KIF3A KIF5A MED1 NDFIP1 ORMDL3 P4HA2-AS1 PGAP3 PHF5A PSMG1 RERE RMI2 SLC22A5 SLC2A4RG TRAPPC2L
Blood Red Count	1.18	16	9	20.0	-0.11	6.5e-01	AHI1 BACH2 FADS3 GSDMB HHEX KIF5A LINGO4 LOC644172 MED1 NDFIP1 ORMDL3 PGAP3 RPS26 RTF1 SLC2A4RG TLR1
Blood White Count	9.13	22	16	35.6	0.68	4.4e-05	AC034220.3 AHI1 BACH2 CASC3 CLEC16A ENO1 FADS3 GSDMB IL1RL1 KIF3A MED1 MED24 NDFIP1 ORMDL3 P4HA2-AS1 PGAP3 RIN3 RP11-396B14.2 RTF1 SLC22A5 ZNF652 ZNF76
Heel T-Score	1.15	15	7	15.6	-0.12	6.7e-01	BACH2 CARF DDX5 DMWD ENO1 FADS3 GLB1 IQCH KIF1B LOC644172 PHF5A RERE RIN3 RPS26 ZNF76
BMI	0.94	11	4	8.9	0.08	8.1e-01	CARF IQCH MED24 PSMG1 PTP4A1 RHOT1 RPS26 SLC2A4RG SLC4A9 SMAD3 TLR1
Height	1.62	21	14	31.1	-0.53	5.0e-03	AC034220.3 AHI1 CARF DDX5 DMWD FADS3 FAM89B IL1R1 IQCH KIAA1109 KIF1B MED1 P4HA2-AS1 PHF5A RERE RHOT1 RTF1 SLC22A5 STAT6 ZNF652 ZNF76
Waist Hip Ratio (WHR)	1.15	5	2	4.4	0.12	8.2e-01	DMWD IQCH MED24 PRR5L RP11-396B14.2
Systolic Blood Pressure	1.15	12	9	20.0	0.57	5.5e-02	CARF DDX5 DMWD EEFSEC ENO1 HHEX LOC644172 RERE RTF1 SLC2A4RG SMAD3 ZNF652
Smoking Status	1.57	6	3	6.7	0.50	2.5e-01	IQCH PGAP3 PHF5A RERE RPS26 ZNF652
Allergy or Eczema	24.85	61	52	115.6	0.93	1.2e-35	AC093642.3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A D2HGDH ENO1 FBXO18 FLG GLDC GPR182 GSDMB IL18R1 IL1R1 IL1RL1 IL4R IL7R IQCH JAZF1 KIAA1109 KIAA1432 KIF3A KRT222 LINGO4 LOC644172 LRRC32 MED24 NDFIP1 NRROS ORMDL3 P4HA2-AS1 PGAP3 PHF5A PRKCQ PRR5L PSMG1 RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RP11-574K11.5 RPS26 RTF1 S100A11 SLC22A5 SLC25A46 SLC2A4RG SLC9A2 SMAD3 SMCP SPATA5 STAT6 TLR1 TNFSF4 TSLP UBAC2 WDR36 ZNF652
Cardiovascular Disease	1.24	6	2	4.4	0.97	1.6e-03	EEFSEC RERE RTF1 SLC22A5 SLC2A4RG ZNF652
Hypothyroidism (self reported)	3.11	12	7	15.6	-0.11	7.2e-01	AHI1 BACH2 CD247 FADS3 FBXO18 IL7R KIAA1109 PHF5A RERE RPS26 TLR1 UBAC2
Type 2 Diabetes (T2D) (2018)	1.36	3	1	2.2	0.00	1.0e+00	HHEX JAZF1 PGAP3
Lung FEV1/FVC ratio	4.59	29	17	37.8	-0.74	1.0e-07	ADAM19 BACH2 CARF D2HGDH DDX5 DMWD EEFSEC FAM89B GLDC GSDMB IL18R1 IL1RL1 IL7R IQCH KIAA1432 MED24 ORMDL3 P4HA2-AS1 PRKCQ RERE RP11-396B14.2 RP11-574K11.5 RPS26 SLC22A5 SLC9A2 SMAD3 STAT6 ZNF652 ZNF76
Lung FVC	2.01	19	12	26.7	-0.12	5.7e-01	AC034220.3 AHI1 CARF CLEC16A GSDMB IQCH KIF1B LINGO4 LOC644172 MED1 ORMDL3 P4HA2-AS1 PGAP3 RIN3 RP11-574K11.5 RPS26 RTF1 SLC22A5 SLC2A4RG
Neuroticism	1.03	2	0	0.0	0.00	1.0e+00	AHI1 IQCH
Chronotype (morning person)	1.24	2	0	0.0	-0.35	6.5e-01	KIAA1109 WDR36
Hair Pigment	0.16	10	7	15.6	-0.38	2.8e-01	AHI1 FADS3 JAZF1 KIAA1432 KIF1B KIF5A RERE RPS26 TRAPPC2L ZNF76
Tanning	0.22	1	1	2.2	0.00	1.0e+00	TRAPPC2L
Hand grip strength (left)	1.72	4	4	8.9	-0.98	3.4e-04	AC034220.3 KIF1B P4HA2-AS1 SLC22A5
Number of treatments/medications taken	2.59	5	1	2.2	0.98	3.4e-03	CLEC16A FADS3 P4HA2-AS1 SLC9A2 ZNF652
Relative age of first facial hair	1.04	2	1	2.2	0.00	1.0e+00	LOC644172 PSMG1
Systolic blood pressure, automated reading	1.24	7	3	6.7	0.98	5.5e-05	DMWD ENO1 HHEX LOC644172 RERE RTF1 SLC2A4RG
Angina	1.20	1	1	2.2	0.00	1.0e+00	ZNF652
Vitamin and mineral supplements	1.48	1	1	2.2	0.00	1.0e+00	STAT6
Medication: Metformin	1.35	1	0	0.0	0.00	1.0e+00	HHEX
Impedance of leg (right)	1.07	5	4	8.9	0.27	6.6e-01	GPR182 LOC644172 RIN3 RPS26 ZNF652
Leg fat-free mass (left)	1.24	8	4	8.9	-0.80	5.2e-03	AC034220.3 KIAA1109 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9 ZNF76
Trunk fat percentage	1.07	5	3	6.7	0.99	7.4e-04	FLG IQCH PHF5A RERE SMAD3
Hand grip strength (right)	1.85	5	4	8.9	-0.97	9.4e-05	AC034220.3 KIF1B P4HA2-AS1 SLC22A5 STAT6
Current tobacco smoking	1.49	2	1	2.2	0.00	1.0e+00	CARF PHF5A
Maternal smoking around birth	1.19	1	0	0.0	0.00	1.0e+00	PHF5A
Taking other prescription medications	4.41	7	2	4.4	0.92	4.4e-04	ADAM19 AHI1 D2HGDH GSDMB IL1RL1 ORMDL3 ZNF652
Age when periods started (menarche)	1.42	4	1	2.2	0.17	8.3e-01	EEFSEC PSMG1 RPS26 RTF1
Heel bone mineral density (BMD) T-score, automated (left)	1.13	3	1	2.2	0.00	1.0e+00	FADS3 GLB1 RERE
High blood pressure	1.52	10	3	6.7	0.83	7.6e-04	AC034220.3 EEFSEC HHEX P4HA2-AS1 RERE RPS26 RTF1 SLC22A5 SLC2A4RG ZNF652
Hayfever, allergic rhinitis or eczema	22.50	58	44	97.8	0.93	3.1e-35	AC093642.3 AHI1 BACH2 CAMK4 CD247 CLEC16A D2HGDH ENO1 FBXO18 FLG GLDC GPR182 GSDMB IL18R1 IL1R1 IL1RL1 IL4R IL7R JAZF1 KIAA1109 KIAA1432 KIF3A KRT222 LINGO4 LOC644172 LRRC32 MED24 NDFIP1 NRROS ORMDL3 P4HA2-AS1 PGAP3 PHF5A PRKCQ PRR5L PSMG1 RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RPS26 RTF1 S100A11 SLC22A5 SLC25A46 SLC2A4RG SLC9A2 SMAD3 SMCP SPATA5 STAT6 TLR1 TNFSF4 TSLP UBAC2 WDR36 ZNF652
Multivitamins +/- minerals	1.24	1	0	0.0	0.00	1.0e+00	STAT6
Medication: Levothyroxine sodium	2.72	6	3	6.7	0.23	6.1e-01	AHI1 BACH2 FADS3 FBXO18 IL7R RPS26
Sitting height	1.20	10	7	15.6	-0.52	5.8e-02	AC034220.3 DMWD FADS3 KIAA1109 P4HA2-AS1 RTF1 SLC22A5 SLC4A9 STAT6 ZNF652
Chronic bronchitis/emphysema (father)	1.71	1	0	0.0	0.00	1.0e+00	IQCH
Body mass index (BMI)	0.89	6	1	2.2	0.10	8.5e-01	PSMG1 RERE RHOT1 RPS26 SLC2A4RG SMAD3
Impedance of leg (left)	1.03	7	4	8.9	0.21	6.5e-01	GPR182 LOC644172 RIN3 RPS26 S100A11 SLC22A5 ZNF652
Leg predicted mass (left)	1.25	8	4	8.9	-0.80	5.4e-03	AC034220.3 KIAA1109 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9 ZNF76
Trunk fat mass	0.96	6	2	4.4	0.99	1.0e-04	FLG IQCH PHF5A RERE SLC2A4RG SMAD3
Waist circumference	1.02	4	3	6.7	0.56	4.4e-01	IQCH RPS26 SLC2A4RG SMAD3
Past tobacco smoking	1.29	4	1	2.2	-0.21	7.9e-01	GLDC IQCH PSMG1 RPS26
Had menopause	0.91	1	0	0.0	0.00	1.0e+00	DDX5
Forced vital capacity (FVC)	1.38	9	4	8.9	-0.62	3.3e-02	AHI1 CARF DMWD IQCH LINGO4 MED1 RP11-574K11.5 SLC2A4RG ZNF76
Heel bone mineral density (BMD) T-score, automated (right)	1.22	4	2	4.4	-0.99	1.2e-02	ENO1 FADS3 GLB1 RERE
Qualifications: None of the above	1.01	1	1	2.2	0.00	1.0e+00	RPS26
Heart attack	1.45	3	0	0.0	0.00	1.0e+00	CARF KIF5A ZNF652
Allergy	28.53	71	59	131.1	-0.96	1.1e-55	AC034220.3 AC093642.3 AHI1 BACH2 CAMK4 CASC3 CD247 CLEC16A D2HGDH DOCK9-AS2 EEFSEC ENO1 FADS3 FBXO18 FLG GLB1 GLDC GPR182 GSDMB HHEX HRNR IL18R1 IL1R1 IL1RL1 IL4R IL7R IQCH JAZF1 KIAA1109 KIAA1432 KIF1B KIF3A KIF5A KRT222 LINGO4 LOC644172 LRRC32 MED24 NDFIP1 NRROS ORMDL3 P4HA2-AS1 PGAP3 PHF5A PRKCQ PRR5L PSMG1 RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RP11-574K11.5 RPS26 RTF1 S100A11 SLC22A5 SLC25A46 SLC2A4RG SLC9A2 SMAD3 SMCP SPATA5 STAT6 TLR1 TNFSF4 TSLP UBAC2 WDR36 ZNF652 ZNF76
Diabetes (self-reported)	1.26	1	1	2.2	0.00	1.0e+00	HHEX
Hayfever/allergic rhinitis (self-reported)	11.89	27	19	42.2	0.96	5.2e-22	AC093642.3 BACH2 CAMK4 CD247 CLEC16A D2HGDH GLDC GPR182 GSDMB IL18R1 IL1RL1 IL7R KIAA1109 LRRC32 ORMDL3 RANBP6 RP11-396B14.2 RPS26 SLC25A46 SLC9A2 SMAD3 SPATA5 STAT6 TLR1 TNFSF4 TSLP WDR36
Medication: Simvastatin	1.34	1	0	0.0	0.00	1.0e+00	DMWD
Fluid intelligence score	1.01	1	0	0.0	0.00	1.0e+00	RPS26
Neuroticism score	1.00	1	0	0.0	0.00	1.0e+00	PHF5A
Weight	1.01	9	4	8.9	-0.24	4.7e-01	AC034220.3 FLG IQCH P4HA2-AS1 RPS26 SLC22A5 SLC2A4RG SLC4A9 SMAD3
Impedance of arm (right)	1.44	13	9	20.0	0.66	1.1e-02	EEFSEC KIF1B LOC644172 LRRC32 MED24 NDFIP1 ORMDL3 PHF5A PRR5L RIN3 RPS26 SMAD3 ZNF652
Arm fat percentage (right)	0.99	5	2	4.4	1.00	2.2e-04	CARF IQCH PHF5A RERE SMAD3
Trunk fat-free mass	1.36	10	8	17.8	-0.88	1.3e-04	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 RTF1 SLC22A5 SLC4A9 STAT6 ZNF76
Hip circumference	0.87	5	2	4.4	0.43	4.7e-01	MED24 PSMG1 SLC2A4RG SLC4A9 SMAD3
Father's age at death	1.49	1	0	0.0	0.00	1.0e+00	SLC22A5
Falls in the last year	0.91	1	0	0.0	0.00	1.0e+00	CARF
Hair/balding pattern: Pattern 3	1.22	2	0	0.0	0.00	1.0e+00	AC034220.3 LOC644172
Number of live births	1.14	1	1	2.2	0.00	1.0e+00	FADS3
Forced expiratory volume in 1-second (FEV1)	2.07	9	6	13.3	-0.93	1.6e-05	ADAM19 AHI1 LINGO4 P4HA2-AS1 RP11-574K11.5 RPS26 SLC22A5 SLC2A4RG ZNF76
Pulse rate	1.23	1	1	2.2	0.00	1.0e+00	FADS3
Qualifications: A levels/AS levels or equivalent	0.84	1	0	0.0	0.00	1.0e+00	RPS26
Mouth/teeth dental problems: Dentures	1.19	1	0	0.0	0.00	1.0e+00	PGAP3
Asthma	28.46	78	61	135.6	1.00	1.5e-109	AC034220.3 AC093642.3 ADAM19 AHI1 BACH2 CAMK4 CARF CASC3 CD247 CLEC16A D2HGDH DDX5 DMWD DOCK9-AS2 EEFSEC ENO1 FADS3 FAM89B FLG GLDC GPR182 GSDMB HHEX HRNR IL18R1 IL1R1 IL1RL1 IL4R IL7R IQCH JAZF1 KIAA1109 KIAA1432 KIF1B KIF3A KIF5A KRT222 LINGO4 LOC644172 LRRC32 MED1 MED24 METRNL MYBPH NDFIP1 NRROS ORMDL3 P4HA2-AS1 PGAP3 PHF5A PRKCQ PRR5L PTP4A1 RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RP11-574K11.5 RPS26 RTF1 S100A11 SLC22A5 SLC25A46 SLC2A4RG SLC4A9 SLC9A2 SMAD3 SMCP STAT6 TLR1 TNFSF4 TRAPPC2L TSLP UBAC2 WDR36 ZNF652 ZNF76
Medication: Ibuprofen (e.g. Nurofen)	1.33	1	1	2.2	0.00	1.0e+00	STAT6
Forced expiratory volume in 1-second (FEV1), Best measure	2.12	12	5	11.1	-0.91	2.0e-06	ADAM19 AHI1 EEFSEC LINGO4 MED1 P4HA2-AS1 RERE RP11-574K11.5 RPS26 SLC22A5 SLC2A4RG ZNF76
Impedance of arm (left)	1.40	14	6	13.3	0.50	7.1e-02	EEFSEC KIF1B LOC644172 LRRC32 MED24 ORMDL3 PHF5A PRR5L RHOT1 RIN3 RPS26 SLC2A4RG SMAD3 ZNF652
Arm fat mass (right)	0.89	5	2	4.4	0.54	3.4e-01	IQCH RERE RPS26 SLC2A4RG SMAD3
Trunk predicted mass	1.35	10	8	17.8	-0.89	1.3e-04	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 RTF1 SLC22A5 SLC4A9 STAT6 ZNF76
Standing height	1.69	12	9	20.0	-0.69	4.7e-03	AC034220.3 DDX5 DMWD FADS3 KIAA1109 P4HA2-AS1 PHF5A RTF1 SLC22A5 STAT6 ZNF652 ZNF76
Tense / 'highly strung'	1.15	1	0	0.0	0.00	1.0e+00	RERE
Hair/balding pattern: Pattern 4	1.50	5	1	2.2	0.72	1.7e-01	FADS3 KIF1B LOC644172 RERE S100A11
Birth weight of first child	1.48	1	0	0.0	0.00	1.0e+00	RPS26
Peak expiratory flow (PEF)	1.34	3	1	2.2	0.00	1.0e+00	ADAM19 SLC22A5 ZNF76
Medication: Paracetamol	1.33	1	1	2.2	0.00	1.0e+00	STAT6
Headache pain in last month	1.94	3	1	2.2	0.00	1.0e+00	DMWD RPS26 STAT6
Medication for cholesterol, blood pressure or diabetes	1.18	1	0	0.0	0.00	1.0e+00	ZNF652
Gout (self-reported)	1.40	1	1	2.2	0.00	1.0e+00	KIF5A
Hypothyroidism/myxoedema (self-reported)	2.97	8	4	8.9	0.06	8.8e-01	AHI1 BACH2 CD247 FADS3 FBXO18 IL7R KIAA1109 RPS26
Medication: Ventolin 100micrograms inhaler	12.07	24	9	20.0	0.99	1.5e-27	AC093642.3 AHI1 BACH2 CD247 CLEC16A D2HGDH GLDC GPR182 GSDMB IL18R1 IL1RL1 KIAA1109 LINGO4 LRRC32 NDFIP1 ORMDL3 PGAP3 RPS26 SLC22A5 SLC9A2 SMAD3 STAT6 TLR1 ZNF652
Birth weight	1.25	1	1	2.2	0.00	1.0e+00	HHEX
Forced vital capacity (FVC), Best measure	1.34	9	2	4.4	-0.74	5.9e-03	AHI1 CARF IQCH LINGO4 MED1 RP11-574K11.5 RPS26 SLC2A4RG ZNF76
Body fat percentage	1.09	8	3	6.7	0.82	1.3e-02	CARF FLG IQCH PHF5A PSMG1 RERE SLC2A4RG SMAD3
Leg fat percentage (right)	1.29	6	2	4.4	1.00	2.9e-05	CARF IQCH NRROS RERE SLC2A4RG SMAD3
Arm fat-free mass (right)	1.30	9	8	17.8	-0.76	6.8e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC2A4RG SLC4A9 ZNF76
Comparative body size at age 10	1.07	2	1	2.2	0.00	1.0e+00	SMAD3 ZNF652
Worry too long after embarrassment	0.93	2	0	0.0	0.00	1.0e+00	AHI1 IQCH
Seen a psychiatrist for nerves, anxiety, tension or depression	1.08	1	0	0.0	0.00	1.0e+00	FADS3
Wheeze or whistling in the chest in last year	11.67	41	18	40.0	0.98	3.2e-39	AC093642.3 ADAM19 BACH2 CASC3 CD247 CLEC16A D2HGDH DMWD DOCK9-AS2 FADS3 GLDC GPR182 GSDMB IL18R1 IL1R1 IL1RL1 JAZF1 KIAA1109 KIAA1432 LINGO4 LRRC32 MED24 NRROS ORMDL3 PGAP3 RERE RHOT1 RIN3 RMI2 RP11-396B14.2 RP11-574K11.5 SLC22A5 SLC25A46 SLC2A4RG SLC9A2 SMAD3 TRAPPC2L TSLP UBAC2 WDR36 ZNF652
Reason for reducing amount of alcohol drunk: Health precaution	1.30	1	0	0.0	0.00	1.0e+00	RPS26
Age at first live birth	1.07	1	0	0.0	0.00	1.0e+00	RPS26
Shortness of breath walking on level ground	1.34	1	0	0.0	0.00	1.0e+00	LRRC32
Qualifications: College or University degree	1.14	3	1	2.2	0.00	1.0e+00	LINGO4 RERE RPS26
Medication for pain relief, constipation, heartburn	1.28	1	1	2.2	0.00	1.0e+00	STAT6
Neck or shoulder pain in last month	0.84	1	0	0.0	0.00	1.0e+00	RPS26
Medication: Blood pressure	1.31	1	1	2.2	0.00	1.0e+00	ZNF652
Angina (self-reported)	1.14	1	0	0.0	0.00	1.0e+00	ZNF652
Migraine (self-reported)	1.59	2	1	2.2	0.00	1.0e+00	CARF STAT6
Medication: Ibuprofen	1.24	1	1	2.2	0.00	1.0e+00	STAT6
Medication: Allopurinol	1.31	1	1	2.2	0.00	1.0e+00	KIF5A
Medication: Seretide 50 evohaler	6.22	8	1	2.2	0.97	4.3e-09	BACH2 D2HGDH IL18R1 IL1RL1 P4HA2-AS1 SLC22A5 SMAD3 ZNF652
Whole body fat mass	0.94	6	2	4.4	0.99	8.1e-05	FLG IQCH PHF5A RERE SLC2A4RG SMAD3
Leg fat mass (right)	0.98	5	3	6.7	0.57	3.1e-01	IQCH RERE RPS26 SLC2A4RG SMAD3
Arm predicted mass (right)	1.31	9	8	17.8	-0.75	7.5e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC2A4RG SLC4A9 ZNF76
Pulse rate, automated reading	1.48	2	1	2.2	0.00	1.0e+00	FADS3 RPS26
Alcohol intake frequency.	1.19	2	0	0.0	0.00	1.0e+00	RPS26 STAT6
Comparative height size at age 10	1.42	8	4	8.9	-0.76	1.1e-02	AC034220.3 DMWD FAM89B HHEX P4HA2-AS1 SLC22A5 SMAD3 ZNF76
Overall health rating	1.10	2	1	2.2	0.00	1.0e+00	CBLC ZNF652
Chest pain or discomfort	2.12	1	0	0.0	0.00	1.0e+00	IL1RL1
Had major operations	1.13	1	0	0.0	0.00	1.0e+00	ZNF652
Supplements: Vitamin C	1.00	1	0	0.0	0.00	1.0e+00	ORMDL3
Knee pain experienced in last month	1.26	1	0	0.0	0.00	1.0e+00	RP11-396B14.2
Hypertension (Self-reported)	1.50	9	3	6.7	0.82	1.9e-03	AC034220.3 EEFSEC P4HA2-AS1 RERE RPS26 RTF1 SLC22A5 SLC2A4RG ZNF652
Illnesses of father: Heart disease	1.50	1	0	0.0	0.00	1.0e+00	SMAD3
Forced expiratory volume in 1-second (FEV1), predicted	1.51	5	4	8.9	-0.82	2.4e-02	AC034220.3 FADS3 P4HA2-AS1 SLC22A5 ZNF76
Whole body fat-free mass	1.32	9	7	15.6	-0.87	4.9e-04	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9 STAT6 ZNF76
Leg fat-free mass (right)	1.25	8	4	8.9	-0.80	5.1e-03	AC034220.3 KIAA1109 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9
Arm fat percentage (left)	0.97	6	3	6.7	0.74	9.2e-02	CARF IQCH PHF5A PSMG1 RERE SMAD3
Mood swings	0.90	1	0	0.0	0.00	1.0e+00	PHF5A
Long-standing illness, disability or infirmity	2.51	2	0	0.0	0.00	1.0e+00	SLC2A4RG ZNF652
Diabetes diagnosed by doctor	1.41	2	1	2.2	0.00	1.0e+00	HHEX JAZF1
Medication for cholesterol	1.35	1	0	0.0	0.00	1.0e+00	SLC2A4RG
Mineral and other dietary supplements	1.37	1	0	0.0	0.00	1.0e+00	STAT6
Asthma (self-reported)	28.06	79	61	135.6	1.00	2.8e-112	AC034220.3 AC093642.3 ADAM19 AHI1 BACH2 CAMK4 CARF CASC3 CD247 CLEC16A D2HGDH DDX5 DMWD DOCK9-AS2 EEFSEC ENO1 FADS3 FBXO18 FLG GLDC GPR182 GSDMB HHEX HRNR IL18R1 IL1R1 IL1RL1 IL4R IL7R IQCH JAZF1 KIAA1109 KIAA1432 KIF1B KIF3A KIF5A KRT222 LINGO4 LOC644172 LRRC32 MED1 MED24 METRNL MYBPH NDFIP1 NRROS ORMDL3 P4HA2-AS1 PGAP3 PHF5A PRKCQ PRR5L PTP4A1 RANBP6 RERE RIN3 RMI2 RP11-396B14.2 RP11-574K11.5 RPS26 RTF1 S100A11 SLC22A5 SLC25A46 SLC2A4RG SLC4A9 SLC9A2 SMAD3 SMCP SPATA5 STAT6 TLR1 TNFSF4 TRAPPC2L TSLP UBAC2 WDR36 ZNF652 ZNF76
Illnesses of father: None of the above (group 1)	1.35	1	0	0.0	0.00	1.0e+00	SMAD3
Smoking status: Current	1.39	2	1	2.2	0.00	1.0e+00	CARF PHF5A
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.18	6	3	6.7	0.02	9.6e-01	ADAM19 GSDMB MED1 ORMDL3 PGAP3 SLC2A4RG
Whole body water mass	1.33	9	7	15.6	-0.87	5.0e-04	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9 STAT6 ZNF76
Leg predicted mass (right)	1.26	7	4	8.9	-0.87	2.1e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC4A9
Arm fat mass (left)	0.88	5	2	4.4	0.57	3.1e-01	IQCH RERE RPS26 SLC2A4RG SMAD3
Number of self-reported non-cancer illnesses	4.83	13	3	6.7	0.93	1.3e-07	D2HGDH EEFSEC GSDMB IL1RL1 IQCH LINGO4 LRRC32 ORMDL3 P4HA2-AS1 RP11-396B14.2 SLC22A5 SLC2A4RG ZNF652
Average weekly champagne plus white wine intake	1.17	1	0	0.0	0.00	1.0e+00	FADS3
Miserableness	1.35	1	0	0.0	0.00	1.0e+00	RERE
Wears glasses or contact lenses	1.56	1	0	0.0	0.00	1.0e+00	DDX5
Medication: Blood pressure	1.64	4	0	0.0	0.98	4.6e-03	AC034220.3 P4HA2-AS1 SLC22A5 SLC2A4RG
High cholesterol (Self-reported)	1.00	1	0	0.0	0.00	1.0e+00	CARF
Medication: Bendroflumethiazide	1.53	3	0	0.0	0.99	1.4e-02	AC034220.3 P4HA2-AS1 SLC22A5
Medication: Paracetamol	1.11	1	1	2.2	0.00	1.0e+00	STAT6
Alcohol drinker status: Never	1.19	1	0	0.0	0.00	1.0e+00	SLC9A2
Ever smoked	1.25	2	0	0.0	0.00	1.0e+00	IQCH PSMG1
Basal metabolic rate	1.24	9	6	13.3	-0.78	4.8e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC2A4RG SLC4A9 ZNF76
Leg fat percentage (left)	1.30	6	1	2.2	0.99	2.1e-04	CARF IQCH RERE RHOT1 SLC2A4RG SMAD3
Arm fat-free mass (left)	1.26	9	5	11.1	-0.76	6.5e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC2A4RG SLC4A9 ZNF76
Number of operations (self-reported)	1.34	1	0	0.0	0.00	1.0e+00	IQCH
Irritability	0.99	1	0	0.0	0.00	1.0e+00	FADS3
Diastolic blood pressure, automated reading	1.51	9	3	6.7	0.73	2.7e-02	AC034220.3 CARF LOC644172 P4HA2-AS1 RERE RPS26 RTF1 SLC2A4RG ZNF652
Myopia	1.34	3	0	0.0	0.00	1.0e+00	GSDMB ORMDL3 STAT6
Vascular/heart problems diagnosed by doctor	1.71	9	4	8.9	-0.74	9.7e-03	AC034220.3 EEFSEC P4HA2-AS1 RERE RTF1 SLC22A5 SLC2A4RG SMAD3 ZNF652
Cholesterol lowering medication	1.18	1	0	0.0	0.00	1.0e+00	CARF
Pain experienced in last month	1.33	2	0	0.0	0.00	1.0e+00	RPS26 STAT6
Heart attack/myocardial infarction (self-reported)	1.50	2	0	0.0	0.00	1.0e+00	CARF ZNF652
Impedance of whole body	1.22	10	6	13.3	0.38	2.8e-01	EEFSEC KIF1B LOC644172 LRRC32 MED24 PHF5A RHOT1 RIN3 RPS26 ZNF652
Leg fat mass (left)	0.98	6	2	4.4	0.64	1.7e-01	FLG IQCH RERE RPS26 SLC2A4RG SMAD3
Arm predicted mass (left)	1.30	9	7	15.6	-0.76	6.2e-03	AC034220.3 LOC644172 P4HA2-AS1 RIN3 RPS26 SLC22A5 SLC2A4RG SLC4A9 ZNF76

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	10	0.286	2.1
GTEx	Adipose Visceral Omentum	8	0.393	2.2
GTEx	Adrenal Gland	3	0.206	2.0
GTEx	Artery Aorta	14	0.470	2.2
GTEx	Artery Coronary	1	0.084	2.0
GTEx	Artery Tibial	20	0.532	2.2
GTEx	Brain Caudate basal ganglia	5	0.543	2.0
GTEx	Brain Cerebellar Hemisphere	3	0.201	2.2
GTEx	Brain Cerebellum	6	0.303	2.2
GTEx	Brain Cortex	7	0.677	2.3
GTEx	Brain Frontal Cortex BA9	5	0.541	2.3
GTEx	Brain Hippocampus	2	0.381	1.8
GTEx	Brain Hypothalamus	2	0.338	2.3
GTEx	Brain Nucleus accumbens basal ganglia	7	0.808	2.4
GTEx	Brain Putamen basal ganglia	5	0.801	2.2
GTEx	Breast Mammary Tissue	13	0.658	2.3
GTEx	Breast Mammary Tissue (Male)	7	0.587	2.4
GTEx	Breast Mammary Tissue (Female)	8	0.486	2.1
GTEx	Cells EBV-transformed lymphocytes	7	0.493	2.0
GTEx	Cells Transformed fibroblasts	26	0.619	2.4
GTEx	Colon Sigmoid	8	0.547	2.3
GTEx	Colon Transverse	11	0.533	2.4
GTEx	Esophagus Gastroesophageal Junction	7	0.484	2.1
GTEx	Esophagus Mucosa	16	0.482	2.2
GTEx	Esophagus Muscularis	14	0.433	2.2
GTEx	Heart Atrial Appendage	8	0.506	2.5
GTEx	Heart Left Ventricle	5	0.327	2.0
GTEx	Liver	3	0.418	2.0
GTEx	Lung	11	0.383	2.3
GTEx	Muscle Skeletal	15	0.519	2.2
GTEx	Nerve Tibial	21	0.486	2.2
GTEx	Ovary	6	0.660	2.2
GTEx	Pancreas	10	0.612	2.4
GTEx	Pituitary	6	0.538	2.3
GTEx	Prostate	5	0.600	2.2
GTEx	Skin Not Sun Exposed Suprapubic	22	0.894	2.4
GTEx	Skin Sun Exposed Lower leg	22	0.605	2.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.9
GTEx	Spleen	10	0.709	2.5
GTEx	Stomach	6	0.412	2.1
GTEx	Testis	23	0.729	2.2
GTEx	Thyroid	26	0.650	2.3
GTEx	Uterus	3	0.529	2.0
GTEx	Vagina	1	0.157	1.7
GTEx	Whole Blood	14	0.704	2.5
METSIM	Adipose	22	0.478	2.2
NTR	Blood	22	0.916	2.4
ROSMAP	Brain Pre-frontal Cortex	22	0.501	2.2
YFS	Blood	31	0.672	2.3
CommonMind	Brain Pre-frontal Cortex	29	0.539	2.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	8	0.483	2.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	25	0.566	2.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	5	0.453	2.1
The Cancer Genome Atlas	Colon Adenocarcinoma	16	0.774	2.3
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.583	2.1
The Cancer Genome Atlas	Glioblastoma Multiforme	7	0.683	2.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	17	0.622	2.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	22	0.536	2.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	10	0.487	2.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	20	0.464	2.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	7	0.633	2.4
The Cancer Genome Atlas	Lung Adenocarcinoma	17	0.578	2.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	21	0.836	2.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	7	0.438	2.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	11	0.660	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.226	2.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	23	0.496	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	5	0.718	2.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.280	2.0
The Cancer Genome Atlas	Skin Cutaneous Melanoma	3	0.561	2.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	13	0.771	2.6
The Cancer Genome Atlas	Testicular Germ Cell Tumors	9	0.703	2.4
The Cancer Genome Atlas	Thyroid Carcinoma	32	0.620	2.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	4	0.781	2.0