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chr2:241,941,773-243,048,760

Best TWAS P=5.35e-29 · Best GWAS P=8.24e-28 conditioned to 0.489

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	D2HGDH	0.29	0.12	enet	6	0.14	1.2e-16	-10.931	11.2	5.3e-29	-0.92	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	D2HGDH	0.43	0.28	lasso	7	0.28	3.0e-23	9.147	9.5	1.5e-21	-0.80	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC114730.7	0.42	0.24	lasso	6	0.22	4.9e-18	9.147	9.5	1.4e-21	-0.81	0.99	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	D2HGDH	0.52	0.26	lasso	4	0.27	2.3e-14	9.147	8.8	1.2e-18	-0.70	0.96	0.04	FALSE
5	GTEx	Adipose Visceral Omentum	AC114730.7	0.43	0.22	lasso	3	0.23	5.0e-12	9.147	9.0	2.4e-19	-0.73	0.97	0.03	FALSE
6	GTEx	Adrenal Gland	D2HGDH	0.39	0.32	lasso	1	0.31	1.3e-11	9.147	9.2	5.8e-20	-0.75	0.37	0.63	FALSE
7	GTEx	Adrenal Gland	AC114730.7	0.29	0.27	lasso	1	0.23	6.8e-09	9.147	9.2	5.8e-20	-0.75	0.59	0.40	FALSE
8	GTEx	Artery Aorta	D2HGDH	0.23	0.15	lasso	2	0.15	1.1e-08	9.147	8.9	7.3e-19	-0.75	0.25	0.75	FALSE
9	GTEx	Artery Tibial	D2HGDH	0.50	0.32	lasso	7	0.31	7.7e-25	9.147	9.2	3.2e-20	-0.75	1.00	0.00	FALSE
10	GTEx	Artery Tibial	AC114730.8	0.15	0.12	lasso	1	0.12	2.6e-09	9.147	9.2	5.8e-20	-0.75	0.85	0.14	FALSE
11	GTEx	Artery Tibial	AC114730.7	0.40	0.27	lasso	5	0.26	1.7e-20	9.147	9.2	3.3e-20	-0.75	1.00	0.00	FALSE
12	GTEx	Brain Caudate basal ganglia	AC114730.7	0.40	0.22	lasso	2	0.19	4.6e-06	9.114	9.1	7.5e-20	-0.77	0.21	0.57	FALSE
13	GTEx	Brain Cerebellar Hemisphere	AC114730.7	0.54	0.37	lasso	2	0.36	3.5e-10	9.108	9.9	4.1e-23	-0.85	0.15	0.85	FALSE
14	GTEx	Brain Cerebellum	D2HGDH	0.55	0.32	lasso	5	0.29	2.9e-09	9.114	9.3	1.7e-20	-0.77	0.41	0.58	FALSE
15	GTEx	Brain Cerebellum	AC114730.7	0.58	0.40	lasso	5	0.42	6.9e-14	9.114	9.3	1.2e-20	-0.77	0.68	0.32	FALSE
16	GTEx	Brain Cortex	D2HGDH	0.56	0.31	enet	26	0.38	1.9e-11	9.114	8.4	5.3e-17	-0.78	0.03	0.97	FALSE
17	GTEx	Brain Cortex	AC114730.7	0.42	0.30	enet	22	0.33	8.3e-10	9.147	7.8	9.5e-15	-0.68	0.28	0.66	FALSE
18	GTEx	Brain Frontal Cortex BA9	D2HGDH	0.42	0.23	lasso	4	0.26	1.7e-07	9.114	10.4	2.9e-25	-0.90	0.01	0.98	FALSE
19	GTEx	Brain Frontal Cortex BA9	AC114730.7	0.36	0.22	lasso	4	0.19	1.2e-05	9.114	9.3	1.7e-20	-0.75	0.28	0.43	FALSE
20	GTEx	Brain Hypothalamus	D2HGDH	0.64	0.24	lasso	10	0.16	1.1e-04	9.222	9.4	5.1e-21	-0.74	0.10	0.85	FALSE
21	GTEx	Brain Hypothalamus	AC114730.7	0.55	0.21	enet	17	0.22	8.6e-06	9.222	9.5	1.9e-21	-0.73	0.18	0.39	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	D2HGDH	0.54	0.43	lasso	1	0.41	3.3e-12	9.147	9.2	5.8e-20	-0.75	0.70	0.30	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	AC114730.7	0.42	0.25	lasso	4	0.26	1.2e-07	9.147	9.2	3.1e-20	-0.76	0.54	0.31	FALSE
24	GTEx	Brain Putamen basal ganglia	D2HGDH	0.46	0.20	enet	15	0.30	6.7e-08	9.147	8.6	7.0e-18	-0.73	0.01	0.95	FALSE
25	GTEx	Brain Putamen basal ganglia	AC114730.7	0.39	0.24	enet	24	0.26	6.4e-07	9.114	7.7	1.5e-14	-0.62	0.04	0.86	FALSE
26	GTEx	Breast Mammary Tissue	D2HGDH	0.31	0.19	enet	5	0.19	2.8e-10	9.147	9.1	1.1e-19	-0.76	0.99	0.01	FALSE
27	GTEx	Breast Mammary Tissue	AC114730.7	0.27	0.18	enet	8	0.18	1.9e-09	9.147	9.2	5.7e-20	-0.75	0.98	0.02	FALSE
28	GTEx	Breast Mammary Tissue (Male)	D2HGDH	0.43	0.24	lasso	6	0.20	1.9e-05	9.147	10.1	4.8e-24	-0.83	0.02	0.89	FALSE
29	GTEx	Breast Mammary Tissue (Male)	AC114730.7	0.30	0.17	lasso	3	0.20	2.8e-05	9.147	10.3	5.9e-25	-0.88	0.01	0.92	FALSE
30	GTEx	Cells EBV-transformed lymphocytes	D2HGDH	0.23	0.26	lasso	1	0.24	1.9e-08	9.147	9.2	5.8e-20	-0.75	0.35	0.57	FALSE
31	GTEx	Cells Transformed fibroblasts	D2HGDH	0.44	0.27	lasso	11	0.30	1.2e-22	9.108	10.3	1.0e-24	-0.86	0.97	0.03	FALSE
32	GTEx	Cells Transformed fibroblasts	AC114730.8	0.32	0.12	lasso	4	0.16	4.5e-12	9.222	10.8	4.6e-27	-0.89	0.01	0.99	FALSE
33	GTEx	Cells Transformed fibroblasts	AC114730.7	0.27	0.17	lasso	4	0.16	3.6e-12	9.108	9.1	7.3e-20	-0.77	0.99	0.01	FALSE
34	GTEx	Colon Sigmoid	D2HGDH	0.48	0.24	enet	27	0.28	3.0e-10	9.147	5.7	1.2e-08	-0.48	0.87	0.10	FALSE
35	GTEx	Colon Sigmoid	AC114730.7	0.41	0.19	enet	31	0.18	5.4e-07	9.147	5.4	5.5e-08	-0.46	0.58	0.30	FALSE
36	GTEx	Colon Transverse	D2HGDH	0.48	0.27	lasso	4	0.25	2.8e-12	9.222	9.9	3.6e-23	-0.80	0.34	0.66	FALSE
37	GTEx	Colon Transverse	AC114730.7	0.53	0.26	enet	26	0.24	1.1e-11	9.222	8.5	2.2e-17	-0.71	0.78	0.22	FALSE
38	GTEx	Esophagus Mucosa	D2HGDH	0.34	0.21	enet	7	0.22	8.7e-15	9.222	9.5	1.4e-21	-0.82	0.61	0.39	FALSE
39	GTEx	Esophagus Mucosa	AC114730.7	0.31	0.18	enet	6	0.18	2.3e-12	9.147	9.7	2.2e-22	-0.81	0.38	0.62	FALSE
40	GTEx	Esophagus Muscularis	D2HGDH	0.21	0.19	lasso	2	0.18	7.0e-11	9.147	9.2	5.7e-20	-0.75	0.94	0.06	FALSE
41	GTEx	Heart Left Ventricle	D2HGDH	0.23	0.12	enet	14	0.17	3.7e-09	9.147	9.6	1.3e-21	-0.83	0.02	0.98	FALSE
42	GTEx	Liver	AC114730.8	0.23	-0.01	enet	27	0.03	6.5e-02	0.083	6.4	1.5e-10	-0.32	0.03	0.17	FALSE
43	GTEx	Lung	D2HGDH	0.37	0.26	enet	11	0.29	1.9e-22	9.147	8.9	3.7e-19	-0.72	1.00	0.00	FALSE
44	GTEx	Lung	AC114730.7	0.32	0.21	enet	9	0.23	7.3e-18	9.147	8.6	8.0e-18	-0.70	1.00	0.00	FALSE
45	GTEx	Muscle Skeletal	D2HGDH	0.26	0.11	lasso	2	0.14	3.0e-13	-10.931	10.9	9.0e-28	-0.94	0.00	1.00	FALSE
46	GTEx	Muscle Skeletal	AC114730.7	0.17	0.09	lasso	2	0.09	9.5e-09	9.222	9.3	1.2e-20	-0.75	0.86	0.14	FALSE
47	GTEx	Nerve Tibial	D2HGDH	0.54	0.30	lasso	6	0.30	1.3e-21	9.147	9.2	3.1e-20	-0.76	1.00	0.00	FALSE
48	GTEx	Nerve Tibial	AC114730.8	0.26	0.10	lasso	4	0.07	1.0e-05	9.147	9.4	7.5e-21	-0.76	0.27	0.71	FALSE
49	GTEx	Nerve Tibial	AC114730.7	0.47	0.23	lasso	6	0.23	1.6e-16	9.147	9.0	2.4e-19	-0.73	1.00	0.00	FALSE
50	GTEx	Pancreas	D2HGDH	0.48	0.32	lasso	11	0.31	1.4e-13	9.147	9.5	2.9e-21	-0.74	0.77	0.23	FALSE
51	GTEx	Pancreas	AC114730.8	0.20	0.15	lasso	3	0.14	1.7e-06	9.147	9.8	7.0e-23	-0.73	0.07	0.81	FALSE
52	GTEx	Pancreas	AC114730.7	0.36	0.25	lasso	4	0.25	6.4e-11	9.147	9.0	2.5e-19	-0.73	0.71	0.29	FALSE
53	GTEx	Pituitary	D2HGDH	0.42	0.30	enet	27	0.28	8.7e-08	9.108	9.1	6.6e-20	-0.66	0.31	0.54	FALSE
54	GTEx	Pituitary	AC114730.7	0.49	0.32	enet	20	0.34	1.7e-09	9.114	8.9	6.1e-19	-0.63	0.36	0.55	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	D2HGDH	0.37	0.17	lasso	2	0.18	6.1e-10	9.147	9.2	5.1e-20	-0.76	0.95	0.05	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	AC114730.7	0.35	0.19	lasso	2	0.18	5.3e-10	9.147	9.2	5.5e-20	-0.75	0.96	0.04	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	AC114730.11	0.19	0.13	lasso	6	0.12	3.0e-07	-3.444	-5.4	8.5e-08	0.39	0.83	0.12	FALSE
58	GTEx	Skin Sun Exposed Lower leg	ING5	0.14	0.12	enet	7	0.12	6.1e-10	-3.444	-5.6	2.7e-08	0.40	1.00	0.00	FALSE
59	GTEx	Skin Sun Exposed Lower leg	D2HGDH	0.38	0.25	lasso	6	0.25	1.3e-20	9.147	9.2	4.8e-20	-0.78	1.00	0.00	FALSE
60	GTEx	Skin Sun Exposed Lower leg	AC114730.7	0.35	0.28	lasso	3	0.28	6.2e-23	9.147	8.8	1.2e-18	-0.75	1.00	0.00	FALSE
61	GTEx	Spleen	ING5	0.49	0.20	lasso	8	0.20	9.7e-06	-3.444	-6.5	1.2e-10	0.44	0.15	0.11	FALSE
62	GTEx	Spleen	AC114730.7	0.31	0.22	lasso	3	0.20	6.3e-06	9.147	9.2	4.7e-20	-0.76	0.16	0.48	FALSE
63	GTEx	Testis	D2HGDH	0.64	0.39	enet	20	0.42	4.5e-20	9.147	8.7	4.0e-18	-0.72	0.99	0.01	FALSE
64	GTEx	Testis	AC114730.8	0.18	0.04	enet	57	0.03	2.1e-02	9.147	8.2	1.6e-16	-0.45	0.01	0.87	FALSE
65	GTEx	Testis	AC114730.7	0.53	0.30	enet	17	0.29	3.3e-13	9.147	8.6	5.6e-18	-0.71	0.99	0.01	FALSE
66	GTEx	Thyroid	D2HGDH	0.42	0.30	lasso	5	0.30	2.3e-23	9.147	9.1	8.9e-20	-0.75	1.00	0.00	FALSE
67	GTEx	Thyroid	AC114730.8	0.17	0.10	lasso	2	0.10	2.6e-08	9.147	9.2	3.9e-20	-0.75	0.94	0.05	FALSE
68	GTEx	Thyroid	AC114730.7	0.35	0.26	lasso	3	0.26	5.0e-20	9.147	9.1	6.3e-20	-0.75	1.00	0.00	FALSE
69	GTEx	Uterus	AC093642.3	0.35	-0.01	enet	25	0.07	1.8e-02	-3.513	-7.8	7.8e-15	0.46	0.02	0.28	TRUE
70	GTEx	Whole Blood	D2HGDH	0.12	0.08	lasso	3	0.08	5.7e-08	9.222	9.9	2.4e-23	-0.81	0.09	0.91	FALSE
71	GTEx	Whole Blood	AC114730.7	0.11	0.08	lasso	3	0.08	4.1e-08	9.147	9.7	2.8e-22	-0.80	0.12	0.88	FALSE
72	METSIM	Adipose	PDCD1	0.05	0.00	blup	171	0.02	1.9e-03	-10.931	-7.7	1.5e-14	0.44	0.00	0.92	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	GAL3ST2	0.10	0.09	lasso	1	0.08	5.8e-11	9.222	-9.2	2.9e-20	0.73	1.00	0.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	D2HGDH	0.44	0.33	lasso	6	0.35	2.1e-46	9.222	9.8	9.2e-23	-0.74	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GAL3ST2	0.05	0.00	enet	7	0.03	8.1e-05	9.222	-7.4	1.7e-13	0.52	0.01	0.64	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	D2HGDH	0.06	0.02	blup	28	0.04	1.3e-05	-10.931	9.4	4.2e-21	-0.86	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	D2HGDH	0.08	0.03	blup	28	0.04	4.6e-05	9.222	7.3	3.8e-13	-0.52	0.01	0.70	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAL3ST2	0.03	0.03	enet	3	0.03	8.9e-04	9.222	-9.3	1.6e-20	0.76	0.03	0.75	FALSE