Best TWAS P=5.38e-09 · Best GWAS P=9.96e-08 conditioned to 0.361
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CARF | 0.17 | 0.07 | enet | 23 | 0.09 | 6.2e-08 | -4.4 | 5.2 | 2.3e-07 | -0.61 | 0.22 | 0.73 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | NBEAL1 | 0.09 | 0.07 | lasso | 3 | 0.06 | 5.7e-06 | -5.1 | 5.3 | 1.4e-07 | -0.83 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | NBEAL1 | 0.09 | 0.08 | lasso | 3 | 0.02 | 1.9e-02 | -5.1 | 5.1 | 2.7e-07 | -0.78 | 0.01 | 0.96 | FALSE |
| 4 | GTEx | Artery Tibial | CARF | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.5e-03 | -5.1 | 5.5 | 2.9e-08 | -0.72 | 0.03 | 0.90 | FALSE |
| 5 | GTEx | Artery Tibial | NBEAL1 | 0.24 | 0.29 | lasso | 6 | 0.29 | 1.1e-22 | -5.1 | 5.1 | 2.9e-07 | -0.79 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | CARF | 0.11 | 0.11 | enet | 13 | 0.13 | 8.0e-10 | -4.2 | 5.4 | 7.5e-08 | -0.62 | 0.14 | 0.84 | FALSE |
| 7 | GTEx | Colon Sigmoid | CARF | 0.12 | 0.06 | enet | 11 | 0.06 | 3.4e-03 | -4.3 | 5.5 | 4.0e-08 | -0.72 | 0.03 | 0.80 | FALSE |
| 8 | GTEx | Esophagus Muscularis | CARF | 0.09 | 0.07 | enet | 20 | 0.10 | 1.4e-06 | -3.9 | 5.1 | 2.9e-07 | -0.66 | 0.08 | 0.88 | FALSE |
| 9 | GTEx | Muscle Skeletal | ICA1L | 0.18 | 0.14 | lasso | 8 | 0.14 | 5.5e-14 | -5.0 | -5.4 | 5.7e-08 | 0.76 | 0.01 | 0.98 | FALSE |
| 10 | GTEx | Nerve Tibial | CARF | 0.08 | 0.07 | enet | 12 | 0.06 | 3.8e-05 | -4.6 | 5.3 | 1.2e-07 | -0.49 | 0.12 | 0.85 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | CARF | 0.22 | 0.08 | lasso | 9 | 0.10 | 5.7e-06 | -4.6 | 5.8 | 5.4e-09 | -0.83 | 0.02 | 0.97 | TRUE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | NBEAL1 | 0.16 | 0.08 | lasso | 8 | 0.08 | 5.2e-05 | -5.1 | 5.1 | 3.0e-07 | -0.78 | 0.01 | 0.97 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | CARF | 0.11 | 0.09 | lasso | 3 | 0.10 | 5.0e-09 | -4.4 | 5.2 | 1.5e-07 | -0.58 | 0.13 | 0.84 | FALSE |
| 14 | GTEx | Testis | CARF | 0.38 | 0.30 | lasso | 6 | 0.30 | 1.4e-13 | -5.0 | 5.2 | 2.3e-07 | -0.79 | 0.01 | 0.98 | FALSE |
| 15 | METSIM | Adipose | ICA1L | 0.11 | 0.04 | bslmm | 265 | 0.05 | 6.7e-08 | -5.1 | -5.4 | 6.9e-08 | 0.80 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | ICA1L | 0.10 | 0.01 | blup | 59 | 0.02 | 1.6e-02 | -5.1 | -5.4 | 5.7e-08 | 0.82 | 0.00 | 0.95 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | WDR12 | 0.04 | 0.02 | lasso | 2 | 0.02 | 1.4e-03 | -4.6 | -5.2 | 1.6e-07 | 0.83 | 0.01 | 0.56 | FALSE |