Hub : Traits :

Rheumatoid Arthritis

90 significantly associated models · 32 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 1829482 3261925 1 1 2.7e-09 4.6e-08 6.3e-02 88 MMEL1
2 1 37628741 39108725 2 1 1.9e-08 7.6e-08 9.0e-07 16 INPP5B
3 1 113236087 115222434 11 5 8.6e-49 1.7e-102 NaN NaN DCLRE1B PHTF1 PTPN22
4 2 60422555 61938725 2 1 9.7e-08 5.4e-08 1.1e-01 91 PUS10
5 2 99468341 101456989 1 1 3.9e-08 7.4e-09 2.1e-02 84 AFF3
6 3 11900101 13321852 1 1 1.3e-07 1.2e-06 4.6e-01 98 MKRN2
7 5 54699883 56226605 1 1 1.1e-12 2.7e-14 5.1e-03 86 ANKRD55
8 5 101392473 103061825 1 1 2.3e-09 1.0e-09 2.6e-02 87 PAM
9 6 44002373 44513341 1 1 3.2e-08 1.0e-07 3.5e-02 84 TCTE1
10 7 127878155 129284182 1 1 4.7e-12 8.5e-10 8.4e-04 70 IRF5
11 10 63414038 64105321 1 1 2.5e-08 4.9e-10 1.6e-04 63 ARID5B
12 11 36262540 36777339 1 1 4.7e-08 2.2e-08 1.9e-01 94 TRAF6
13 12 111522000 112941571 1 1 2.4e-07 6.8e-07 5.7e-04 52 ALDH2
14 18 12538482 13133577 1 1 3.0e-07 1.1e-06 1.0e-01 89 PTPN2
15 22 39499604 40026309 1 1 4.3e-09 4.5e-08 7.7e-01 100 SYNGR1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Intelligence (Savage-Jansen 2018) 1.07 1 0 0.0 0.00 1.0e+00 PAM
Worry (Nagel 2018) 1.76 2 0 0.0 0.00 1.0e+00 ARID5B PAM
Crohns Disease (2017) 5.15 4 2 4.4 -0.26 6.7e-01 ANKRD55 DCLRE1B PTPN2 TCTE1
Irritable Bowel Disease (IBD) 3.45 3 1 2.2 0.00 1.0e+00 ANKRD55 PTPN2 TCTE1
Ulcerative Colitis (UC) 2.72 2 0 0.0 0.00 1.0e+00 IRF5 PTPN2
Reaction Time 1.66 1 0 0.0 0.00 1.0e+00 ALDH2
Verbal and Numeric Reasoning (VNR) 1.36 1 0 0.0 0.00 1.0e+00 PAM
Breast Cancer 2.48 2 1 2.2 -0.52 4.8e-01 DCLRE1B PHTF1
Age at First Birth 1.34 1 0 0.0 0.00 1.0e+00 AFF3
Coronary Artery Disease (CAD) 2.50 1 0 0.0 0.00 1.0e+00 ALDH2
Crohns Disease (2012) 3.86 2 1 2.2 0.00 1.0e+00 DCLRE1B PTPN2
LDL Cholesterol 1.26 1 0 0.0 0.00 1.0e+00 ALDH2
Lupus 9.28 4 1 2.2 0.86 6.0e-02 ANKRD55 ARID5B DCLRE1B IRF5
Primary Biliary Cirrhosis 6.13 4 2 4.4 0.64 3.6e-01 IRF5 MMEL1 PAM SYNGR1
Ulcerative Colitis 3.01 1 1 2.2 0.00 1.0e+00 IRF5
Blood Eosinophil Count 4.00 6 5 11.1 0.41 4.2e-01 ALDH2 INPP5B IRF5 MKRN2 PTPN2 PUS10
Blood Platelet Count 0.96 5 3 6.7 0.40 5.1e-01 ALDH2 ARID5B IRF5 PAM SYNGR1
Blood Red Count 1.28 5 5 11.1 0.60 2.8e-01 AFF3 ALDH2 ANKRD55 PAM PTPN2
Blood White Count 3.23 6 4 8.9 0.13 7.6e-01 ALDH2 DCLRE1B MKRN2 PAM PHTF1 SYNGR1
Heel T-Score 1.11 6 1 2.2 0.39 4.4e-01 AFF3 ANKRD55 ARID5B INPP5B IRF5 PHTF1
BMI 0.58 1 0 0.0 0.00 1.0e+00 MKRN2
Height 0.64 7 5 11.1 -0.39 3.9e-01 ALDH2 ARID5B INPP5B IRF5 MKRN2 PAM PUS10
Waist Hip Ratio (WHR) 1.10 1 1 2.2 0.00 1.0e+00 PAM
Systolic Blood Pressure 1.73 2 2 4.4 0.00 1.0e+00 ALDH2 ARID5B
Smoking Status 1.16 1 0 0.0 0.00 1.0e+00 PHTF1
Allergy or Eczema 3.01 4 1 2.2 0.58 4.2e-01 ANKRD55 PTPN22 PUS10 TRAF6
Cardiovascular Disease 0.88 1 1 2.2 0.00 1.0e+00 ALDH2
Hypothyroidism (self reported) 28.04 11 8 17.8 0.97 1.6e-08 ALDH2 ARID5B DCLRE1B INPP5B IRF5 MMEL1 PAM PHTF1 PTPN2 PTPN22 SYNGR1
Type 2 Diabetes (T2D) (2018) 1.04 1 0 0.0 0.00 1.0e+00 PAM
Lung FEV1/FVC ratio 0.91 1 0 0.0 0.00 1.0e+00 ARID5B
Lung FVC 1.23 3 0 0.0 0.00 1.0e+00 AFF3 ARID5B PAM
Hair Pigment 0.14 1 1 2.2 0.00 1.0e+00 SYNGR1
Tanning 0.41 2 1 2.2 0.00 1.0e+00 PTPN2 SYNGR1
Number of treatments/medications taken 1.85 1 0 0.0 0.00 1.0e+00 DCLRE1B
Sensitivity / hurt feelings 1.00 1 0 0.0 0.00 1.0e+00 MMEL1
Other serious medical condition/disability diagnosed by doctor 3.31 2 0 0.0 0.00 1.0e+00 DCLRE1B PTPN2
Systolic blood pressure, automated reading 1.37 2 1 2.2 0.00 1.0e+00 ALDH2 ARID5B
Impedance of leg (right) 1.00 1 0 0.0 0.00 1.0e+00 PAM
Leg fat-free mass (left) 0.84 2 0 0.0 0.00 1.0e+00 ARID5B MKRN2
Trunk fat percentage 0.62 2 0 0.0 0.00 1.0e+00 MKRN2 SYNGR1
Current tobacco smoking 1.52 1 0 0.0 0.00 1.0e+00 PHTF1
Fed-up feelings 0.78 1 0 0.0 0.00 1.0e+00 ALDH2
Taking other prescription medications 4.33 1 1 2.2 0.00 1.0e+00 DCLRE1B
Age when periods started (menarche) 1.99 2 0 0.0 0.00 1.0e+00 DCLRE1B PUS10
High blood pressure 1.23 1 1 2.2 0.00 1.0e+00 ALDH2
Hayfever, allergic rhinitis or eczema 2.42 2 0 0.0 0.00 1.0e+00 PUS10 TRAF6
Medication: Levothyroxine sodium 18.29 9 6 13.3 0.99 9.6e-09 ALDH2 ARID5B DCLRE1B INPP5B MMEL1 PAM PHTF1 PTPN2 PTPN22
Sitting height 0.57 1 0 0.0 0.00 1.0e+00 PUS10
Impedance of leg (left) 1.02 3 0 0.0 0.00 1.0e+00 ARID5B MMEL1 PAM
Leg predicted mass (left) 0.85 2 0 0.0 0.00 1.0e+00 ARID5B MKRN2
Trunk fat mass 0.72 2 0 0.0 0.00 1.0e+00 MKRN2 SYNGR1
Waist circumference 0.59 1 0 0.0 0.00 1.0e+00 MKRN2
Past tobacco smoking 1.29 1 0 0.0 0.00 1.0e+00 PHTF1
Alcohol usually taken with meals 1.55 1 0 0.0 0.00 1.0e+00 AFF3
Heel bone mineral density (BMD) T-score, automated (right) 1.26 1 0 0.0 0.00 1.0e+00 ARID5B
Mouth/teeth dental problems 1.00 1 0 0.0 0.00 1.0e+00 IRF5
Allergy 1.89 1 0 0.0 0.00 1.0e+00 TRAF6
Fluid intelligence score 1.44 1 0 0.0 0.00 1.0e+00 PAM
Weight 0.83 1 0 0.0 0.00 1.0e+00 MKRN2
Arm fat percentage (right) 0.60 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk fat-free mass 0.78 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Hip circumference 0.83 1 0 0.0 0.00 1.0e+00 MKRN2
Father's age at death 1.16 1 0 0.0 0.00 1.0e+00 ALDH2
Worrier / anxious feelings 1.28 1 0 0.0 0.00 1.0e+00 PAM
Frequency of tiredness / lethargy in last 2 weeks 1.31 1 0 0.0 0.00 1.0e+00 PTPN2
Forced expiratory volume in 1-second (FEV1) 0.85 1 0 0.0 0.00 1.0e+00 AFF3
Mouth/teeth dental problems: Dentures 0.93 1 0 0.0 0.00 1.0e+00 ARID5B
Asthma 1.52 1 0 0.0 0.00 1.0e+00 INPP5B
Impedance of arm (left) 0.49 1 0 0.0 0.00 1.0e+00 ALDH2
Arm fat mass (right) 0.61 1 0 0.0 0.00 1.0e+00 MKRN2
Trunk predicted mass 0.78 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Standing height 0.62 5 0 0.0 -0.69 2.0e-01 ALDH2 ARID5B INPP5B IRF5 MKRN2
Gout (self-reported) 1.37 1 0 0.0 0.00 1.0e+00 IRF5
Hypothyroidism/myxoedema (self-reported) 22.88 11 6 13.3 0.98 1.2e-08 ALDH2 ARID5B DCLRE1B INPP5B IRF5 MMEL1 PAM PHTF1 PTPN2 PTPN22 SYNGR1
Body fat percentage 0.63 1 0 0.0 0.00 1.0e+00 MKRN2
Arm fat-free mass (right) 0.67 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Worry too long after embarrassment 1.71 1 0 0.0 0.00 1.0e+00 DCLRE1B
Qualifications: College or University degree 1.37 2 0 0.0 0.00 1.0e+00 AFF3 PAM
Medication for pain relief, constipation, heartburn 1.04 1 0 0.0 0.00 1.0e+00 PAM
Medication: Allopurinol 1.49 1 0 0.0 0.00 1.0e+00 IRF5
Mean time to correctly identify matches 1.30 1 0 0.0 0.00 1.0e+00 ALDH2
Whole body fat mass 0.69 1 0 0.0 0.00 1.0e+00 MKRN2
Leg fat mass (right) 0.71 1 0 0.0 0.00 1.0e+00 MKRN2
Arm predicted mass (right) 0.63 1 0 0.0 0.00 1.0e+00 ALDH2
Alcohol intake frequency. 1.73 1 0 0.0 0.00 1.0e+00 PUS10
Comparative height size at age 10 0.73 1 0 0.0 0.00 1.0e+00 ALDH2
Suffer from 'nerves' 1.14 1 0 0.0 0.00 1.0e+00 PAM
Overall health rating 1.41 1 0 0.0 0.00 1.0e+00 DCLRE1B
Hypertension (Self-reported) 1.03 1 1 2.2 0.00 1.0e+00 ALDH2
Whole body fat-free mass 0.79 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Leg fat-free mass (right) 0.84 1 0 0.0 0.00 1.0e+00 ARID5B
Arm fat percentage (left) 0.56 1 0 0.0 0.00 1.0e+00 MKRN2
Long-standing illness, disability or infirmity 3.13 1 0 0.0 0.00 1.0e+00 DCLRE1B
Mouth/teeth dental problems: Mouth ulcers 3.36 3 1 2.2 0.00 1.0e+00 AFF3 IRF5 PAM
Medication for cholesterol 1.33 1 0 0.0 0.00 1.0e+00 ALDH2
Asthma (self-reported) 1.48 1 0 0.0 0.00 1.0e+00 INPP5B
Smoking status: Current 1.57 1 0 0.0 0.00 1.0e+00 PHTF1
Whole body water mass 0.80 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Leg predicted mass (right) 0.85 1 0 0.0 0.00 1.0e+00 ARID5B
Arm fat mass (left) 0.57 1 0 0.0 0.00 1.0e+00 MKRN2
Number of self-reported non-cancer illnesses 1.61 1 0 0.0 0.00 1.0e+00 ALDH2
Medication: Blood pressure 1.34 1 1 2.2 0.00 1.0e+00 ALDH2
Illnesses of father: High blood pressure 1.41 1 0 0.0 0.00 1.0e+00 ALDH2
Ever smoked 1.39 1 0 0.0 0.00 1.0e+00 PHTF1
Basal metabolic rate 0.81 3 0 0.0 0.00 1.0e+00 ALDH2 ARID5B MKRN2
Arm fat-free mass (left) 0.74 2 0 0.0 0.00 1.0e+00 ALDH2 ARID5B
Diastolic blood pressure, automated reading 1.75 1 1 2.2 0.00 1.0e+00 ALDH2
Ever depressed for a whole week 1.35 1 0 0.0 0.00 1.0e+00 ALDH2
Vascular/heart problems diagnosed by doctor 1.05 1 1 2.2 0.00 1.0e+00 ALDH2
Leg fat mass (left) 0.67 1 0 0.0 0.00 1.0e+00 MKRN2
Arm predicted mass (left) 0.74 1 0 0.0 0.00 1.0e+00 ALDH2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.4
GTEx Adipose Visceral Omentum 3 0.151 1.4
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 1 0.035 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 3 0.082 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 2 0.138 1.5
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 1 0.111 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 1 0.052 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 5 0.122 1.4
GTEx Colon Sigmoid 1 0.070 1.5
GTEx Colon Transverse 3 0.150 1.5
GTEx Esophagus Gastroesophageal Junction 1 0.072 1.4
GTEx Esophagus Mucosa 1 0.031 1.4
GTEx Esophagus Muscularis 1 0.032 1.5
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.4
GTEx Lung 1 0.036 1.5
GTEx Muscle Skeletal 1 0.036 1.4
GTEx Nerve Tibial 3 0.071 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 1 0.028 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 2 0.145 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 2 0.065 1.4
GTEx Thyroid 1 0.026 1.4
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.5
GTEx Whole Blood 1 0.052 1.5
METSIM Adipose 7 0.155 1.4
NTR Blood 1 0.042 1.5
ROSMAP Brain Pre-frontal Cortex 4 0.093 1.5
YFS Blood 3 0.066 1.5
CommonMind Brain Pre-frontal Cortex 3 0.057 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 6 0.142 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.101 1.4
The Cancer Genome Atlas Esophageal Carcinoma 1 0.153 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.104 1.7
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.038 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.051 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.154 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.049 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.095 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.036 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.066 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.126 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.080 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 4 0.090 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.152 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.099 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.082 1.5
The Cancer Genome Atlas Thyroid Carcinoma 5 0.101 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4