Best TWAS P=5.94e-08 · Best GWAS P=2.6e-07 conditioned to 0.899
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | INO80E | 0.17 | 0.12 | enet | 14 | 0.13 | 2.3e-07 | 3.9 | 5.3 | 1.3e-07 | 0.84 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | MAPK3 | 0.12 | 0.05 | lasso | 10 | 0.04 | 3.7e-04 | 4.9 | 5.4 | 5.9e-08 | 0.94 | 0.03 | 0.96 | TRUE |
| 3 | GTEx | Esophagus Muscularis | INO80E | 0.10 | 0.11 | enet | 20 | 0.07 | 4.6e-05 | -5.0 | 5.4 | 6.7e-08 | 0.83 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Heart Left Ventricle | INO80E | 0.06 | 0.07 | lasso | 7 | 0.08 | 6.1e-05 | -4.9 | 5.1 | 2.7e-07 | 0.91 | 0.03 | 0.94 | FALSE |
| 5 | GTEx | Whole Blood | MAPK3 | 0.09 | 0.05 | enet | 30 | 0.09 | 7.8e-09 | 5.2 | 5.1 | 3.0e-07 | 0.82 | 0.02 | 0.98 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RP11-345J4.8 | 0.02 | 0.00 | blup | 192 | 0.01 | 1.9e-02 | -1.0 | -5.2 | 2.2e-07 | -0.70 | 0.02 | 0.19 | FALSE |