TWAS hub - HHEX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1140	0.0490	0.0067	0.024	NA	-0.002	NA	-0.006	2.9e-02	NA	4.2e-01	NA	9.5e-01
2	YFS	Blood	0.0926	0.0250	0.0000	0.039	0.074	0.080	0.079	0.082	7.1e-13	4.4e-23	7.3e-25	1.2e-24	2.3e-25
3	TCGA	Lung Squamous Cell Carcinoma	0.0300	0.0192	0.0083	0.004	0.022	0.004	NA	0.005	1.2e-01	1.4e-03	9.6e-02	NA	8.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Eosinophil Count	28.3	218.1	249.6	15.0	15.8	13.4
Type 2 Diabetes (T2D) (2012)	26.9	31.0	35.0	-5.9	-4.9	-5.8
Type 2 Diabetes (T2D) (2018)	20.6	38.6	49.8	-7.1	-5.3	-6.1
Respiratory disease	18.1	40.3	45.3	6.7	6.0	6.3
Diabetes diagnosed by doctor	16.8	27.7	37.6	-6.1	-4.3	-5.2
Diabetes (self-reported)	16.2	25.0	34.5	-5.9	-3.6	-5.3
Medication: Metformin	13.5	19.0	24.9	-5.0	-3.4	-4.5
Birth weight	12.4	27.0	34.9	5.9	4.1	5.4
Asthma	12.1	23.9	25.6	4.9	4.7	5.1
Asthma (self-reported)	11.6	23.1	24.4	4.7	4.7	4.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	9.0	10.7	11.0	3.2	3.3	3.3
Allergy	8.9	20.4	21.7	-4.4	-4.5	-4.7
Irritable Bowel Disease (IBD)	7.7	18.4	24.2	4.9	4.6	3.2
Diabetes (mother)	7.6	9.7	12.4	-3.3	-2.4	-3.5
Diabetes (father)	7.5	9.3	10.9	-3.1	-3.3	-2.7
Medication: Seretide 50 evohaler	7.4	8.5	11.0	2.7	3.3	2.6
Ulcerative Colitis (UC)	7.2	13.5	16.6	3.9	4.1	2.9
Illnesses of father: None of the above (group 1)	7.1	8.8	11.2	3.0	3.4	2.5
Medication: Bendroflumethiazide	6.9	10.5	12.2	3.5	2.8	3.4
Illnesses of siblings: Diabetes	6.8	8.3	9.9	-3.1	-2.6	-2.8
Eye problems/disorders: Diabetes related eye disease	6.5	7.1	9.7	-3.1	-2.0	-2.7
Medication: Ventolin 100micrograms inhaler	5.9	7.6	8.7	3.0	2.6	2.7
Medication: Blood pressure	5.9	11.2	14.2	3.8	2.4	3.6
Allergy or Eczema	5.7	15.1	16.8	3.8	4.1	3.8
Systolic blood pressure, automated reading	5.6	16.3	20.8	4.4	2.9	4.6
Illness, injury, bereavement, stress in last 2 years	5.5	6.8	9.2	2.4	2.3	3.0
Medication: Amlodipine	5.4	7.6	9.8	3.1	2.3	2.8
Hayfever, allergic rhinitis or eczema	5.3	11.5	12.7	3.2	3.6	3.5
Fasting Glucose	4.9	5.8	6.4	-2.4	-2.3	-2.5
Financial difficulties in last 2 years	4.9	6.6	9.0	-2.2	-2.4	-3.0
High blood pressure	4.8	13.4	16.7	4.1	3.1	3.7
Crohns Disease (2017)	4.7	10.3	15.9	4.0	3.2	2.3
Systolic Blood Pressure	4.6	22.9	26.7	5.2	4.3	4.9
Pulse rate	4.4	7.3	9.7	-2.5	-3.1	-2.5
Wheeze or whistling in the chest in last year	4.4	7.9	10.9	2.6	2.4	3.3
High blood pressure (siblings)	4.3	6.2	7.0	2.7	2.5	2.3
Diastolic blood pressure, automated reading	4.3	13.3	18.6	4.0	2.3	4.3
Vascular/heart problems diagnosed by doctor	4.3	11.8	13.7	-3.7	-2.9	-3.6
Hypertension (Self-reported)	4.2	11.5	15.1	3.9	2.9	3.4
Ever had stillbirth, spontaneous miscarriage or termination	4.2	4.5	7.3	-1.9	-2.7	-1.6
Triglycerides	4.1	6.7	12.7	-1.8	-3.6	-2.0
Ulcerative Colitis	4.1	6.0	7.7	2.7	2.8	1.7
Medication: Ramipril	4.0	5.1	7.1	2.1	2.0	2.7
Leg fat percentage (right)	3.9	14.0	16.6	3.7	3.4	4.1
Leg fat percentage (left)	3.8	13.7	15.8	3.7	3.4	4.0
Cardiovascular Disease	3.6	12.0	14.9	3.8	2.6	3.9
Pulse wave reflection index	3.5	4.3	5.1	2.2	1.8	2.3
Coronary Artery Disease (CAD)	3.4	4.1	8.1	-2.1	-2.8	0.0
Handedness (chirality/laterality): Left-handed	3.4	4.1	6.7	2.6	1.5	1.9
Supplements: Glucosamine	3.1	4.0	5.1	-2.3	-2.2	-1.4
BMI	3.0	17.4	22.4	3.7	4.7	4.0
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	4.1	2.0	1.8	2.0
Rheumatoid Arthritis	2.9	3.9	7.0	-1.7	-2.6	-1.4
Comparative height size at age 10	2.9	15.9	19.2	-4.4	-3.1	-4.3
Leg fat mass (right)	2.8	10.9	13.0	3.3	3.0	3.6
Leg fat mass (left)	2.8	10.8	12.7	3.2	3.1	3.6
Hand grip strength (right)	2.7	7.4	10.2	3.2	1.7	3.0
Maternal smoking around birth	2.7	3.9	6.0	2.1	1.2	2.4
Body mass index (BMI)	2.7	11.5	12.0	3.3	3.4	3.5
Body fat percentage	2.7	10.8	14.0	3.2	2.9	3.7
Age at first live birth	2.7	4.8	6.1	-2.5	-2.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	11.1	-2.7	-2.6	-3.3
Illnesses of father: Heart disease	2.6	3.6	5.3	-1.9	-2.3	-1.3
Medication: Gliclazide	2.6	3.0	4.4	-2.1	-1.7	-1.3
Blood Red Count	2.5	23.9	35.0	-5.4	-2.8	-5.9
Waist Hip Ratio (WHR)	2.5	11.4	12.0	-3.4	-3.5	-3.2
Happiness	2.5	3.0	5.9	-1.5	-2.4	-1.0
Age at last live birth	2.5	3.6	5.1	-1.9	-2.3	-1.5
Arm fat percentage (left)	2.5	10.2	14.9	3.0	2.6	3.9
Arm fat percentage (right)	2.4	9.6	14.0	2.9	2.6	3.7
Lupus	2.3	3.5	5.1	-1.6	-1.6	-2.2
Trunk fat percentage	2.3	9.1	12.6	2.9	2.5	3.5
Average weekly fortified wine intake	2.3	2.7	3.9	2.0	1.7	1.1
Forced vital capacity (FVC), Best measure	2.3	8.3	11.4	-2.4	-2.8	-3.4
Whole body fat mass	2.3	9.5	11.5	3.0	2.8	3.4
Hand grip strength (left)	2.2	5.9	8.6	2.9	1.8	2.4
Father’s age at death	2.2	2.9	4.7	-2.2	-0.9	-1.8
Arm fat mass (right)	2.2	8.9	11.1	2.8	2.8	3.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	4.1	1.8	2.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	3.6	-1.9	-1.0	-1.7
Crohns Disease (2012)	2.0	3.2	5.2	2.3	1.9	1.0
Leg pain on walking	2.0	2.5	4.3	1.4	1.0	2.1
Arm fat mass (left)	2.0	8.0	10.0	2.6	2.6	3.2
Number of self-reported non-cancer illnesses	2.0	3.5	4.7	2.2	1.7	1.7
Average weekly champagne plus white wine intake	2.0	2.7	3.7	1.0	1.9	1.9
Qualifications: CSEs or equivalent	1.9	2.5	6.2	0.8	2.5	0.7
Trunk fat mass	1.9	8.1	10.6	2.8	2.5	3.2
Glaucoma (self-reported)	1.9	2.2	5.9	0.9	2.4	0.4
Alcohol intake frequency.	1.9	4.5	6.2	-2.0	-1.8	-2.5
High blood pressure (mother)	1.8	2.5	3.5	1.3	1.9	1.5
Hip circumference	1.8	7.9	10.4	2.5	3.2	2.6
Medication for hormone replacement therapy	1.7	1.9	4.0	-1.3	-0.3	-2.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	2.6	-1.4	-1.2	-1.6
Qualifications: College or University degree	1.7	5.3	6.2	-2.0	-2.4	-2.5
Friendships satisfaction	1.7	2.1	3.8	-1.4	-2.0	-0.8
Pain all over the body in last month	1.6	1.7	4.2	0.9	2.0	0.5
Number of operations (self-reported)	1.5	2.3	5.3	-1.2	-2.3	0.2
Risk taking	1.5	2.2	3.0	-1.3	-1.7	-1.4
Had major operations	1.4	1.6	3.3	-0.8	-1.8	-1.0
Commuting to job workplace: Public transport	1.4	1.7	3.9	-0.8	-2.0	-0.7
HbA1C	1.3	1.5	2.4	-1.1	-0.8	-1.5
Ever had hysterectomy (womb removed)	1.3	1.4	3.1	1.8	-0.1	1.1
Angina	1.3	1.7	2.5	-1.6	-1.4	-0.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.2	1.5	0.5	1.4
Angina (self-reported)	1.3	1.8	2.7	-1.6	-1.4	-0.9
Pulse rate, automated reading	1.3	4.1	7.7	-1.8	-2.8	-1.2
Wears glasses or contact lenses	1.3	1.5	2.5	1.3	0.5	1.6
Number of incorrect matches in round	1.2	1.9	4.4	-0.9	-0.8	-2.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	5.0	-1.6	-2.2	-2.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	1.9	1.4	0.9	1.3
Medication: Allopurinol	1.2	1.6	3.3	0.8	0.8	1.8
Alcohol drinker status: Previous	1.2	1.4	2.5	-0.5	-1.6	-1.2
Blood White Count	1.1	8.1	11.3	2.6	3.4	2.5
Chronotype (morning person)	1.1	2.5	3.4	-1.4	-1.9	-1.4
Weight	1.1	5.4	5.7	2.2	2.3	2.4
Medication: Lansoprazole	1.1	1.3	2.2	0.9	0.9	1.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	3.3	1.8	0.5	1.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.8	1.0	-0.4	1.7
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.4	1.6	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.8	-1.0	-1.0	-2.2
Primary Biliary Cirrhosis	1.0	1.5	1.9	-1.4	-0.9	-1.3
Medication: Levothyroxine sodium	1.0	1.8	2.7	1.5	0.5	1.6
Qualifications: None of the above	1.0	2.2	3.1	1.8	0.7	1.7
Mouth/teeth dental problems	1.0	1.5	3.0	-1.7	-0.8	-1.0
Loud music exposure frequency	1.0	1.1	1.3	-1.0	-1.1	-0.9
Comparative body size at age 10	1.0	2.7	3.7	0.9	1.9	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.7	-1.1	-1.3	-0.7
Mineral and other dietary supplements	1.0	1.4	1.8	1.4	1.2	1.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.0	0.8	1.0	1.4
Medication: Atorvastatin	1.0	1.2	1.8	-0.9	-1.3	-1.0
Average weekly beer plus cider intake	1.0	1.4	3.9	0.4	0.4	2.0
Alzheimer’s Disease (including proxy)	0.9	1.4	3.2	-0.6	-0.7	-1.8
Pack years adult smoking proportion	0.9	1.3	2.4	-1.5	-0.8	-1.0
Stomach or abdominal pain in last month	0.9	1.1	1.7	-0.8	-1.0	-1.3
Had menopause	0.9	1.2	1.8	1.4	-0.1	1.3
Forced vital capacity (FVC)	0.9	3.5	4.9	-1.1	-2.2	-2.1
Illnesses of mother	0.9	1.1	2.3	-1.0	-0.4	-1.5
Medication for cholesterol	0.9	1.3	1.8	-1.3	-0.8	-1.3
Schizophrenia (2014)	0.8	1.7	2.6	-0.8	-1.4	-1.6
Neuroticism	0.8	1.9	4.0	-1.0	-2.0	-0.8
Waist circumference	0.8	3.0	3.5	1.6	1.9	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.7	-0.2	-1.6	-1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	1.3	0.5	1.2
Alcohol intake versus 10 years previously	0.8	1.2	1.8	-1.3	-1.3	-0.5
Number of live births	0.8	1.2	2.7	-0.4	-0.7	-1.7
Overall health rating	0.8	1.6	2.2	1.5	1.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.6	-0.4	-1.6	-0.2
Smoking status: Current	0.8	1.3	1.7	-0.9	-1.2	-1.3
Ever depressed for a whole week	0.8	1.0	1.9	-0.8	-0.5	-1.4
Schizophrenia (2018)	0.7	1.4	1.8	-1.0	-1.2	-1.3
Major Depression (MDD)	0.7	0.9	1.7	-1.3	-0.2	-0.9
Reaction Time	0.7	1.3	2.5	1.6	0.2	1.1
Lung FVC	0.7	3.4	7.0	-0.5	-2.6	-1.7
Number of treatments/medications taken	0.7	1.2	1.5	1.0	1.0	1.2
Current tobacco smoking	0.7	1.1	1.4	-0.9	-1.0	-1.2
Falls in the last year	0.7	0.9	1.9	-0.6	-1.4	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.1	1.6	1.3	0.6	1.2
Birth weight of first child	0.7	1.2	2.5	-1.0	-1.6	-0.6
Family relationship satisfaction	0.7	0.9	1.5	1.2	0.4	1.0
Commuting to job workplace: Walk	0.7	0.7	1.9	0.1	0.4	1.4
Breast cancer (self-reported)	0.7	0.8	2.4	-0.0	-0.2	1.6
Osteoarthritis (self-reported)	0.7	0.9	1.5	-1.2	-1.1	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	1.8	-1.2	-1.3	-1.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.6	-0.9	-1.6	-1.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	-0.3	-0.9	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	0.7	1.3	0.4
Neuroticism (2016)	0.6	0.8	1.5	-1.0	-1.2	0.0
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.4	0.0	-1.5	0.1
Severe depression (siblings)	0.6	0.6	0.6	-0.7	-0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	-0.3	-0.7	-1.1
Impedance of arm (right)	0.6	2.7	3.7	-1.9	-1.9	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.0	-0.3	-1.4	-0.8
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	1.3	0.1	0.9
Tense / ‘highly strung’	0.6	1.0	1.8	1.0	-0.2	1.3
Medication: Ibuprofen	0.6	0.7	1.1	0.1	1.1	0.9
Mean time to correctly identify matches	0.6	1.2	2.5	1.6	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.8	-0.7	-1.4	-1.2
Medication: Lisinopril	0.6	0.8	0.9	-1.0	-0.6	-1.0
Myopia	0.6	0.9	1.9	-0.7	-0.4	-1.4
HDL Cholesterol	0.5	0.8	1.8	0.2	1.3	0.7
Medication: Atenolol	0.5	0.7	1.0	-0.7	-0.7	-1.0
Past tobacco smoking	0.5	0.9	2.7	-0.3	1.6	0.0
Alcohol usually taken with meals	0.5	0.8	1.6	-0.9	-1.3	-0.2
Hearing difficulty/problems with background noise	0.5	0.8	1.2	-0.7	-0.9	-1.1
Illnesses of siblings	0.5	0.8	1.1	-1.0	-1.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.4	-0.7	-1.5	-0.4
Prospective memory result	0.5	0.6	1.1	-0.7	-1.0	-0.5
Impedance of arm (left)	0.5	2.2	3.3	-1.7	-1.8	-0.7
Standing height	0.5	4.6	5.1	-2.0	-2.1	-2.2
Exposure to tobacco smoke at home	0.5	0.5	0.9	0.7	0.4	1.0
Breastfed as a baby	0.5	0.6	1.0	1.0	0.6	0.7
Medication: Paracetamol	0.5	0.9	1.3	1.0	0.5	1.1
Heart disease (mother)	0.5	0.6	0.9	0.5	0.8	1.0
Medication: Aspirin	0.5	0.7	1.2	-0.8	-1.1	-0.6
Loneliness, isolation	0.5	0.8	2.1	-0.2	1.4	-0.4
Ever had bowel cancer screening	0.5	0.6	0.7	0.8	-0.5	0.8
Ever taken oral contraceptive pill	0.5	0.6	0.6	0.8	0.6	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	-0.0	1.3	-0.3
High cholesterol (Self-reported)	0.5	0.9	1.5	0.2	-1.2	1.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.5	0.3	-0.1	1.2
Pack years of smoking	0.5	0.7	1.3	-1.1	-0.8	-0.5
Bipolar Disorder (2011)	0.4	0.4	0.7	-0.8	0.7	0.0
Height	0.4	7.9	11.6	-2.4	-3.4	-2.5
Smoking Status	0.4	0.8	2.0	-0.6	-1.4	-0.4
Relative age of first facial hair	0.4	0.8	1.6	0.2	0.9	1.3
Townsend deprivation index at recruitment	0.4	0.6	1.0	-0.8	-1.0	-0.4
Age when periods started (menarche)	0.4	0.9	1.5	0.6	1.0	1.2
Leg predicted mass (left)	0.4	2.0	2.5	1.4	1.2	1.6
Had other major operations	0.4	0.4	0.7	-0.8	-0.7	-0.4
Medication: Cholesterol lowering	0.4	0.7	1.2	-0.9	-1.1	-0.0
Headache pain in last month	0.4	0.7	1.1	1.1	0.1	0.9
Gout (self-reported)	0.4	0.6	1.5	0.5	0.3	1.2
Smoking status: Previous	0.4	0.7	1.1	0.9	-0.4	1.0
Eye problems/disorders: Cataract	0.4	0.4	0.7	-0.8	-0.3	-0.8
Back pain experienced in last month	0.4	0.6	1.5	0.3	0.2	1.2
Hearing aid user	0.4	0.5	0.7	0.9	0.2	0.8
Financial situation satisfaction	0.4	0.5	0.8	-0.5	-0.9	-0.6
Illnesses of father: High blood pressure	0.4	0.5	0.7	0.8	0.7	0.6
Ever smoked	0.4	0.7	2.0	-0.1	-1.4	-0.3
Irritability	0.4	0.7	1.6	0.2	-1.3	0.8
Fractured/broken bones in last 5 years	0.4	0.5	0.7	-0.7	-0.6	-0.8
Arm predicted mass (left)	0.4	2.0	2.7	1.5	1.6	1.1
Depression (Nagel 2018)	0.3	0.5	1.3	0.3	-1.2	0.3
Schizophrenia vs Biploar Disorder	0.3	0.3	0.8	0.9	-0.2	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.4	1.2	-0.7	0.5
Mean Putamen Volume	0.3	0.4	0.8	-0.9	-0.1	-0.5
LDL Cholesterol	0.3	0.5	1.4	0.5	-1.2	0.0
Vitamin and mineral supplements	0.3	0.4	1.0	0.4	1.0	0.3
Leg fat-free mass (left)	0.3	1.7	2.2	1.3	1.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	0.2	-1.1	-0.1
Taking other prescription medications	0.3	0.5	0.9	0.9	0.8	0.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.6	-0.1	-0.8
Heart attack	0.3	0.4	1.1	-1.0	-0.2	0.3
Medication: Simvastatin	0.3	0.5	1.0	-0.3	-1.0	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	0.9	-0.9	-1.0	-0.8
Arm fat-free mass (right)	0.3	1.4	1.8	1.3	1.3	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.4	0.5	-0.9
Number of full brothers	0.3	0.4	1.0	0.1	-1.0	-0.4
Health satisfaction	0.3	0.4	0.9	0.5	0.9	0.5
Shortness of breath walking on level ground	0.3	0.3	0.5	0.3	0.6	0.7
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.6	-0.9	-0.3
Chest pain or discomfort	0.3	0.5	1.1	-0.6	-1.1	0.0
Supplements: Vitamin C	0.3	0.3	0.7	-0.4	0.0	-0.8
Leg fat-free mass (right)	0.3	1.6	1.8	1.3	1.2	1.3
Average weekly red wine intake	0.3	0.4	0.8	0.9	0.2	0.6
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.7	0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.6	-0.2	-0.9
Leg predicted mass (right)	0.3	1.4	1.4	1.2	1.1	1.2
Arm fat-free mass (left)	0.3	1.4	2.0	1.2	1.4	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.9	-0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-1.0	-0.2	0.3
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.7	-0.6	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.6	-0.4	-0.2	-0.8
Blood Platelet Count	0.2	1.8	2.4	1.6	1.4	1.0
Hypothyroidism (self reported)	0.2	0.4	0.7	0.8	-0.2	0.6
Supplements: Zinc	0.2	0.2	0.5	0.1	0.7	0.2
Impedance of leg (right)	0.2	1.1	1.3	-1.2	-0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	-0.7	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.7	-0.3	0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	-0.0	-0.9	0.0
Impedance of leg (left)	0.2	1.0	1.3	-1.1	-0.8	-1.2
Nervous feelings	0.2	0.3	0.6	-0.5	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-1.0	0.1	0.3
Fluid intelligence score	0.2	0.5	0.9	0.0	-0.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.1	0.6	0.7
Lung cancer (father)	0.2	0.3	0.5	0.1	-0.6	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.5	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.3	-0.3	-0.9
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	-0.8	0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.7	0.6	0.2
Medication: Blood pressure	0.2	0.3	0.9	0.1	0.9	0.4
Migraine (self-reported)	0.2	0.3	0.7	0.3	0.1	-0.8
Arm predicted mass (right)	0.2	1.2	1.7	1.2	1.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.3	0.7	0.4
Knee pain experienced in last month	0.2	0.3	0.5	-0.5	-0.7	-0.0
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.3	-0.3	-0.9
Mother’s age at death	0.2	0.2	0.4	-0.2	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.8	-0.2	-0.5
Basal metabolic rate	0.2	1.3	1.7	1.1	1.3	1.0
Age started oral contraceptive pill	0.2	0.3	0.5	-0.5	-0.2	-0.7
Cholesterol lowering medication	0.2	0.4	1.0	-0.2	-1.0	0.2
Supplements: Calcium	0.2	0.2	0.4	0.4	0.3	-0.7
Impedance of whole body	0.2	1.2	1.5	-1.2	-1.2	-0.8
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	-0.4	-0.2	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.4	-0.7	-0.4
Worry (Nagel 2018)	0.1	0.3	0.5	0.4	-0.7	0.4
Heel T-Score	0.1	0.5	0.7	-0.8	-0.8	-0.2
Lung FEV1/FVC ratio	0.1	0.7	1.7	-1.3	0.2	-0.7
Average weekly spirits intake	0.1	0.2	0.4	0.3	-0.6	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.4	0.2	0.1	0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.0	-0.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	0.2	0.4
Relative age voice broke	0.1	0.1	0.1	-0.3	0.3	0.2
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	-0.2	-0.4
Neuroticism score	0.1	0.2	0.6	-0.2	-0.8	-0.1
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	-0.3	-0.4
Depression (self-reported)	0.1	0.1	0.2	0.2	-0.0	0.4
Length of working week for main job	0.1	0.1	0.2	0.4	0.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	0.3	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.4	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	0.3	-0.3
Worry too long after embarrassment	0.1	0.2	0.4	-0.4	-0.6	-0.2
Number of children fathered	0.1	0.1	0.2	0.5	-0.1	0.4
Pulse wave peak to peak time	0.1	0.1	0.2	0.4	0.2	0.4
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.6	0.2	0.3
Number of full sisters	0.1	0.1	0.2	-0.2	-0.4	-0.5
Whole body fat-free mass	0.1	0.6	0.9	0.9	0.9	0.6
Mood swings	0.1	0.2	0.3	0.0	0.5	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.3	-0.3
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.3	-0.3
Whole body water mass	0.1	0.6	0.7	0.8	0.9	0.6
Miserableness	0.1	0.1	0.3	0.1	-0.0	-0.6
Guilty feelings	0.1	0.1	0.2	-0.5	-0.3	-0.0
Alcohol drinker status: Never	0.1	0.1	0.3	-0.5	-0.3	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	-0.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	-0.5	0.2	-0.4
Heart disease (siblings)	0.1	0.1	0.3	0.1	-0.6	0.2
Breast Cancer	0.0	0.1	0.2	0.1	0.5	-0.2
Ovarian Cancer	0.0	0.0	0.1	-0.0	-0.3	0.2
Prostate Cancer	0.0	0.0	0.0	0.1	-0.0	0.0
Age at First Birth	0.0	0.0	0.0	-0.1	0.1	-0.1
Hair Pigment	0.0	0.1	0.2	-0.3	0.5	-0.4
Tanning	0.0	0.4	1.1	0.3	1.0	-0.2
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.2	0.0
Fed-up feelings	0.0	0.0	0.1	-0.4	0.1	-0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.0	0.2	-0.2
Sitting height	0.0	0.3	0.5	0.3	-0.5	-0.7
Trunk fat-free mass	0.0	0.1	0.1	0.2	0.4	-0.3
Time employed in main current job	0.0	0.1	0.1	0.3	0.2	0.3
Noisy workplace	0.0	0.1	0.2	0.1	0.0	0.4
Trunk predicted mass	0.0	0.1	0.2	0.2	0.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	-0.0	-0.4	0.2
Blood clot in the leg (DVT)	0.0	0.1	0.2	-0.0	0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.0	0.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.1	-0.0	-0.2
Medication: Omeprazole	0.0	0.0	0.0	0.0	-0.0	0.2
Suffer from ‘nerves’	0.0	0.1	0.2	0.0	-0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.0	-0.4	0.2
Medication: Paracetamol	0.0	0.0	0.1	0.2	-0.3	0.0
Unable to work because of sickness or disability	0.0	0.0	0.1	0.0	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.2	-0.0
Pain experienced in last month	0.0	0.1	0.2	0.4	-0.1	0.0

Hub : Genes

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Trait associations