Best TWAS P=1.04e-13 · Best GWAS P=4.65e-12 conditioned to 0.00377
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FURIN | 0.12 | 0.14 | lasso | 2 | 0.13 | 1.2e-15 | 6.9 | -6.9 | 6.4e-12 | -1.00 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | FES | 0.21 | 0.09 | lasso | 5 | 0.05 | 1.3e-03 | -5.4 | 5.7 | 1.1e-08 | 0.60 | 0.47 | 0.08 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | -5.4 | 6.2 | 7.5e-10 | 0.77 | 0.52 | 0.48 | FALSE |
4 | GTEx | Lung | FES | 0.24 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | -5.4 | 5.9 | 4.4e-09 | 0.64 | 0.33 | 0.60 | FALSE |
5 | GTEx | Thyroid | FES | 0.33 | 0.19 | lasso | 6 | 0.18 | 4.3e-14 | -5.2 | 5.4 | 7.2e-08 | 0.60 | 0.95 | 0.05 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.06 | 1.9e-05 | -6.0 | 6.2 | 6.1e-10 | 0.74 | 0.01 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | -5.4 | 7.4 | 1.7e-13 | 0.77 | 0.27 | 0.73 | FALSE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FES | 0.06 | 0.02 | blup | 46 | 0.02 | 2.4e-02 | -5.4 | 6.5 | 8.5e-11 | 0.64 | 0.01 | 0.80 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | -6.4 | 6.2 | 8.0e-10 | 0.82 | 0.00 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | -6.2 | 5.8 | 5.1e-09 | 0.84 | 0.01 | 0.87 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | -6.2 | 6.8 | 7.7e-12 | 0.71 | 0.08 | 0.92 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | -6.0 | 6.3 | 3.6e-10 | 0.88 | 0.02 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HDDC3 | 0.16 | 0.10 | enet | 9 | 0.12 | 2.1e-07 | -3.2 | 6.3 | 2.9e-10 | 0.56 | 0.28 | 0.66 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | -5.4 | 6.1 | 1.2e-09 | 0.76 | 0.05 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FES | 0.08 | 0.07 | enet | 7 | 0.08 | 4.2e-09 | -5.4 | 5.9 | 4.2e-09 | 0.66 | 0.62 | 0.38 | FALSE |
16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FES | 0.13 | 0.16 | lasso | 2 | 0.14 | 6.1e-10 | -5.4 | 5.3 | 1.0e-07 | 0.61 | 0.81 | 0.19 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FES | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.1e-09 | -5.4 | 5.7 | 1.3e-08 | 0.65 | 0.44 | 0.56 | FALSE |
18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FES | 0.04 | 0.01 | blup | 46 | 0.02 | 1.7e-02 | -6.0 | 7.4 | 1.0e-13 | 0.63 | 0.01 | 0.40 | TRUE |
19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FES | 0.32 | 0.26 | lasso | 2 | 0.25 | 2.0e-09 | -5.6 | 5.6 | 1.9e-08 | 0.62 | 0.72 | 0.26 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | -5.6 | 6.1 | 1.0e-09 | 0.72 | 0.85 | 0.15 | FALSE |