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chr7:127,878,155-129,284,182

Best TWAS P=4.73e-12 · Best GWAS P=8.52e-10 conditioned to 0.000836

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	IRF5	0.16	0.08	lasso	4	0.08	8.2e-05	5.6	5.9	3.4e-09	0.32	0.09	0.78	FALSE
2	GTEx	Colon Transverse	IRF5	0.21	0.22	lasso	4	0.22	8.0e-11	5.6	5.7	1.2e-08	0.31	0.07	0.93	FALSE
3	GTEx	Esophagus Mucosa	IRF5	0.13	0.14	lasso	4	0.13	4.6e-09	5.6	5.6	2.6e-08	0.29	0.07	0.93	FALSE
4	GTEx	Esophagus Muscularis	IRF5	0.21	0.12	lasso	5	0.11	3.9e-07	5.6	5.8	5.6e-09	0.32	0.11	0.88	FALSE
5	GTEx	Nerve Tibial	IRF5	0.13	0.09	enet	10	0.07	1.2e-05	5.6	5.9	2.9e-09	0.34	0.08	0.91	FALSE
6	GTEx	Skin Sun Exposed Lower leg	IRF5	0.10	0.14	lasso	2	0.12	1.9e-10	5.6	5.7	9.7e-09	0.32	0.07	0.93	FALSE
7	GTEx	Whole Blood	IRF5	0.17	0.06	lasso	4	0.09	1.2e-08	-4.6	5.6	2.2e-08	0.31	0.18	0.82	FALSE
8	METSIM	Adipose	IRF5	0.05	0.04	lasso	7	0.04	2.2e-06	5.6	5.7	1.2e-08	0.38	0.08	0.92	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	IRF5	0.27	0.25	bslmm	336	0.25	7.1e-32	-4.6	5.2	2.2e-07	0.33	0.92	0.08	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	IRF5	0.10	0.09	lasso	4	0.08	1.6e-16	5.6	5.7	1.3e-08	0.30	0.07	0.93	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	IRF5	0.29	0.26	enet	6	0.29	3.1e-17	-5.7	6.0	1.7e-09	0.36	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IRF5	0.14	0.12	enet	7	0.15	1.8e-16	5.6	5.5	4.7e-08	0.22	0.07	0.93	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IRF5	0.09	0.04	lasso	4	0.06	2.3e-04	5.6	5.7	1.2e-08	0.30	0.06	0.87	FALSE
14	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IRF5	0.17	0.09	enet	6	0.15	1.8e-07	-5.0	6.9	4.7e-12	0.46	0.14	0.85	TRUE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	IRF5	0.18	0.11	enet	9	0.14	1.6e-15	5.6	6.1	9.4e-10	0.34	0.06	0.94	FALSE
16	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IRF5	0.14	0.15	enet	6	0.14	7.0e-10	-5.7	6.2	4.5e-10	0.36	0.04	0.96	FALSE
17	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IRF5	0.09	0.10	lasso	3	0.08	4.6e-04	-5.7	5.8	7.3e-09	0.34	0.03	0.55	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	IRF5	0.23	0.26	lasso	3	0.26	3.6e-27	-5.7	5.9	3.4e-09	0.34	0.04	0.96	FALSE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	IRF5	0.41	0.13	blup	33	0.23	3.5e-06	-5.7	6.0	1.6e-09	0.46	0.04	0.82	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	IRF5	0.22	0.21	enet	9	0.26	4.6e-25	-5.7	6.6	5.4e-11	0.43	0.05	0.95	FALSE